Incidental Mutation 'R1701:Or51a10'
ID 189723
Institutional Source Beutler Lab
Gene Symbol Or51a10
Ensembl Gene ENSMUSG00000049797
Gene Name olfactory receptor family 51 subfamily A member 10
Synonyms MOR13-6, GA_x6K02T2PBJ9-6784380-6783436, Olfr642
MMRRC Submission 039734-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R1701 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103698615-103699559 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103699402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 53 (E53G)
Ref Sequence ENSEMBL: ENSMUSP00000148961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052660] [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000214299]
AlphaFold Q924X8
Predicted Effect possibly damaging
Transcript: ENSMUST00000052660
AA Change: E53G

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000061462
Gene: ENSMUSG00000049797
AA Change: E53G

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 8.5e-119 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.7e-7 PFAM
Pfam:7tm_1 43 294 4.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000074064
SMART Domains Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2.6e-124 PFAM
Pfam:7TM_GPCR_Srsx 37 255 3.1e-7 PFAM
Pfam:7tm_1 43 294 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000214299
AA Change: E53G

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,190,142 (GRCm39) L53P probably damaging Het
Acadsb T A 7: 131,026,213 (GRCm39) F19I probably benign Het
Aldh3a2 C T 11: 61,147,598 (GRCm39) G303S probably damaging Het
Anks1b T C 10: 89,885,816 (GRCm39) Y171H probably damaging Het
Anxa7 A T 14: 20,510,229 (GRCm39) I385N probably damaging Het
Astn1 A T 1: 158,331,877 (GRCm39) T324S possibly damaging Het
Ccdc88a T C 11: 29,427,427 (GRCm39) V235A possibly damaging Het
Crhr2 T C 6: 55,076,255 (GRCm39) K258R probably damaging Het
Ctnnd1 T C 2: 84,439,335 (GRCm39) E786G probably damaging Het
Ctnnd2 G A 15: 30,922,127 (GRCm39) D918N probably damaging Het
Dnah9 A G 11: 65,802,750 (GRCm39) S200P probably damaging Het
Dot1l T C 10: 80,626,576 (GRCm39) S1266P possibly damaging Het
Efemp1 A G 11: 28,871,750 (GRCm39) T422A possibly damaging Het
Fam135b T C 15: 71,331,578 (GRCm39) H1137R probably damaging Het
Flot2 C T 11: 77,940,373 (GRCm39) S40L possibly damaging Het
Fras1 G A 5: 96,748,643 (GRCm39) S706N probably benign Het
Gbf1 T C 19: 46,250,114 (GRCm39) L357P probably damaging Het
Gpatch2l A G 12: 86,335,726 (GRCm39) S476G probably benign Het
Hbb-bh2 T C 7: 103,489,450 (GRCm39) T34A probably benign Het
Ints8 A G 4: 11,231,656 (GRCm39) L443P probably damaging Het
Intu T A 3: 40,618,694 (GRCm39) D233E probably damaging Het
Itprid2 A G 2: 79,466,394 (GRCm39) K75E probably damaging Het
Kctd1 T A 18: 15,102,617 (GRCm39) I259L possibly damaging Het
Lama5 A G 2: 179,863,162 (GRCm39) C108R probably damaging Het
Lgals3bp T C 11: 118,284,781 (GRCm39) Y266C probably damaging Het
Lrig2 T C 3: 104,401,993 (GRCm39) I111V probably benign Het
Mtcl2 T C 2: 156,872,539 (GRCm39) N936S probably damaging Het
Myh8 G T 11: 67,170,964 (GRCm39) C125F probably damaging Het
Or2d3c C A 7: 106,526,129 (GRCm39) C179F probably damaging Het
Or2h2 C T 17: 37,396,623 (GRCm39) V145M probably benign Het
Or5ac21 T C 16: 59,123,651 (GRCm39) I46T probably benign Het
Or5p76 T G 7: 108,122,731 (GRCm39) Q142P probably benign Het
Or5w16 T A 2: 87,576,894 (GRCm39) M118K probably damaging Het
Or6c202 T C 10: 128,995,974 (GRCm39) Q293R probably damaging Het
Or8g4 A T 9: 39,662,365 (GRCm39) I228F probably damaging Het
Pate8 A G 9: 36,493,114 (GRCm39) probably benign Het
Phc2 C T 4: 128,645,400 (GRCm39) P836S probably damaging Het
Pla2g7 T C 17: 43,911,415 (GRCm39) F189S probably damaging Het
Ptprk A G 10: 28,342,054 (GRCm39) D487G probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rad54l2 A G 9: 106,577,692 (GRCm39) probably null Het
Robo4 G T 9: 37,314,739 (GRCm39) V198L probably benign Het
Selenbp1 C A 3: 94,844,701 (GRCm39) H119Q probably damaging Het
Slc25a13 T C 6: 6,152,525 (GRCm39) probably null Het
Slc35f5 A G 1: 125,498,330 (GRCm39) E176G possibly damaging Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Tenm4 G A 7: 96,552,096 (GRCm39) V2512M probably damaging Het
Tmc8 A G 11: 117,682,188 (GRCm39) probably null Het
Trim30d C T 7: 104,133,389 (GRCm39) W21* probably null Het
Ube3c G A 5: 29,806,200 (GRCm39) V281I probably benign Het
Usp17ld T C 7: 102,899,783 (GRCm39) K383R probably benign Het
Vmn1r172 A T 7: 23,359,529 (GRCm39) Y138F probably damaging Het
Vmn1r180 T C 7: 23,652,395 (GRCm39) V186A possibly damaging Het
Vmn2r25 T A 6: 123,828,754 (GRCm39) probably null Het
Vmn2r61 T C 7: 41,949,935 (GRCm39) F785S probably damaging Het
Zfp141 T A 7: 42,125,470 (GRCm39) Y334F probably benign Het
Zfp609 T C 9: 65,638,282 (GRCm39) I317V probably benign Het
Zfp879 A G 11: 50,724,060 (GRCm39) I259T possibly damaging Het
Other mutations in Or51a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01457:Or51a10 APN 7 103,699,376 (GRCm39) missense probably damaging 1.00
IGL01933:Or51a10 APN 7 103,699,021 (GRCm39) missense probably damaging 1.00
IGL01980:Or51a10 APN 7 103,699,300 (GRCm39) missense probably benign 0.21
IGL02161:Or51a10 APN 7 103,698,797 (GRCm39) missense possibly damaging 0.66
IGL02639:Or51a10 APN 7 103,698,988 (GRCm39) missense probably damaging 0.99
I2289:Or51a10 UTSW 7 103,698,961 (GRCm39) missense probably damaging 1.00
R0418:Or51a10 UTSW 7 103,698,979 (GRCm39) missense probably benign 0.00
R1647:Or51a10 UTSW 7 103,699,376 (GRCm39) missense probably damaging 1.00
R1648:Or51a10 UTSW 7 103,699,376 (GRCm39) missense probably damaging 1.00
R2142:Or51a10 UTSW 7 103,699,507 (GRCm39) missense probably damaging 1.00
R2165:Or51a10 UTSW 7 103,698,845 (GRCm39) missense probably benign 0.22
R2655:Or51a10 UTSW 7 103,698,638 (GRCm39) missense probably benign 0.03
R6216:Or51a10 UTSW 7 103,698,902 (GRCm39) missense probably damaging 1.00
R6759:Or51a10 UTSW 7 103,699,334 (GRCm39) missense probably damaging 1.00
R6925:Or51a10 UTSW 7 103,698,947 (GRCm39) missense probably benign 0.16
R7243:Or51a10 UTSW 7 103,698,962 (GRCm39) missense probably damaging 1.00
R7684:Or51a10 UTSW 7 103,698,667 (GRCm39) missense probably damaging 0.99
R7699:Or51a10 UTSW 7 103,699,800 (GRCm39) start gained probably benign
R8316:Or51a10 UTSW 7 103,698,829 (GRCm39) missense probably damaging 1.00
R8458:Or51a10 UTSW 7 103,698,875 (GRCm39) missense possibly damaging 0.93
R8836:Or51a10 UTSW 7 103,699,055 (GRCm39) missense probably benign 0.07
R9161:Or51a10 UTSW 7 103,699,725 (GRCm39) start gained probably benign
R9519:Or51a10 UTSW 7 103,698,636 (GRCm39) missense probably benign 0.00
Z1176:Or51a10 UTSW 7 103,699,480 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AACTGCGGATGATGATGGACATACC -3'
(R):5'- TTGAGACTCTTGCTGGACCCACTC -3'

Sequencing Primer
(F):5'- GGTTACAGATAGCCACGTACCG -3'
(R):5'- GCTGGACCCACTCTTCAC -3'
Posted On 2014-05-14