Incidental Mutation 'R1716:Myh4'
| ID |
191040 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh4
|
| Ensembl Gene |
ENSMUSG00000057003 |
| Gene Name |
myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms |
MYH-2B, MM, MHC2B, MyHC-IIb, Myhsf, Minimsc, Minmus |
| MMRRC Submission |
039749-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.386)
|
| Stock # |
R1716 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67128855-67151272 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 67141135 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 732
(S732R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018632]
[ENSMUST00000170942]
|
| AlphaFold |
Q5SX39 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000018632
AA Change: S732R
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000018632
Gene: ENSMUSG00000057003
AA Change: S732R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
4.7e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
2.5e-168 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170942
AA Change: S732R
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000127514
Gene: ENSMUSG00000057003
AA Change: S732R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-15 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
low complexity region
|
928 |
942 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, knock-out(1) Targeted, other(2) |
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
A |
G |
7: 78,731,946 (GRCm39) |
T2A |
unknown |
Het |
| Adgrf3 |
T |
A |
5: 30,402,549 (GRCm39) |
Q493L |
probably benign |
Het |
| Ak6 |
T |
C |
13: 100,792,177 (GRCm39) |
S207P |
probably benign |
Het |
| Ang |
A |
G |
14: 51,338,937 (GRCm39) |
D26G |
probably benign |
Het |
| Ang |
T |
C |
14: 51,338,957 (GRCm39) |
F33L |
probably damaging |
Het |
| Arhgef38 |
T |
A |
3: 132,846,598 (GRCm39) |
Y389F |
probably benign |
Het |
| Arhgef7 |
C |
A |
8: 11,858,713 (GRCm39) |
|
probably null |
Het |
| Bicd2 |
C |
A |
13: 49,531,786 (GRCm39) |
H343N |
probably benign |
Het |
| Casp4 |
G |
A |
9: 5,308,919 (GRCm39) |
|
probably null |
Het |
| Cd22 |
A |
G |
7: 30,577,103 (GRCm39) |
F68S |
probably damaging |
Het |
| Cd46 |
T |
A |
1: 194,760,117 (GRCm39) |
Q245L |
probably benign |
Het |
| Cntnap2 |
A |
T |
6: 47,084,826 (GRCm39) |
R1096* |
probably null |
Het |
| Cntnap3 |
A |
G |
13: 64,909,816 (GRCm39) |
V763A |
probably damaging |
Het |
| Cyp3a11 |
T |
C |
5: 145,805,776 (GRCm39) |
T171A |
probably benign |
Het |
| Defa30 |
A |
G |
8: 21,625,431 (GRCm39) |
Y65C |
probably damaging |
Het |
| Defb18 |
A |
T |
1: 18,306,875 (GRCm39) |
M27K |
probably benign |
Het |
| Dnah17 |
A |
G |
11: 117,923,424 (GRCm39) |
S4071P |
probably benign |
Het |
| Dnah7b |
T |
A |
1: 46,230,943 (GRCm39) |
D1400E |
probably damaging |
Het |
| Dpysl5 |
C |
T |
5: 30,935,338 (GRCm39) |
T147I |
probably benign |
Het |
| Dsg4 |
C |
T |
18: 20,595,518 (GRCm39) |
R574* |
probably null |
Het |
| Entrep2 |
A |
T |
7: 64,426,633 (GRCm39) |
|
probably null |
Het |
| Epm2a |
A |
G |
10: 11,324,580 (GRCm39) |
E223G |
probably benign |
Het |
| Etl4 |
T |
C |
2: 20,748,492 (GRCm39) |
S75P |
probably damaging |
Het |
| Fbxw15 |
T |
A |
9: 109,386,204 (GRCm39) |
M312L |
probably benign |
Het |
| Fcgr4 |
C |
T |
1: 170,847,672 (GRCm39) |
T90I |
probably damaging |
Het |
| Fras1 |
T |
A |
5: 96,700,584 (GRCm39) |
D201E |
probably benign |
Het |
| Gadl1 |
A |
T |
9: 115,835,576 (GRCm39) |
K335* |
probably null |
Het |
| Gcsam |
T |
G |
16: 45,440,356 (GRCm39) |
V133G |
probably damaging |
Het |
| Gml |
G |
T |
15: 74,685,665 (GRCm39) |
L107I |
possibly damaging |
Het |
| Golga2 |
T |
A |
2: 32,192,909 (GRCm39) |
L409Q |
probably damaging |
Het |
| Gtf2a1l |
A |
T |
17: 89,002,008 (GRCm39) |
Q241L |
probably benign |
Het |
| Gtf3c3 |
A |
G |
1: 54,438,419 (GRCm39) |
Y799H |
probably damaging |
Het |
| Guca1b |
T |
G |
17: 47,702,126 (GRCm39) |
|
probably benign |
Het |
| Igdcc4 |
C |
A |
9: 65,034,179 (GRCm39) |
H617Q |
probably damaging |
Het |
| Ip6k1 |
G |
A |
9: 107,918,195 (GRCm39) |
E77K |
possibly damaging |
Het |
| Itga2b |
A |
C |
11: 102,351,603 (GRCm39) |
I574S |
probably benign |
Het |
| Kcnk7 |
A |
T |
19: 5,756,859 (GRCm39) |
I283F |
probably damaging |
Het |
| Kirrel3 |
T |
A |
9: 34,934,843 (GRCm39) |
L450M |
probably damaging |
Het |
| Lmntd1 |
A |
T |
6: 145,365,600 (GRCm39) |
S176R |
probably damaging |
Het |
| Lrrc39 |
C |
T |
3: 116,373,216 (GRCm39) |
T292I |
probably benign |
Het |
| Ltbp1 |
A |
T |
17: 75,622,019 (GRCm39) |
H801L |
probably benign |
Het |
| Macf1 |
T |
A |
4: 123,295,196 (GRCm39) |
Q3318L |
probably damaging |
Het |
| Man1b1 |
T |
A |
2: 25,235,032 (GRCm39) |
N282K |
probably benign |
Het |
| Map2k6 |
A |
T |
11: 110,388,727 (GRCm39) |
E223V |
probably damaging |
Het |
| Marf1 |
C |
A |
16: 13,960,450 (GRCm39) |
R531S |
possibly damaging |
Het |
| Mfge8 |
G |
A |
7: 78,792,191 (GRCm39) |
R245C |
probably damaging |
Het |
| Mogat1 |
T |
G |
1: 78,514,681 (GRCm39) |
N318K |
probably benign |
Het |
| Myt1l |
T |
A |
12: 29,861,537 (GRCm39) |
D106E |
unknown |
Het |
| Ndc1 |
T |
C |
4: 107,241,992 (GRCm39) |
F302L |
probably damaging |
Het |
| Ndrg4 |
C |
T |
8: 96,438,956 (GRCm39) |
A290V |
probably benign |
Het |
| Nfia |
A |
T |
4: 97,951,365 (GRCm39) |
K397N |
probably damaging |
Het |
| Nlrp4e |
A |
T |
7: 23,020,458 (GRCm39) |
Q315L |
possibly damaging |
Het |
| Oga |
C |
A |
19: 45,740,613 (GRCm39) |
K907N |
probably benign |
Het |
| Or10p22 |
A |
C |
10: 128,826,721 (GRCm39) |
*313C |
probably null |
Het |
| Or1ad8 |
T |
A |
11: 50,898,679 (GRCm39) |
N293K |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,710,780 (GRCm39) |
I1481V |
possibly damaging |
Het |
| Phldb2 |
C |
T |
16: 45,595,413 (GRCm39) |
G883D |
probably benign |
Het |
| Pik3c2b |
T |
A |
1: 133,022,564 (GRCm39) |
Y1169N |
probably damaging |
Het |
| Plcl1 |
A |
T |
1: 55,734,997 (GRCm39) |
I113F |
probably damaging |
Het |
| Pomt2 |
T |
C |
12: 87,171,610 (GRCm39) |
I457V |
probably benign |
Het |
| Ppil1 |
T |
C |
17: 29,480,809 (GRCm39) |
N38S |
possibly damaging |
Het |
| Prf1 |
A |
G |
10: 61,136,231 (GRCm39) |
N169S |
probably benign |
Het |
| Prmt8 |
A |
C |
6: 127,703,486 (GRCm39) |
|
probably null |
Het |
| Ptprg |
T |
A |
14: 12,154,360 (GRCm38) |
S694T |
probably benign |
Het |
| Rab12 |
A |
T |
17: 66,807,315 (GRCm39) |
M138K |
possibly damaging |
Het |
| Reln |
T |
C |
5: 22,160,093 (GRCm39) |
T2159A |
probably damaging |
Het |
| Retsat |
A |
T |
6: 72,583,063 (GRCm39) |
Y36F |
probably damaging |
Het |
| Rgs14 |
A |
T |
13: 55,526,696 (GRCm39) |
Q116L |
probably damaging |
Het |
| Rlbp1 |
A |
T |
7: 79,025,684 (GRCm39) |
N252K |
probably damaging |
Het |
| Rtraf |
A |
G |
14: 19,862,242 (GRCm39) |
L215P |
probably damaging |
Het |
| Sec1 |
A |
T |
7: 45,328,789 (GRCm39) |
M86K |
probably benign |
Het |
| Sec24b |
A |
T |
3: 129,834,665 (GRCm39) |
S42T |
possibly damaging |
Het |
| Serpinb9d |
T |
C |
13: 33,380,500 (GRCm39) |
S129P |
probably damaging |
Het |
| Slc35f5 |
T |
G |
1: 125,512,269 (GRCm39) |
D356E |
possibly damaging |
Het |
| Smpd4 |
T |
C |
16: 17,460,365 (GRCm39) |
S694P |
probably damaging |
Het |
| Spag6 |
G |
T |
2: 18,750,420 (GRCm39) |
|
probably null |
Het |
| Spata31d1c |
T |
C |
13: 65,181,030 (GRCm39) |
I43T |
possibly damaging |
Het |
| Ssh1 |
T |
C |
5: 114,090,081 (GRCm39) |
D314G |
possibly damaging |
Het |
| Tnfrsf17 |
G |
A |
16: 11,137,595 (GRCm39) |
D111N |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,553,635 (GRCm39) |
I30994T |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,614,320 (GRCm39) |
F8737L |
probably damaging |
Het |
| Ush1c |
G |
T |
7: 45,845,152 (GRCm39) |
F890L |
probably benign |
Het |
| Usp36 |
C |
T |
11: 118,162,957 (GRCm39) |
|
probably null |
Het |
| Vmn2r115 |
T |
C |
17: 23,566,795 (GRCm39) |
Y436H |
probably benign |
Het |
| Vmn2r94 |
T |
A |
17: 18,477,635 (GRCm39) |
M259L |
probably benign |
Het |
| Wwp1 |
T |
C |
4: 19,659,698 (GRCm39) |
T197A |
probably benign |
Het |
| Zbtb37 |
T |
A |
1: 160,847,814 (GRCm39) |
M398L |
probably benign |
Het |
| Zfp804b |
C |
T |
5: 6,819,673 (GRCm39) |
C1130Y |
probably benign |
Het |
| Zfp9 |
A |
G |
6: 118,441,712 (GRCm39) |
C317R |
probably damaging |
Het |
| Zscan20 |
T |
C |
4: 128,480,334 (GRCm39) |
H719R |
probably damaging |
Het |
|
| Other mutations in Myh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01471:Myh4
|
APN |
11 |
67,146,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Myh4
|
APN |
11 |
67,151,015 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01737:Myh4
|
APN |
11 |
67,134,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Myh4
|
APN |
11 |
67,142,760 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02334:Myh4
|
APN |
11 |
67,136,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02376:Myh4
|
APN |
11 |
67,136,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Myh4
|
APN |
11 |
67,149,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02450:Myh4
|
APN |
11 |
67,142,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02524:Myh4
|
APN |
11 |
67,140,066 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02612:Myh4
|
APN |
11 |
67,147,305 (GRCm39) |
missense |
probably benign |
|
|
IGL03024:Myh4
|
APN |
11 |
67,139,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Myh4
|
APN |
11 |
67,149,982 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03084:Myh4
|
APN |
11 |
67,142,777 (GRCm39) |
splice site |
probably null |
|
|
IGL03188:Myh4
|
APN |
11 |
67,137,369 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03204:Myh4
|
APN |
11 |
67,141,122 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL03252:Myh4
|
APN |
11 |
67,143,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03345:Myh4
|
APN |
11 |
67,146,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mr_chicken
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Mrs_muir
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Willies
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F6893:Myh4
|
UTSW |
11 |
67,146,283 (GRCm39) |
missense |
probably null |
0.12 |
|
PIT1430001:Myh4
|
UTSW |
11 |
67,149,658 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4458001:Myh4
|
UTSW |
11 |
67,131,821 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0099:Myh4
|
UTSW |
11 |
67,150,173 (GRCm39) |
missense |
probably benign |
|
|
R0194:Myh4
|
UTSW |
11 |
67,143,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0346:Myh4
|
UTSW |
11 |
67,151,152 (GRCm39) |
missense |
probably benign |
|
|
R0427:Myh4
|
UTSW |
11 |
67,149,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0483:Myh4
|
UTSW |
11 |
67,143,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Myh4
|
UTSW |
11 |
67,141,157 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0854:Myh4
|
UTSW |
11 |
67,149,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0940:Myh4
|
UTSW |
11 |
67,133,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Myh4
|
UTSW |
11 |
67,142,577 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1108:Myh4
|
UTSW |
11 |
67,146,532 (GRCm39) |
missense |
probably null |
0.01 |
|
R1162:Myh4
|
UTSW |
11 |
67,149,439 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1194:Myh4
|
UTSW |
11 |
67,146,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1347:Myh4
|
UTSW |
11 |
67,135,567 (GRCm39) |
splice site |
probably benign |
|
|
R1457:Myh4
|
UTSW |
11 |
67,139,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1531:Myh4
|
UTSW |
11 |
67,141,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1766:Myh4
|
UTSW |
11 |
67,147,121 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1796:Myh4
|
UTSW |
11 |
67,151,150 (GRCm39) |
missense |
probably benign |
|
|
R1856:Myh4
|
UTSW |
11 |
67,146,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Myh4
|
UTSW |
11 |
67,145,569 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2069:Myh4
|
UTSW |
11 |
67,137,192 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Myh4
|
UTSW |
11 |
67,146,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2406:Myh4
|
UTSW |
11 |
67,150,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2414:Myh4
|
UTSW |
11 |
67,141,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2848:Myh4
|
UTSW |
11 |
67,139,459 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3111:Myh4
|
UTSW |
11 |
67,137,276 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3744:Myh4
|
UTSW |
11 |
67,146,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Myh4
|
UTSW |
11 |
67,149,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3877:Myh4
|
UTSW |
11 |
67,148,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4498:Myh4
|
UTSW |
11 |
67,142,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Myh4
|
UTSW |
11 |
67,146,395 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4601:Myh4
|
UTSW |
11 |
67,141,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4673:Myh4
|
UTSW |
11 |
67,137,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4684:Myh4
|
UTSW |
11 |
67,136,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4736:Myh4
|
UTSW |
11 |
67,131,746 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4837:Myh4
|
UTSW |
11 |
67,149,818 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4866:Myh4
|
UTSW |
11 |
67,139,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4869:Myh4
|
UTSW |
11 |
67,143,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Myh4
|
UTSW |
11 |
67,131,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4921:Myh4
|
UTSW |
11 |
67,144,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Myh4
|
UTSW |
11 |
67,144,241 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Myh4
|
UTSW |
11 |
67,144,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Myh4
|
UTSW |
11 |
67,147,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5087:Myh4
|
UTSW |
11 |
67,146,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Myh4
|
UTSW |
11 |
67,143,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Myh4
|
UTSW |
11 |
67,150,017 (GRCm39) |
splice site |
probably null |
|
|
R5354:Myh4
|
UTSW |
11 |
67,146,551 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5371:Myh4
|
UTSW |
11 |
67,150,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Myh4
|
UTSW |
11 |
67,142,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5774:Myh4
|
UTSW |
11 |
67,144,034 (GRCm39) |
nonsense |
probably null |
|
|
R5902:Myh4
|
UTSW |
11 |
67,141,733 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5941:Myh4
|
UTSW |
11 |
67,150,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6045:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6156:Myh4
|
UTSW |
11 |
67,141,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6301:Myh4
|
UTSW |
11 |
67,146,159 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6318:Myh4
|
UTSW |
11 |
67,134,268 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6352:Myh4
|
UTSW |
11 |
67,143,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Myh4
|
UTSW |
11 |
67,146,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Myh4
|
UTSW |
11 |
67,149,455 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6666:Myh4
|
UTSW |
11 |
67,142,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Myh4
|
UTSW |
11 |
67,137,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Myh4
|
UTSW |
11 |
67,143,794 (GRCm39) |
splice site |
probably null |
|
|
R6857:Myh4
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7029:Myh4
|
UTSW |
11 |
67,137,251 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7076:Myh4
|
UTSW |
11 |
67,143,999 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7145:Myh4
|
UTSW |
11 |
67,151,054 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7179:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7365:Myh4
|
UTSW |
11 |
67,133,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Myh4
|
UTSW |
11 |
67,134,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7553:Myh4
|
UTSW |
11 |
67,147,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Myh4
|
UTSW |
11 |
67,147,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Myh4
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Myh4
|
UTSW |
11 |
67,131,756 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8154:Myh4
|
UTSW |
11 |
67,144,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8343:Myh4
|
UTSW |
11 |
67,143,390 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R8446:Myh4
|
UTSW |
11 |
67,144,347 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8534:Myh4
|
UTSW |
11 |
67,134,335 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8710:Myh4
|
UTSW |
11 |
67,143,158 (GRCm39) |
missense |
probably benign |
|
|
R8775:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8775-TAIL:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8852:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Myh4
|
UTSW |
11 |
67,137,362 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8954:Myh4
|
UTSW |
11 |
67,143,806 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8957:Myh4
|
UTSW |
11 |
67,141,780 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9065:Myh4
|
UTSW |
11 |
67,139,573 (GRCm39) |
missense |
probably benign |
|
|
R9280:Myh4
|
UTSW |
11 |
67,146,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9296:Myh4
|
UTSW |
11 |
67,146,130 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9310:Myh4
|
UTSW |
11 |
67,145,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9314:Myh4
|
UTSW |
11 |
67,151,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Myh4
|
UTSW |
11 |
67,141,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9516:Myh4
|
UTSW |
11 |
67,141,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Myh4
|
UTSW |
11 |
67,139,290 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9773:Myh4
|
UTSW |
11 |
67,137,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Myh4
|
UTSW |
11 |
67,137,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,147,097 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myh4
|
UTSW |
11 |
67,144,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,139,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGGCATCCGCATCTGTAGGAAG -3'
(R):5'- AGGCAGACACTCTTTGCTCCTCAC -3'
Sequencing Primer
(F):5'- TCTATGCAGACTTCAAGCAGAG -3'
(R):5'- ATGAGCTGAGCCAGCTTTTC -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation