Mutagenetix > Incidental Mutation

Incidental Mutation 'R1709:Xirp2'

190285

Institutional Source

Beutler Lab

Gene Symbol

Xirp2

Ensembl Gene

ENSMUSG00000027022

Gene Name

xin actin-binding repeat containing 2

Synonyms

mXin beta, 2310008C07Rik, 2310003D02Rik, Cmya3, myomaxin, A530024P18Rik

MMRRC Submission

039742-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.364) question?

Stock #

R1709 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

67276343-67356964 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 67340215 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 819 (I819V)

Ref Sequence

ENSEMBL: ENSMUSP00000107966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028410] [ENSMUST00000112347]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000028410
AA Change: I819V

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000028410
Gene: ENSMUSG00000027022
AA Change: I819V

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4e-9	PFAM
Pfam:Xin	384	398	7.6e-10	PFAM
Pfam:Xin	420	435	6.4e-9	PFAM
Pfam:Xin	458	473	5.3e-9	PFAM
Pfam:Xin	536	551	4.1e-12	PFAM
Pfam:Xin	574	588	2.1e-8	PFAM
Pfam:Xin	609	623	6e-9	PFAM
Pfam:Xin	642	656	5.6e-8	PFAM
Pfam:Xin	679	693	5.9e-8	PFAM
Pfam:Xin	784	799	1.1e-10	PFAM
Pfam:Xin	822	837	3.9e-11	PFAM
Pfam:Xin	861	875	8.6e-12	PFAM
Pfam:Xin	894	909	2.8e-10	PFAM
Pfam:Xin	1006	1021	3.1e-9	PFAM
Pfam:Xin	1079	1094	6.7e-10	PFAM
Pfam:Xin	1117	1132	1.5e-10	PFAM
Pfam:Xin	1154	1169	2.4e-8	PFAM
Pfam:Xin	1256	1271	4.6e-8	PFAM
Pfam:Xin	1292	1305	1.6e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC
LIM	3256	3308	4.45e-12	SMART
low complexity region	3356	3367	N/A	INTRINSIC
low complexity region	3549	3565	N/A	INTRINSIC
low complexity region	3614	3625	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000112347
AA Change: I819V

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000107966
Gene: ENSMUSG00000027022
AA Change: I819V

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4.3e-8	PFAM
Pfam:Xin	383	398	6.9e-9	PFAM
Pfam:Xin	420	435	1.8e-8	PFAM
Pfam:Xin	458	473	6.9e-8	PFAM
Pfam:Xin	536	551	2.8e-10	PFAM
Pfam:Xin	608	623	2.4e-8	PFAM
Pfam:Xin	642	657	1.7e-7	PFAM
Pfam:Xin	784	799	3.5e-9	PFAM
Pfam:Xin	822	837	8.9e-10	PFAM
Pfam:Xin	861	876	3.9e-10	PFAM
Pfam:Xin	894	909	5.4e-9	PFAM
Pfam:Xin	1006	1021	6.2e-8	PFAM
Pfam:Xin	1079	1094	2.4e-8	PFAM
Pfam:Xin	1117	1132	9.5e-9	PFAM
Pfam:Xin	1291	1306	5.8e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142314

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have an abnormal heart shape, ventricular septal defects, a failure of mature intercalated disc formation, severe growth retardation, and postnatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted(5)

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	A	G	5: 125,566,942 (GRCm39)	K152E	probably benign	Het
Adgrd1	T	C	5: 129,256,292 (GRCm39)	V641A	possibly damaging	Het
Adgrv1	A	T	13: 81,741,179 (GRCm39)	V95E	probably damaging	Het
Agbl5	G	A	5: 31,063,585 (GRCm39)	C872Y	probably damaging	Het
Aldh1a7	G	T	19: 20,693,316 (GRCm39)	T201K	probably damaging	Het
Aox1	C	T	1: 58,116,633 (GRCm39)	A788V	probably benign	Het
Apob	T	C	12: 8,059,306 (GRCm39)	V2563A	probably damaging	Het
Atcay	G	A	10: 81,049,065 (GRCm39)	T179I	probably damaging	Het
Atf5	A	T	7: 44,462,707 (GRCm39)	L139Q	probably benign	Het
Atp13a3	T	C	16: 30,134,659 (GRCm39)	T1205A	probably benign	Het
Atr	C	T	9: 95,753,129 (GRCm39)	T656I	probably benign	Het
Bloc1s3	T	C	7: 19,241,453 (GRCm39)	E25G	possibly damaging	Het
Brap	T	C	5: 121,803,353 (GRCm39)		probably null	Het
C6	G	T	15: 4,820,452 (GRCm39)	A488S	probably benign	Het
Ccin	T	C	4: 43,984,133 (GRCm39)	F180S	probably damaging	Het
Cd207	T	C	6: 83,649,818 (GRCm39)	I256V	possibly damaging	Het
Cdc42bpa	G	T	1: 179,894,789 (GRCm39)	C323F	probably damaging	Het
Cfap57	T	C	4: 118,428,901 (GRCm39)	T1022A	probably benign	Het
Cmtr2	A	T	8: 110,948,581 (GRCm39)	Q297L	probably benign	Het
Coro7	A	T	16: 4,452,305 (GRCm39)		probably null	Het
Cpsf2	T	A	12: 101,965,801 (GRCm39)	Y589N	probably damaging	Het
Cpxm2	T	C	7: 131,661,563 (GRCm39)	Y408C	probably damaging	Het
Crocc	A	G	4: 140,753,410 (GRCm39)		probably null	Het
Cryzl1	A	C	16: 91,509,124 (GRCm39)	F59C	probably damaging	Het
Csmd2	T	C	4: 128,389,988 (GRCm39)	V2241A	probably damaging	Het
Cxcl15	C	A	5: 90,949,275 (GRCm39)	H147N	unknown	Het
Dennd4a	A	G	9: 64,796,887 (GRCm39)	T860A	possibly damaging	Het
Dnah10	C	T	5: 124,837,155 (GRCm39)	P966L	probably damaging	Het
Dpp9	T	A	17: 56,501,431 (GRCm39)	M594L	probably benign	Het
Dspp	C	A	5: 104,323,590 (GRCm39)	N244K	probably damaging	Het
Efcab8	T	A	2: 153,656,290 (GRCm39)		probably null	Het
Elapor2	C	T	5: 9,490,726 (GRCm39)	R579*	probably null	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fbxw17	A	G	13: 50,585,693 (GRCm39)	M299V	probably benign	Het
Fbxw7	T	A	3: 84,883,659 (GRCm39)	I530N	probably damaging	Het
Gp2	C	A	7: 119,050,808 (GRCm39)	D308Y	probably null	Het
Gpd2	G	A	2: 57,247,667 (GRCm39)	V537M	probably damaging	Het
Gpr18	T	A	14: 122,149,404 (GRCm39)	Y207F	probably damaging	Het
Grip1	A	T	10: 119,733,620 (GRCm39)	D20V	probably damaging	Het
Gzmf	A	C	14: 56,444,397 (GRCm39)	F59V	probably damaging	Het
H3c1	T	A	13: 23,945,964 (GRCm39)	I125F	probably damaging	Het
Igfn1	T	C	1: 135,883,311 (GRCm39)	I2732V	probably benign	Het
Ipo8	A	T	6: 148,684,226 (GRCm39)	D855E	probably benign	Het
Klrk1	A	T	6: 129,591,682 (GRCm39)		probably null	Het
Megf11	A	G	9: 64,602,694 (GRCm39)	Y876C	probably damaging	Het
Mettl8	G	T	2: 70,812,495 (GRCm39)	Q12K	probably benign	Het
Mrgprf	T	C	7: 144,861,954 (GRCm39)	F172S	probably benign	Het
Mycbp2	G	A	14: 103,461,852 (GRCm39)	T1432I	probably damaging	Het
Nek11	A	C	9: 105,225,260 (GRCm39)	L84R	probably damaging	Het
Nlrp1b	T	C	11: 71,092,099 (GRCm39)	E9G	probably benign	Het
Nrxn1	T	C	17: 90,344,615 (GRCm39)	I433V	probably damaging	Het
Nup153	A	G	13: 46,847,450 (GRCm39)	C660R	probably damaging	Het
Or1o11	T	A	17: 37,757,091 (GRCm39)	Y226*	probably null	Het
Or2a25	T	C	6: 42,889,078 (GRCm39)	V207A	possibly damaging	Het
Or4z4	G	T	19: 12,076,245 (GRCm39)	P253T	probably damaging	Het
Or5h26	T	A	16: 58,988,264 (GRCm39)	M81L	probably benign	Het
P2rx7	T	A	5: 122,808,528 (GRCm39)	N303K	possibly damaging	Het
Pank4	T	C	4: 155,054,504 (GRCm39)	L159P	probably damaging	Het
Pcdhb22	A	T	18: 37,651,553 (GRCm39)	H7L	probably benign	Het
Pdzd8	A	T	19: 59,289,771 (GRCm39)	I543N	probably benign	Het
Pramel25	T	C	4: 143,520,116 (GRCm39)	V120A	possibly damaging	Het
Prrc2b	C	A	2: 32,084,473 (GRCm39)	R313S	probably damaging	Het
Rbm12b1	T	C	4: 12,145,827 (GRCm39)	C600R	probably benign	Het
Rem1	G	A	2: 152,476,455 (GRCm39)	V238M	probably damaging	Het
Rfx6	T	A	10: 51,554,498 (GRCm39)	M113K	possibly damaging	Het
Rlf	A	T	4: 121,007,020 (GRCm39)	D653E	probably benign	Het
Rnf130	A	G	11: 49,978,213 (GRCm39)	D258G	possibly damaging	Het
Robo2	A	G	16: 73,753,411 (GRCm39)	V822A	possibly damaging	Het
Rps6kc1	G	T	1: 190,532,533 (GRCm39)	Q490K	possibly damaging	Het
Scn9a	T	C	2: 66,313,850 (GRCm39)	Y1945C	probably damaging	Het
Setd2	T	A	9: 110,378,925 (GRCm39)	D913E	probably benign	Het
Sfr1	G	T	19: 47,723,442 (GRCm39)	E315D	possibly damaging	Het
Smarca5	G	A	8: 81,435,849 (GRCm39)	R763*	probably null	Het
Sugct	A	C	13: 17,847,151 (GRCm39)	I44S	probably damaging	Het
Syce1l	A	G	8: 114,380,662 (GRCm39)		probably null	Het
Tbc1d8b	A	G	X: 138,634,829 (GRCm39)	I654V	probably benign	Het
Tcf23	T	A	5: 31,130,852 (GRCm39)	Y163*	probably null	Het
Terf2ip	TG	T	8: 112,738,238 (GRCm39)		probably null	Het
Tmem158	T	C	9: 123,088,950 (GRCm39)	S221G	possibly damaging	Het
Tnrc6a	A	G	7: 122,769,205 (GRCm39)	T332A	probably benign	Het
Trappc4	T	C	9: 44,318,508 (GRCm39)	T31A	probably benign	Het
Trim27	T	C	13: 21,372,235 (GRCm39)		probably null	Het
Ttyh2	T	A	11: 114,599,301 (GRCm39)	L330Q	probably damaging	Het
Tubgcp3	A	T	8: 12,689,532 (GRCm39)	L578*	probably null	Het
Txndc11	C	A	16: 10,946,565 (GRCm39)	E83*	probably null	Het
Utp20	T	C	10: 88,585,159 (GRCm39)	K2635R	probably benign	Het
V1ra8	C	T	6: 90,180,304 (GRCm39)	T169I	probably damaging	Het
Vcl	G	A	14: 21,069,441 (GRCm39)	V706I	probably benign	Het
Vmn2r106	A	T	17: 20,499,373 (GRCm39)	D179E	probably benign	Het
Vmn2r80	T	C	10: 79,030,223 (GRCm39)	M683T	probably benign	Het
Zfp735	T	C	11: 73,602,589 (GRCm39)	F511S	probably benign	Het
Zfp831	T	C	2: 174,487,683 (GRCm39)	V786A	probably benign	Het
Zfp992	T	A	4: 146,550,949 (GRCm39)	H223Q	probably benign	Het
Zfyve19	A	C	2: 119,041,300 (GRCm39)	Q72P	probably damaging	Het

Other mutations in Xirp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Xirp2	APN	2	67,343,719 (GRCm39)	missense	probably benign	0.37
IGL00336:Xirp2	APN	2	67,342,942 (GRCm39)	missense	possibly damaging	0.93
IGL00596:Xirp2	APN	2	67,345,226 (GRCm39)	missense	probably benign	0.08
IGL00862:Xirp2	APN	2	67,347,247 (GRCm39)	missense	probably benign	0.00
IGL01124:Xirp2	APN	2	67,338,959 (GRCm39)	missense	probably damaging	0.99
IGL01289:Xirp2	APN	2	67,343,525 (GRCm39)	missense	probably damaging	0.99
IGL01293:Xirp2	APN	2	67,345,528 (GRCm39)	missense	possibly damaging	0.51
IGL01372:Xirp2	APN	2	67,344,334 (GRCm39)	missense	possibly damaging	0.93
IGL01385:Xirp2	APN	2	67,340,021 (GRCm39)	missense	probably damaging	0.99
IGL01411:Xirp2	APN	2	67,344,427 (GRCm39)	missense	probably benign	0.00
IGL01413:Xirp2	APN	2	67,340,270 (GRCm39)	missense	probably damaging	1.00
IGL01551:Xirp2	APN	2	67,343,849 (GRCm39)	missense	probably benign
IGL01672:Xirp2	APN	2	67,338,846 (GRCm39)	missense	probably benign
IGL01724:Xirp2	APN	2	67,356,411 (GRCm39)	missense	probably benign
IGL01739:Xirp2	APN	2	67,345,482 (GRCm39)	missense	probably benign	0.15
IGL01807:Xirp2	APN	2	67,345,375 (GRCm39)	missense	probably benign
IGL02006:Xirp2	APN	2	67,342,306 (GRCm39)	missense	possibly damaging	0.85
IGL02030:Xirp2	APN	2	67,339,325 (GRCm39)	missense	probably benign	0.06
IGL02066:Xirp2	APN	2	67,356,415 (GRCm39)	missense	probably benign
IGL02138:Xirp2	APN	2	67,347,300 (GRCm39)	missense	probably benign	0.15
IGL02250:Xirp2	APN	2	67,344,356 (GRCm39)	missense	probably benign	0.03
IGL02265:Xirp2	APN	2	67,347,494 (GRCm39)	missense	possibly damaging	0.94
IGL02274:Xirp2	APN	2	67,338,995 (GRCm39)	missense	probably benign	0.12
IGL02322:Xirp2	APN	2	67,339,082 (GRCm39)	missense	probably benign	0.00
IGL02327:Xirp2	APN	2	67,340,444 (GRCm39)	missense	probably damaging	1.00
IGL02378:Xirp2	APN	2	67,344,112 (GRCm39)	missense	probably benign	0.00
IGL02492:Xirp2	APN	2	67,346,511 (GRCm39)	missense	probably damaging	0.99
IGL02549:Xirp2	APN	2	67,343,446 (GRCm39)	missense	probably benign	0.03
IGL02578:Xirp2	APN	2	67,341,591 (GRCm39)	missense	probably damaging	0.96
IGL02635:Xirp2	APN	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
IGL02654:Xirp2	APN	2	67,345,015 (GRCm39)	missense	possibly damaging	0.86
IGL02663:Xirp2	APN	2	67,339,802 (GRCm39)	missense	possibly damaging	0.92
IGL02795:Xirp2	APN	2	67,339,480 (GRCm39)	missense	probably damaging	1.00
IGL02934:Xirp2	APN	2	67,346,020 (GRCm39)	missense	probably benign	0.33
IGL03003:Xirp2	APN	2	67,345,906 (GRCm39)	missense	possibly damaging	0.93
IGL03069:Xirp2	APN	2	67,339,876 (GRCm39)	missense	possibly damaging	0.91
IGL03286:Xirp2	APN	2	67,346,654 (GRCm39)	missense	probably damaging	0.99
IGL03326:Xirp2	APN	2	67,312,590 (GRCm39)	missense	probably benign	0.01
IGL03381:Xirp2	APN	2	67,344,570 (GRCm39)	missense	probably benign	0.34
IGL03394:Xirp2	APN	2	67,345,538 (GRCm39)	missense	probably damaging	0.99
Ordovician	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
silurian	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
3-1:Xirp2	UTSW	2	67,338,542 (GRCm39)	missense	possibly damaging	0.95
H8562:Xirp2	UTSW	2	67,345,801 (GRCm39)	missense	probably benign
PIT4142001:Xirp2	UTSW	2	67,349,706 (GRCm39)	splice site	probably benign
PIT4260001:Xirp2	UTSW	2	67,341,941 (GRCm39)	missense	possibly damaging	0.96
PIT4445001:Xirp2	UTSW	2	67,340,116 (GRCm39)	missense	possibly damaging	0.84
PIT4531001:Xirp2	UTSW	2	67,345,826 (GRCm39)	missense	possibly damaging	0.73
R0015:Xirp2	UTSW	2	67,341,243 (GRCm39)	nonsense	probably null
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0066:Xirp2	UTSW	2	67,342,484 (GRCm39)	missense	possibly damaging	0.85
R0109:Xirp2	UTSW	2	67,349,622 (GRCm39)	missense	probably damaging	1.00
R0111:Xirp2	UTSW	2	67,338,722 (GRCm39)	missense	probably damaging	0.99
R0115:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0117:Xirp2	UTSW	2	67,347,464 (GRCm39)	missense	possibly damaging	0.94
R0133:Xirp2	UTSW	2	67,347,468 (GRCm39)	missense	probably benign
R0282:Xirp2	UTSW	2	67,343,724 (GRCm39)	missense	probably damaging	0.96
R0463:Xirp2	UTSW	2	67,345,262 (GRCm39)	missense	probably benign	0.02
R0481:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0488:Xirp2	UTSW	2	67,345,165 (GRCm39)	missense	possibly damaging	0.90
R0548:Xirp2	UTSW	2	67,344,758 (GRCm39)	missense	probably benign	0.00
R0557:Xirp2	UTSW	2	67,346,695 (GRCm39)	missense	probably benign	0.33
R0582:Xirp2	UTSW	2	67,339,210 (GRCm39)	missense	probably benign
R0723:Xirp2	UTSW	2	67,342,559 (GRCm39)	missense	probably damaging	0.98
R0835:Xirp2	UTSW	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
R1160:Xirp2	UTSW	2	67,340,231 (GRCm39)	missense	possibly damaging	0.92
R1189:Xirp2	UTSW	2	67,343,805 (GRCm39)	missense	probably damaging	0.96
R1474:Xirp2	UTSW	2	67,355,411 (GRCm39)	missense	probably benign	0.00
R1513:Xirp2	UTSW	2	67,341,874 (GRCm39)	missense	probably benign	0.00
R1514:Xirp2	UTSW	2	67,344,667 (GRCm39)	nonsense	probably null
R1519:Xirp2	UTSW	2	67,346,023 (GRCm39)	missense	probably benign	0.44
R1532:Xirp2	UTSW	2	67,344,283 (GRCm39)	missense	probably benign	0.00
R1537:Xirp2	UTSW	2	67,340,357 (GRCm39)	missense	probably damaging	0.98
R1541:Xirp2	UTSW	2	67,342,634 (GRCm39)	missense	possibly damaging	0.70
R1543:Xirp2	UTSW	2	67,338,383 (GRCm39)	missense	probably benign
R1607:Xirp2	UTSW	2	67,340,639 (GRCm39)	nonsense	probably null
R1620:Xirp2	UTSW	2	67,341,179 (GRCm39)	missense	probably damaging	0.98
R1713:Xirp2	UTSW	2	67,342,762 (GRCm39)	missense	probably benign	0.25
R1828:Xirp2	UTSW	2	67,345,582 (GRCm39)	missense	possibly damaging	0.86
R1834:Xirp2	UTSW	2	67,341,484 (GRCm39)	missense	probably damaging	0.99
R1905:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1907:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1943:Xirp2	UTSW	2	67,342,959 (GRCm39)	missense	probably benign	0.34
R1971:Xirp2	UTSW	2	67,342,039 (GRCm39)	missense	possibly damaging	0.48
R1998:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R2075:Xirp2	UTSW	2	67,340,545 (GRCm39)	missense	probably benign	0.33
R2132:Xirp2	UTSW	2	67,338,392 (GRCm39)	missense	possibly damaging	0.72
R2175:Xirp2	UTSW	2	67,340,258 (GRCm39)	missense	probably damaging	0.99
R2310:Xirp2	UTSW	2	67,356,591 (GRCm39)	missense	probably benign	0.19
R2338:Xirp2	UTSW	2	67,341,114 (GRCm39)	missense	probably damaging	0.98
R2426:Xirp2	UTSW	2	67,344,815 (GRCm39)	missense	probably benign	0.02
R2483:Xirp2	UTSW	2	67,355,336 (GRCm39)	missense	probably benign
R3084:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R3113:Xirp2	UTSW	2	67,340,491 (GRCm39)	missense	probably benign	0.33
R3903:Xirp2	UTSW	2	67,338,380 (GRCm39)	missense	probably benign	0.40
R3916:Xirp2	UTSW	2	67,341,766 (GRCm39)	missense	probably benign	0.25
R3928:Xirp2	UTSW	2	67,342,013 (GRCm39)	missense	possibly damaging	0.85
R4025:Xirp2	UTSW	2	67,341,746 (GRCm39)	missense	probably benign	0.12
R4135:Xirp2	UTSW	2	67,355,741 (GRCm39)	missense	probably benign	0.00
R4223:Xirp2	UTSW	2	67,346,837 (GRCm39)	missense	possibly damaging	0.66
R4257:Xirp2	UTSW	2	67,346,383 (GRCm39)	missense	probably benign	0.31
R4499:Xirp2	UTSW	2	67,343,782 (GRCm39)	missense	probably benign	0.08
R4577:Xirp2	UTSW	2	67,344,241 (GRCm39)	missense	probably damaging	0.99
R4739:Xirp2	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
R4758:Xirp2	UTSW	2	67,346,879 (GRCm39)	missense	probably damaging	0.98
R4834:Xirp2	UTSW	2	67,346,750 (GRCm39)	missense	probably benign	0.26
R4855:Xirp2	UTSW	2	67,341,408 (GRCm39)	missense	possibly damaging	0.96
R4923:Xirp2	UTSW	2	67,343,237 (GRCm39)	missense	probably benign
R4936:Xirp2	UTSW	2	67,340,163 (GRCm39)	missense	possibly damaging	0.85
R5032:Xirp2	UTSW	2	67,356,014 (GRCm39)	missense	possibly damaging	0.84
R5049:Xirp2	UTSW	2	67,347,478 (GRCm39)	missense	probably benign	0.03
R5077:Xirp2	UTSW	2	67,344,821 (GRCm39)	missense	probably benign
R5090:Xirp2	UTSW	2	67,355,814 (GRCm39)	missense	possibly damaging	0.83
R5107:Xirp2	UTSW	2	67,340,054 (GRCm39)	missense	probably damaging	0.99
R5107:Xirp2	UTSW	2	67,342,205 (GRCm39)	missense	probably damaging	1.00
R5187:Xirp2	UTSW	2	67,345,711 (GRCm39)	missense	probably benign	0.01
R5241:Xirp2	UTSW	2	67,312,704 (GRCm39)	nonsense	probably null
R5307:Xirp2	UTSW	2	67,341,506 (GRCm39)	missense	probably damaging	0.99
R5342:Xirp2	UTSW	2	67,343,805 (GRCm39)	missense	probably damaging	0.96
R5370:Xirp2	UTSW	2	67,342,496 (GRCm39)	missense	possibly damaging	0.72
R5375:Xirp2	UTSW	2	67,342,250 (GRCm39)	missense	probably damaging	0.99
R5407:Xirp2	UTSW	2	67,341,313 (GRCm39)	missense	probably benign	0.33
R5514:Xirp2	UTSW	2	67,335,465 (GRCm39)	missense	probably benign	0.03
R5531:Xirp2	UTSW	2	67,345,646 (GRCm39)	missense	probably benign	0.42
R5590:Xirp2	UTSW	2	67,344,379 (GRCm39)	missense	probably benign	0.23
R5646:Xirp2	UTSW	2	67,341,134 (GRCm39)	missense	probably damaging	0.99
R5649:Xirp2	UTSW	2	67,347,239 (GRCm39)	missense	probably benign	0.00
R5686:Xirp2	UTSW	2	67,312,642 (GRCm39)	missense	probably damaging	0.99
R5761:Xirp2	UTSW	2	67,341,311 (GRCm39)	missense	probably benign	0.00
R5777:Xirp2	UTSW	2	67,340,348 (GRCm39)	missense	possibly damaging	0.92
R5785:Xirp2	UTSW	2	67,340,006 (GRCm39)	missense	probably damaging	0.96
R5843:Xirp2	UTSW	2	67,307,129 (GRCm39)	start gained	probably benign
R5846:Xirp2	UTSW	2	67,339,587 (GRCm39)	missense	probably damaging	0.98
R5875:Xirp2	UTSW	2	67,335,424 (GRCm39)	missense	probably benign	0.00
R5896:Xirp2	UTSW	2	67,340,290 (GRCm39)	missense	possibly damaging	0.91
R5896:Xirp2	UTSW	2	67,339,042 (GRCm39)	missense	probably benign	0.32
R5901:Xirp2	UTSW	2	67,343,410 (GRCm39)	missense	possibly damaging	0.91
R5934:Xirp2	UTSW	2	67,355,148 (GRCm39)	missense	possibly damaging	0.92
R5950:Xirp2	UTSW	2	67,341,664 (GRCm39)	missense	possibly damaging	0.95
R5996:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6013:Xirp2	UTSW	2	67,341,287 (GRCm39)	missense	possibly damaging	0.48
R6048:Xirp2	UTSW	2	67,338,587 (GRCm39)	missense	possibly damaging	0.96
R6111:Xirp2	UTSW	2	67,342,161 (GRCm39)	missense	possibly damaging	0.86
R6180:Xirp2	UTSW	2	67,335,921 (GRCm39)	critical splice donor site	probably null
R6342:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6346:Xirp2	UTSW	2	67,346,425 (GRCm39)	missense	probably benign	0.00
R6603:Xirp2	UTSW	2	67,346,888 (GRCm39)	missense	probably benign
R6604:Xirp2	UTSW	2	67,340,189 (GRCm39)	missense	possibly damaging	0.86
R6669:Xirp2	UTSW	2	67,343,699 (GRCm39)	missense	possibly damaging	0.78
R6701:Xirp2	UTSW	2	67,346,569 (GRCm39)	missense	possibly damaging	0.94
R6726:Xirp2	UTSW	2	67,343,212 (GRCm39)	missense	possibly damaging	0.88
R6833:Xirp2	UTSW	2	67,340,294 (GRCm39)	missense	probably benign	0.12
R6897:Xirp2	UTSW	2	67,338,911 (GRCm39)	missense	probably damaging	1.00
R6933:Xirp2	UTSW	2	67,345,201 (GRCm39)	missense	probably benign	0.34
R7020:Xirp2	UTSW	2	67,355,913 (GRCm39)	missense	probably benign
R7042:Xirp2	UTSW	2	67,343,633 (GRCm39)	missense	probably benign	0.12
R7060:Xirp2	UTSW	2	67,345,952 (GRCm39)	missense	probably damaging	1.00
R7179:Xirp2	UTSW	2	67,340,177 (GRCm39)	missense	probably benign	0.00
R7229:Xirp2	UTSW	2	67,355,895 (GRCm39)	missense	probably damaging	0.99
R7253:Xirp2	UTSW	2	67,343,826 (GRCm39)	missense	probably benign
R7284:Xirp2	UTSW	2	67,347,173 (GRCm39)	missense	probably benign
R7450:Xirp2	UTSW	2	67,340,159 (GRCm39)	missense	possibly damaging	0.86
R7476:Xirp2	UTSW	2	67,340,978 (GRCm39)	missense	probably benign	0.01
R7489:Xirp2	UTSW	2	67,355,904 (GRCm39)	missense	possibly damaging	0.83
R7513:Xirp2	UTSW	2	67,341,108 (GRCm39)	missense	possibly damaging	0.86
R7549:Xirp2	UTSW	2	67,339,241 (GRCm39)	missense	possibly damaging	0.91
R7563:Xirp2	UTSW	2	67,340,245 (GRCm39)	missense	probably damaging	0.99
R7567:Xirp2	UTSW	2	67,346,326 (GRCm39)	missense	probably benign	0.02
R7577:Xirp2	UTSW	2	67,345,309 (GRCm39)	missense	possibly damaging	0.65
R7597:Xirp2	UTSW	2	67,356,099 (GRCm39)	missense	possibly damaging	0.84
R7610:Xirp2	UTSW	2	67,356,306 (GRCm39)	missense	possibly damaging	0.92
R7613:Xirp2	UTSW	2	67,344,842 (GRCm39)	missense	probably benign	0.00
R7669:Xirp2	UTSW	2	67,342,521 (GRCm39)	missense	probably benign	0.00
R7670:Xirp2	UTSW	2	67,340,917 (GRCm39)	missense	possibly damaging	0.91
R7673:Xirp2	UTSW	2	67,347,431 (GRCm39)	missense	probably damaging	1.00
R7682:Xirp2	UTSW	2	67,339,193 (GRCm39)	missense	probably damaging	0.99
R7755:Xirp2	UTSW	2	67,345,526 (GRCm39)	missense	probably benign
R7805:Xirp2	UTSW	2	67,340,325 (GRCm39)	missense	probably benign	0.23
R7815:Xirp2	UTSW	2	67,339,756 (GRCm39)	missense	probably damaging	1.00
R7823:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R7842:Xirp2	UTSW	2	67,355,289 (GRCm39)	missense	probably benign	0.00
R7863:Xirp2	UTSW	2	67,343,074 (GRCm39)	missense	probably benign	0.03
R7895:Xirp2	UTSW	2	67,339,841 (GRCm39)	missense	probably damaging	0.96
R7948:Xirp2	UTSW	2	67,349,658 (GRCm39)	missense	possibly damaging	0.95
R8083:Xirp2	UTSW	2	67,339,043 (GRCm39)	missense	possibly damaging	0.71
R8125:Xirp2	UTSW	2	67,342,379 (GRCm39)	missense	probably benign	0.25
R8154:Xirp2	UTSW	2	67,342,017 (GRCm39)	missense	possibly damaging	0.48
R8169:Xirp2	UTSW	2	67,343,543 (GRCm39)	missense	probably benign	0.00
R8213:Xirp2	UTSW	2	67,307,210 (GRCm39)	missense	probably damaging	0.96
R8215:Xirp2	UTSW	2	67,346,853 (GRCm39)	missense	probably benign	0.08
R8230:Xirp2	UTSW	2	67,346,009 (GRCm39)	missense	probably damaging	0.99
R8266:Xirp2	UTSW	2	67,338,918 (GRCm39)	missense	probably damaging	0.98
R8350:Xirp2	UTSW	2	67,355,713 (GRCm39)	missense	probably benign
R8432:Xirp2	UTSW	2	67,340,962 (GRCm39)	missense	probably benign
R8441:Xirp2	UTSW	2	67,343,159 (GRCm39)	missense	possibly damaging	0.85
R8677:Xirp2	UTSW	2	67,346,978 (GRCm39)	missense	probably damaging	0.98
R8773:Xirp2	UTSW	2	67,355,527 (GRCm39)	missense	probably benign
R8794:Xirp2	UTSW	2	67,341,557 (GRCm39)	missense	probably damaging	0.98
R8930:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8932:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8939:Xirp2	UTSW	2	67,346,488 (GRCm39)	missense	probably benign	0.04
R9263:Xirp2	UTSW	2	67,345,289 (GRCm39)	missense	possibly damaging	0.76
R9313:Xirp2	UTSW	2	67,347,322 (GRCm39)	missense	probably damaging	0.99
R9350:Xirp2	UTSW	2	67,349,653 (GRCm39)	missense	probably damaging	1.00
R9375:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R9442:Xirp2	UTSW	2	67,342,235 (GRCm39)	nonsense	probably null
R9447:Xirp2	UTSW	2	67,338,950 (GRCm39)	missense	probably damaging	0.98
R9457:Xirp2	UTSW	2	67,345,976 (GRCm39)	missense	probably benign	0.03
R9507:Xirp2	UTSW	2	67,344,280 (GRCm39)	missense	possibly damaging	0.95
R9529:Xirp2	UTSW	2	67,355,540 (GRCm39)	missense	possibly damaging	0.93
R9569:Xirp2	UTSW	2	67,341,242 (GRCm39)	missense	probably damaging	1.00
R9607:Xirp2	UTSW	2	67,341,106 (GRCm39)	missense	possibly damaging	0.72
R9648:Xirp2	UTSW	2	67,346,599 (GRCm39)	missense	probably benign
R9651:Xirp2	UTSW	2	67,344,167 (GRCm39)	missense	possibly damaging	0.72
R9678:Xirp2	UTSW	2	67,339,788 (GRCm39)	missense	possibly damaging	0.91
R9691:Xirp2	UTSW	2	67,340,539 (GRCm39)	missense	possibly damaging	0.91
R9777:Xirp2	UTSW	2	67,347,379 (GRCm39)	missense	possibly damaging	0.85
RF035:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
RF040:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
X0063:Xirp2	UTSW	2	67,346,467 (GRCm39)	missense	probably benign	0.04
X0065:Xirp2	UTSW	2	67,345,462 (GRCm39)	missense	probably benign	0.34
Z1088:Xirp2	UTSW	2	67,343,665 (GRCm39)	missense	probably benign	0.03
Z1176:Xirp2	UTSW	2	67,344,923 (GRCm39)	missense	probably benign	0.17
Z1176:Xirp2	UTSW	2	67,341,737 (GRCm39)	missense	probably damaging	0.99
Z1176:Xirp2	UTSW	2	67,355,576 (GRCm39)	missense	probably damaging	1.00
Z1177:Xirp2	UTSW	2	67,355,715 (GRCm39)	missense	probably benign
Z1177:Xirp2	UTSW	2	67,340,537 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- CTTTGAGACAACCCCACTCTATGCC -3'
(R):5'- AGCCACATGCAGGTTCTAACATCAC -3'

Sequencing Primer
(F):5'- CACTCTATGCCATTCAAGATCATC -3'
(R):5'- ATCTTCAGAGTTGGTCATCAAGG -3'

Posted On

2014-05-14