Mutagenetix > Incidental Mutation

Incidental Mutation 'R1709:Nlrp1b'

190346

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

039742-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R1709 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

71043928-71121559 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 71092099 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 9 (E9G)

Ref Sequence

ENSEMBL: ENSMUSP00000104155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108514] [ENSMUST00000108515] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably benign
Transcript: ENSMUST00000094046

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108514
AA Change: E9G

PolyPhen 2 Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000104154
Gene: ENSMUSG00000070390
AA Change: E9G

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.1e-40	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	814	1068	2.4e-136	PFAM
Pfam:CARD	1086	1169	3.7e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108515
AA Change: E9G

PolyPhen 2 Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000104155
Gene: ENSMUSG00000070390
AA Change: E9G

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.9e-41	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	815	1067	5e-104	PFAM
Pfam:CARD	1086	1169	1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108516

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000136493

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	A	G	5: 125,566,942 (GRCm39)	K152E	probably benign	Het
Adgrd1	T	C	5: 129,256,292 (GRCm39)	V641A	possibly damaging	Het
Adgrv1	A	T	13: 81,741,179 (GRCm39)	V95E	probably damaging	Het
Agbl5	G	A	5: 31,063,585 (GRCm39)	C872Y	probably damaging	Het
Aldh1a7	G	T	19: 20,693,316 (GRCm39)	T201K	probably damaging	Het
Aox1	C	T	1: 58,116,633 (GRCm39)	A788V	probably benign	Het
Apob	T	C	12: 8,059,306 (GRCm39)	V2563A	probably damaging	Het
Atcay	G	A	10: 81,049,065 (GRCm39)	T179I	probably damaging	Het
Atf5	A	T	7: 44,462,707 (GRCm39)	L139Q	probably benign	Het
Atp13a3	T	C	16: 30,134,659 (GRCm39)	T1205A	probably benign	Het
Atr	C	T	9: 95,753,129 (GRCm39)	T656I	probably benign	Het
Bloc1s3	T	C	7: 19,241,453 (GRCm39)	E25G	possibly damaging	Het
Brap	T	C	5: 121,803,353 (GRCm39)		probably null	Het
C6	G	T	15: 4,820,452 (GRCm39)	A488S	probably benign	Het
Ccin	T	C	4: 43,984,133 (GRCm39)	F180S	probably damaging	Het
Cd207	T	C	6: 83,649,818 (GRCm39)	I256V	possibly damaging	Het
Cdc42bpa	G	T	1: 179,894,789 (GRCm39)	C323F	probably damaging	Het
Cfap57	T	C	4: 118,428,901 (GRCm39)	T1022A	probably benign	Het
Cmtr2	A	T	8: 110,948,581 (GRCm39)	Q297L	probably benign	Het
Coro7	A	T	16: 4,452,305 (GRCm39)		probably null	Het
Cpsf2	T	A	12: 101,965,801 (GRCm39)	Y589N	probably damaging	Het
Cpxm2	T	C	7: 131,661,563 (GRCm39)	Y408C	probably damaging	Het
Crocc	A	G	4: 140,753,410 (GRCm39)		probably null	Het
Cryzl1	A	C	16: 91,509,124 (GRCm39)	F59C	probably damaging	Het
Csmd2	T	C	4: 128,389,988 (GRCm39)	V2241A	probably damaging	Het
Cxcl15	C	A	5: 90,949,275 (GRCm39)	H147N	unknown	Het
Dennd4a	A	G	9: 64,796,887 (GRCm39)	T860A	possibly damaging	Het
Dnah10	C	T	5: 124,837,155 (GRCm39)	P966L	probably damaging	Het
Dpp9	T	A	17: 56,501,431 (GRCm39)	M594L	probably benign	Het
Dspp	C	A	5: 104,323,590 (GRCm39)	N244K	probably damaging	Het
Efcab8	T	A	2: 153,656,290 (GRCm39)		probably null	Het
Elapor2	C	T	5: 9,490,726 (GRCm39)	R579*	probably null	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fbxw17	A	G	13: 50,585,693 (GRCm39)	M299V	probably benign	Het
Fbxw7	T	A	3: 84,883,659 (GRCm39)	I530N	probably damaging	Het
Gp2	C	A	7: 119,050,808 (GRCm39)	D308Y	probably null	Het
Gpd2	G	A	2: 57,247,667 (GRCm39)	V537M	probably damaging	Het
Gpr18	T	A	14: 122,149,404 (GRCm39)	Y207F	probably damaging	Het
Grip1	A	T	10: 119,733,620 (GRCm39)	D20V	probably damaging	Het
Gzmf	A	C	14: 56,444,397 (GRCm39)	F59V	probably damaging	Het
H3c1	T	A	13: 23,945,964 (GRCm39)	I125F	probably damaging	Het
Igfn1	T	C	1: 135,883,311 (GRCm39)	I2732V	probably benign	Het
Ipo8	A	T	6: 148,684,226 (GRCm39)	D855E	probably benign	Het
Klrk1	A	T	6: 129,591,682 (GRCm39)		probably null	Het
Megf11	A	G	9: 64,602,694 (GRCm39)	Y876C	probably damaging	Het
Mettl8	G	T	2: 70,812,495 (GRCm39)	Q12K	probably benign	Het
Mrgprf	T	C	7: 144,861,954 (GRCm39)	F172S	probably benign	Het
Mycbp2	G	A	14: 103,461,852 (GRCm39)	T1432I	probably damaging	Het
Nek11	A	C	9: 105,225,260 (GRCm39)	L84R	probably damaging	Het
Nrxn1	T	C	17: 90,344,615 (GRCm39)	I433V	probably damaging	Het
Nup153	A	G	13: 46,847,450 (GRCm39)	C660R	probably damaging	Het
Or1o11	T	A	17: 37,757,091 (GRCm39)	Y226*	probably null	Het
Or2a25	T	C	6: 42,889,078 (GRCm39)	V207A	possibly damaging	Het
Or4z4	G	T	19: 12,076,245 (GRCm39)	P253T	probably damaging	Het
Or5h26	T	A	16: 58,988,264 (GRCm39)	M81L	probably benign	Het
P2rx7	T	A	5: 122,808,528 (GRCm39)	N303K	possibly damaging	Het
Pank4	T	C	4: 155,054,504 (GRCm39)	L159P	probably damaging	Het
Pcdhb22	A	T	18: 37,651,553 (GRCm39)	H7L	probably benign	Het
Pdzd8	A	T	19: 59,289,771 (GRCm39)	I543N	probably benign	Het
Pramel25	T	C	4: 143,520,116 (GRCm39)	V120A	possibly damaging	Het
Prrc2b	C	A	2: 32,084,473 (GRCm39)	R313S	probably damaging	Het
Rbm12b1	T	C	4: 12,145,827 (GRCm39)	C600R	probably benign	Het
Rem1	G	A	2: 152,476,455 (GRCm39)	V238M	probably damaging	Het
Rfx6	T	A	10: 51,554,498 (GRCm39)	M113K	possibly damaging	Het
Rlf	A	T	4: 121,007,020 (GRCm39)	D653E	probably benign	Het
Rnf130	A	G	11: 49,978,213 (GRCm39)	D258G	possibly damaging	Het
Robo2	A	G	16: 73,753,411 (GRCm39)	V822A	possibly damaging	Het
Rps6kc1	G	T	1: 190,532,533 (GRCm39)	Q490K	possibly damaging	Het
Scn9a	T	C	2: 66,313,850 (GRCm39)	Y1945C	probably damaging	Het
Setd2	T	A	9: 110,378,925 (GRCm39)	D913E	probably benign	Het
Sfr1	G	T	19: 47,723,442 (GRCm39)	E315D	possibly damaging	Het
Smarca5	G	A	8: 81,435,849 (GRCm39)	R763*	probably null	Het
Sugct	A	C	13: 17,847,151 (GRCm39)	I44S	probably damaging	Het
Syce1l	A	G	8: 114,380,662 (GRCm39)		probably null	Het
Tbc1d8b	A	G	X: 138,634,829 (GRCm39)	I654V	probably benign	Het
Tcf23	T	A	5: 31,130,852 (GRCm39)	Y163*	probably null	Het
Terf2ip	TG	T	8: 112,738,238 (GRCm39)		probably null	Het
Tmem158	T	C	9: 123,088,950 (GRCm39)	S221G	possibly damaging	Het
Tnrc6a	A	G	7: 122,769,205 (GRCm39)	T332A	probably benign	Het
Trappc4	T	C	9: 44,318,508 (GRCm39)	T31A	probably benign	Het
Trim27	T	C	13: 21,372,235 (GRCm39)		probably null	Het
Ttyh2	T	A	11: 114,599,301 (GRCm39)	L330Q	probably damaging	Het
Tubgcp3	A	T	8: 12,689,532 (GRCm39)	L578*	probably null	Het
Txndc11	C	A	16: 10,946,565 (GRCm39)	E83*	probably null	Het
Utp20	T	C	10: 88,585,159 (GRCm39)	K2635R	probably benign	Het
V1ra8	C	T	6: 90,180,304 (GRCm39)	T169I	probably damaging	Het
Vcl	G	A	14: 21,069,441 (GRCm39)	V706I	probably benign	Het
Vmn2r106	A	T	17: 20,499,373 (GRCm39)	D179E	probably benign	Het
Vmn2r80	T	C	10: 79,030,223 (GRCm39)	M683T	probably benign	Het
Xirp2	A	G	2: 67,340,215 (GRCm39)	I819V	probably benign	Het
Zfp735	T	C	11: 73,602,589 (GRCm39)	F511S	probably benign	Het
Zfp831	T	C	2: 174,487,683 (GRCm39)	V786A	probably benign	Het
Zfp992	T	A	4: 146,550,949 (GRCm39)	H223Q	probably benign	Het
Zfyve19	A	C	2: 119,041,300 (GRCm39)	Q72P	probably damaging	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71,072,007 (GRCm39)	intron	probably benign
IGL00571:Nlrp1b	APN	11	71,054,799 (GRCm39)	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71,072,682 (GRCm39)	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71,072,233 (GRCm39)	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71,052,506 (GRCm39)	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71,063,057 (GRCm39)	missense	possibly damaging	0.96
IGL02552:Nlrp1b	APN	11	71,072,878 (GRCm39)	missense	possibly damaging	0.57
IGL02588:Nlrp1b	APN	11	71,073,105 (GRCm39)	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71,051,998 (GRCm39)	missense	probably benign
IGL02955:Nlrp1b	APN	11	71,060,637 (GRCm39)	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71,059,685 (GRCm39)	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71,052,665 (GRCm39)	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71,072,659 (GRCm39)	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71,052,741 (GRCm39)	missense	possibly damaging	0.82
androcles	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
Fangled	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
glitz	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
honeydew	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
Mush	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
Thorn	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R0001:Nlrp1b	UTSW	11	71,052,585 (GRCm39)	missense	probably damaging	1.00
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71,052,755 (GRCm39)	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71,062,997 (GRCm39)	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71,054,925 (GRCm39)	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71,052,591 (GRCm39)	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71,109,070 (GRCm39)	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71,073,241 (GRCm39)	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71,047,005 (GRCm39)	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71,072,173 (GRCm39)	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71,072,512 (GRCm39)	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71,072,290 (GRCm39)	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71,046,885 (GRCm39)	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71,072,124 (GRCm39)	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71,092,085 (GRCm39)	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71,073,637 (GRCm39)	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71,107,681 (GRCm39)	critical splice donor site	probably null
R1770:Nlrp1b	UTSW	11	71,050,979 (GRCm39)	missense	probably benign	0.22
R1775:Nlrp1b	UTSW	11	71,052,647 (GRCm39)	missense	probably damaging	1.00
R1851:Nlrp1b	UTSW	11	71,073,442 (GRCm39)	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71,072,964 (GRCm39)	missense	probably damaging	0.96
R2063:Nlrp1b	UTSW	11	71,051,912 (GRCm39)	missense	probably benign	0.09
R2189:Nlrp1b	UTSW	11	71,060,621 (GRCm39)	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71,046,815 (GRCm39)	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71,047,110 (GRCm39)	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71,047,552 (GRCm39)	splice site	probably null
R3079:Nlrp1b	UTSW	11	71,108,794 (GRCm39)	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71,047,126 (GRCm39)	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71,072,437 (GRCm39)	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71,063,911 (GRCm39)	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71,052,588 (GRCm39)	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71,119,151 (GRCm39)	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71,052,669 (GRCm39)	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71,072,232 (GRCm39)	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71,073,489 (GRCm39)	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71,108,710 (GRCm39)	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71,108,103 (GRCm39)	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71,109,160 (GRCm39)	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71,050,898 (GRCm39)	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71,072,359 (GRCm39)	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
R5388:Nlrp1b	UTSW	11	71,062,967 (GRCm39)	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71,108,701 (GRCm39)	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71,108,102 (GRCm39)	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71,072,229 (GRCm39)	missense	probably benign
R5826:Nlrp1b	UTSW	11	71,072,022 (GRCm39)	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71,108,691 (GRCm39)	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71,072,572 (GRCm39)	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71,107,836 (GRCm39)	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71,046,905 (GRCm39)	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71,109,283 (GRCm39)	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71,119,223 (GRCm39)	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71,072,527 (GRCm39)	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71,108,530 (GRCm39)	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71,119,259 (GRCm39)	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71,108,122 (GRCm39)	missense	probably benign
R6938:Nlrp1b	UTSW	11	71,109,042 (GRCm39)	missense	probably damaging	1.00
R7098:Nlrp1b	UTSW	11	71,109,100 (GRCm39)	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71,062,901 (GRCm39)	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71,072,482 (GRCm39)	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71,072,943 (GRCm39)	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71,072,376 (GRCm39)	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71,059,665 (GRCm39)	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71,108,537 (GRCm39)	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71,107,747 (GRCm39)	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71,062,897 (GRCm39)	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71,119,243 (GRCm39)	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71,052,545 (GRCm39)	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71,073,356 (GRCm39)	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71,073,204 (GRCm39)	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71,050,919 (GRCm39)	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71,073,288 (GRCm39)	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71,052,632 (GRCm39)	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71,108,658 (GRCm39)	missense	probably damaging	1.00
R9145:Nlrp1b	UTSW	11	71,109,193 (GRCm39)	missense	probably benign
R9184:Nlrp1b	UTSW	11	71,072,067 (GRCm39)	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71,060,573 (GRCm39)	missense	probably benign
R9322:Nlrp1b	UTSW	11	71,108,118 (GRCm39)	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71,072,913 (GRCm39)	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71,109,095 (GRCm39)	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71,073,132 (GRCm39)	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71,073,096 (GRCm39)	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71,108,050 (GRCm39)	missense	probably benign	0.03
Z1177:Nlrp1b	UTSW	11	71,072,125 (GRCm39)	nonsense	probably null
Z1186:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,135 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,539 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,396 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,378 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,370 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,280 (GRCm39)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,073,266 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,073,148 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,625 (GRCm39)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,072,534 (GRCm39)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,073,503 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- ATGCCTGATTCTCCCCACTAGAGC -3'
(R):5'- TGTCCTATGAAGCCCAAACCCCTG -3'

Sequencing Primer
(F):5'- GCTTTGAGCATCACATGGGAATC -3'
(R):5'- CTGATGAAAGGCTATCTGACCCTG -3'

Posted On

2014-05-14