Incidental Mutation 'R0013:Glp2r'
ID 19103
Institutional Source Beutler Lab
Gene Symbol Glp2r
Ensembl Gene ENSMUSG00000049928
Gene Name glucagon-like peptide 2 receptor
Synonyms GLP-2, 9530092J08Rik
MMRRC Submission 038308-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0013 (G1)
Quality Score
Status Validated
Chromosome 11
Chromosomal Location 67554877-67661979 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 67600538 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 437 (G437V)
Ref Sequence ENSEMBL: ENSMUSP00000061560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021289] [ENSMUST00000051765]
AlphaFold Q5IXF8
Predicted Effect probably benign
Transcript: ENSMUST00000021289
SMART Domains Protein: ENSMUSP00000021289
Gene: ENSMUSG00000049928

DomainStartEndE-ValueType
Pfam:7tm_2 17 225 4.8e-54 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000051765
AA Change: G437V

PolyPhen 2 Score 0.880 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000061560
Gene: ENSMUSG00000049928
AA Change: G437V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:HRM 53 122 3.4e-16 PFAM
Pfam:7tm_2 137 394 1.5e-79 PFAM
Meta Mutation Damage Score 0.1300 question?
Coding Region Coverage
  • 1x: 79.5%
  • 3x: 71.1%
  • 10x: 47.6%
  • 20x: 27.2%
Validation Efficiency 94% (77/82)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp2 A T 18: 80,172,960 (GRCm39) V483D probably damaging Het
Agl A T 3: 116,570,257 (GRCm39) C911* probably null Het
Arap2 G A 5: 62,840,827 (GRCm39) L680F probably damaging Het
C2cd3 T A 7: 100,065,269 (GRCm39) L685H probably damaging Het
Dhx33 A T 11: 70,884,461 (GRCm39) F448L probably damaging Het
Dnmbp G A 19: 43,890,670 (GRCm39) P366S probably benign Het
Elmod1 G A 9: 53,820,185 (GRCm39) probably benign Het
Galnt18 T C 7: 111,153,664 (GRCm39) N320S probably damaging Het
Gm9936 A G 5: 114,995,408 (GRCm39) probably benign Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Ints11 T C 4: 155,971,625 (GRCm39) F315S probably damaging Het
Itga11 A T 9: 62,683,895 (GRCm39) N1059Y possibly damaging Het
Kdm5d A T Y: 941,715 (GRCm39) K1305N probably benign Homo
Mboat7 A G 7: 3,686,821 (GRCm39) S340P probably damaging Het
Mex3c G A 18: 73,723,622 (GRCm39) A572T probably benign Het
Myo9a A T 9: 59,767,489 (GRCm39) probably benign Het
Myog T A 1: 134,217,973 (GRCm39) H60Q probably damaging Het
Pgm5 A C 19: 24,710,904 (GRCm39) probably null Het
Plb1 T A 5: 32,506,959 (GRCm39) probably benign Het
Ppm1e A G 11: 87,139,884 (GRCm39) probably benign Het
Prss46 G T 9: 110,679,123 (GRCm39) S108I probably damaging Het
Ptma C T 1: 86,457,498 (GRCm39) probably benign Het
Ptprc T C 1: 138,041,297 (GRCm39) probably null Het
Rrn3 T A 16: 13,630,977 (GRCm39) D604E possibly damaging Het
Scn4a A G 11: 106,239,231 (GRCm39) probably benign Het
Sis A G 3: 72,817,809 (GRCm39) L1468P possibly damaging Het
Slit3 A G 11: 35,598,745 (GRCm39) M1450V probably benign Het
Tppp A G 13: 74,169,479 (GRCm39) K73R possibly damaging Het
Tut4 T A 4: 108,388,152 (GRCm39) probably benign Het
Uba7 A T 9: 107,855,448 (GRCm39) Y375F probably damaging Het
Ugcg T C 4: 59,213,931 (GRCm39) L171P possibly damaging Het
Vsig2 T C 9: 37,453,872 (GRCm39) probably benign Het
Zfp839 T A 12: 110,834,820 (GRCm39) S692T possibly damaging Het
Other mutations in Glp2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Glp2r APN 11 67,600,470 (GRCm39) missense probably benign
IGL02244:Glp2r APN 11 67,612,817 (GRCm39) missense probably damaging 1.00
IGL02484:Glp2r APN 11 67,630,992 (GRCm39) missense possibly damaging 0.90
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0195:Glp2r UTSW 11 67,600,534 (GRCm39) missense probably damaging 0.99
R1612:Glp2r UTSW 11 67,633,033 (GRCm39) missense possibly damaging 0.46
R1699:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
R1944:Glp2r UTSW 11 67,637,618 (GRCm39) missense probably benign 0.01
R3971:Glp2r UTSW 11 67,637,641 (GRCm39) missense possibly damaging 0.65
R4417:Glp2r UTSW 11 67,555,342 (GRCm39) intron probably benign
R4681:Glp2r UTSW 11 67,621,453 (GRCm39) splice site probably null
R4914:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4918:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4938:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4940:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4941:Glp2r UTSW 11 67,637,529 (GRCm39) splice site probably null
R4963:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4966:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R5023:Glp2r UTSW 11 67,631,858 (GRCm39) missense possibly damaging 0.82
R5121:Glp2r UTSW 11 67,612,926 (GRCm39) splice site probably null
R5313:Glp2r UTSW 11 67,648,357 (GRCm39) missense probably damaging 0.96
R5705:Glp2r UTSW 11 67,600,565 (GRCm39) missense probably benign 0.30
R5790:Glp2r UTSW 11 67,655,625 (GRCm39) missense probably damaging 1.00
R6074:Glp2r UTSW 11 67,637,640 (GRCm39) missense unknown
R6595:Glp2r UTSW 11 67,655,603 (GRCm39) missense probably benign 0.10
R6910:Glp2r UTSW 11 67,621,497 (GRCm39) missense probably benign 0.28
R7511:Glp2r UTSW 11 67,648,417 (GRCm39) missense probably damaging 0.98
R7627:Glp2r UTSW 11 67,637,589 (GRCm39) missense unknown
R7681:Glp2r UTSW 11 67,600,505 (GRCm39) missense probably benign 0.45
R7779:Glp2r UTSW 11 67,600,609 (GRCm39) nonsense probably null
R8743:Glp2r UTSW 11 67,612,901 (GRCm39) missense probably damaging 0.98
R8841:Glp2r UTSW 11 67,653,555 (GRCm39) missense probably damaging 1.00
R9093:Glp2r UTSW 11 67,621,459 (GRCm39) nonsense probably null
R9380:Glp2r UTSW 11 67,637,572 (GRCm39) missense possibly damaging 0.67
R9576:Glp2r UTSW 11 67,655,622 (GRCm39) missense probably benign 0.01
R9733:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
Z1186:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1186:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1186:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1186:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1186:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1187:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1187:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1188:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1188:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1188:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1189:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1189:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1190:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1190:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1190:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1190:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1191:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1191:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1192:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Posted On 2013-03-25