Incidental Mutation 'R1655:Olfr1339'
ID 189011
Institutional Source Beutler Lab
Gene Symbol Olfr1339
Ensembl Gene ENSMUSG00000070820
Gene Name olfactory receptor 1339
Synonyms GA_x6K02T2QD9B-18815145-18814198, MOR258-2
MMRRC Submission 039691-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R1655 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 118732175-118736906 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118734999 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 157 (S157G)
Ref Sequence ENSEMBL: ENSMUSP00000148988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094832] [ENSMUST00000217522]
AlphaFold Q8VGB1
Predicted Effect probably benign
Transcript: ENSMUST00000094832
AA Change: S157G

PolyPhen 2 Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000092428
Gene: ENSMUSG00000070820
AA Change: S157G

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 307 4.1e-7 PFAM
Pfam:7tm_1 44 293 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217522
AA Change: S157G

PolyPhen 2 Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833427G06Rik A T 9: 51,083,621 (GRCm38) I136N probably damaging Het
9530053A07Rik A T 7: 28,147,110 (GRCm38) N1076Y probably damaging Het
A730061H03Rik A T 14: 55,560,333 (GRCm38) probably benign Het
Abca1 C T 4: 53,050,964 (GRCm38) A1582T probably benign Het
Acot8 A T 2: 164,803,108 (GRCm38) S52T probably benign Het
Atcay C T 10: 81,213,397 (GRCm38) V124M probably damaging Het
Cep295 C T 9: 15,340,883 (GRCm38) E397K probably damaging Het
Cfap46 A T 7: 139,642,520 (GRCm38) Y1180* probably null Het
Clptm1 T A 7: 19,645,867 (GRCm38) H148L probably benign Het
Clstn3 A G 6: 124,437,427 (GRCm38) L743P probably damaging Het
Crtc3 A T 7: 80,598,776 (GRCm38) M313K possibly damaging Het
Csgalnact1 T A 8: 68,373,689 (GRCm38) I326F possibly damaging Het
Dennd6b G T 15: 89,196,340 (GRCm38) T19K unknown Het
Disp1 A T 1: 183,087,004 (GRCm38) I1284N probably benign Het
Dnah2 A G 11: 69,473,854 (GRCm38) Y1992H probably damaging Het
Dnah6 C T 6: 73,205,732 (GRCm38) V205I possibly damaging Het
Dst G T 1: 34,282,576 (GRCm38) G4391* probably null Het
Dytn A G 1: 63,661,198 (GRCm38) S258P probably damaging Het
Emilin3 T A 2: 160,910,866 (GRCm38) probably null Het
Ermn C T 2: 58,052,584 (GRCm38) V45I probably benign Het
Fat4 T C 3: 38,957,318 (GRCm38) V2189A probably damaging Het
Filip1l T C 16: 57,571,851 (GRCm38) I934T probably damaging Het
Gbp9 T A 5: 105,081,692 (GRCm38) Q472L possibly damaging Het
Gimap5 G T 6: 48,753,176 (GRCm38) E227* probably null Het
Gsdmc C T 15: 63,780,043 (GRCm38) V240M probably benign Het
H2-Q4 G T 17: 35,382,905 (GRCm38) V248F probably damaging Het
Helz2 T C 2: 181,234,147 (GRCm38) E1518G probably damaging Het
Hmcn1 A G 1: 150,630,333 (GRCm38) V3814A probably benign Het
Ifna7 A G 4: 88,816,660 (GRCm38) T145A probably benign Het
Itgam T A 7: 128,115,163 (GRCm38) M947K probably benign Het
Itpr2 T G 6: 146,376,148 (GRCm38) N608H probably damaging Het
Klra2 T A 6: 131,220,211 (GRCm38) N242I probably damaging Het
Lonrf2 A T 1: 38,811,824 (GRCm38) L219Q probably damaging Het
Ly6c2 T C 15: 75,108,563 (GRCm38) I126V probably benign Het
Mr1 G A 1: 155,132,455 (GRCm38) T258M probably benign Het
Mrps35 T G 6: 147,060,228 (GRCm38) D200E possibly damaging Het
Nbeal2 A C 9: 110,632,872 (GRCm38) S1506A probably damaging Het
Ncoa7 T C 10: 30,698,245 (GRCm38) probably null Het
Nlrp4a A T 7: 26,449,651 (GRCm38) I228F possibly damaging Het
Olfr1047 A G 2: 86,228,080 (GRCm38) V297A possibly damaging Het
Olfr368 A G 2: 37,331,939 (GRCm38) Y64C probably damaging Het
Olfr483 A T 7: 108,103,464 (GRCm38) I52F probably damaging Het
Paxx T C 2: 25,460,316 (GRCm38) E93G probably damaging Het
Per2 C A 1: 91,448,768 (GRCm38) G128W probably damaging Het
Piezo1 A G 8: 122,496,822 (GRCm38) I796T probably benign Het
Pkhd1 A G 1: 20,584,129 (GRCm38) S235P probably damaging Het
Pole T A 5: 110,335,922 (GRCm38) F259Y probably damaging Het
Pus7 T A 5: 23,747,800 (GRCm38) K512* probably null Het
Ralyl A T 3: 14,107,236 (GRCm38) Y55F probably damaging Het
Rgs14 T A 13: 55,383,534 (GRCm38) M451K probably benign Het
Rhag T C 17: 40,831,596 (GRCm38) F231L probably damaging Het
Ric8a T C 7: 140,860,895 (GRCm38) C94R probably benign Het
Rictor T A 15: 6,772,212 (GRCm38) D460E probably benign Het
Rpn1 T C 6: 88,100,944 (GRCm38) V454A possibly damaging Het
Sacs A G 14: 61,191,782 (GRCm38) D427G probably benign Het
Scai A T 2: 39,080,117 (GRCm38) V545D possibly damaging Het
Serpinb3a A G 1: 107,046,212 (GRCm38) V323A probably damaging Het
Slc13a5 C A 11: 72,257,378 (GRCm38) C277F probably benign Het
Slc15a1 A T 14: 121,465,899 (GRCm38) Y557N probably benign Het
Slc34a2 T C 5: 53,069,419 (GRCm38) V628A probably benign Het
Slc8a2 G T 7: 16,141,135 (GRCm38) G436V probably damaging Het
Sphkap G A 1: 83,277,515 (GRCm38) R838* probably null Het
Supt5 T C 7: 28,330,024 (GRCm38) I103V probably benign Het
Tdrd1 T A 19: 56,843,216 (GRCm38) Y346* probably null Het
Tg T G 15: 66,828,568 (GRCm38) probably null Het
Top1 T A 2: 160,703,696 (GRCm38) probably null Het
Trmt12 T C 15: 58,873,227 (GRCm38) L158P probably damaging Het
Tssk4 A G 14: 55,651,695 (GRCm38) N226S probably damaging Het
Unc80 G T 1: 66,672,756 (GRCm38) V2746F possibly damaging Het
Usp34 T A 11: 23,375,051 (GRCm38) V999E probably benign Het
Virma T C 4: 11,494,786 (GRCm38) V29A probably damaging Het
Zfp40 A T 17: 23,177,266 (GRCm38) Y48N probably benign Het
Zfp609 A G 9: 65,703,554 (GRCm38) V709A possibly damaging Het
Other mutations in Olfr1339
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Olfr1339 APN 4 118,734,606 (GRCm38) missense probably benign 0.01
R0433:Olfr1339 UTSW 4 118,735,090 (GRCm38) missense probably benign 0.20
R0600:Olfr1339 UTSW 4 118,734,789 (GRCm38) missense probably damaging 0.99
R0737:Olfr1339 UTSW 4 118,735,224 (GRCm38) missense probably benign 0.01
R1167:Olfr1339 UTSW 4 118,734,632 (GRCm38) missense possibly damaging 0.83
R2152:Olfr1339 UTSW 4 118,735,249 (GRCm38) missense possibly damaging 0.90
R3883:Olfr1339 UTSW 4 118,734,685 (GRCm38) missense probably benign 0.38
R4715:Olfr1339 UTSW 4 118,734,655 (GRCm38) missense probably damaging 1.00
R4750:Olfr1339 UTSW 4 118,734,733 (GRCm38) missense possibly damaging 0.66
R4887:Olfr1339 UTSW 4 118,734,688 (GRCm38) missense probably benign 0.20
R4888:Olfr1339 UTSW 4 118,734,688 (GRCm38) missense probably benign 0.20
R5624:Olfr1339 UTSW 4 118,735,371 (GRCm38) missense probably damaging 1.00
R7268:Olfr1339 UTSW 4 118,735,408 (GRCm38) missense probably damaging 1.00
R7783:Olfr1339 UTSW 4 118,734,902 (GRCm38) missense probably damaging 1.00
R7796:Olfr1339 UTSW 4 118,734,685 (GRCm38) missense probably damaging 0.97
R8676:Olfr1339 UTSW 4 118,735,038 (GRCm38) missense probably damaging 1.00
Z1177:Olfr1339 UTSW 4 118,735,456 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCATCTCCTCTGCCAGAAGAAAAC -3'
(R):5'- GCGGATTCTCAGAATGGTGGCAAAG -3'

Sequencing Primer
(F):5'- GAAAACTATCTCCTATTCTGGGTGTG -3'
(R):5'- TGCAGACGTAAGAGGCCAG -3'
Posted On 2014-05-09