Incidental Mutation 'R1710:Fmo3'
ID 190390
Institutional Source Beutler Lab
Gene Symbol Fmo3
Ensembl Gene ENSMUSG00000026691
Gene Name flavin containing monooxygenase 3
Synonyms
MMRRC Submission 039743-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1710 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 162781369-162812097 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 162795356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 160 (F160L)
Ref Sequence ENSEMBL: ENSMUSP00000028010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028010]
AlphaFold P97501
Predicted Effect possibly damaging
Transcript: ENSMUST00000028010
AA Change: F160L

PolyPhen 2 Score 0.594 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000028010
Gene: ENSMUSG00000026691
AA Change: F160L

DomainStartEndE-ValueType
Pfam:FMO-like 2 534 7.7e-286 PFAM
Pfam:Pyr_redox_2 3 245 4.4e-15 PFAM
Pfam:Pyr_redox_3 6 220 1.1e-11 PFAM
Pfam:NAD_binding_8 7 71 3.1e-7 PFAM
Pfam:K_oxygenase 79 224 6.7e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142759
Meta Mutation Damage Score 0.6502 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency 98% (117/120)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 114 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503L19Rik A T 18: 70,601,134 (GRCm39) S249R possibly damaging Het
Acadvl T A 11: 69,901,181 (GRCm39) I638F probably damaging Het
Acnat2 T A 4: 49,380,587 (GRCm39) T264S probably benign Het
Acrv1 C T 9: 36,605,551 (GRCm39) Q33* probably null Het
Actrt3 T A 3: 30,653,901 (GRCm39) N33I probably damaging Het
Alyref2 T C 1: 171,331,168 (GRCm39) probably benign Het
Ank2 C A 3: 126,726,709 (GRCm39) E3712* probably null Het
Ano7 C A 1: 93,313,346 (GRCm39) H161Q probably benign Het
Arhgap10 C A 8: 78,085,216 (GRCm39) E451* probably null Het
Arhgap29 T A 3: 121,801,729 (GRCm39) Y748N probably damaging Het
Arhgap45 C T 10: 79,853,932 (GRCm39) Q149* probably null Het
Asap2 C T 12: 21,274,393 (GRCm39) H371Y probably damaging Het
Atp6v1b1 T C 6: 83,735,372 (GRCm39) I480T probably benign Het
BC034090 T C 1: 155,101,610 (GRCm39) D218G possibly damaging Het
Brdt A T 5: 107,491,450 (GRCm39) D74V probably damaging Het
C4b A G 17: 34,962,638 (GRCm39) probably benign Het
Card11 T A 5: 140,888,660 (GRCm39) K233* probably null Het
Catip T G 1: 74,401,929 (GRCm39) F35V possibly damaging Het
Ccdc13 C T 9: 121,648,647 (GRCm39) G247R probably damaging Het
Cep97 T A 16: 55,735,385 (GRCm39) D471V probably damaging Het
Col17a1 A T 19: 47,659,370 (GRCm39) L403Q probably damaging Het
Crbn A G 6: 106,767,906 (GRCm39) S194P possibly damaging Het
Degs1l A G 1: 180,878,884 (GRCm39) M1V probably null Het
Dennd10 A G 19: 60,806,021 (GRCm39) Y102C probably damaging Het
Dhx58 T A 11: 100,594,400 (GRCm39) H97L probably benign Het
Dnah8 T C 17: 31,073,914 (GRCm39) I4528T probably damaging Het
Dpyd A G 3: 118,404,092 (GRCm39) probably null Het
Entpd1 A T 19: 40,714,680 (GRCm39) Q263L probably benign Het
Entrep1 A T 19: 23,957,059 (GRCm39) I317N probably damaging Het
Esyt3 T C 9: 99,218,244 (GRCm39) I130M probably benign Het
Etv1 T C 12: 38,902,261 (GRCm39) F264S probably benign Het
Fat1 T C 8: 45,463,519 (GRCm39) S1354P probably benign Het
Fat4 C A 3: 39,005,304 (GRCm39) T1901N probably damaging Het
Fbxw13 C T 9: 109,010,586 (GRCm39) V351I probably damaging Het
Fyb2 T A 4: 104,861,113 (GRCm39) D592E probably damaging Het
Gjb4 T C 4: 127,245,663 (GRCm39) M93V possibly damaging Het
Gm5089 C A 14: 122,673,566 (GRCm39) G52* probably null Het
Gm6401 G T 14: 41,788,840 (GRCm39) N76K probably benign Het
Gm6871 A G 7: 41,195,901 (GRCm39) S279P probably damaging Het
Gtf2ird2 T G 5: 134,240,081 (GRCm39) V301G probably benign Het
H2bw2 A C X: 135,828,216 (GRCm39) D35A unknown Het
Hfm1 A G 5: 107,028,380 (GRCm39) F817L probably damaging Het
Hfm1 T C 5: 107,043,869 (GRCm39) E589G probably damaging Het
Hivep2 A T 10: 14,005,249 (GRCm39) K616* probably null Het
Hmcn1 A T 1: 150,551,735 (GRCm39) I2623N probably damaging Het
Igf2bp3 G T 6: 49,082,565 (GRCm39) A339E probably damaging Het
Insyn2b T A 11: 34,354,263 (GRCm39) probably null Het
Irx4 T C 13: 73,415,757 (GRCm39) I182T possibly damaging Het
Jcad T C 18: 4,674,511 (GRCm39) S758P probably damaging Het
Klhdc4 A T 8: 122,526,226 (GRCm39) Y304* probably null Het
Lama1 A G 17: 68,060,786 (GRCm39) I705V probably benign Het
Mbd5 A G 2: 49,147,044 (GRCm39) N418S probably benign Het
Mmp21 C T 7: 133,279,014 (GRCm39) V279I probably damaging Het
Morc4 A C X: 138,755,279 (GRCm39) C272W probably damaging Het
Mrm1 A T 11: 84,709,518 (GRCm39) C180S probably damaging Het
Ncor1 T C 11: 62,313,831 (GRCm39) D103G probably damaging Het
Ndrg4 A G 8: 96,437,314 (GRCm39) D251G probably damaging Het
Ndufaf5 T C 2: 140,035,522 (GRCm39) V246A possibly damaging Het
Noa1 T C 5: 77,457,572 (GRCm39) E111G possibly damaging Het
Nod1 C A 6: 54,921,044 (GRCm39) V425F probably damaging Het
Nos1 A T 5: 118,033,984 (GRCm39) I369F probably damaging Het
Nsun5 C T 5: 135,400,170 (GRCm39) H98Y probably damaging Het
Optn G A 2: 5,057,941 (GRCm39) T76I possibly damaging Het
Or14c39 G A 7: 86,344,318 (GRCm39) R218H probably benign Het
Or4k15c C G 14: 50,321,827 (GRCm39) V104L probably benign Het
Or5k1b A G 16: 58,581,504 (GRCm39) F12L probably benign Het
Or8d1b A G 9: 38,887,202 (GRCm39) I77V probably damaging Het
Or8g28 T C 9: 39,169,867 (GRCm39) I37V probably benign Het
Or9g19 C T 2: 85,600,199 (GRCm39) T18I probably benign Het
Oscar C T 7: 3,614,855 (GRCm39) W22* probably null Het
Palmd T A 3: 116,717,306 (GRCm39) Y397F probably damaging Het
Plk1 A G 7: 121,768,121 (GRCm39) D447G probably damaging Het
Plscr5 T A 9: 92,087,581 (GRCm39) N183K probably damaging Het
Polk T G 13: 96,625,712 (GRCm39) D364A probably damaging Het
Polr3d T C 14: 70,680,450 (GRCm39) T36A probably benign Het
Ppp1r10 A T 17: 36,237,428 (GRCm39) R199S probably damaging Het
Prkcz C T 4: 155,346,969 (GRCm39) D388N probably damaging Het
Prrc2b T C 2: 32,102,234 (GRCm39) L769P probably damaging Het
Psg26 A G 7: 18,213,966 (GRCm39) V232A probably damaging Het
Pth2r T C 1: 65,375,997 (GRCm39) V85A possibly damaging Het
Rbpms2 T C 9: 65,566,494 (GRCm39) probably benign Het
Reps1 A T 10: 17,994,698 (GRCm39) D514V possibly damaging Het
Riok3 G T 18: 12,276,018 (GRCm39) R238L probably benign Het
Rnf19a T C 15: 36,244,353 (GRCm39) Q569R probably damaging Het
Rorb G A 19: 18,937,865 (GRCm39) T267I probably damaging Het
Rrm2b A T 15: 37,929,340 (GRCm39) M70K probably damaging Het
Rsf1 A T 7: 97,311,556 (GRCm39) E762V possibly damaging Het
S100a2 G A 3: 90,498,699 (GRCm39) V67I probably benign Het
Skp1 T A 11: 52,133,442 (GRCm39) D42E probably benign Het
Slc22a4 A T 11: 53,918,801 (GRCm39) M1K probably null Het
Slc2a9 T A 5: 38,539,387 (GRCm39) Q371L probably damaging Het
Slc4a9 A G 18: 36,665,075 (GRCm39) T475A probably benign Het
Slc8b1 A G 5: 120,657,717 (GRCm39) N60S probably damaging Het
Slx4 A C 16: 3,817,022 (GRCm39) D66E probably benign Het
Smg8 A T 11: 86,977,113 (GRCm39) I156N probably damaging Het
Snx25 A T 8: 46,569,244 (GRCm39) C218S possibly damaging Het
Sulf2 T C 2: 165,920,992 (GRCm39) I784V probably benign Het
Tatdn2 G T 6: 113,674,888 (GRCm39) R72L possibly damaging Het
Tbc1d8 T C 1: 39,445,918 (GRCm39) D91G possibly damaging Het
Tifab C A 13: 56,324,433 (GRCm39) R3S probably benign Het
Tm4sf1 A T 3: 57,200,304 (GRCm39) S104T probably damaging Het
Tmem132e T A 11: 82,334,343 (GRCm39) I618N probably damaging Het
Ttc7b A T 12: 100,369,667 (GRCm39) D367E probably damaging Het
Txlnb A G 10: 17,719,203 (GRCm39) D678G possibly damaging Het
Vgll4 A G 6: 114,934,895 (GRCm39) probably null Het
Vmn2r124 A T 17: 18,282,187 (GRCm39) probably benign Het
Vmn2r2 T C 3: 64,024,820 (GRCm39) D587G probably benign Het
Vmn2r84 G A 10: 130,226,968 (GRCm39) A290V probably benign Het
Vps13c T A 9: 67,818,811 (GRCm39) S1077R probably benign Het
Vsig10 C T 5: 117,489,719 (GRCm39) A495V probably benign Het
Vwa3a A T 7: 120,403,254 (GRCm39) probably null Het
Zfhx2 C A 14: 55,303,455 (GRCm39) A1510S possibly damaging Het
Zfp142 T A 1: 74,611,389 (GRCm39) D601V probably damaging Het
Zfp62 T C 11: 49,108,510 (GRCm39) I867T probably benign Het
Other mutations in Fmo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00975:Fmo3 APN 1 162,791,599 (GRCm39) missense probably benign 0.15
IGL01124:Fmo3 APN 1 162,785,830 (GRCm39) missense probably damaging 1.00
IGL01645:Fmo3 APN 1 162,791,575 (GRCm39) missense possibly damaging 0.53
IGL01710:Fmo3 APN 1 162,810,612 (GRCm39) missense probably damaging 1.00
IGL01943:Fmo3 APN 1 162,794,575 (GRCm39) missense probably benign 0.01
IGL02489:Fmo3 APN 1 162,781,856 (GRCm39) missense possibly damaging 0.75
IGL02503:Fmo3 APN 1 162,796,433 (GRCm39) missense probably benign 0.03
IGL02743:Fmo3 APN 1 162,786,052 (GRCm39) missense probably damaging 1.00
IGL02974:Fmo3 APN 1 162,810,619 (GRCm39) missense probably damaging 1.00
IGL03023:Fmo3 APN 1 162,786,034 (GRCm39) missense probably benign 0.00
R0554:Fmo3 UTSW 1 162,781,901 (GRCm39) missense probably benign 0.03
R0629:Fmo3 UTSW 1 162,785,796 (GRCm39) splice site probably benign
R1209:Fmo3 UTSW 1 162,791,597 (GRCm39) missense probably benign 0.00
R1213:Fmo3 UTSW 1 162,795,392 (GRCm39) missense probably damaging 1.00
R1612:Fmo3 UTSW 1 162,795,454 (GRCm39) missense probably damaging 1.00
R1636:Fmo3 UTSW 1 162,781,994 (GRCm39) missense probably benign
R1764:Fmo3 UTSW 1 162,786,142 (GRCm39) missense possibly damaging 0.79
R1775:Fmo3 UTSW 1 162,796,294 (GRCm39) missense possibly damaging 0.54
R1906:Fmo3 UTSW 1 162,794,475 (GRCm39) missense probably damaging 1.00
R2363:Fmo3 UTSW 1 162,781,884 (GRCm39) missense probably damaging 0.98
R2418:Fmo3 UTSW 1 162,794,527 (GRCm39) missense probably benign
R2519:Fmo3 UTSW 1 162,785,874 (GRCm39) missense probably damaging 1.00
R3940:Fmo3 UTSW 1 162,791,555 (GRCm39) missense probably benign 0.01
R3977:Fmo3 UTSW 1 162,786,147 (GRCm39) missense probably damaging 0.99
R4779:Fmo3 UTSW 1 162,796,407 (GRCm39) missense probably damaging 1.00
R4846:Fmo3 UTSW 1 162,781,880 (GRCm39) missense possibly damaging 0.94
R4892:Fmo3 UTSW 1 162,796,300 (GRCm39) missense probably benign 0.00
R5102:Fmo3 UTSW 1 162,791,546 (GRCm39) missense probably benign 0.01
R5516:Fmo3 UTSW 1 162,781,995 (GRCm39) nonsense probably null
R6035:Fmo3 UTSW 1 162,791,605 (GRCm39) missense probably damaging 0.97
R6035:Fmo3 UTSW 1 162,791,605 (GRCm39) missense probably damaging 0.97
R7050:Fmo3 UTSW 1 162,791,473 (GRCm39) missense probably damaging 0.98
R7088:Fmo3 UTSW 1 162,796,434 (GRCm39) missense probably benign 0.04
R7205:Fmo3 UTSW 1 162,781,857 (GRCm39) missense possibly damaging 0.90
R7371:Fmo3 UTSW 1 162,781,796 (GRCm39) missense possibly damaging 0.57
R7685:Fmo3 UTSW 1 162,785,901 (GRCm39) missense possibly damaging 0.73
R8458:Fmo3 UTSW 1 162,794,509 (GRCm39) missense possibly damaging 0.89
R8821:Fmo3 UTSW 1 162,796,407 (GRCm39) missense probably damaging 1.00
R9371:Fmo3 UTSW 1 162,796,281 (GRCm39) missense probably benign 0.18
R9564:Fmo3 UTSW 1 162,786,021 (GRCm39) missense probably damaging 1.00
R9764:Fmo3 UTSW 1 162,794,524 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGAACAAGCTTTGCTGTTGAGTCTCTC -3'
(R):5'- CTGCATTCCTTAGACACCTGTAACCAG -3'

Sequencing Primer
(F):5'- TGATGCAACTGgtgtgtgtg -3'
(R):5'- ACCACTGAAAAGCACGGT -3'
Posted On 2014-05-14