Incidental Mutation 'R0026:Vmn2r61'
| ID |
189169 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
038321-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R0026 (G1)
|
| Quality Score |
58 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 41924898 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Arginine
at position 484
(I484R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166131
AA Change: I484R
PolyPhen 2
Score 0.644 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: I484R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206855
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.9%
- 10x: 97.8%
- 20x: 96.3%
|
| Validation Efficiency |
93% (70/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
A |
3: 137,772,566 (GRCm39) |
I585N |
possibly damaging |
Het |
| A830005F24Rik |
C |
T |
13: 48,667,848 (GRCm39) |
|
probably benign |
Het |
| Abca16 |
C |
T |
7: 120,077,146 (GRCm39) |
|
probably benign |
Het |
| Acot10 |
G |
A |
15: 20,666,322 (GRCm39) |
L140F |
probably benign |
Het |
| Adam19 |
G |
T |
11: 46,027,086 (GRCm39) |
C573F |
probably damaging |
Het |
| Aff3 |
A |
G |
1: 38,242,974 (GRCm39) |
S948P |
probably benign |
Het |
| Anxa3 |
T |
A |
5: 96,986,260 (GRCm39) |
Y300N |
probably benign |
Het |
| BC016579 |
T |
C |
16: 45,460,730 (GRCm39) |
T113A |
probably benign |
Het |
| Bmpr1b |
A |
G |
3: 141,576,494 (GRCm39) |
L113P |
probably benign |
Het |
| Casq1 |
T |
C |
1: 172,046,967 (GRCm39) |
|
probably benign |
Het |
| Cdc16 |
T |
A |
8: 13,809,130 (GRCm39) |
|
probably null |
Het |
| Cep135 |
C |
T |
5: 76,754,581 (GRCm39) |
R353* |
probably null |
Het |
| Cma1 |
A |
T |
14: 56,179,621 (GRCm39) |
C188S |
probably damaging |
Het |
| Csf3r |
A |
G |
4: 125,925,677 (GRCm39) |
T151A |
probably benign |
Het |
| Cyp4b1 |
C |
T |
4: 115,504,718 (GRCm39) |
G56D |
possibly damaging |
Het |
| Dbn1 |
T |
C |
13: 55,625,597 (GRCm39) |
E275G |
probably damaging |
Het |
| Dlgap2 |
C |
T |
8: 14,777,363 (GRCm39) |
Q203* |
probably null |
Het |
| Ephb3 |
A |
G |
16: 21,033,667 (GRCm39) |
D251G |
probably damaging |
Het |
| Fancd2os |
G |
T |
6: 113,574,652 (GRCm39) |
T118N |
probably damaging |
Het |
| Gm10801 |
T |
C |
2: 98,494,254 (GRCm39) |
|
probably benign |
Het |
| Got1l1 |
C |
T |
8: 27,690,276 (GRCm39) |
V132I |
probably benign |
Het |
| H2-M9 |
T |
C |
17: 36,952,419 (GRCm39) |
|
probably benign |
Het |
| Ibtk |
A |
G |
9: 85,572,356 (GRCm39) |
V1278A |
probably benign |
Het |
| Kctd3 |
T |
C |
1: 188,708,818 (GRCm39) |
T519A |
probably damaging |
Het |
| Lgsn |
T |
A |
1: 31,242,524 (GRCm39) |
V202D |
probably damaging |
Het |
| Madd |
A |
G |
2: 91,006,053 (GRCm39) |
F381L |
possibly damaging |
Het |
| Map1s |
G |
A |
8: 71,367,282 (GRCm39) |
G729D |
probably damaging |
Het |
| Mlycd |
A |
G |
8: 120,137,174 (GRCm39) |
I465V |
probably benign |
Het |
| Mrgprb1 |
T |
C |
7: 48,096,952 (GRCm39) |
R108G |
possibly damaging |
Het |
| Mrgprx2 |
T |
A |
7: 48,131,771 (GRCm39) |
H106L |
possibly damaging |
Het |
| Ncor1 |
T |
C |
11: 62,329,255 (GRCm39) |
Y6C |
probably damaging |
Het |
| Nfkb1 |
T |
C |
3: 135,297,334 (GRCm39) |
D773G |
probably damaging |
Het |
| Nxnl1 |
A |
G |
8: 72,019,217 (GRCm39) |
S3P |
probably damaging |
Het |
| Or12d17 |
T |
A |
17: 37,777,694 (GRCm39) |
V199D |
probably damaging |
Het |
| Or8b54 |
G |
A |
9: 38,686,892 (GRCm39) |
V114I |
probably benign |
Het |
| Otud7a |
T |
C |
7: 63,385,549 (GRCm39) |
F338L |
probably benign |
Het |
| Pdcl3 |
T |
A |
1: 39,030,361 (GRCm39) |
L14Q |
probably damaging |
Het |
| Pla2g7 |
T |
A |
17: 43,905,821 (GRCm39) |
|
probably benign |
Het |
| Prpf31 |
T |
A |
7: 3,642,667 (GRCm39) |
N413K |
probably benign |
Het |
| Rapgef5 |
T |
C |
12: 117,652,896 (GRCm39) |
S307P |
probably benign |
Het |
| Relt |
C |
A |
7: 100,499,428 (GRCm39) |
E164* |
probably null |
Het |
| Rnf185 |
T |
C |
11: 3,376,617 (GRCm39) |
D86G |
probably damaging |
Het |
| Rrm2b |
T |
C |
15: 37,953,985 (GRCm39) |
E21G |
probably benign |
Het |
| Scn5a |
A |
G |
9: 119,351,632 (GRCm39) |
I783T |
probably damaging |
Het |
| Senp1 |
T |
C |
15: 97,974,549 (GRCm39) |
R88G |
probably damaging |
Het |
| Skint5 |
A |
T |
4: 113,403,665 (GRCm39) |
|
probably benign |
Het |
| Slc35b1 |
T |
C |
11: 95,281,468 (GRCm39) |
S294P |
probably benign |
Het |
| Slc5a2 |
T |
A |
7: 127,869,225 (GRCm39) |
I335N |
probably damaging |
Het |
| Spata31e2 |
T |
A |
1: 26,722,450 (GRCm39) |
D910V |
probably benign |
Het |
| Sstr1 |
T |
A |
12: 58,259,644 (GRCm39) |
M89K |
probably damaging |
Het |
| Szt2 |
A |
T |
4: 118,241,969 (GRCm39) |
S1612R |
possibly damaging |
Het |
| Taf1c |
T |
C |
8: 120,330,975 (GRCm39) |
|
probably null |
Het |
| Taf1d |
T |
A |
9: 15,219,944 (GRCm39) |
S64R |
probably damaging |
Het |
| Tmem125 |
A |
G |
4: 118,399,270 (GRCm39) |
S54P |
possibly damaging |
Het |
| Ttf1 |
T |
A |
2: 28,961,361 (GRCm39) |
I583N |
possibly damaging |
Het |
| Uchl4 |
A |
T |
9: 64,142,653 (GRCm39) |
|
probably null |
Het |
| Unc5b |
A |
T |
10: 60,610,371 (GRCm39) |
I482N |
possibly damaging |
Het |
| Unc80 |
C |
A |
1: 66,560,743 (GRCm39) |
Q824K |
probably benign |
Het |
| Utrn |
T |
C |
10: 12,601,940 (GRCm39) |
|
probably benign |
Het |
| Vps13b |
T |
C |
15: 35,923,447 (GRCm39) |
I3774T |
possibly damaging |
Het |
| Yipf1 |
T |
A |
4: 107,202,357 (GRCm39) |
L240* |
probably null |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
|
| Posted On |
2014-05-13 |
Incidental Mutation