Incidental Mutation 'R1655:Virma'
ID 189008
Institutional Source Beutler Lab
Gene Symbol Virma
Ensembl Gene ENSMUSG00000040720
Gene Name vir like m6A methyltransferase associated
Synonyms 1110037F02Rik
MMRRC Submission 039691-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1655 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 11485958-11550684 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 11494786 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 29 (V29A)
Ref Sequence ENSEMBL: ENSMUSP00000103943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055372] [ENSMUST00000059914] [ENSMUST00000108307]
AlphaFold A2AIV2
Predicted Effect probably damaging
Transcript: ENSMUST00000055372
AA Change: V29A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000063188
Gene: ENSMUSG00000040720
AA Change: V29A

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000059914
AA Change: V29A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000058078
Gene: ENSMUSG00000040720
AA Change: V29A

DomainStartEndE-ValueType
low complexity region 139 153 N/A INTRINSIC
low complexity region 172 198 N/A INTRINSIC
low complexity region 236 267 N/A INTRINSIC
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1008 1020 N/A INTRINSIC
low complexity region 1112 1124 N/A INTRINSIC
low complexity region 1224 1232 N/A INTRINSIC
low complexity region 1443 1458 N/A INTRINSIC
low complexity region 1460 1474 N/A INTRINSIC
low complexity region 1618 1634 N/A INTRINSIC
low complexity region 1684 1697 N/A INTRINSIC
low complexity region 1750 1757 N/A INTRINSIC
low complexity region 1796 1808 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108307
AA Change: V29A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000103943
Gene: ENSMUSG00000040720
AA Change: V29A

DomainStartEndE-ValueType
Pfam:VIR_N 5 266 2e-110 PFAM
low complexity region 276 297 N/A INTRINSIC
low complexity region 615 625 N/A INTRINSIC
low complexity region 1058 1070 N/A INTRINSIC
low complexity region 1162 1174 N/A INTRINSIC
low complexity region 1274 1282 N/A INTRINSIC
low complexity region 1493 1508 N/A INTRINSIC
low complexity region 1510 1524 N/A INTRINSIC
low complexity region 1668 1684 N/A INTRINSIC
low complexity region 1734 1747 N/A INTRINSIC
low complexity region 1800 1807 N/A INTRINSIC
low complexity region 1846 1858 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833427G06Rik A T 9: 51,083,621 (GRCm38) I136N probably damaging Het
9530053A07Rik A T 7: 28,147,110 (GRCm38) N1076Y probably damaging Het
A730061H03Rik A T 14: 55,560,333 (GRCm38) probably benign Het
Abca1 C T 4: 53,050,964 (GRCm38) A1582T probably benign Het
Acot8 A T 2: 164,803,108 (GRCm38) S52T probably benign Het
Atcay C T 10: 81,213,397 (GRCm38) V124M probably damaging Het
Cep295 C T 9: 15,340,883 (GRCm38) E397K probably damaging Het
Cfap46 A T 7: 139,642,520 (GRCm38) Y1180* probably null Het
Clptm1 T A 7: 19,645,867 (GRCm38) H148L probably benign Het
Clstn3 A G 6: 124,437,427 (GRCm38) L743P probably damaging Het
Crtc3 A T 7: 80,598,776 (GRCm38) M313K possibly damaging Het
Csgalnact1 T A 8: 68,373,689 (GRCm38) I326F possibly damaging Het
Dennd6b G T 15: 89,196,340 (GRCm38) T19K unknown Het
Disp1 A T 1: 183,087,004 (GRCm38) I1284N probably benign Het
Dnah2 A G 11: 69,473,854 (GRCm38) Y1992H probably damaging Het
Dnah6 C T 6: 73,205,732 (GRCm38) V205I possibly damaging Het
Dst G T 1: 34,282,576 (GRCm38) G4391* probably null Het
Dytn A G 1: 63,661,198 (GRCm38) S258P probably damaging Het
Emilin3 T A 2: 160,910,866 (GRCm38) probably null Het
Ermn C T 2: 58,052,584 (GRCm38) V45I probably benign Het
Fat4 T C 3: 38,957,318 (GRCm38) V2189A probably damaging Het
Filip1l T C 16: 57,571,851 (GRCm38) I934T probably damaging Het
Gbp9 T A 5: 105,081,692 (GRCm38) Q472L possibly damaging Het
Gimap5 G T 6: 48,753,176 (GRCm38) E227* probably null Het
Gsdmc C T 15: 63,780,043 (GRCm38) V240M probably benign Het
H2-Q4 G T 17: 35,382,905 (GRCm38) V248F probably damaging Het
Helz2 T C 2: 181,234,147 (GRCm38) E1518G probably damaging Het
Hmcn1 A G 1: 150,630,333 (GRCm38) V3814A probably benign Het
Ifna7 A G 4: 88,816,660 (GRCm38) T145A probably benign Het
Itgam T A 7: 128,115,163 (GRCm38) M947K probably benign Het
Itpr2 T G 6: 146,376,148 (GRCm38) N608H probably damaging Het
Klra2 T A 6: 131,220,211 (GRCm38) N242I probably damaging Het
Lonrf2 A T 1: 38,811,824 (GRCm38) L219Q probably damaging Het
Ly6c2 T C 15: 75,108,563 (GRCm38) I126V probably benign Het
Mr1 G A 1: 155,132,455 (GRCm38) T258M probably benign Het
Mrps35 T G 6: 147,060,228 (GRCm38) D200E possibly damaging Het
Nbeal2 A C 9: 110,632,872 (GRCm38) S1506A probably damaging Het
Ncoa7 T C 10: 30,698,245 (GRCm38) probably null Het
Nlrp4a A T 7: 26,449,651 (GRCm38) I228F possibly damaging Het
Olfr1047 A G 2: 86,228,080 (GRCm38) V297A possibly damaging Het
Olfr1339 A G 4: 118,734,999 (GRCm38) S157G probably benign Het
Olfr368 A G 2: 37,331,939 (GRCm38) Y64C probably damaging Het
Olfr483 A T 7: 108,103,464 (GRCm38) I52F probably damaging Het
Paxx T C 2: 25,460,316 (GRCm38) E93G probably damaging Het
Per2 C A 1: 91,448,768 (GRCm38) G128W probably damaging Het
Piezo1 A G 8: 122,496,822 (GRCm38) I796T probably benign Het
Pkhd1 A G 1: 20,584,129 (GRCm38) S235P probably damaging Het
Pole T A 5: 110,335,922 (GRCm38) F259Y probably damaging Het
Pus7 T A 5: 23,747,800 (GRCm38) K512* probably null Het
Ralyl A T 3: 14,107,236 (GRCm38) Y55F probably damaging Het
Rgs14 T A 13: 55,383,534 (GRCm38) M451K probably benign Het
Rhag T C 17: 40,831,596 (GRCm38) F231L probably damaging Het
Ric8a T C 7: 140,860,895 (GRCm38) C94R probably benign Het
Rictor T A 15: 6,772,212 (GRCm38) D460E probably benign Het
Rpn1 T C 6: 88,100,944 (GRCm38) V454A possibly damaging Het
Sacs A G 14: 61,191,782 (GRCm38) D427G probably benign Het
Scai A T 2: 39,080,117 (GRCm38) V545D possibly damaging Het
Serpinb3a A G 1: 107,046,212 (GRCm38) V323A probably damaging Het
Slc13a5 C A 11: 72,257,378 (GRCm38) C277F probably benign Het
Slc15a1 A T 14: 121,465,899 (GRCm38) Y557N probably benign Het
Slc34a2 T C 5: 53,069,419 (GRCm38) V628A probably benign Het
Slc8a2 G T 7: 16,141,135 (GRCm38) G436V probably damaging Het
Sphkap G A 1: 83,277,515 (GRCm38) R838* probably null Het
Supt5 T C 7: 28,330,024 (GRCm38) I103V probably benign Het
Tdrd1 T A 19: 56,843,216 (GRCm38) Y346* probably null Het
Tg T G 15: 66,828,568 (GRCm38) probably null Het
Top1 T A 2: 160,703,696 (GRCm38) probably null Het
Trmt12 T C 15: 58,873,227 (GRCm38) L158P probably damaging Het
Tssk4 A G 14: 55,651,695 (GRCm38) N226S probably damaging Het
Unc80 G T 1: 66,672,756 (GRCm38) V2746F possibly damaging Het
Usp34 T A 11: 23,375,051 (GRCm38) V999E probably benign Het
Zfp40 A T 17: 23,177,266 (GRCm38) Y48N probably benign Het
Zfp609 A G 9: 65,703,554 (GRCm38) V709A possibly damaging Het
Other mutations in Virma
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Virma APN 4 11,519,424 (GRCm38) splice site probably benign
IGL00477:Virma APN 4 11,519,006 (GRCm38) missense probably damaging 0.99
IGL01293:Virma APN 4 11,521,114 (GRCm38) missense probably damaging 1.00
IGL01410:Virma APN 4 11,518,929 (GRCm38) nonsense probably null
IGL01531:Virma APN 4 11,528,753 (GRCm38) missense probably damaging 1.00
IGL01672:Virma APN 4 11,527,792 (GRCm38) missense probably damaging 1.00
IGL01724:Virma APN 4 11,528,672 (GRCm38) missense probably damaging 1.00
IGL01747:Virma APN 4 11,526,877 (GRCm38) missense probably damaging 1.00
IGL01776:Virma APN 4 11,527,792 (GRCm38) missense probably damaging 1.00
IGL02064:Virma APN 4 11,513,163 (GRCm38) missense possibly damaging 0.87
IGL02243:Virma APN 4 11,546,031 (GRCm38) missense probably damaging 1.00
IGL02244:Virma APN 4 11,546,031 (GRCm38) missense probably damaging 1.00
IGL02445:Virma APN 4 11,527,029 (GRCm38) missense probably damaging 0.97
IGL02546:Virma APN 4 11,494,804 (GRCm38) missense probably damaging 0.99
IGL02807:Virma APN 4 11,507,079 (GRCm38) splice site probably benign
IGL02967:Virma APN 4 11,514,096 (GRCm38) missense probably benign 0.01
IGL03211:Virma APN 4 11,548,770 (GRCm38) nonsense probably null
IGL03242:Virma APN 4 11,527,669 (GRCm38) missense possibly damaging 0.70
IGL03256:Virma APN 4 11,542,207 (GRCm38) splice site probably benign
IGL03327:Virma APN 4 11,518,984 (GRCm38) missense probably benign 0.00
IGL03346:Virma APN 4 11,518,984 (GRCm38) missense probably benign 0.00
PIT4802001:Virma UTSW 4 11,546,008 (GRCm38) missense probably damaging 0.99
R0142:Virma UTSW 4 11,548,783 (GRCm38) missense probably benign 0.04
R0355:Virma UTSW 4 11,528,626 (GRCm38) nonsense probably null
R0522:Virma UTSW 4 11,519,416 (GRCm38) critical splice donor site probably null
R0600:Virma UTSW 4 11,498,769 (GRCm38) missense probably damaging 0.99
R1435:Virma UTSW 4 11,528,621 (GRCm38) missense probably damaging 1.00
R1489:Virma UTSW 4 11,521,164 (GRCm38) missense probably damaging 1.00
R1568:Virma UTSW 4 11,528,776 (GRCm38) missense probably damaging 0.99
R1616:Virma UTSW 4 11,544,954 (GRCm38) missense probably damaging 1.00
R1695:Virma UTSW 4 11,494,814 (GRCm38) missense probably damaging 0.98
R1835:Virma UTSW 4 11,540,511 (GRCm38) missense probably benign 0.02
R1951:Virma UTSW 4 11,513,907 (GRCm38) missense probably benign 0.00
R1991:Virma UTSW 4 11,519,242 (GRCm38) missense probably benign 0.06
R2145:Virma UTSW 4 11,548,726 (GRCm38) splice site probably benign
R2172:Virma UTSW 4 11,527,843 (GRCm38) missense possibly damaging 0.82
R2217:Virma UTSW 4 11,544,924 (GRCm38) missense probably damaging 1.00
R2218:Virma UTSW 4 11,544,924 (GRCm38) missense probably damaging 1.00
R2248:Virma UTSW 4 11,518,927 (GRCm38) missense probably damaging 1.00
R2342:Virma UTSW 4 11,501,316 (GRCm38) missense probably damaging 1.00
R3424:Virma UTSW 4 11,513,177 (GRCm38) nonsense probably null
R4397:Virma UTSW 4 11,513,901 (GRCm38) missense possibly damaging 0.81
R4449:Virma UTSW 4 11,498,828 (GRCm38) critical splice donor site probably null
R4660:Virma UTSW 4 11,513,505 (GRCm38) missense probably damaging 1.00
R4698:Virma UTSW 4 11,528,636 (GRCm38) missense probably damaging 0.99
R4878:Virma UTSW 4 11,544,971 (GRCm38) missense probably damaging 1.00
R4937:Virma UTSW 4 11,521,147 (GRCm38) nonsense probably null
R5031:Virma UTSW 4 11,542,116 (GRCm38) nonsense probably null
R5040:Virma UTSW 4 11,528,746 (GRCm38) missense probably benign 0.01
R5061:Virma UTSW 4 11,494,840 (GRCm38) missense possibly damaging 0.95
R5091:Virma UTSW 4 11,519,392 (GRCm38) missense probably benign 0.00
R5137:Virma UTSW 4 11,546,297 (GRCm38) missense probably damaging 1.00
R5262:Virma UTSW 4 11,539,926 (GRCm38) missense probably benign 0.01
R5297:Virma UTSW 4 11,494,819 (GRCm38) missense probably damaging 1.00
R5730:Virma UTSW 4 11,542,154 (GRCm38) missense probably benign 0.44
R5818:Virma UTSW 4 11,513,319 (GRCm38) missense possibly damaging 0.92
R5835:Virma UTSW 4 11,514,036 (GRCm38) missense probably damaging 1.00
R6125:Virma UTSW 4 11,521,172 (GRCm38) missense probably damaging 0.98
R6197:Virma UTSW 4 11,505,498 (GRCm38) missense probably damaging 0.96
R6222:Virma UTSW 4 11,527,820 (GRCm38) missense probably damaging 1.00
R6793:Virma UTSW 4 11,539,968 (GRCm38) missense probably damaging 1.00
R7028:Virma UTSW 4 11,519,249 (GRCm38) missense possibly damaging 0.50
R7356:Virma UTSW 4 11,513,595 (GRCm38) missense probably damaging 0.99
R7383:Virma UTSW 4 11,514,026 (GRCm38) missense probably damaging 0.98
R7391:Virma UTSW 4 11,508,099 (GRCm38) missense probably damaging 0.99
R7425:Virma UTSW 4 11,546,211 (GRCm38) missense possibly damaging 0.95
R7556:Virma UTSW 4 11,518,927 (GRCm38) missense probably damaging 1.00
R7715:Virma UTSW 4 11,513,016 (GRCm38) splice site probably null
R7715:Virma UTSW 4 11,549,682 (GRCm38) missense probably damaging 1.00
R7986:Virma UTSW 4 11,540,023 (GRCm38) missense probably benign 0.01
R7990:Virma UTSW 4 11,513,983 (GRCm38) missense probably benign 0.00
R8048:Virma UTSW 4 11,539,918 (GRCm38) nonsense probably null
R8050:Virma UTSW 4 11,528,643 (GRCm38) missense probably benign 0.22
R8165:Virma UTSW 4 11,542,128 (GRCm38) missense probably benign 0.00
R8412:Virma UTSW 4 11,521,261 (GRCm38) critical splice donor site probably null
R8544:Virma UTSW 4 11,516,949 (GRCm38) missense probably benign
R8551:Virma UTSW 4 11,513,397 (GRCm38) missense probably damaging 1.00
R8699:Virma UTSW 4 11,528,678 (GRCm38) missense probably benign 0.04
R8739:Virma UTSW 4 11,540,643 (GRCm38) critical splice donor site probably null
R8950:Virma UTSW 4 11,519,047 (GRCm38) nonsense probably null
R9015:Virma UTSW 4 11,540,494 (GRCm38) missense probably benign 0.27
R9038:Virma UTSW 4 11,526,922 (GRCm38) missense possibly damaging 0.93
R9115:Virma UTSW 4 11,498,744 (GRCm38) missense probably benign 0.15
R9294:Virma UTSW 4 11,513,507 (GRCm38) nonsense probably null
R9404:Virma UTSW 4 11,513,626 (GRCm38) missense probably benign 0.17
R9477:Virma UTSW 4 11,528,753 (GRCm38) missense probably damaging 1.00
R9532:Virma UTSW 4 11,507,078 (GRCm38) critical splice donor site probably null
R9649:Virma UTSW 4 11,486,045 (GRCm38) start codon destroyed probably null 0.08
R9657:Virma UTSW 4 11,544,898 (GRCm38) missense probably damaging 0.99
R9780:Virma UTSW 4 11,513,442 (GRCm38) missense possibly damaging 0.75
R9800:Virma UTSW 4 11,546,007 (GRCm38) missense probably damaging 0.99
X0020:Virma UTSW 4 11,486,055 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGTTTTAGTGATGAGGGTTCAACCCAG -3'
(R):5'- TCTATCTCCAACACATAGGGGCTGC -3'

Sequencing Primer
(F):5'- cccaagtgccaggattagag -3'
(R):5'- CTCTGTTGTCAGGTAAGCCA -3'
Posted On 2014-05-09