Incidental Mutation 'R1707:Parp14'
ID 190186
Institutional Source Beutler Lab
Gene Symbol Parp14
Ensembl Gene ENSMUSG00000034422
Gene Name poly (ADP-ribose) polymerase family, member 14
Synonyms CoaSt6, collaborator of Stat6, 1600029O10Rik
MMRRC Submission 039740-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.493) question?
Stock # R1707 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 35653244-35691914 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 35678219 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 583 (L583R)
Ref Sequence ENSEMBL: ENSMUSP00000037657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042665]
AlphaFold Q2EMV9
PDB Structure Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000042665
AA Change: L583R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422
AA Change: L583R

DomainStartEndE-ValueType
low complexity region 38 49 N/A INTRINSIC
low complexity region 93 115 N/A INTRINSIC
RRM 228 297 4.71e-2 SMART
coiled coil region 443 468 N/A INTRINSIC
Blast:A1pp 693 746 6e-6 BLAST
low complexity region 771 795 N/A INTRINSIC
A1pp 814 948 7.62e-41 SMART
A1pp 1026 1160 5.88e-24 SMART
A1pp 1239 1358 6.82e-20 SMART
PDB:1X4R|A 1532 1619 9e-53 PDB
Pfam:PARP 1632 1817 2.5e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142946
Meta Mutation Damage Score 0.6300 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.9%
Validation Efficiency 96% (82/85)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik A T 1: 159,898,372 (GRCm39) probably benign Het
4931429P17Rik A G 13: 48,114,481 (GRCm39) noncoding transcript Het
Acox3 T A 5: 35,758,908 (GRCm39) I373N possibly damaging Het
Adgrb1 G T 15: 74,401,192 (GRCm39) A63S probably damaging Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Aplp2 A T 9: 31,062,215 (GRCm39) H692Q probably damaging Het
Arhgap24 T C 5: 103,039,953 (GRCm39) S297P probably benign Het
Arhgap9 C T 10: 127,164,758 (GRCm39) P561S probably benign Het
Arhgef10l T G 4: 140,291,600 (GRCm39) D62A probably damaging Het
Asb14 T G 14: 26,623,079 (GRCm39) F150L probably benign Het
Atp8b3 A T 10: 80,357,635 (GRCm39) probably null Het
Atrnl1 A G 19: 57,675,169 (GRCm39) D686G probably benign Het
Bmpr1a A T 14: 34,147,098 (GRCm39) probably benign Het
Cc2d2a T A 5: 43,881,030 (GRCm39) probably null Het
Ccin T A 4: 43,983,947 (GRCm39) I118N probably benign Het
Cd8b1 G A 6: 71,303,168 (GRCm39) G81D probably damaging Het
Cep126 G A 9: 8,100,383 (GRCm39) S717L probably benign Het
Cip2a A C 16: 48,838,767 (GRCm39) Q861H probably damaging Het
Colgalt2 C T 1: 152,276,114 (GRCm39) R76W probably damaging Het
Copg1 A T 6: 87,882,192 (GRCm39) T596S probably benign Het
Cpb1 G A 3: 20,329,655 (GRCm39) R24W probably damaging Het
Csad T A 15: 102,088,407 (GRCm39) D134V probably damaging Het
Dchs2 A G 3: 83,034,912 (GRCm39) probably benign Het
Ddb2 A G 2: 91,064,554 (GRCm39) W119R probably damaging Het
Dhx57 A T 17: 80,582,655 (GRCm39) S317T probably damaging Het
Dlc1 A G 8: 37,404,763 (GRCm39) V342A probably benign Het
Dpp4 G A 2: 62,189,679 (GRCm39) probably benign Het
Dst G T 1: 34,206,727 (GRCm39) W1005L probably damaging Het
Ehmt1 T C 2: 24,695,150 (GRCm39) M989V probably benign Het
Entr1 T A 2: 26,277,618 (GRCm39) N69Y probably damaging Het
Gm5422 G A 10: 31,124,458 (GRCm39) noncoding transcript Het
Gm9944 A G 4: 144,179,833 (GRCm39) probably benign Het
Gtf2ird2 T C 5: 134,245,829 (GRCm39) Y696H probably damaging Het
H2-M11 T G 17: 36,859,658 (GRCm39) V217G probably damaging Het
Hunk C T 16: 90,183,295 (GRCm39) probably benign Het
Impg1 T C 9: 80,285,799 (GRCm39) probably null Het
Ints11 T G 4: 155,959,655 (GRCm39) D87E probably benign Het
Intu T A 3: 40,595,073 (GRCm39) S21T probably benign Het
Intu C A 3: 40,637,931 (GRCm39) D472E possibly damaging Het
Kbtbd3 T A 9: 4,316,985 (GRCm39) N45K probably benign Het
Kif1c C T 11: 70,619,223 (GRCm39) L953F probably damaging Het
Klrg2 C G 6: 38,613,729 (GRCm39) E91D possibly damaging Het
Lamc3 T C 2: 31,802,141 (GRCm39) probably null Het
Magi2 T G 5: 20,420,491 (GRCm39) M309R probably damaging Het
Magohb G A 6: 131,261,600 (GRCm39) P147S probably damaging Het
Mdn1 A G 4: 32,693,504 (GRCm39) D1043G probably damaging Het
Mtmr3 T C 11: 4,454,095 (GRCm39) D203G probably damaging Het
Mvp C T 7: 126,600,744 (GRCm39) V86I probably benign Het
Naip5 A T 13: 100,379,363 (GRCm39) F226I probably damaging Het
Nasp T A 4: 116,476,133 (GRCm39) Q51L probably damaging Het
Nf1 T A 11: 79,426,430 (GRCm39) F1594I probably damaging Het
Nod2 A C 8: 89,397,104 (GRCm39) E816A possibly damaging Het
Nom1 G A 5: 29,640,316 (GRCm39) S214N probably damaging Het
Or2l13b T C 16: 19,348,927 (GRCm39) T248A probably benign Het
Or8c9 T A 9: 38,241,197 (GRCm39) F105I probably damaging Het
Pclo T C 5: 14,763,238 (GRCm39) S3904P unknown Het
Pkhd1 T A 1: 20,621,064 (GRCm39) probably benign Het
Plaat1 A G 16: 29,046,978 (GRCm39) K166E probably damaging Het
Polr1e A C 4: 45,027,469 (GRCm39) D233A probably damaging Het
Prr29 T C 11: 106,267,509 (GRCm39) V124A probably damaging Het
Rasgrp1 A T 2: 117,129,028 (GRCm39) V197E probably damaging Het
Rgma A T 7: 73,067,707 (GRCm39) T415S unknown Het
Sacs G T 14: 61,447,211 (GRCm39) V3086L probably benign Het
Sash1 A G 10: 8,606,141 (GRCm39) S750P probably benign Het
Scpppq1 T A 5: 104,222,099 (GRCm39) probably benign Het
Sema6a A T 18: 47,416,512 (GRCm39) S372T probably benign Het
Sis A G 3: 72,816,420 (GRCm39) probably benign Het
Skint8 T A 4: 111,796,769 (GRCm39) V291D probably damaging Het
Slc12a8 A G 16: 33,371,377 (GRCm39) N171S probably damaging Het
Slc25a40 G A 5: 8,490,793 (GRCm39) probably null Het
Spag6l A T 16: 16,598,492 (GRCm39) I333N probably benign Het
Sspo T A 6: 48,454,811 (GRCm39) F2999L probably damaging Het
Stambpl1 A C 19: 34,216,221 (GRCm39) T363P probably damaging Het
Tenm4 A T 7: 96,537,892 (GRCm39) N1785Y probably damaging Het
Tln2 C T 9: 67,283,089 (GRCm39) S293N probably benign Het
Tmed3 G A 9: 89,584,833 (GRCm39) L141F probably damaging Het
Tmem30c G T 16: 57,086,843 (GRCm39) T320K possibly damaging Het
Tnn T C 1: 159,972,714 (GRCm39) Y296C probably damaging Het
Ttn C T 2: 76,620,430 (GRCm39) A15802T probably damaging Het
Usp53 T C 3: 122,741,049 (GRCm39) M734V probably benign Het
Vmn1r24 A G 6: 57,933,497 (GRCm39) I7T probably benign Het
Vmn1r74 T A 7: 11,581,504 (GRCm39) V268E probably damaging Het
Xirp1 A T 9: 119,847,841 (GRCm39) H347Q possibly damaging Het
Other mutations in Parp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Parp14 APN 16 35,661,445 (GRCm39) missense probably benign 0.00
IGL00497:Parp14 APN 16 35,655,206 (GRCm39) missense probably damaging 1.00
IGL00754:Parp14 APN 16 35,659,741 (GRCm39) missense probably benign 0.15
IGL00960:Parp14 APN 16 35,661,589 (GRCm39) missense probably benign 0.20
IGL01321:Parp14 APN 16 35,676,929 (GRCm39) missense probably benign
IGL01397:Parp14 APN 16 35,679,098 (GRCm39) missense probably benign 0.19
IGL01591:Parp14 APN 16 35,678,877 (GRCm39) missense possibly damaging 0.71
IGL01728:Parp14 APN 16 35,677,805 (GRCm39) missense probably damaging 1.00
IGL01734:Parp14 APN 16 35,678,970 (GRCm39) missense probably benign 0.00
IGL02156:Parp14 APN 16 35,678,967 (GRCm39) missense probably benign 0.13
IGL02951:Parp14 APN 16 35,678,903 (GRCm39) missense probably benign 0.06
IGL03067:Parp14 APN 16 35,676,878 (GRCm39) missense probably benign 0.10
IGL03135:Parp14 APN 16 35,678,381 (GRCm39) missense probably damaging 1.00
IGL03141:Parp14 APN 16 35,659,663 (GRCm39) missense probably benign 0.00
IGL03146:Parp14 APN 16 35,678,823 (GRCm39) nonsense probably null
IGL03333:Parp14 APN 16 35,661,800 (GRCm39) missense probably benign 0.08
IGL03391:Parp14 APN 16 35,678,640 (GRCm39) missense probably benign
thurston UTSW 16 35,664,785 (GRCm39) splice site probably benign
PIT4585001:Parp14 UTSW 16 35,678,975 (GRCm39) missense probably benign 0.03
R0306:Parp14 UTSW 16 35,676,944 (GRCm39) missense probably benign
R0506:Parp14 UTSW 16 35,661,779 (GRCm39) missense possibly damaging 0.70
R0586:Parp14 UTSW 16 35,661,382 (GRCm39) missense probably benign 0.00
R0606:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0612:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R0699:Parp14 UTSW 16 35,680,955 (GRCm39) missense probably damaging 1.00
R0786:Parp14 UTSW 16 35,661,172 (GRCm39) missense possibly damaging 0.86
R0883:Parp14 UTSW 16 35,678,888 (GRCm39) missense probably benign 0.03
R0900:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1087:Parp14 UTSW 16 35,678,658 (GRCm39) missense probably damaging 1.00
R1104:Parp14 UTSW 16 35,664,785 (GRCm39) splice site probably benign
R1120:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1134:Parp14 UTSW 16 35,655,272 (GRCm39) missense probably damaging 1.00
R1153:Parp14 UTSW 16 35,678,041 (GRCm39) missense possibly damaging 0.49
R1159:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1160:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1237:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1238:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1239:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1423:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1511:Parp14 UTSW 16 35,677,594 (GRCm39) missense probably benign 0.00
R1518:Parp14 UTSW 16 35,677,008 (GRCm39) missense possibly damaging 0.79
R1619:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1792:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1831:Parp14 UTSW 16 35,678,958 (GRCm39) missense possibly damaging 0.77
R1840:Parp14 UTSW 16 35,683,819 (GRCm39) missense probably damaging 1.00
R1889:Parp14 UTSW 16 35,677,130 (GRCm39) missense probably benign 0.09
R1902:Parp14 UTSW 16 35,673,888 (GRCm39) critical splice donor site probably null
R1943:Parp14 UTSW 16 35,656,499 (GRCm39) missense probably damaging 1.00
R1954:Parp14 UTSW 16 35,678,671 (GRCm39) missense probably benign 0.08
R2115:Parp14 UTSW 16 35,678,904 (GRCm39) missense probably benign 0.16
R2216:Parp14 UTSW 16 35,677,575 (GRCm39) missense probably benign 0.00
R2519:Parp14 UTSW 16 35,678,573 (GRCm39) missense possibly damaging 0.95
R3851:Parp14 UTSW 16 35,674,118 (GRCm39) missense possibly damaging 0.92
R4052:Parp14 UTSW 16 35,678,771 (GRCm39) missense probably benign 0.05
R4671:Parp14 UTSW 16 35,678,691 (GRCm39) missense probably benign 0.00
R4867:Parp14 UTSW 16 35,677,697 (GRCm39) missense probably benign 0.01
R4941:Parp14 UTSW 16 35,666,403 (GRCm39) missense probably benign
R4992:Parp14 UTSW 16 35,661,512 (GRCm39) missense probably benign 0.05
R5055:Parp14 UTSW 16 35,664,733 (GRCm39) missense probably benign 0.00
R5073:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
R5170:Parp14 UTSW 16 35,677,649 (GRCm39) missense probably benign 0.21
R5422:Parp14 UTSW 16 35,686,545 (GRCm39) missense probably benign 0.01
R5543:Parp14 UTSW 16 35,655,137 (GRCm39) missense probably benign 0.00
R5549:Parp14 UTSW 16 35,661,505 (GRCm39) missense probably benign 0.00
R5553:Parp14 UTSW 16 35,677,306 (GRCm39) missense probably benign 0.01
R5691:Parp14 UTSW 16 35,683,909 (GRCm39) missense probably benign 0.12
R5774:Parp14 UTSW 16 35,678,780 (GRCm39) missense probably damaging 1.00
R5855:Parp14 UTSW 16 35,661,297 (GRCm39) nonsense probably null
R5942:Parp14 UTSW 16 35,659,737 (GRCm39) missense probably damaging 0.98
R5990:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R5991:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6018:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6022:Parp14 UTSW 16 35,661,827 (GRCm39) missense probably benign 0.14
R6075:Parp14 UTSW 16 35,677,389 (GRCm39) missense probably damaging 0.99
R6395:Parp14 UTSW 16 35,676,918 (GRCm39) missense probably benign 0.00
R6525:Parp14 UTSW 16 35,680,811 (GRCm39) missense probably benign 0.05
R6683:Parp14 UTSW 16 35,655,047 (GRCm39) missense probably damaging 1.00
R7525:Parp14 UTSW 16 35,677,861 (GRCm39) missense probably benign 0.00
R8011:Parp14 UTSW 16 35,677,004 (GRCm39) missense probably benign 0.00
R8192:Parp14 UTSW 16 35,691,584 (GRCm39) missense probably benign 0.01
R8367:Parp14 UTSW 16 35,678,124 (GRCm39) missense probably benign 0.36
R8526:Parp14 UTSW 16 35,661,307 (GRCm39) missense possibly damaging 0.87
R8751:Parp14 UTSW 16 35,677,181 (GRCm39) missense probably benign 0.32
R8962:Parp14 UTSW 16 35,677,187 (GRCm39) missense probably damaging 1.00
R9231:Parp14 UTSW 16 35,661,583 (GRCm39) missense probably damaging 0.98
R9363:Parp14 UTSW 16 35,678,586 (GRCm39) missense possibly damaging 0.90
R9366:Parp14 UTSW 16 35,659,630 (GRCm39) critical splice donor site probably null
R9379:Parp14 UTSW 16 35,680,853 (GRCm39) missense probably benign 0.08
R9562:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9565:Parp14 UTSW 16 35,677,775 (GRCm39) missense probably benign 0.16
R9696:Parp14 UTSW 16 35,661,252 (GRCm39) missense probably damaging 0.96
R9696:Parp14 UTSW 16 35,661,251 (GRCm39) missense possibly damaging 0.67
X0026:Parp14 UTSW 16 35,677,527 (GRCm39) nonsense probably null
X0060:Parp14 UTSW 16 35,655,077 (GRCm39) missense probably damaging 0.99
Z1088:Parp14 UTSW 16 35,661,956 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,665,708 (GRCm39) missense probably damaging 1.00
Z1177:Parp14 UTSW 16 35,691,573 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- AGCCTGTAACAATGACCTTTGCCG -3'
(R):5'- TTGAAGGGCTTCCGTGCAGATG -3'

Sequencing Primer
(F):5'- CGGGGTTTCTGAAGTCAATTCATTC -3'
(R):5'- ATCCAAGAGAAGGTGTTCTCC -3'
Posted On 2014-05-14