Incidental Mutation 'R0020:Cyp2j11'
ID 19038
Institutional Source Beutler Lab
Gene Symbol Cyp2j11
Ensembl Gene ENSMUSG00000066097
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms Cyp2j11-ps
MMRRC Submission 038315-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R0020 (G1)
Quality Score
Status Validated
Chromosome 4
Chromosomal Location 96182745-96236899 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 96195641 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 352 (H352Y)
Ref Sequence ENSEMBL: ENSMUSP00000132180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015368]
AlphaFold Q3UNV2
Predicted Effect probably benign
Transcript: ENSMUST00000015368
AA Change: H352Y

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000132180
Gene: ENSMUSG00000066097
AA Change: H352Y

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:p450 44 500 4.3e-133 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 82.6%
  • 3x: 76.6%
  • 10x: 60.3%
  • 20x: 42.3%
Validation Efficiency 92% (100/109)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg2 C T 5: 137,652,064 (GRCm39) V432M probably benign Het
Akap11 A T 14: 78,755,617 (GRCm39) I74K probably benign Het
Atf2 T C 2: 73,676,628 (GRCm39) D122G possibly damaging Het
Brd10 A T 19: 29,693,597 (GRCm39) D2032E probably damaging Het
Ccser1 C A 6: 61,290,788 (GRCm39) T490K possibly damaging Het
Cip2a A T 16: 48,821,975 (GRCm39) H201L probably damaging Het
Clstn1 G A 4: 149,719,253 (GRCm39) V361M probably damaging Het
Cnga4 G T 7: 105,054,884 (GRCm39) R53L probably damaging Het
Col6a3 T A 1: 90,739,272 (GRCm39) I319F probably damaging Het
Cst11 T A 2: 148,613,253 (GRCm39) Y24F probably damaging Het
Cstb T A 10: 78,263,170 (GRCm39) V65E probably benign Het
Ezr G T 17: 7,010,126 (GRCm39) Q308K probably damaging Het
F3 A T 3: 121,525,265 (GRCm39) N169Y probably damaging Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Fcho1 C T 8: 72,169,514 (GRCm39) G131R probably benign Het
Fhl5 A T 4: 25,200,054 (GRCm39) V260E probably benign Het
Kcna10 A T 3: 107,102,736 (GRCm39) I456F probably damaging Het
Loxl2 T C 14: 69,898,242 (GRCm39) V232A probably damaging Het
Megf10 G T 18: 57,420,965 (GRCm39) V868F possibly damaging Het
Megf9 A G 4: 70,406,386 (GRCm39) V260A probably benign Het
Nampt A T 12: 32,891,012 (GRCm39) S278C probably damaging Het
Nap1l1 A C 10: 111,326,884 (GRCm39) E148D probably benign Het
Pamr1 C T 2: 102,472,423 (GRCm39) T574I probably benign Het
Pde4d T A 13: 110,091,104 (GRCm39) C35S possibly damaging Het
Pkd1l1 A G 11: 8,825,765 (GRCm39) probably benign Het
Pkd2 A G 5: 104,651,382 (GRCm39) E910G probably damaging Het
Pkhd1l1 A G 15: 44,420,268 (GRCm39) Y3002C probably damaging Het
Ppp6r2 T A 15: 89,143,342 (GRCm39) M163K probably damaging Het
Prdm4 T C 10: 85,743,487 (GRCm39) N256S probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rimoc1 T C 15: 4,021,350 (GRCm39) probably benign Het
Scube2 A G 7: 109,430,095 (GRCm39) probably benign Het
Slco1a8 A T 6: 141,918,076 (GRCm39) V600E possibly damaging Het
Sptbn5 T A 2: 119,896,112 (GRCm39) I779F probably damaging Het
Tamalin T C 15: 101,128,433 (GRCm39) V157A probably damaging Het
Uspl1 A G 5: 149,146,589 (GRCm39) T447A probably damaging Het
Zfp282 T G 6: 47,856,943 (GRCm39) W59G probably damaging Het
Zfp629 C G 7: 127,210,341 (GRCm39) E489D probably benign Het
Zfp746 C A 6: 48,041,641 (GRCm39) A362S probably benign Het
Other mutations in Cyp2j11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Cyp2j11 APN 4 96,227,332 (GRCm39) missense probably benign
IGL01816:Cyp2j11 APN 4 96,183,161 (GRCm39) missense probably damaging 1.00
IGL02406:Cyp2j11 APN 4 96,236,776 (GRCm39) missense possibly damaging 0.56
E7848:Cyp2j11 UTSW 4 96,207,602 (GRCm39) missense probably benign 0.09
R0020:Cyp2j11 UTSW 4 96,195,641 (GRCm39) missense probably benign 0.19
R1298:Cyp2j11 UTSW 4 96,195,497 (GRCm39) critical splice donor site probably null
R1411:Cyp2j11 UTSW 4 96,233,453 (GRCm39) missense probably benign 0.03
R1428:Cyp2j11 UTSW 4 96,183,117 (GRCm39) missense probably benign 0.01
R1740:Cyp2j11 UTSW 4 96,207,613 (GRCm39) missense probably benign 0.00
R1818:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1819:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1917:Cyp2j11 UTSW 4 96,228,211 (GRCm39) missense probably damaging 1.00
R2084:Cyp2j11 UTSW 4 96,227,438 (GRCm39) missense probably damaging 1.00
R2146:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2148:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2150:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R4963:Cyp2j11 UTSW 4 96,204,619 (GRCm39) missense probably damaging 1.00
R5335:Cyp2j11 UTSW 4 96,195,589 (GRCm39) missense probably damaging 1.00
R5450:Cyp2j11 UTSW 4 96,228,113 (GRCm39) missense probably benign 0.44
R5688:Cyp2j11 UTSW 4 96,233,358 (GRCm39) missense probably damaging 1.00
R5978:Cyp2j11 UTSW 4 96,207,589 (GRCm39) missense probably damaging 1.00
R6061:Cyp2j11 UTSW 4 96,236,853 (GRCm39) start gained probably benign
R6075:Cyp2j11 UTSW 4 96,233,322 (GRCm39) missense probably benign 0.04
R6912:Cyp2j11 UTSW 4 96,183,108 (GRCm39) missense probably benign 0.00
R7338:Cyp2j11 UTSW 4 96,195,524 (GRCm39) missense possibly damaging 0.64
R7394:Cyp2j11 UTSW 4 96,204,677 (GRCm39) missense probably benign 0.00
R7464:Cyp2j11 UTSW 4 96,233,357 (GRCm39) missense probably damaging 1.00
R7972:Cyp2j11 UTSW 4 96,185,871 (GRCm39) missense probably damaging 1.00
R8152:Cyp2j11 UTSW 4 96,195,529 (GRCm39) missense probably damaging 1.00
R8328:Cyp2j11 UTSW 4 96,236,605 (GRCm39) missense probably benign 0.03
R8383:Cyp2j11 UTSW 4 96,236,695 (GRCm39) missense probably benign 0.00
R8519:Cyp2j11 UTSW 4 96,207,539 (GRCm39) missense probably benign 0.44
R8789:Cyp2j11 UTSW 4 96,227,405 (GRCm39) missense probably damaging 0.99
R9268:Cyp2j11 UTSW 4 96,207,781 (GRCm39) intron probably benign
R9323:Cyp2j11 UTSW 4 96,195,619 (GRCm39) missense probably benign 0.01
R9457:Cyp2j11 UTSW 4 96,195,596 (GRCm39) missense probably damaging 0.98
R9590:Cyp2j11 UTSW 4 96,195,614 (GRCm39) missense probably benign 0.11
Z1176:Cyp2j11 UTSW 4 96,195,673 (GRCm39) missense probably damaging 0.99
Z1176:Cyp2j11 UTSW 4 96,195,540 (GRCm39) missense probably damaging 0.99
Posted On 2013-03-25