|Institutional Source||Beutler Lab|
|Gene Name||poly (ADP-ribose) polymerase family, member 14|
|Synonyms||collaborator of Stat6, 1600029O10Rik, CoaSt6|
|Is this an essential gene?||Possibly non essential (E-score: 0.395)|
|Stock #||R1707 (G1)|
|Chromosomal Location||35832874-35871544 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to C at 35857849 bp|
|Amino Acid Change||Leucine to Arginine at position 583 (L583R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000037657 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000042665]|
|PDB Structure||Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]|
|Predicted Effect||probably damaging
AA Change: L583R
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: L583R
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.6300|
|Coding Region Coverage||
|Validation Efficiency||96% (82/85)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Parp14||
(F):5'- AGCCTGTAACAATGACCTTTGCCG -3'
(R):5'- TTGAAGGGCTTCCGTGCAGATG -3'
(F):5'- CGGGGTTTCTGAAGTCAATTCATTC -3'
(R):5'- ATCCAAGAGAAGGTGTTCTCC -3'