Incidental Mutation 'R1654:Arhgef12'
| ID |
188943 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef12
|
| Ensembl Gene |
ENSMUSG00000059495 |
| Gene Name |
Rho guanine nucleotide exchange factor 12 |
| Synonyms |
2310014B11Rik, LARG |
| MMRRC Submission |
039690-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.931)
|
| Stock # |
R1654 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
42875138-43017069 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 42908956 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 658
(D658G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072767]
[ENSMUST00000165665]
|
| AlphaFold |
Q8R4H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072767
AA Change: D657G
PolyPhen 2
Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000072547
Gene: ENSMUSG00000059495
AA Change: D657G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
368 |
558 |
8.6e-87 |
PFAM |
|
low complexity region
|
583 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
733 |
N/A |
INTRINSIC |
|
RhoGEF
|
791 |
976 |
6.35e-66 |
SMART |
|
PH
|
1020 |
1134 |
6.26e-6 |
SMART |
|
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165665
AA Change: D658G
PolyPhen 2
Score 0.829 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000126598
Gene: ENSMUSG00000059495
AA Change: D658G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
369 |
559 |
1.6e-88 |
PFAM |
|
low complexity region
|
584 |
597 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
677 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
RhoGEF
|
792 |
977 |
6.35e-66 |
SMART |
|
PH
|
1021 |
1135 |
6.26e-6 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
C |
T |
11: 109,688,225 (GRCm39) |
S90N |
probably benign |
Het |
| Apc2 |
C |
T |
10: 80,137,676 (GRCm39) |
T39I |
possibly damaging |
Het |
| Arfgef3 |
C |
T |
10: 18,500,896 (GRCm39) |
R1118K |
probably null |
Het |
| Asph |
G |
T |
4: 9,453,315 (GRCm39) |
R736S |
probably benign |
Het |
| Bcas1 |
C |
T |
2: 170,191,166 (GRCm39) |
G542E |
probably damaging |
Het |
| Brd8 |
A |
T |
18: 34,744,279 (GRCm39) |
V183E |
probably damaging |
Het |
| C1rl |
G |
A |
6: 124,470,869 (GRCm39) |
G59E |
probably damaging |
Het |
| Cacna1i |
C |
A |
15: 80,273,411 (GRCm39) |
A1699D |
probably damaging |
Het |
| Card6 |
G |
T |
15: 5,128,214 (GRCm39) |
Q1061K |
probably benign |
Het |
| Cd163 |
G |
T |
6: 124,294,540 (GRCm39) |
C566F |
probably damaging |
Het |
| Cd84 |
C |
T |
1: 171,712,173 (GRCm39) |
T263I |
possibly damaging |
Het |
| Cep63 |
T |
C |
9: 102,464,112 (GRCm39) |
I740V |
possibly damaging |
Het |
| Chaf1b |
C |
A |
16: 93,691,791 (GRCm39) |
A279D |
probably damaging |
Het |
| Chsy3 |
A |
T |
18: 59,309,488 (GRCm39) |
Y247F |
probably damaging |
Het |
| Cpxm1 |
G |
A |
2: 130,235,466 (GRCm39) |
L509F |
possibly damaging |
Het |
| Disc1 |
A |
T |
8: 125,875,204 (GRCm39) |
Q558L |
possibly damaging |
Het |
| Dnah3 |
A |
T |
7: 119,525,672 (GRCm39) |
L3894Q |
probably damaging |
Het |
| Dnmt1 |
G |
T |
9: 20,847,870 (GRCm39) |
T105N |
possibly damaging |
Het |
| Dock6 |
A |
T |
9: 21,716,139 (GRCm39) |
L1732Q |
probably damaging |
Het |
| Dsc2 |
T |
C |
18: 20,179,303 (GRCm39) |
N255S |
probably benign |
Het |
| Dsel |
A |
T |
1: 111,790,242 (GRCm39) |
Y98N |
probably damaging |
Het |
| Enox1 |
T |
A |
14: 77,848,814 (GRCm39) |
I375N |
possibly damaging |
Het |
| Epha4 |
T |
A |
1: 77,351,405 (GRCm39) |
|
probably null |
Het |
| Fktn |
A |
G |
4: 53,761,220 (GRCm39) |
I446V |
probably benign |
Het |
| Garin4 |
T |
C |
1: 190,895,678 (GRCm39) |
R322G |
probably benign |
Het |
| Gm7361 |
G |
T |
5: 26,466,097 (GRCm39) |
R153L |
probably damaging |
Het |
| Grin2c |
C |
T |
11: 115,151,679 (GRCm39) |
V94I |
probably benign |
Het |
| Kalrn |
T |
G |
16: 33,796,108 (GRCm39) |
L1222F |
probably damaging |
Het |
| Krt80 |
T |
C |
15: 101,249,590 (GRCm39) |
K255E |
probably damaging |
Het |
| Lcn6 |
T |
A |
2: 25,570,787 (GRCm39) |
|
probably null |
Het |
| Lonp2 |
T |
G |
8: 87,358,078 (GRCm39) |
L100V |
probably damaging |
Het |
| Lyn |
G |
A |
4: 3,789,912 (GRCm39) |
A482T |
probably damaging |
Het |
| Mapk4 |
A |
G |
18: 74,064,010 (GRCm39) |
F404S |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,173,747 (GRCm39) |
|
probably null |
Het |
| Medag |
T |
C |
5: 149,345,600 (GRCm39) |
Y94H |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,037,911 (GRCm39) |
L809P |
possibly damaging |
Het |
| Mgam |
T |
C |
6: 40,734,421 (GRCm39) |
S743P |
probably damaging |
Het |
| Mia2 |
C |
A |
12: 59,155,619 (GRCm39) |
T445K |
possibly damaging |
Het |
| Mtcl3 |
A |
T |
10: 29,022,931 (GRCm39) |
|
probably null |
Het |
| Nars1 |
C |
G |
18: 64,645,120 (GRCm39) |
A43P |
probably damaging |
Het |
| Nav3 |
T |
C |
10: 109,688,984 (GRCm39) |
N431S |
possibly damaging |
Het |
| Ndufaf5 |
A |
G |
2: 140,019,220 (GRCm39) |
|
probably null |
Het |
| Nlrp1b |
T |
G |
11: 71,072,124 (GRCm39) |
E573A |
probably damaging |
Het |
| Nlrp3 |
T |
C |
11: 59,433,949 (GRCm39) |
V4A |
probably benign |
Het |
| Or2y1d |
G |
A |
11: 49,321,329 (GRCm39) |
G9R |
probably benign |
Het |
| Or56b2 |
A |
T |
7: 104,337,420 (GRCm39) |
Y66F |
probably benign |
Het |
| Or5ac15 |
T |
C |
16: 58,940,052 (GRCm39) |
N127S |
possibly damaging |
Het |
| Pcdhb12 |
A |
T |
18: 37,569,754 (GRCm39) |
D300V |
probably damaging |
Het |
| Pik3c2a |
A |
T |
7: 115,968,083 (GRCm39) |
C804S |
probably benign |
Het |
| Pkp4 |
A |
T |
2: 59,167,963 (GRCm39) |
Q725L |
probably damaging |
Het |
| Ptpre |
T |
A |
7: 135,255,657 (GRCm39) |
S119T |
probably benign |
Het |
| Ptprk |
G |
A |
10: 28,259,643 (GRCm39) |
R361H |
probably damaging |
Het |
| Ptprr |
T |
C |
10: 116,024,268 (GRCm39) |
V193A |
probably benign |
Het |
| Rfx2 |
C |
T |
17: 57,115,263 (GRCm39) |
A19T |
probably benign |
Het |
| Rgs4 |
T |
A |
1: 169,572,880 (GRCm39) |
M19L |
probably benign |
Het |
| Rnf157 |
T |
C |
11: 116,249,541 (GRCm39) |
H225R |
probably damaging |
Het |
| Rnf44 |
A |
T |
13: 54,829,592 (GRCm39) |
D341E |
possibly damaging |
Het |
| Sct |
T |
A |
7: 140,858,767 (GRCm39) |
Q55L |
probably damaging |
Het |
| Sh3rf1 |
A |
T |
8: 61,814,779 (GRCm39) |
H446L |
possibly damaging |
Het |
| Shisa3 |
A |
T |
5: 67,768,402 (GRCm39) |
I101F |
probably damaging |
Het |
| Slc6a13 |
A |
G |
6: 121,313,885 (GRCm39) |
I543V |
probably benign |
Het |
| Spef2 |
G |
A |
15: 9,634,738 (GRCm39) |
A1024V |
probably damaging |
Het |
| St6galnac6 |
T |
C |
2: 32,509,521 (GRCm39) |
S330P |
probably damaging |
Het |
| Stard9 |
G |
T |
2: 120,534,203 (GRCm39) |
A3487S |
probably benign |
Het |
| Suclg2 |
T |
C |
6: 95,632,532 (GRCm39) |
S46G |
probably damaging |
Het |
| Syne2 |
T |
C |
12: 76,147,868 (GRCm39) |
V6469A |
possibly damaging |
Het |
| Tada2b |
C |
T |
5: 36,641,139 (GRCm39) |
G88D |
probably damaging |
Het |
| Tll1 |
A |
T |
8: 64,570,937 (GRCm39) |
|
probably null |
Het |
| Tph2 |
T |
A |
10: 115,020,712 (GRCm39) |
H28L |
probably benign |
Het |
| Trmt6 |
C |
A |
2: 132,657,755 (GRCm39) |
V34L |
possibly damaging |
Het |
| Ttc22 |
A |
G |
4: 106,491,408 (GRCm39) |
T204A |
probably damaging |
Het |
| Umodl1 |
A |
T |
17: 31,206,942 (GRCm39) |
M778L |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,810,065 (GRCm39) |
H2282R |
probably damaging |
Het |
| Vmn2r77 |
T |
A |
7: 86,461,123 (GRCm39) |
S816R |
probably damaging |
Het |
| Vps13c |
T |
A |
9: 67,858,969 (GRCm39) |
F2806L |
probably damaging |
Het |
| Zbtb4 |
C |
A |
11: 69,669,995 (GRCm39) |
A906D |
probably damaging |
Het |
| Zscan29 |
A |
G |
2: 120,995,260 (GRCm39) |
V421A |
probably benign |
Het |
|
| Other mutations in Arhgef12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Arhgef12
|
APN |
9 |
42,931,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arhgef12
|
APN |
9 |
42,893,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01529:Arhgef12
|
APN |
9 |
42,901,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Arhgef12
|
APN |
9 |
42,934,137 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02039:Arhgef12
|
APN |
9 |
42,883,563 (GRCm39) |
missense |
probably benign |
|
|
IGL02135:Arhgef12
|
APN |
9 |
42,883,461 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02272:Arhgef12
|
APN |
9 |
42,912,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Arhgef12
|
APN |
9 |
42,893,339 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02507:Arhgef12
|
APN |
9 |
42,903,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02574:Arhgef12
|
APN |
9 |
42,916,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Arhgef12
|
APN |
9 |
42,917,200 (GRCm39) |
nonsense |
probably null |
|
|
IGL02803:Arhgef12
|
APN |
9 |
42,883,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02892:Arhgef12
|
APN |
9 |
42,912,268 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02937:Arhgef12
|
APN |
9 |
42,927,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02992:Arhgef12
|
APN |
9 |
42,910,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Arhgef12
|
APN |
9 |
42,937,524 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03146:Arhgef12
|
APN |
9 |
42,885,866 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03193:Arhgef12
|
APN |
9 |
42,903,829 (GRCm39) |
splice site |
probably benign |
|
|
IGL03398:Arhgef12
|
APN |
9 |
42,889,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Arhgef12
|
UTSW |
9 |
42,889,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0143:Arhgef12
|
UTSW |
9 |
42,916,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arhgef12
|
UTSW |
9 |
42,883,300 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0330:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0364:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0426:Arhgef12
|
UTSW |
9 |
42,882,286 (GRCm39) |
splice site |
probably null |
|
|
R0658:Arhgef12
|
UTSW |
9 |
42,893,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Arhgef12
|
UTSW |
9 |
42,904,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0693:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0990:Arhgef12
|
UTSW |
9 |
42,883,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Arhgef12
|
UTSW |
9 |
42,955,552 (GRCm39) |
unclassified |
probably benign |
|
|
R1395:Arhgef12
|
UTSW |
9 |
42,917,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arhgef12
|
UTSW |
9 |
42,938,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Arhgef12
|
UTSW |
9 |
42,903,874 (GRCm39) |
splice site |
probably benign |
|
|
R1458:Arhgef12
|
UTSW |
9 |
42,900,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1722:Arhgef12
|
UTSW |
9 |
42,932,013 (GRCm39) |
makesense |
probably null |
|
|
R1773:Arhgef12
|
UTSW |
9 |
42,916,838 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1895:Arhgef12
|
UTSW |
9 |
42,917,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Arhgef12
|
UTSW |
9 |
42,890,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2215:Arhgef12
|
UTSW |
9 |
42,917,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Arhgef12
|
UTSW |
9 |
42,912,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3967:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3968:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4111:Arhgef12
|
UTSW |
9 |
42,883,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Arhgef12
|
UTSW |
9 |
42,929,645 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Arhgef12
|
UTSW |
9 |
42,886,525 (GRCm39) |
nonsense |
probably null |
|
|
R4462:Arhgef12
|
UTSW |
9 |
42,893,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Arhgef12
|
UTSW |
9 |
42,888,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4603:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4650:Arhgef12
|
UTSW |
9 |
42,893,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Arhgef12
|
UTSW |
9 |
42,883,449 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4823:Arhgef12
|
UTSW |
9 |
42,931,992 (GRCm39) |
missense |
probably benign |
|
|
R4840:Arhgef12
|
UTSW |
9 |
42,886,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4912:Arhgef12
|
UTSW |
9 |
42,904,361 (GRCm39) |
nonsense |
probably null |
|
|
R5176:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5426:Arhgef12
|
UTSW |
9 |
42,897,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5838:Arhgef12
|
UTSW |
9 |
42,916,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Arhgef12
|
UTSW |
9 |
42,900,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6741:Arhgef12
|
UTSW |
9 |
42,883,503 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6959:Arhgef12
|
UTSW |
9 |
42,927,249 (GRCm39) |
missense |
probably benign |
|
|
R7252:Arhgef12
|
UTSW |
9 |
42,927,205 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7470:Arhgef12
|
UTSW |
9 |
42,951,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7658:Arhgef12
|
UTSW |
9 |
42,903,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7724:Arhgef12
|
UTSW |
9 |
42,938,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Arhgef12
|
UTSW |
9 |
42,882,595 (GRCm39) |
nonsense |
probably null |
|
|
R8074:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R8155:Arhgef12
|
UTSW |
9 |
42,953,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8270:Arhgef12
|
UTSW |
9 |
42,882,354 (GRCm39) |
missense |
probably benign |
|
|
R8407:Arhgef12
|
UTSW |
9 |
42,937,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8527:Arhgef12
|
UTSW |
9 |
42,908,944 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9116:Arhgef12
|
UTSW |
9 |
42,893,241 (GRCm39) |
splice site |
probably benign |
|
|
R9127:Arhgef12
|
UTSW |
9 |
42,885,870 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9602:Arhgef12
|
UTSW |
9 |
42,895,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Arhgef12
|
UTSW |
9 |
42,929,650 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9733:Arhgef12
|
UTSW |
9 |
42,901,294 (GRCm39) |
nonsense |
probably null |
|
|
R9735:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R9760:Arhgef12
|
UTSW |
9 |
42,903,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Arhgef12
|
UTSW |
9 |
42,901,285 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1176:Arhgef12
|
UTSW |
9 |
42,882,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1186:Arhgef12
|
UTSW |
9 |
42,911,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTCTGGCTCTTGAAGGTGACTC -3'
(R):5'- CGCTCTGCAACACATGCTTCTGAC -3'
Sequencing Primer
(F):5'- ctcttgaAGGTGACTCTGGCTC -3'
(R):5'- AACACATGCTTCTGACCATTG -3'
|
| Posted On |
2014-05-09 |
Incidental Mutation