Mutagenetix > Incidental Mutation

Incidental Mutation 'R1702:Vmn1r180'

189796

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

MMRRC Submission

039735-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R1702 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23952969 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 186 (V186I)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

possibly damaging
Transcript: ENSMUST00000173816
AA Change: V186I

PolyPhen 2 Score 0.520 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: V186I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 96.9%
20x: 94.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	T	A	11: 78,289,028	C2126S	probably damaging	Het
Abca15	T	C	7: 120,382,702	V1080A	probably benign	Het
Abcg4	A	C	9: 44,275,073	V553G	probably damaging	Het
Ache	T	C	5: 137,290,989	V319A	possibly damaging	Het
Acsm2	T	A	7: 119,573,564	M134K	possibly damaging	Het
Ank2	A	T	3: 126,955,899	S494T	probably benign	Het
Asic3	A	T	5: 24,415,456	T202S	probably damaging	Het
Baiap3	T	A	17: 25,244,805	H886L	probably damaging	Het
Cidea	T	A	18: 67,366,421	I126K	probably damaging	Het
Cmklr1	T	G	5: 113,613,842	K366T	probably benign	Het
Cntrl	A	T	2: 35,171,836		probably null	Het
Crhr2	A	G	6: 55,092,535	F378S	probably damaging	Het
Deaf1	C	G	7: 141,314,954	R303T	probably damaging	Het
Dnah9	T	A	11: 66,085,195	N1343Y	possibly damaging	Het
Dopey2	A	G	16: 93,747,621	K99E	possibly damaging	Het
Dpp4	A	T	2: 62,386,429		probably null	Het
Dst	T	C	1: 34,167,340	V598A	probably damaging	Het
Ece2	C	T	16: 20,631,246	R136C	probably damaging	Het
Egf	C	A	3: 129,690,811	V453L	probably benign	Het
Egr3	T	A	14: 70,079,767	F342L	probably damaging	Het
Eif2ak2	A	T	17: 78,856,634	I434N	probably damaging	Het
Emc1	A	G	4: 139,375,201	T936A	probably damaging	Het
Fmod	A	T	1: 134,040,762	E180V	probably damaging	Het
Gabrg3	T	C	7: 56,985,100	T112A	probably damaging	Het
Gak	T	C	5: 108,606,376		probably null	Het
Gas2	T	A	7: 51,953,341		probably null	Het
Gm11639	C	T	11: 104,691,006	P58L	probably benign	Het
Gm2381	T	A	7: 42,820,231	Q156H	probably benign	Het
Golga2	T	A	2: 32,299,275	S273T	probably damaging	Het
Homez	T	A	14: 54,856,995	T419S	probably damaging	Het
Igfbp6	T	A	15: 102,148,182	Y184*	probably null	Het
Il11	A	G	7: 4,773,734	S86P	probably damaging	Het
Itgal	A	G	7: 127,305,025	N270S	probably benign	Het
Lama2	T	C	10: 27,190,529	R1119G	probably benign	Het
Lamp3	G	T	16: 19,676,072	N294K	probably benign	Het
Mars	T	C	10: 127,310,079	I113M	possibly damaging	Het
Mgat5b	A	G	11: 116,948,659	T334A	possibly damaging	Het
Mis18bp1	A	G	12: 65,161,744	I65T	probably benign	Het
Mmrn2	A	T	14: 34,397,914	N247I	probably benign	Het
Muc6	G	T	7: 141,650,487	N322K	probably damaging	Het
Mx2	A	G	16: 97,558,683	H551R	probably benign	Het
Mylk	T	A	16: 34,921,944	V942E	probably benign	Het
Nes	A	G	3: 87,975,979	E515G	probably benign	Het
Nfatc3	T	G	8: 106,092,160	S503R	probably damaging	Het
Nkain3	C	A	4: 20,158,339		probably null	Het
Noxa1	A	G	2: 25,092,584	V73A	probably damaging	Het
Nup160	A	T	2: 90,683,958	E83D	probably damaging	Het
Olfr1427	C	A	19: 12,099,166	V158L	probably benign	Het
Olfr205	C	A	16: 59,329,141	V123L	probably benign	Het
Olfr530	A	T	7: 140,372,742	Y289*	probably null	Het
Olfr923	A	G	9: 38,828,543	Y284C	probably damaging	Het
Plxnb2	A	G	15: 89,161,984		probably null	Het
Rundc3b	A	G	5: 8,512,318	V350A	probably benign	Het
Scn1a	C	T	2: 66,318,223	D993N	probably damaging	Het
Sec24c	G	T	14: 20,686,573	G226V	probably null	Het
Sept11	T	A	5: 93,156,924	I200N	probably damaging	Het
Shank3	G	T	15: 89,499,896	G14C	probably damaging	Het
Slc25a39	T	C	11: 102,406,626	D5G	possibly damaging	Het
Stoml3	A	T	3: 53,505,431	T169S	probably benign	Het
Taf1b	T	A	12: 24,509,126	I83K	possibly damaging	Het
Tarbp1	T	A	8: 126,428,218	Q1389L	probably damaging	Het
Thbs1	T	A	2: 118,113,442	D180E	probably benign	Het
Tmc5	T	A	7: 118,672,239	V925D	probably benign	Het
Tmem62	T	C	2: 120,979,227	V130A	probably damaging	Het
Tpp2	C	T	1: 43,990,548	P997L	probably damaging	Het
Trip12	A	T	1: 84,745,063	I127N	probably damaging	Het
Ttc37	A	G	13: 76,122,743	K153R	possibly damaging	Het
Upp2	T	C	2: 58,771,550	F142L	possibly damaging	Het
Usf3	C	T	16: 44,219,632	Q1492*	probably null	Het
Vcp	T	C	4: 42,990,840	D205G	probably damaging	Het
Washc2	T	C	6: 116,229,306	S496P	probably damaging	Het
Wee2	T	C	6: 40,464,201	I480T	probably benign	Het
Xylt2	T	A	11: 94,668,745	H357L	probably damaging	Het
Zbed4	T	C	15: 88,780,853	S375P	probably damaging	Het
Zfp442	A	T	2: 150,409,180	Y266*	probably null	Het
Zfp600	A	G	4: 146,196,927	T722A	probably benign	Het
Zfp976	T	A	7: 42,616,000	H55L	possibly damaging	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23952523	missense	probably benign	0.36
IGL01309:Vmn1r180	APN	7	23952999	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23953075	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23952990	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23952651	missense	probably benign	0.06
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Predicted Primers

PCR Primer
(F):5'- ACCTAATCATTACCCCAGGGTCAGG -3'
(R):5'- CCAGCATCAGGATAGTATGGGTTGC -3'

Sequencing Primer
(F):5'- CCCAGACAGGTGATTTTAAGC -3'
(R):5'- GCTCTGGTCTCAGCTTGG -3'

Posted On

2014-05-14