Incidental Mutation 'R1710:Hfm1'
| ID |
190417 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hfm1
|
| Ensembl Gene |
ENSMUSG00000043410 |
| Gene Name |
HFM1, ATP-dependent DNA helicase homolog |
| Synonyms |
LOC381663, A330009G12Rik, Mer3, Sec63d1 |
| MMRRC Submission |
039743-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R1710 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
106840192-106926321 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 106880514 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 817
(F817L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112590
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112690]
[ENSMUST00000117588]
[ENSMUST00000148495]
|
| AlphaFold |
D3Z4R1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112690
AA Change: F817L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108310
Gene: ENSMUSG00000043410
AA Change: F817L
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117588
AA Change: F817L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112590
Gene: ENSMUSG00000043410
AA Change: F817L
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148495
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000155171
AA Change: F74L
|
| SMART Domains |
Protein: ENSMUSP00000118674
Gene: ENSMUSG00000043410
AA Change: F74L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
22 |
N/A |
INTRINSIC |
|
Sec63
|
33 |
304 |
3.04e-42 |
SMART |
|
Blast:Sec63
|
344 |
402 |
7e-19 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183903
|
| Meta Mutation Damage Score |
0.3558 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.5%
|
| Validation Efficiency |
98% (117/120) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
PHENOTYPE: Meiosis ais disrupted in homozygotes and bothe sexes are sterile [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930503L19Rik |
A |
T |
18: 70,468,063 (GRCm38) |
S249R |
possibly damaging |
Het |
| 9130409I23Rik |
A |
G |
1: 181,051,319 (GRCm38) |
M1V |
probably null |
Het |
| Acadvl |
T |
A |
11: 70,010,355 (GRCm38) |
I638F |
probably damaging |
Het |
| Acnat2 |
T |
A |
4: 49,380,587 (GRCm38) |
T264S |
probably benign |
Het |
| Acrv1 |
C |
T |
9: 36,694,255 (GRCm38) |
Q33* |
probably null |
Het |
| Actrt3 |
T |
A |
3: 30,599,752 (GRCm38) |
N33I |
probably damaging |
Het |
| Alyref2 |
T |
C |
1: 171,503,600 (GRCm38) |
|
probably benign |
Het |
| Ank2 |
C |
A |
3: 126,933,060 (GRCm38) |
E3712* |
probably null |
Het |
| Ano7 |
C |
A |
1: 93,385,624 (GRCm38) |
H161Q |
probably benign |
Het |
| Arhgap10 |
C |
A |
8: 77,358,587 (GRCm38) |
E451* |
probably null |
Het |
| Arhgap29 |
T |
A |
3: 122,008,080 (GRCm38) |
Y748N |
probably damaging |
Het |
| Arhgap45 |
C |
T |
10: 80,018,098 (GRCm38) |
Q149* |
probably null |
Het |
| Asap2 |
C |
T |
12: 21,224,392 (GRCm38) |
H371Y |
probably damaging |
Het |
| Atp6v1b1 |
T |
C |
6: 83,758,390 (GRCm38) |
I480T |
probably benign |
Het |
| BC034090 |
T |
C |
1: 155,225,864 (GRCm38) |
D218G |
possibly damaging |
Het |
| Brdt |
A |
T |
5: 107,343,584 (GRCm38) |
D74V |
probably damaging |
Het |
| C4b |
A |
G |
17: 34,743,664 (GRCm38) |
|
probably benign |
Het |
| Card11 |
T |
A |
5: 140,902,905 (GRCm38) |
K233* |
probably null |
Het |
| Catip |
T |
G |
1: 74,362,770 (GRCm38) |
F35V |
possibly damaging |
Het |
| Ccdc13 |
C |
T |
9: 121,819,581 (GRCm38) |
G247R |
probably damaging |
Het |
| Cep97 |
T |
A |
16: 55,915,022 (GRCm38) |
D471V |
probably damaging |
Het |
| Col17a1 |
A |
T |
19: 47,670,931 (GRCm38) |
L403Q |
probably damaging |
Het |
| Crbn |
A |
G |
6: 106,790,945 (GRCm38) |
S194P |
possibly damaging |
Het |
| Dhx58 |
T |
A |
11: 100,703,574 (GRCm38) |
H97L |
probably benign |
Het |
| Dnah8 |
T |
C |
17: 30,854,940 (GRCm38) |
I4528T |
probably damaging |
Het |
| Dpyd |
A |
G |
3: 118,610,443 (GRCm38) |
|
probably null |
Het |
| Entpd1 |
A |
T |
19: 40,726,236 (GRCm38) |
Q263L |
probably benign |
Het |
| Esyt3 |
T |
C |
9: 99,336,191 (GRCm38) |
I130M |
probably benign |
Het |
| Etv1 |
T |
C |
12: 38,852,262 (GRCm38) |
F264S |
probably benign |
Het |
| Fam189a2 |
A |
T |
19: 23,979,695 (GRCm38) |
I317N |
probably damaging |
Het |
| Fam196b |
T |
A |
11: 34,404,263 (GRCm38) |
|
probably null |
Het |
| Fam45a |
A |
G |
19: 60,817,583 (GRCm38) |
Y102C |
probably damaging |
Het |
| Fat1 |
T |
C |
8: 45,010,482 (GRCm38) |
S1354P |
probably benign |
Het |
| Fat4 |
C |
A |
3: 38,951,155 (GRCm38) |
T1901N |
probably damaging |
Het |
| Fbxw13 |
C |
T |
9: 109,181,518 (GRCm38) |
V351I |
probably damaging |
Het |
| Fmo3 |
A |
G |
1: 162,967,787 (GRCm38) |
F160L |
possibly damaging |
Het |
| Fyb2 |
T |
A |
4: 105,003,916 (GRCm38) |
D592E |
probably damaging |
Het |
| Gjb4 |
T |
C |
4: 127,351,870 (GRCm38) |
M93V |
possibly damaging |
Het |
| Gm5089 |
C |
A |
14: 122,436,154 (GRCm38) |
G52* |
probably null |
Het |
| Gm6401 |
G |
T |
14: 41,966,883 (GRCm38) |
N76K |
probably benign |
Het |
| Gm6871 |
A |
G |
7: 41,546,477 (GRCm38) |
S279P |
probably damaging |
Het |
| Gtf2ird2 |
T |
G |
5: 134,211,240 (GRCm38) |
V301G |
probably benign |
Het |
| H2bfm |
A |
C |
X: 136,927,467 (GRCm38) |
D35A |
unknown |
Het |
| Hivep2 |
A |
T |
10: 14,129,505 (GRCm38) |
K616* |
probably null |
Het |
| Hmcn1 |
A |
T |
1: 150,675,984 (GRCm38) |
I2623N |
probably damaging |
Het |
| Igf2bp3 |
G |
T |
6: 49,105,631 (GRCm38) |
A339E |
probably damaging |
Het |
| Irx4 |
T |
C |
13: 73,267,638 (GRCm38) |
I182T |
possibly damaging |
Het |
| Jcad |
T |
C |
18: 4,674,511 (GRCm38) |
S758P |
probably damaging |
Het |
| Klhdc4 |
A |
T |
8: 121,799,487 (GRCm38) |
Y304* |
probably null |
Het |
| Lama1 |
A |
G |
17: 67,753,791 (GRCm38) |
I705V |
probably benign |
Het |
| Mbd5 |
A |
G |
2: 49,257,032 (GRCm38) |
N418S |
probably benign |
Het |
| Mmp21 |
C |
T |
7: 133,677,285 (GRCm38) |
V279I |
probably damaging |
Het |
| Morc4 |
A |
C |
X: 139,854,530 (GRCm38) |
C272W |
probably damaging |
Het |
| Mrm1 |
A |
T |
11: 84,818,692 (GRCm38) |
C180S |
probably damaging |
Het |
| Ncor1 |
T |
C |
11: 62,423,005 (GRCm38) |
D103G |
probably damaging |
Het |
| Ndrg4 |
A |
G |
8: 95,710,686 (GRCm38) |
D251G |
probably damaging |
Het |
| Ndufaf5 |
T |
C |
2: 140,193,602 (GRCm38) |
V246A |
possibly damaging |
Het |
| Noa1 |
T |
C |
5: 77,309,725 (GRCm38) |
E111G |
possibly damaging |
Het |
| Nod1 |
C |
A |
6: 54,944,059 (GRCm38) |
V425F |
probably damaging |
Het |
| Nos1 |
A |
T |
5: 117,895,919 (GRCm38) |
I369F |
probably damaging |
Het |
| Nsun5 |
C |
T |
5: 135,371,316 (GRCm38) |
H98Y |
probably damaging |
Het |
| Olfr1013 |
C |
T |
2: 85,769,855 (GRCm38) |
T18I |
probably benign |
Het |
| Olfr172 |
A |
G |
16: 58,761,141 (GRCm38) |
F12L |
probably benign |
Het |
| Olfr292 |
G |
A |
7: 86,695,110 (GRCm38) |
R218H |
probably benign |
Het |
| Olfr726 |
C |
G |
14: 50,084,370 (GRCm38) |
V104L |
probably benign |
Het |
| Olfr933 |
A |
G |
9: 38,975,906 (GRCm38) |
I77V |
probably damaging |
Het |
| Olfr945 |
T |
C |
9: 39,258,571 (GRCm38) |
I37V |
probably benign |
Het |
| Optn |
G |
A |
2: 5,053,130 (GRCm38) |
T76I |
possibly damaging |
Het |
| Oscar |
C |
T |
7: 3,611,856 (GRCm38) |
W22* |
probably null |
Het |
| Palmd |
T |
A |
3: 116,923,657 (GRCm38) |
Y397F |
probably damaging |
Het |
| Plk1 |
A |
G |
7: 122,168,898 (GRCm38) |
D447G |
probably damaging |
Het |
| Plscr5 |
T |
A |
9: 92,205,528 (GRCm38) |
N183K |
probably damaging |
Het |
| Polk |
T |
G |
13: 96,489,204 (GRCm38) |
D364A |
probably damaging |
Het |
| Polr3d |
T |
C |
14: 70,443,010 (GRCm38) |
T36A |
probably benign |
Het |
| Ppp1r10 |
A |
T |
17: 35,926,536 (GRCm38) |
R199S |
probably damaging |
Het |
| Prkcz |
C |
T |
4: 155,262,512 (GRCm38) |
D388N |
probably damaging |
Het |
| Prrc2b |
T |
C |
2: 32,212,222 (GRCm38) |
L769P |
probably damaging |
Het |
| Psg26 |
A |
G |
7: 18,480,041 (GRCm38) |
V232A |
probably damaging |
Het |
| Pth2r |
T |
C |
1: 65,336,838 (GRCm38) |
V85A |
possibly damaging |
Het |
| Rbpms2 |
T |
C |
9: 65,659,212 (GRCm38) |
|
probably benign |
Het |
| Reps1 |
A |
T |
10: 18,118,950 (GRCm38) |
D514V |
possibly damaging |
Het |
| Riok3 |
G |
T |
18: 12,142,961 (GRCm38) |
R238L |
probably benign |
Het |
| Rnf19a |
T |
C |
15: 36,244,207 (GRCm38) |
Q569R |
probably damaging |
Het |
| Rorb |
G |
A |
19: 18,960,501 (GRCm38) |
T267I |
probably damaging |
Het |
| Rrm2b |
A |
T |
15: 37,929,096 (GRCm38) |
M70K |
probably damaging |
Het |
| Rsf1 |
A |
T |
7: 97,662,349 (GRCm38) |
E762V |
possibly damaging |
Het |
| S100a2 |
G |
A |
3: 90,591,392 (GRCm38) |
V67I |
probably benign |
Het |
| Skp1a |
T |
A |
11: 52,242,615 (GRCm38) |
D42E |
probably benign |
Het |
| Slc22a4 |
A |
T |
11: 54,027,975 (GRCm38) |
M1K |
probably null |
Het |
| Slc2a9 |
T |
A |
5: 38,382,044 (GRCm38) |
Q371L |
probably damaging |
Het |
| Slc4a9 |
A |
G |
18: 36,532,022 (GRCm38) |
T475A |
probably benign |
Het |
| Slc8b1 |
A |
G |
5: 120,519,652 (GRCm38) |
N60S |
probably damaging |
Het |
| Slx4 |
A |
C |
16: 3,999,158 (GRCm38) |
D66E |
probably benign |
Het |
| Smg8 |
A |
T |
11: 87,086,287 (GRCm38) |
I156N |
probably damaging |
Het |
| Snx25 |
A |
T |
8: 46,116,207 (GRCm38) |
C218S |
possibly damaging |
Het |
| Sulf2 |
T |
C |
2: 166,079,072 (GRCm38) |
I784V |
probably benign |
Het |
| Tatdn2 |
G |
T |
6: 113,697,927 (GRCm38) |
R72L |
possibly damaging |
Het |
| Tbc1d8 |
T |
C |
1: 39,406,837 (GRCm38) |
D91G |
possibly damaging |
Het |
| Tifab |
C |
A |
13: 56,176,620 (GRCm38) |
R3S |
probably benign |
Het |
| Tm4sf1 |
A |
T |
3: 57,292,883 (GRCm38) |
S104T |
probably damaging |
Het |
| Tmem132e |
T |
A |
11: 82,443,517 (GRCm38) |
I618N |
probably damaging |
Het |
| Ttc7b |
A |
T |
12: 100,403,408 (GRCm38) |
D367E |
probably damaging |
Het |
| Txlnb |
A |
G |
10: 17,843,455 (GRCm38) |
D678G |
possibly damaging |
Het |
| Vgll4 |
A |
G |
6: 114,957,934 (GRCm38) |
|
probably null |
Het |
| Vmn2r124 |
A |
T |
17: 18,061,925 (GRCm38) |
|
probably benign |
Het |
| Vmn2r2 |
T |
C |
3: 64,117,399 (GRCm38) |
D587G |
probably benign |
Het |
| Vmn2r84 |
G |
A |
10: 130,391,099 (GRCm38) |
A290V |
probably benign |
Het |
| Vps13c |
T |
A |
9: 67,911,529 (GRCm38) |
S1077R |
probably benign |
Het |
| Vsig10 |
C |
T |
5: 117,351,654 (GRCm38) |
A495V |
probably benign |
Het |
| Vwa3a |
A |
T |
7: 120,804,031 (GRCm38) |
|
probably null |
Het |
| Zfhx2 |
C |
A |
14: 55,065,998 (GRCm38) |
A1510S |
possibly damaging |
Het |
| Zfp142 |
T |
A |
1: 74,572,230 (GRCm38) |
D601V |
probably damaging |
Het |
| Zfp62 |
T |
C |
11: 49,217,683 (GRCm38) |
I867T |
probably benign |
Het |
|
| Other mutations in Hfm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Hfm1
|
APN |
5 |
106,902,130 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
IGL01295:Hfm1
|
APN |
5 |
106,917,606 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
IGL01725:Hfm1
|
APN |
5 |
106,917,379 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01758:Hfm1
|
APN |
5 |
106,904,793 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01911:Hfm1
|
APN |
5 |
106,911,544 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02337:Hfm1
|
APN |
5 |
106,904,267 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL02472:Hfm1
|
APN |
5 |
106,873,928 (GRCm38) |
splice site |
probably benign |
|
|
IGL02496:Hfm1
|
APN |
5 |
106,901,761 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02545:Hfm1
|
APN |
5 |
106,895,287 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02584:Hfm1
|
APN |
5 |
106,878,662 (GRCm38) |
splice site |
probably null |
|
|
IGL02728:Hfm1
|
APN |
5 |
106,878,823 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL02881:Hfm1
|
APN |
5 |
106,874,252 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03108:Hfm1
|
APN |
5 |
106,895,934 (GRCm38) |
unclassified |
probably benign |
|
|
IGL03351:Hfm1
|
APN |
5 |
106,911,575 (GRCm38) |
nonsense |
probably null |
|
|
IGL03353:Hfm1
|
APN |
5 |
106,856,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0024:Hfm1
|
UTSW |
5 |
106,856,924 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0024:Hfm1
|
UTSW |
5 |
106,856,924 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0094:Hfm1
|
UTSW |
5 |
106,917,478 (GRCm38) |
missense |
probably benign |
|
|
R0633:Hfm1
|
UTSW |
5 |
106,917,601 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R0644:Hfm1
|
UTSW |
5 |
106,898,256 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1078:Hfm1
|
UTSW |
5 |
106,878,830 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1120:Hfm1
|
UTSW |
5 |
106,904,218 (GRCm38) |
splice site |
probably benign |
|
|
R1166:Hfm1
|
UTSW |
5 |
106,911,411 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1242:Hfm1
|
UTSW |
5 |
106,874,901 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1414:Hfm1
|
UTSW |
5 |
106,872,353 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1450:Hfm1
|
UTSW |
5 |
106,918,458 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1529:Hfm1
|
UTSW |
5 |
106,853,123 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1622:Hfm1
|
UTSW |
5 |
106,893,523 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R1710:Hfm1
|
UTSW |
5 |
106,896,003 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1757:Hfm1
|
UTSW |
5 |
106,880,360 (GRCm38) |
splice site |
probably null |
|
|
R1856:Hfm1
|
UTSW |
5 |
106,847,676 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1984:Hfm1
|
UTSW |
5 |
106,898,576 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1985:Hfm1
|
UTSW |
5 |
106,898,576 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2040:Hfm1
|
UTSW |
5 |
106,901,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2122:Hfm1
|
UTSW |
5 |
106,896,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2426:Hfm1
|
UTSW |
5 |
106,847,653 (GRCm38) |
splice site |
probably null |
|
|
R2474:Hfm1
|
UTSW |
5 |
106,872,416 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R2926:Hfm1
|
UTSW |
5 |
106,874,282 (GRCm38) |
nonsense |
probably null |
|
|
R2944:Hfm1
|
UTSW |
5 |
106,872,330 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3705:Hfm1
|
UTSW |
5 |
106,892,839 (GRCm38) |
unclassified |
probably benign |
|
|
R4256:Hfm1
|
UTSW |
5 |
106,904,797 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R4455:Hfm1
|
UTSW |
5 |
106,886,508 (GRCm38) |
splice site |
probably null |
|
|
R4538:Hfm1
|
UTSW |
5 |
106,874,890 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4540:Hfm1
|
UTSW |
5 |
106,874,221 (GRCm38) |
nonsense |
probably null |
|
|
R4591:Hfm1
|
UTSW |
5 |
106,847,667 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4745:Hfm1
|
UTSW |
5 |
106,901,843 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4747:Hfm1
|
UTSW |
5 |
106,917,523 (GRCm38) |
missense |
probably benign |
|
|
R4765:Hfm1
|
UTSW |
5 |
106,842,539 (GRCm38) |
missense |
probably benign |
0.21 |
|
R4821:Hfm1
|
UTSW |
5 |
106,854,740 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4842:Hfm1
|
UTSW |
5 |
106,892,751 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4944:Hfm1
|
UTSW |
5 |
106,874,213 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5093:Hfm1
|
UTSW |
5 |
106,901,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5399:Hfm1
|
UTSW |
5 |
106,917,562 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R5414:Hfm1
|
UTSW |
5 |
106,902,076 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5436:Hfm1
|
UTSW |
5 |
106,892,772 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R5459:Hfm1
|
UTSW |
5 |
106,904,763 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5485:Hfm1
|
UTSW |
5 |
106,847,662 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5585:Hfm1
|
UTSW |
5 |
106,911,439 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5631:Hfm1
|
UTSW |
5 |
106,904,763 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5705:Hfm1
|
UTSW |
5 |
106,911,453 (GRCm38) |
missense |
probably benign |
0.21 |
|
R5804:Hfm1
|
UTSW |
5 |
106,878,589 (GRCm38) |
splice site |
probably null |
|
|
R5959:Hfm1
|
UTSW |
5 |
106,874,917 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Hfm1
|
UTSW |
5 |
106,898,643 (GRCm38) |
splice site |
probably null |
|
|
R6191:Hfm1
|
UTSW |
5 |
106,886,553 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6345:Hfm1
|
UTSW |
5 |
106,841,638 (GRCm38) |
missense |
probably benign |
|
|
R6580:Hfm1
|
UTSW |
5 |
106,847,709 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6651:Hfm1
|
UTSW |
5 |
106,847,687 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6761:Hfm1
|
UTSW |
5 |
106,895,279 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6835:Hfm1
|
UTSW |
5 |
106,878,815 (GRCm38) |
nonsense |
probably null |
|
|
R6891:Hfm1
|
UTSW |
5 |
106,917,374 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R6924:Hfm1
|
UTSW |
5 |
106,850,410 (GRCm38) |
splice site |
probably null |
|
|
R6980:Hfm1
|
UTSW |
5 |
106,880,477 (GRCm38) |
missense |
probably benign |
0.31 |
|
R7054:Hfm1
|
UTSW |
5 |
106,896,043 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7058:Hfm1
|
UTSW |
5 |
106,911,440 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7189:Hfm1
|
UTSW |
5 |
106,901,703 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7250:Hfm1
|
UTSW |
5 |
106,904,331 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7376:Hfm1
|
UTSW |
5 |
106,895,218 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7577:Hfm1
|
UTSW |
5 |
106,896,043 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7636:Hfm1
|
UTSW |
5 |
106,917,466 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7639:Hfm1
|
UTSW |
5 |
106,898,475 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7639:Hfm1
|
UTSW |
5 |
106,889,925 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7763:Hfm1
|
UTSW |
5 |
106,881,861 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7828:Hfm1
|
UTSW |
5 |
106,881,791 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7905:Hfm1
|
UTSW |
5 |
106,898,553 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8160:Hfm1
|
UTSW |
5 |
106,896,033 (GRCm38) |
missense |
probably null |
0.00 |
|
R8477:Hfm1
|
UTSW |
5 |
106,881,818 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8739:Hfm1
|
UTSW |
5 |
106,898,505 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8968:Hfm1
|
UTSW |
5 |
106,917,573 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9072:Hfm1
|
UTSW |
5 |
106,898,280 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9073:Hfm1
|
UTSW |
5 |
106,898,280 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9152:Hfm1
|
UTSW |
5 |
106,841,745 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9234:Hfm1
|
UTSW |
5 |
106,893,468 (GRCm38) |
missense |
probably benign |
|
|
R9244:Hfm1
|
UTSW |
5 |
106,874,900 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9576:Hfm1
|
UTSW |
5 |
106,874,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9649:Hfm1
|
UTSW |
5 |
106,918,463 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9743:Hfm1
|
UTSW |
5 |
106,874,259 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R9782:Hfm1
|
UTSW |
5 |
106,874,030 (GRCm38) |
missense |
probably benign |
0.38 |
|
R9789:Hfm1
|
UTSW |
5 |
106,917,480 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1177:Hfm1
|
UTSW |
5 |
106,871,820 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGCTACTGTAATGAAGGGACCAAC -3'
(R):5'- CCGTCTCAACGTCTGCCATATAGAAG -3'
Sequencing Primer
(F):5'- CAGACTTCTGCTGGAAACATGG -3'
(R):5'- TGTTAGTGAGTGAATCCTTAAAGAAG -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation