Incidental Mutation 'R1700:Olfr1111'
ID 189624
Institutional Source Beutler Lab
Gene Symbol Olfr1111
Ensembl Gene ENSMUSG00000075158
Gene Name olfactory receptor 1111
Synonyms MOR181-2, GA_x6K02T2Q125-48635468-48634530
MMRRC Submission 039733-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.215) question?
Stock # R1700 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87149181-87152624 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87149779 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Threonine at position 294 (N294T)
Ref Sequence ENSEMBL: ENSMUSP00000150760 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099860] [ENSMUST00000214492] [ENSMUST00000216378]
AlphaFold Q7TR55
Predicted Effect probably damaging
Transcript: ENSMUST00000099860
AA Change: N294T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097446
Gene: ENSMUSG00000075158
AA Change: N294T

Pfam:7tm_4 31 307 2.2e-54 PFAM
Pfam:7tm_1 41 290 7e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214492
AA Change: N294T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216378
AA Change: N294T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402H24Rik G A 2: 130,709,938 (GRCm38) L1010F probably damaging Het
Abcb1b T C 5: 8,849,537 (GRCm38) F936L probably benign Het
Adamts12 T A 15: 11,152,057 (GRCm38) I211N probably benign Het
Adamts16 G A 13: 70,779,518 (GRCm38) probably benign Het
Alas1 C T 9: 106,239,646 (GRCm38) V293I possibly damaging Het
Ap1g1 T C 8: 109,853,612 (GRCm38) Y569H probably damaging Het
Apc2 A G 10: 80,312,769 (GRCm38) D1190G probably damaging Het
Astn2 G A 4: 65,746,354 (GRCm38) Q679* probably null Het
Atp2a1 T A 7: 126,462,909 (GRCm38) H5L probably damaging Het
Baiap3 T C 17: 25,249,328 (GRCm38) K279E probably damaging Het
C2cd2l G A 9: 44,316,612 (GRCm38) P111S probably benign Het
C7 T A 15: 5,002,792 (GRCm38) K646* probably null Het
Ccp110 C T 7: 118,735,313 (GRCm38) T1003I probably damaging Het
Cdh22 T C 2: 165,170,796 (GRCm38) D123G probably damaging Het
Cep295 C T 9: 15,340,883 (GRCm38) E397K probably damaging Het
Clip1 A G 5: 123,630,370 (GRCm38) V722A probably benign Het
Cpsf4l A G 11: 113,702,075 (GRCm38) F174S probably benign Het
Ctnna3 T C 10: 63,852,772 (GRCm38) C332R probably damaging Het
Cxcl10 A T 5: 92,347,855 (GRCm38) N76K probably damaging Het
Dnaja3 G A 16: 4,684,165 (GRCm38) R11K probably null Het
Efcab10 A G 12: 33,395,171 (GRCm38) T28A possibly damaging Het
Esrrg A G 1: 188,043,653 (GRCm38) R103G probably damaging Het
Exosc2 A G 2: 31,670,806 (GRCm38) K23E probably benign Het
Flot2 C T 11: 78,049,547 (GRCm38) S40L possibly damaging Het
Fsip2 T C 2: 82,991,737 (GRCm38) V5938A probably benign Het
Gclc A G 9: 77,776,289 (GRCm38) T143A probably benign Het
Gpr37 A G 6: 25,669,624 (GRCm38) V407A probably benign Het
Gucy2e A T 11: 69,232,058 (GRCm38) M497K probably benign Het
Herc1 T A 9: 66,450,678 (GRCm38) probably null Het
Hnrnpll A C 17: 80,034,105 (GRCm38) S502A probably benign Het
Ipo11 G T 13: 106,795,662 (GRCm38) T975N probably benign Het
Kif17 C T 4: 138,262,698 (GRCm38) Q66* probably null Het
Lrp10 T C 14: 54,469,752 (GRCm38) V682A possibly damaging Het
Lsmem1 A T 12: 40,180,678 (GRCm38) L75Q probably damaging Het
Med16 A T 10: 79,899,335 (GRCm38) Y430N probably benign Het
Med8 C T 4: 118,412,734 (GRCm38) S72L possibly damaging Het
Mex3a A G 3: 88,536,375 (GRCm38) T253A probably damaging Het
Myf6 T C 10: 107,493,359 (GRCm38) K242E probably damaging Het
Ncald T A 15: 37,397,343 (GRCm38) Y31F probably benign Het
Ndufa12 T A 10: 94,199,993 (GRCm38) Y48N probably damaging Het
Olfr1145 T C 2: 87,810,768 (GRCm38) V316A probably benign Het
Olfr638 T A 7: 104,004,122 (GRCm38) Y282* probably null Het
Pde4dip T C 3: 97,703,323 (GRCm38) T1858A probably benign Het
Pgbd1 A G 13: 21,434,481 (GRCm38) L2P probably damaging Het
Piezo1 C T 8: 122,487,502 (GRCm38) R1642H probably damaging Het
Plxna1 A T 6: 89,357,008 (GRCm38) M213K probably damaging Het
Polr1b A G 2: 129,123,121 (GRCm38) N709S probably damaging Het
Pramel1 T A 4: 143,398,429 (GRCm38) W308R probably damaging Het
Prkag2 A T 5: 24,871,541 (GRCm38) I208N probably damaging Het
Ptpro T A 6: 137,443,594 (GRCm38) V1007D probably damaging Het
Rngtt T A 4: 33,330,864 (GRCm38) F156I probably damaging Het
Rpusd3 A G 6: 113,415,533 (GRCm38) *345Q probably null Het
Rrp1b A G 17: 32,057,204 (GRCm38) K575R probably benign Het
Shd G A 17: 55,974,307 (GRCm38) V250I probably damaging Het
Slc12a5 C A 2: 164,992,376 (GRCm38) N749K possibly damaging Het
Sorbs2 T A 8: 45,800,984 (GRCm38) V488D probably damaging Het
Sphkap G A 1: 83,277,515 (GRCm38) R838* probably null Het
Srsf4 C A 4: 131,900,560 (GRCm38) probably benign Het
Strn T C 17: 78,692,402 (GRCm38) Y135C probably damaging Het
Synm T C 7: 67,759,628 (GRCm38) M1V probably null Het
Tas1r3 T G 4: 155,861,570 (GRCm38) Q489P probably benign Het
Tas2r103 A T 6: 133,036,811 (GRCm38) N97K probably damaging Het
Tas2r113 A G 6: 132,893,792 (GRCm38) Y261C possibly damaging Het
Tex21 T C 12: 76,221,672 (GRCm38) E112G probably damaging Het
Trappc8 T C 18: 20,832,998 (GRCm38) S1128G probably damaging Het
Ubap1l A G 9: 65,371,743 (GRCm38) probably benign Het
Ubash3a A G 17: 31,215,044 (GRCm38) D121G probably damaging Het
Ubxn4 A G 1: 128,252,286 (GRCm38) I56V possibly damaging Het
Uri1 T C 7: 37,963,524 (GRCm38) I348M probably damaging Het
Usp21 C A 1: 171,283,722 (GRCm38) L379F probably damaging Het
Vmn1r159 T A 7: 22,842,965 (GRCm38) H214L probably damaging Het
Zdbf2 A G 1: 63,302,741 (GRCm38) E93G unknown Het
Other mutations in Olfr1111
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Olfr1111 APN 2 87,149,825 (GRCm38) missense possibly damaging 0.53
IGL02217:Olfr1111 APN 2 87,149,887 (GRCm38) missense probably benign 0.00
R0789:Olfr1111 UTSW 2 87,149,827 (GRCm38) missense probably damaging 1.00
R1437:Olfr1111 UTSW 2 87,149,771 (GRCm38) missense possibly damaging 0.94
R1696:Olfr1111 UTSW 2 87,150,380 (GRCm38) missense probably benign 0.00
R1717:Olfr1111 UTSW 2 87,149,806 (GRCm38) nonsense probably null
R4965:Olfr1111 UTSW 2 87,150,659 (GRCm38) start codon destroyed possibly damaging 0.89
R5221:Olfr1111 UTSW 2 87,150,481 (GRCm38) missense probably damaging 1.00
R5297:Olfr1111 UTSW 2 87,150,449 (GRCm38) missense probably benign 0.01
R5837:Olfr1111 UTSW 2 87,150,355 (GRCm38) missense probably benign 0.02
R6544:Olfr1111 UTSW 2 87,149,863 (GRCm38) missense probably damaging 1.00
R6911:Olfr1111 UTSW 2 87,149,767 (GRCm38) missense probably damaging 1.00
R8537:Olfr1111 UTSW 2 87,150,038 (GRCm38) missense probably benign 0.02
R8969:Olfr1111 UTSW 2 87,150,584 (GRCm38) missense probably benign
R9747:Olfr1111 UTSW 2 87,150,554 (GRCm38) missense probably benign 0.21
Predicted Primers PCR Primer

Sequencing Primer
(F):5'- tcttgcacaaaacaatttgaagac -3'
Posted On 2014-05-14