|Institutional Source||Beutler Lab|
|Gene Name||receptor (TNFRSF)-interacting serine-threonine kinase 2|
|Synonyms||CCK, RICK, CARD3, D4Bwg0615e, 2210420D18Rik, RIP2, CARDIAK|
|Is this an essential gene?||Probably non essential (E-score: 0.196)|
|Stock #||R1715 (G1)|
|Chromosomal Location||16122733-16163647 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to A at 16155192 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000038833 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000037035] [ENSMUST00000183871]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||Strain: 3622328; 2660793;2446070
FUNCTION: This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
PHENOTYPE: Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. Macrophages homozygous for a knock-in allele show normal LPS signaling. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ripk2||
(F):5'- CAATAATAACTGAACTCAAGAAAGGGGCtgaa -3'
(R):5'- TTAAACAGaatggaggagttagaggaagga -3'
(F):5'- tcattccttcacatacccagtc -3'
(R):5'- gaggtgggagtgggtgg -3'