Incidental Mutation 'R1709:Or2a25'
ID 190314
Institutional Source Beutler Lab
Gene Symbol Or2a25
Ensembl Gene ENSMUSG00000045708
Gene Name olfactory receptor family 2 subfamily A member 25
Synonyms GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
MMRRC Submission 039742-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # R1709 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 42888459-42889391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42889078 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 207 (V207A)
Ref Sequence ENSEMBL: ENSMUSP00000149325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055763] [ENSMUST00000216408]
AlphaFold Q8VGP6
Predicted Effect possibly damaging
Transcript: ENSMUST00000055763
AA Change: V207A

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000052312
Gene: ENSMUSG00000045708
AA Change: V207A

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-60 PFAM
Pfam:7tm_1 40 289 6.3e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216408
AA Change: V207A

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs A G 5: 125,566,942 (GRCm39) K152E probably benign Het
Adgrd1 T C 5: 129,256,292 (GRCm39) V641A possibly damaging Het
Adgrv1 A T 13: 81,741,179 (GRCm39) V95E probably damaging Het
Agbl5 G A 5: 31,063,585 (GRCm39) C872Y probably damaging Het
Aldh1a7 G T 19: 20,693,316 (GRCm39) T201K probably damaging Het
Aox1 C T 1: 58,116,633 (GRCm39) A788V probably benign Het
Apob T C 12: 8,059,306 (GRCm39) V2563A probably damaging Het
Atcay G A 10: 81,049,065 (GRCm39) T179I probably damaging Het
Atf5 A T 7: 44,462,707 (GRCm39) L139Q probably benign Het
Atp13a3 T C 16: 30,134,659 (GRCm39) T1205A probably benign Het
Atr C T 9: 95,753,129 (GRCm39) T656I probably benign Het
Bloc1s3 T C 7: 19,241,453 (GRCm39) E25G possibly damaging Het
Brap T C 5: 121,803,353 (GRCm39) probably null Het
C6 G T 15: 4,820,452 (GRCm39) A488S probably benign Het
Ccin T C 4: 43,984,133 (GRCm39) F180S probably damaging Het
Cd207 T C 6: 83,649,818 (GRCm39) I256V possibly damaging Het
Cdc42bpa G T 1: 179,894,789 (GRCm39) C323F probably damaging Het
Cfap57 T C 4: 118,428,901 (GRCm39) T1022A probably benign Het
Cmtr2 A T 8: 110,948,581 (GRCm39) Q297L probably benign Het
Coro7 A T 16: 4,452,305 (GRCm39) probably null Het
Cpsf2 T A 12: 101,965,801 (GRCm39) Y589N probably damaging Het
Cpxm2 T C 7: 131,661,563 (GRCm39) Y408C probably damaging Het
Crocc A G 4: 140,753,410 (GRCm39) probably null Het
Cryzl1 A C 16: 91,509,124 (GRCm39) F59C probably damaging Het
Csmd2 T C 4: 128,389,988 (GRCm39) V2241A probably damaging Het
Cxcl15 C A 5: 90,949,275 (GRCm39) H147N unknown Het
Dennd4a A G 9: 64,796,887 (GRCm39) T860A possibly damaging Het
Dnah10 C T 5: 124,837,155 (GRCm39) P966L probably damaging Het
Dpp9 T A 17: 56,501,431 (GRCm39) M594L probably benign Het
Dspp C A 5: 104,323,590 (GRCm39) N244K probably damaging Het
Efcab8 T A 2: 153,656,290 (GRCm39) probably null Het
Elapor2 C T 5: 9,490,726 (GRCm39) R579* probably null Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fbxw17 A G 13: 50,585,693 (GRCm39) M299V probably benign Het
Fbxw7 T A 3: 84,883,659 (GRCm39) I530N probably damaging Het
Gp2 C A 7: 119,050,808 (GRCm39) D308Y probably null Het
Gpd2 G A 2: 57,247,667 (GRCm39) V537M probably damaging Het
Gpr18 T A 14: 122,149,404 (GRCm39) Y207F probably damaging Het
Grip1 A T 10: 119,733,620 (GRCm39) D20V probably damaging Het
Gzmf A C 14: 56,444,397 (GRCm39) F59V probably damaging Het
H3c1 T A 13: 23,945,964 (GRCm39) I125F probably damaging Het
Igfn1 T C 1: 135,883,311 (GRCm39) I2732V probably benign Het
Ipo8 A T 6: 148,684,226 (GRCm39) D855E probably benign Het
Klrk1 A T 6: 129,591,682 (GRCm39) probably null Het
Megf11 A G 9: 64,602,694 (GRCm39) Y876C probably damaging Het
Mettl8 G T 2: 70,812,495 (GRCm39) Q12K probably benign Het
Mrgprf T C 7: 144,861,954 (GRCm39) F172S probably benign Het
Mycbp2 G A 14: 103,461,852 (GRCm39) T1432I probably damaging Het
Nek11 A C 9: 105,225,260 (GRCm39) L84R probably damaging Het
Nlrp1b T C 11: 71,092,099 (GRCm39) E9G probably benign Het
Nrxn1 T C 17: 90,344,615 (GRCm39) I433V probably damaging Het
Nup153 A G 13: 46,847,450 (GRCm39) C660R probably damaging Het
Or1o11 T A 17: 37,757,091 (GRCm39) Y226* probably null Het
Or4z4 G T 19: 12,076,245 (GRCm39) P253T probably damaging Het
Or5h26 T A 16: 58,988,264 (GRCm39) M81L probably benign Het
P2rx7 T A 5: 122,808,528 (GRCm39) N303K possibly damaging Het
Pank4 T C 4: 155,054,504 (GRCm39) L159P probably damaging Het
Pcdhb22 A T 18: 37,651,553 (GRCm39) H7L probably benign Het
Pdzd8 A T 19: 59,289,771 (GRCm39) I543N probably benign Het
Pramel25 T C 4: 143,520,116 (GRCm39) V120A possibly damaging Het
Prrc2b C A 2: 32,084,473 (GRCm39) R313S probably damaging Het
Rbm12b1 T C 4: 12,145,827 (GRCm39) C600R probably benign Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Rfx6 T A 10: 51,554,498 (GRCm39) M113K possibly damaging Het
Rlf A T 4: 121,007,020 (GRCm39) D653E probably benign Het
Rnf130 A G 11: 49,978,213 (GRCm39) D258G possibly damaging Het
Robo2 A G 16: 73,753,411 (GRCm39) V822A possibly damaging Het
Rps6kc1 G T 1: 190,532,533 (GRCm39) Q490K possibly damaging Het
Scn9a T C 2: 66,313,850 (GRCm39) Y1945C probably damaging Het
Setd2 T A 9: 110,378,925 (GRCm39) D913E probably benign Het
Sfr1 G T 19: 47,723,442 (GRCm39) E315D possibly damaging Het
Smarca5 G A 8: 81,435,849 (GRCm39) R763* probably null Het
Sugct A C 13: 17,847,151 (GRCm39) I44S probably damaging Het
Syce1l A G 8: 114,380,662 (GRCm39) probably null Het
Tbc1d8b A G X: 138,634,829 (GRCm39) I654V probably benign Het
Tcf23 T A 5: 31,130,852 (GRCm39) Y163* probably null Het
Terf2ip TG T 8: 112,738,238 (GRCm39) probably null Het
Tmem158 T C 9: 123,088,950 (GRCm39) S221G possibly damaging Het
Tnrc6a A G 7: 122,769,205 (GRCm39) T332A probably benign Het
Trappc4 T C 9: 44,318,508 (GRCm39) T31A probably benign Het
Trim27 T C 13: 21,372,235 (GRCm39) probably null Het
Ttyh2 T A 11: 114,599,301 (GRCm39) L330Q probably damaging Het
Tubgcp3 A T 8: 12,689,532 (GRCm39) L578* probably null Het
Txndc11 C A 16: 10,946,565 (GRCm39) E83* probably null Het
Utp20 T C 10: 88,585,159 (GRCm39) K2635R probably benign Het
V1ra8 C T 6: 90,180,304 (GRCm39) T169I probably damaging Het
Vcl G A 14: 21,069,441 (GRCm39) V706I probably benign Het
Vmn2r106 A T 17: 20,499,373 (GRCm39) D179E probably benign Het
Vmn2r80 T C 10: 79,030,223 (GRCm39) M683T probably benign Het
Xirp2 A G 2: 67,340,215 (GRCm39) I819V probably benign Het
Zfp735 T C 11: 73,602,589 (GRCm39) F511S probably benign Het
Zfp831 T C 2: 174,487,683 (GRCm39) V786A probably benign Het
Zfp992 T A 4: 146,550,949 (GRCm39) H223Q probably benign Het
Zfyve19 A C 2: 119,041,300 (GRCm39) Q72P probably damaging Het
Other mutations in Or2a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02302:Or2a25 APN 6 42,889,272 (GRCm39) missense probably damaging 1.00
IGL02604:Or2a25 APN 6 42,888,992 (GRCm39) nonsense probably null
IGL02894:Or2a25 APN 6 42,888,451 (GRCm39) splice site probably benign
R0122:Or2a25 UTSW 6 42,888,889 (GRCm39) missense probably benign 0.00
R0172:Or2a25 UTSW 6 42,888,913 (GRCm39) missense probably benign 0.00
R0371:Or2a25 UTSW 6 42,888,872 (GRCm39) missense probably benign 0.14
R2431:Or2a25 UTSW 6 42,888,946 (GRCm39) missense probably damaging 0.99
R3809:Or2a25 UTSW 6 42,889,271 (GRCm39) missense probably damaging 1.00
R4032:Or2a25 UTSW 6 42,888,559 (GRCm39) missense probably benign 0.08
R4242:Or2a25 UTSW 6 42,888,480 (GRCm39) missense possibly damaging 0.77
R4369:Or2a25 UTSW 6 42,889,211 (GRCm39) nonsense probably null
R4401:Or2a25 UTSW 6 42,889,260 (GRCm39) nonsense probably null
R4565:Or2a25 UTSW 6 42,888,472 (GRCm39) missense probably benign
R5646:Or2a25 UTSW 6 42,888,457 (GRCm39) splice site probably null
R5968:Or2a25 UTSW 6 42,888,480 (GRCm39) missense probably benign
R6804:Or2a25 UTSW 6 42,888,852 (GRCm39) missense probably benign
R6925:Or2a25 UTSW 6 42,888,791 (GRCm39) nonsense probably null
R8170:Or2a25 UTSW 6 42,889,125 (GRCm39) missense possibly damaging 0.73
R8358:Or2a25 UTSW 6 42,888,976 (GRCm39) missense possibly damaging 0.51
R8765:Or2a25 UTSW 6 42,889,102 (GRCm39) missense probably benign 0.34
R9005:Or2a25 UTSW 6 42,889,170 (GRCm39) missense probably damaging 1.00
R9015:Or2a25 UTSW 6 42,888,825 (GRCm39) missense possibly damaging 0.55
R9308:Or2a25 UTSW 6 42,888,931 (GRCm39) missense probably damaging 1.00
R9520:Or2a25 UTSW 6 42,889,051 (GRCm39) missense probably damaging 0.98
R9743:Or2a25 UTSW 6 42,888,835 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGATATGTAGCCATCTGCCACCC -3'
(R):5'- TGCTTGTGCTCCACCAATCTGAAG -3'

Sequencing Primer
(F):5'- CCGATATACTGCTATCATGAGCTGG -3'
(R):5'- CTCAAGAGGTGTCCTCCTTTAAGAG -3'
Posted On 2014-05-14