Incidental Mutation 'R1654:Vmn2r77'
| ID |
188930 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r77
|
| Ensembl Gene |
ENSMUSG00000090949 |
| Gene Name |
vomeronasal 2, receptor 77 |
| Synonyms |
EG546983 |
| MMRRC Submission |
039690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R1654 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 86461123 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 816
(S816R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
| AlphaFold |
L7N2B7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164996
AA Change: S816R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: S816R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
C |
T |
11: 109,688,225 (GRCm39) |
S90N |
probably benign |
Het |
| Apc2 |
C |
T |
10: 80,137,676 (GRCm39) |
T39I |
possibly damaging |
Het |
| Arfgef3 |
C |
T |
10: 18,500,896 (GRCm39) |
R1118K |
probably null |
Het |
| Arhgef12 |
T |
C |
9: 42,908,956 (GRCm39) |
D658G |
possibly damaging |
Het |
| Asph |
G |
T |
4: 9,453,315 (GRCm39) |
R736S |
probably benign |
Het |
| Bcas1 |
C |
T |
2: 170,191,166 (GRCm39) |
G542E |
probably damaging |
Het |
| Brd8 |
A |
T |
18: 34,744,279 (GRCm39) |
V183E |
probably damaging |
Het |
| C1rl |
G |
A |
6: 124,470,869 (GRCm39) |
G59E |
probably damaging |
Het |
| Cacna1i |
C |
A |
15: 80,273,411 (GRCm39) |
A1699D |
probably damaging |
Het |
| Card6 |
G |
T |
15: 5,128,214 (GRCm39) |
Q1061K |
probably benign |
Het |
| Cd163 |
G |
T |
6: 124,294,540 (GRCm39) |
C566F |
probably damaging |
Het |
| Cd84 |
C |
T |
1: 171,712,173 (GRCm39) |
T263I |
possibly damaging |
Het |
| Cep63 |
T |
C |
9: 102,464,112 (GRCm39) |
I740V |
possibly damaging |
Het |
| Chaf1b |
C |
A |
16: 93,691,791 (GRCm39) |
A279D |
probably damaging |
Het |
| Chsy3 |
A |
T |
18: 59,309,488 (GRCm39) |
Y247F |
probably damaging |
Het |
| Cpxm1 |
G |
A |
2: 130,235,466 (GRCm39) |
L509F |
possibly damaging |
Het |
| Disc1 |
A |
T |
8: 125,875,204 (GRCm39) |
Q558L |
possibly damaging |
Het |
| Dnah3 |
A |
T |
7: 119,525,672 (GRCm39) |
L3894Q |
probably damaging |
Het |
| Dnmt1 |
G |
T |
9: 20,847,870 (GRCm39) |
T105N |
possibly damaging |
Het |
| Dock6 |
A |
T |
9: 21,716,139 (GRCm39) |
L1732Q |
probably damaging |
Het |
| Dsc2 |
T |
C |
18: 20,179,303 (GRCm39) |
N255S |
probably benign |
Het |
| Dsel |
A |
T |
1: 111,790,242 (GRCm39) |
Y98N |
probably damaging |
Het |
| Enox1 |
T |
A |
14: 77,848,814 (GRCm39) |
I375N |
possibly damaging |
Het |
| Epha4 |
T |
A |
1: 77,351,405 (GRCm39) |
|
probably null |
Het |
| Fktn |
A |
G |
4: 53,761,220 (GRCm39) |
I446V |
probably benign |
Het |
| Garin4 |
T |
C |
1: 190,895,678 (GRCm39) |
R322G |
probably benign |
Het |
| Gm7361 |
G |
T |
5: 26,466,097 (GRCm39) |
R153L |
probably damaging |
Het |
| Grin2c |
C |
T |
11: 115,151,679 (GRCm39) |
V94I |
probably benign |
Het |
| Kalrn |
T |
G |
16: 33,796,108 (GRCm39) |
L1222F |
probably damaging |
Het |
| Krt80 |
T |
C |
15: 101,249,590 (GRCm39) |
K255E |
probably damaging |
Het |
| Lcn6 |
T |
A |
2: 25,570,787 (GRCm39) |
|
probably null |
Het |
| Lonp2 |
T |
G |
8: 87,358,078 (GRCm39) |
L100V |
probably damaging |
Het |
| Lyn |
G |
A |
4: 3,789,912 (GRCm39) |
A482T |
probably damaging |
Het |
| Mapk4 |
A |
G |
18: 74,064,010 (GRCm39) |
F404S |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,173,747 (GRCm39) |
|
probably null |
Het |
| Medag |
T |
C |
5: 149,345,600 (GRCm39) |
Y94H |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,037,911 (GRCm39) |
L809P |
possibly damaging |
Het |
| Mgam |
T |
C |
6: 40,734,421 (GRCm39) |
S743P |
probably damaging |
Het |
| Mia2 |
C |
A |
12: 59,155,619 (GRCm39) |
T445K |
possibly damaging |
Het |
| Mtcl3 |
A |
T |
10: 29,022,931 (GRCm39) |
|
probably null |
Het |
| Nars1 |
C |
G |
18: 64,645,120 (GRCm39) |
A43P |
probably damaging |
Het |
| Nav3 |
T |
C |
10: 109,688,984 (GRCm39) |
N431S |
possibly damaging |
Het |
| Ndufaf5 |
A |
G |
2: 140,019,220 (GRCm39) |
|
probably null |
Het |
| Nlrp1b |
T |
G |
11: 71,072,124 (GRCm39) |
E573A |
probably damaging |
Het |
| Nlrp3 |
T |
C |
11: 59,433,949 (GRCm39) |
V4A |
probably benign |
Het |
| Or2y1d |
G |
A |
11: 49,321,329 (GRCm39) |
G9R |
probably benign |
Het |
| Or56b2 |
A |
T |
7: 104,337,420 (GRCm39) |
Y66F |
probably benign |
Het |
| Or5ac15 |
T |
C |
16: 58,940,052 (GRCm39) |
N127S |
possibly damaging |
Het |
| Pcdhb12 |
A |
T |
18: 37,569,754 (GRCm39) |
D300V |
probably damaging |
Het |
| Pik3c2a |
A |
T |
7: 115,968,083 (GRCm39) |
C804S |
probably benign |
Het |
| Pkp4 |
A |
T |
2: 59,167,963 (GRCm39) |
Q725L |
probably damaging |
Het |
| Ptpre |
T |
A |
7: 135,255,657 (GRCm39) |
S119T |
probably benign |
Het |
| Ptprk |
G |
A |
10: 28,259,643 (GRCm39) |
R361H |
probably damaging |
Het |
| Ptprr |
T |
C |
10: 116,024,268 (GRCm39) |
V193A |
probably benign |
Het |
| Rfx2 |
C |
T |
17: 57,115,263 (GRCm39) |
A19T |
probably benign |
Het |
| Rgs4 |
T |
A |
1: 169,572,880 (GRCm39) |
M19L |
probably benign |
Het |
| Rnf157 |
T |
C |
11: 116,249,541 (GRCm39) |
H225R |
probably damaging |
Het |
| Rnf44 |
A |
T |
13: 54,829,592 (GRCm39) |
D341E |
possibly damaging |
Het |
| Sct |
T |
A |
7: 140,858,767 (GRCm39) |
Q55L |
probably damaging |
Het |
| Sh3rf1 |
A |
T |
8: 61,814,779 (GRCm39) |
H446L |
possibly damaging |
Het |
| Shisa3 |
A |
T |
5: 67,768,402 (GRCm39) |
I101F |
probably damaging |
Het |
| Slc6a13 |
A |
G |
6: 121,313,885 (GRCm39) |
I543V |
probably benign |
Het |
| Spef2 |
G |
A |
15: 9,634,738 (GRCm39) |
A1024V |
probably damaging |
Het |
| St6galnac6 |
T |
C |
2: 32,509,521 (GRCm39) |
S330P |
probably damaging |
Het |
| Stard9 |
G |
T |
2: 120,534,203 (GRCm39) |
A3487S |
probably benign |
Het |
| Suclg2 |
T |
C |
6: 95,632,532 (GRCm39) |
S46G |
probably damaging |
Het |
| Syne2 |
T |
C |
12: 76,147,868 (GRCm39) |
V6469A |
possibly damaging |
Het |
| Tada2b |
C |
T |
5: 36,641,139 (GRCm39) |
G88D |
probably damaging |
Het |
| Tll1 |
A |
T |
8: 64,570,937 (GRCm39) |
|
probably null |
Het |
| Tph2 |
T |
A |
10: 115,020,712 (GRCm39) |
H28L |
probably benign |
Het |
| Trmt6 |
C |
A |
2: 132,657,755 (GRCm39) |
V34L |
possibly damaging |
Het |
| Ttc22 |
A |
G |
4: 106,491,408 (GRCm39) |
T204A |
probably damaging |
Het |
| Umodl1 |
A |
T |
17: 31,206,942 (GRCm39) |
M778L |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,810,065 (GRCm39) |
H2282R |
probably damaging |
Het |
| Vps13c |
T |
A |
9: 67,858,969 (GRCm39) |
F2806L |
probably damaging |
Het |
| Zbtb4 |
C |
A |
11: 69,669,995 (GRCm39) |
A906D |
probably damaging |
Het |
| Zscan29 |
A |
G |
2: 120,995,260 (GRCm39) |
V421A |
probably benign |
Het |
|
| Other mutations in Vmn2r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGCAACAGACCACATTTGCCAT -3'
(R):5'- GTTCTAAagagagagagagagacagagagaca -3'
Sequencing Primer
(F):5'- GCTGATCTACACATGGTACATGG -3'
(R):5'- gagacagagagacagagatgatag -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation