Incidental Mutation 'R0016:Tcrg-V5'
ID19082
Institutional Source Beutler Lab
Gene Symbol Tcrg-V5
Ensembl Gene ENSMUSG00000076747
Gene NameT cell receptor gamma, variable 5
Synonyms
MMRRC Submission 038311-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.099) question?
Stock #R0016 (G1)
Quality Score
Status Validated
Chromosome13
Chromosomal Location19192433-19192725 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 19192719 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Stop codon at position 112 (W112*)
Ref Sequence ENSEMBL: ENSMUSP00000143714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103555] [ENSMUST00000103556] [ENSMUST00000198330] [ENSMUST00000199017]
Predicted Effect probably benign
Transcript: ENSMUST00000103555
SMART Domains Protein: ENSMUSP00000100336
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 40 134 2.94e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000103556
AA Change: W96*
SMART Domains Protein: ENSMUSP00000100337
Gene: ENSMUSG00000076747
AA Change: W96*

DomainStartEndE-ValueType
IGv 18 95 3.3e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197661
Predicted Effect probably benign
Transcript: ENSMUST00000198330
SMART Domains Protein: ENSMUSP00000142811
Gene: ENSMUSG00000076746

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 121 1.2e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000199017
AA Change: W112*
SMART Domains Protein: ENSMUSP00000143714
Gene: ENSMUSG00000076747
AA Change: W112*

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
IGv 34 111 1.4e-15 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 81.7%
  • 3x: 74.6%
  • 10x: 53.6%
  • 20x: 32.4%
Validation Efficiency 93% (85/91)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A C 1: 71,294,800 V1181G probably benign Het
Adamts12 A T 15: 11,217,829 I291F probably damaging Het
Aspm G C 1: 139,479,544 Q2056H probably benign Het
BC067074 T C 13: 113,366,105 Y115H probably damaging Het
C7 A T 15: 5,046,924 V122E probably benign Het
Casp12 A T 9: 5,352,844 Q152L probably null Het
Cpne8 A G 15: 90,501,405 probably benign Het
Cyp2j7 T A 4: 96,202,147 I347F probably damaging Het
Dync2h1 A G 9: 7,144,346 probably benign Het
Echdc1 A T 10: 29,322,421 probably benign Het
Elovl3 T A 19: 46,132,158 F30Y probably damaging Het
Fam208b A C 13: 3,585,170 probably null Het
Fgd3 C T 13: 49,296,609 D55N probably benign Het
Fhod1 T C 8: 105,331,655 E823G possibly damaging Het
Gapvd1 A G 2: 34,699,913 probably benign Het
Helz2 C A 2: 181,232,759 G1981C probably damaging Het
Kif27 A G 13: 58,354,714 V50A probably damaging Het
Lrp2bp T A 8: 46,012,031 F62L probably damaging Het
Marf1 G A 16: 14,152,265 H197Y probably damaging Het
Mon2 C T 10: 123,035,546 V389M probably damaging Het
Myh8 A G 11: 67,298,525 K1176E probably damaging Het
Nckap1l A G 15: 103,475,636 T554A probably benign Het
Oog3 A G 4: 144,158,071 Y432H probably damaging Het
Sorbs1 A G 19: 40,314,738 probably benign Het
Srgap2 A G 1: 131,349,462 M349T possibly damaging Het
Stc2 A T 11: 31,360,177 D286E probably benign Het
Stk31 T C 6: 49,437,377 Y482H probably damaging Het
Sycp2l A G 13: 41,157,500 probably benign Het
Trim27 A T 13: 21,191,229 E310V probably benign Het
Uvrag T C 7: 98,991,981 K284R probably benign Het
Xylt2 A G 11: 94,669,640 S270P probably damaging Het
Zwint T C 10: 72,657,198 probably benign Het
Other mutations in Tcrg-V5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3794:Tcrg-V5 UTSW 13 19192524 missense probably benign 0.31
R4788:Tcrg-V5 UTSW 13 19192554 missense probably benign 0.35
R5099:Tcrg-V5 UTSW 13 19192716 missense probably damaging 0.99
R5397:Tcrg-V5 UTSW 13 19192558 missense possibly damaging 0.85
R5735:Tcrg-V5 UTSW 13 19192525 missense probably benign 0.18
R7848:Tcrg-V5 UTSW 13 19192679 missense probably damaging 1.00
Posted On2013-03-25