Incidental Mutation 'R1701:Or2d3c'
ID 189725
Institutional Source Beutler Lab
Gene Symbol Or2d3c
Ensembl Gene ENSMUSG00000062553
Gene Name olfactory receptor family 2 subfamily D member 3C
Synonyms MOR260-7, GA_x6K02T2PBJ9-9307730-9306814, Olfr709
MMRRC Submission 039734-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.369) question?
Stock # R1701 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106525744-106526664 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 106526129 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 179 (C179F)
Ref Sequence ENSEMBL: ENSMUSP00000150392 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072368] [ENSMUST00000215468]
AlphaFold A0A140T8J9
Predicted Effect probably damaging
Transcript: ENSMUST00000072368
AA Change: C179F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072205
Gene: ENSMUSG00000062553
AA Change: C179F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.8e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 282 8.4e-9 PFAM
Pfam:7tm_1 41 290 5.9e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215468
AA Change: C179F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,190,142 (GRCm39) L53P probably damaging Het
Acadsb T A 7: 131,026,213 (GRCm39) F19I probably benign Het
Aldh3a2 C T 11: 61,147,598 (GRCm39) G303S probably damaging Het
Anks1b T C 10: 89,885,816 (GRCm39) Y171H probably damaging Het
Anxa7 A T 14: 20,510,229 (GRCm39) I385N probably damaging Het
Astn1 A T 1: 158,331,877 (GRCm39) T324S possibly damaging Het
Ccdc88a T C 11: 29,427,427 (GRCm39) V235A possibly damaging Het
Crhr2 T C 6: 55,076,255 (GRCm39) K258R probably damaging Het
Ctnnd1 T C 2: 84,439,335 (GRCm39) E786G probably damaging Het
Ctnnd2 G A 15: 30,922,127 (GRCm39) D918N probably damaging Het
Dnah9 A G 11: 65,802,750 (GRCm39) S200P probably damaging Het
Dot1l T C 10: 80,626,576 (GRCm39) S1266P possibly damaging Het
Efemp1 A G 11: 28,871,750 (GRCm39) T422A possibly damaging Het
Fam135b T C 15: 71,331,578 (GRCm39) H1137R probably damaging Het
Flot2 C T 11: 77,940,373 (GRCm39) S40L possibly damaging Het
Fras1 G A 5: 96,748,643 (GRCm39) S706N probably benign Het
Gbf1 T C 19: 46,250,114 (GRCm39) L357P probably damaging Het
Gpatch2l A G 12: 86,335,726 (GRCm39) S476G probably benign Het
Hbb-bh2 T C 7: 103,489,450 (GRCm39) T34A probably benign Het
Ints8 A G 4: 11,231,656 (GRCm39) L443P probably damaging Het
Intu T A 3: 40,618,694 (GRCm39) D233E probably damaging Het
Itprid2 A G 2: 79,466,394 (GRCm39) K75E probably damaging Het
Kctd1 T A 18: 15,102,617 (GRCm39) I259L possibly damaging Het
Lama5 A G 2: 179,863,162 (GRCm39) C108R probably damaging Het
Lgals3bp T C 11: 118,284,781 (GRCm39) Y266C probably damaging Het
Lrig2 T C 3: 104,401,993 (GRCm39) I111V probably benign Het
Mtcl2 T C 2: 156,872,539 (GRCm39) N936S probably damaging Het
Myh8 G T 11: 67,170,964 (GRCm39) C125F probably damaging Het
Or2h2 C T 17: 37,396,623 (GRCm39) V145M probably benign Het
Or51a10 T C 7: 103,699,402 (GRCm39) E53G possibly damaging Het
Or5ac21 T C 16: 59,123,651 (GRCm39) I46T probably benign Het
Or5p76 T G 7: 108,122,731 (GRCm39) Q142P probably benign Het
Or5w16 T A 2: 87,576,894 (GRCm39) M118K probably damaging Het
Or6c202 T C 10: 128,995,974 (GRCm39) Q293R probably damaging Het
Or8g4 A T 9: 39,662,365 (GRCm39) I228F probably damaging Het
Pate8 A G 9: 36,493,114 (GRCm39) probably benign Het
Phc2 C T 4: 128,645,400 (GRCm39) P836S probably damaging Het
Pla2g7 T C 17: 43,911,415 (GRCm39) F189S probably damaging Het
Ptprk A G 10: 28,342,054 (GRCm39) D487G probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rad54l2 A G 9: 106,577,692 (GRCm39) probably null Het
Robo4 G T 9: 37,314,739 (GRCm39) V198L probably benign Het
Selenbp1 C A 3: 94,844,701 (GRCm39) H119Q probably damaging Het
Slc25a13 T C 6: 6,152,525 (GRCm39) probably null Het
Slc35f5 A G 1: 125,498,330 (GRCm39) E176G possibly damaging Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Tenm4 G A 7: 96,552,096 (GRCm39) V2512M probably damaging Het
Tmc8 A G 11: 117,682,188 (GRCm39) probably null Het
Trim30d C T 7: 104,133,389 (GRCm39) W21* probably null Het
Ube3c G A 5: 29,806,200 (GRCm39) V281I probably benign Het
Usp17ld T C 7: 102,899,783 (GRCm39) K383R probably benign Het
Vmn1r172 A T 7: 23,359,529 (GRCm39) Y138F probably damaging Het
Vmn1r180 T C 7: 23,652,395 (GRCm39) V186A possibly damaging Het
Vmn2r25 T A 6: 123,828,754 (GRCm39) probably null Het
Vmn2r61 T C 7: 41,949,935 (GRCm39) F785S probably damaging Het
Zfp141 T A 7: 42,125,470 (GRCm39) Y334F probably benign Het
Zfp609 T C 9: 65,638,282 (GRCm39) I317V probably benign Het
Zfp879 A G 11: 50,724,060 (GRCm39) I259T possibly damaging Het
Other mutations in Or2d3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Or2d3c APN 7 106,526,627 (GRCm39) missense probably benign 0.12
IGL02111:Or2d3c APN 7 106,525,823 (GRCm39) missense probably damaging 0.99
IGL02891:Or2d3c APN 7 106,526,288 (GRCm39) missense probably damaging 0.99
PIT4453001:Or2d3c UTSW 7 106,526,049 (GRCm39) missense probably benign 0.07
R1553:Or2d3c UTSW 7 106,526,201 (GRCm39) missense possibly damaging 0.78
R2065:Or2d3c UTSW 7 106,526,162 (GRCm39) missense probably damaging 1.00
R2068:Or2d3c UTSW 7 106,526,162 (GRCm39) missense probably damaging 1.00
R2167:Or2d3c UTSW 7 106,525,797 (GRCm39) missense probably damaging 1.00
R3683:Or2d3c UTSW 7 106,526,301 (GRCm39) nonsense probably null
R4640:Or2d3c UTSW 7 106,525,800 (GRCm39) missense possibly damaging 0.73
R5153:Or2d3c UTSW 7 106,525,776 (GRCm39) missense possibly damaging 0.91
R5221:Or2d3c UTSW 7 106,526,268 (GRCm39) missense probably benign 0.00
R5591:Or2d3c UTSW 7 106,526,489 (GRCm39) missense probably damaging 1.00
R6052:Or2d3c UTSW 7 106,525,896 (GRCm39) missense probably benign 0.05
R7358:Or2d3c UTSW 7 106,526,111 (GRCm39) missense probably damaging 1.00
R7513:Or2d3c UTSW 7 106,526,483 (GRCm39) missense possibly damaging 0.64
R7720:Or2d3c UTSW 7 106,526,618 (GRCm39) missense probably benign 0.27
R7860:Or2d3c UTSW 7 106,525,777 (GRCm39) missense probably benign 0.06
R8814:Or2d3c UTSW 7 106,526,025 (GRCm39) missense probably damaging 1.00
R8989:Or2d3c UTSW 7 106,526,366 (GRCm39) missense probably damaging 1.00
R9342:Or2d3c UTSW 7 106,526,564 (GRCm39) missense possibly damaging 0.90
R9564:Or2d3c UTSW 7 106,525,847 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGGGTCACTGCTGAGTAGAACAC -3'
(R):5'- AGCTGTCTGCAAGCCTCTTCAC -3'

Sequencing Primer
(F):5'- CTCATGTAGGCAAATATTGCTGAGC -3'
(R):5'- TTCACTACTCCACCATCATGAC -3'
Posted On 2014-05-14