Mutagenetix > Incidental Mutation

Incidental Mutation 'R1717:Lrp1'

191141

Institutional Source

Beutler Lab

Gene Symbol

Lrp1

Ensembl Gene

ENSMUSG00000040249

Gene Name

low density lipoprotein receptor-related protein 1

Synonyms

b2b1554Clo, CD91, A2mr

MMRRC Submission

039750-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1717 (G1)

Quality Score

168

Status

Validated

Chromosome

Chromosomal Location

127374030-127457017 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127392138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 2835 (H2835R)

Ref Sequence

ENSEMBL: ENSMUSP00000044004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049149]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000049149
AA Change: H2835R

PolyPhen 2 Score 0.590 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: H2835R

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
LDLa	27	67	1.03e-15	SMART
LDLa	72	111	1.04e-11	SMART
EGF	115	150	8.78e-2	SMART
EGF_CA	151	190	4.49e-8	SMART
low complexity region	222	232	N/A	INTRINSIC
LY	273	315	7.07e-6	SMART
LY	316	359	2.31e-10	SMART
LY	360	402	8.3e-12	SMART
EGF	478	521	9.93e-1	SMART
LY	552	594	8.84e-7	SMART
LY	595	638	6.54e-10	SMART
LY	641	690	2.5e-15	SMART
LY	691	734	1.06e-9	SMART
EGF	807	844	1.38e1	SMART
LDLa	854	893	3.39e-16	SMART
LDLa	895	934	1.73e-13	SMART
LDLa	936	974	4.47e-16	SMART
LDLa	976	1014	2.53e-15	SMART
LDLa	1015	1054	2.95e-16	SMART
LDLa	1062	1100	3.24e-13	SMART
LDLa	1104	1143	2.97e-12	SMART
LDLa	1145	1185	1.24e-9	SMART
EGF	1185	1223	4.97e-1	SMART
EGF	1227	1263	6.02e0	SMART
LY	1290	1332	3.76e-1	SMART
LY	1337	1379	8.56e-14	SMART
LY	1380	1424	8.43e-13	SMART
LY	1425	1469	3.05e-10	SMART
LY	1471	1513	3.88e-3	SMART
EGF	1540	1580	1.85e0	SMART
LY	1606	1650	2.83e-5	SMART
LY	1651	1695	2.01e-10	SMART
LY	1698	1735	1.87e-5	SMART
LY	1736	1777	3.54e-6	SMART
LY	1778	1820	4.17e1	SMART
EGF	1850	1888	1.24e-1	SMART
LY	1915	1957	3.2e-4	SMART
LY	1958	2000	2.33e-15	SMART
LY	2001	2044	7.45e-14	SMART
LY	2045	2087	3.87e-12	SMART
LY	2089	2131	1.37e0	SMART
EGF	2159	2196	1.66e1	SMART
LY	2276	2318	5.57e-4	SMART
LY	2324	2369	3.3e-6	SMART
LY	2370	2412	3.93e-13	SMART
LY	2413	2454	3.62e-3	SMART
EGF_like	2482	2519	3.16e1	SMART
LDLa	2524	2564	3.31e-10	SMART
LDLa	2566	2603	7.21e-11	SMART
LDLa	2605	2642	1.09e-10	SMART
LDLa	2660	2691	6.05e-4	SMART
LDLa	2696	2733	2.49e-14	SMART
LDLa	2734	2772	4.65e-14	SMART
LDLa	2774	2815	3.92e-12	SMART
LDLa	2818	2856	1.51e-13	SMART
LDLa	2858	2900	1.93e-11	SMART
LDLa	2904	2942	1.73e-13	SMART
EGF_CA	2941	2982	6.16e-6	SMART
EGF_CA	2983	3023	2.66e-10	SMART
LY	3050	3094	6.64e-11	SMART
LY	3095	3137	7.17e-16	SMART
LY	3138	3181	4.28e-14	SMART
LY	3182	3224	8.11e-15	SMART
LY	3225	3265	1.44e-6	SMART
EGF	3294	3332	1.02e-2	SMART
LDLa	3334	3372	2.25e-12	SMART
LDLa	3374	3411	9.81e-13	SMART
LDLa	3413	3451	9.81e-13	SMART
LDLa	3453	3492	5.67e-18	SMART
LDLa	3494	3534	7.15e-15	SMART
LDLa	3536	3573	1.79e-15	SMART
EGF_like	3575	3611	4.83e1	SMART
LDLa	3575	3612	1.92e-15	SMART
LDLa	3613	3650	1.18e-15	SMART
LDLa	3654	3693	7.55e-14	SMART
LDLa	3695	3734	1.14e-8	SMART
LDLa	3741	3779	6.28e-11	SMART
EGF	3785	3824	1.06e1	SMART
EGF	3828	3862	1.51e0	SMART
LY	3893	3935	9.43e0	SMART
LY	3951	3993	1.23e-14	SMART
LY	3994	4037	2.98e-13	SMART
LY	4038	4080	4.28e-14	SMART
EGF	4151	4184	3.76e-1	SMART
low complexity region	4185	4198	N/A	INTRINSIC
EGF	4200	4233	3.82e-2	SMART
EGF	4236	4269	4.03e-1	SMART
EGF	4272	4305	5.2e-4	SMART
EGF	4308	4341	1.22e0	SMART
EGF_like	4344	4376	4.11e1	SMART
EGF	4377	4410	5.12e-3	SMART
transmembrane domain	4423	4445	N/A	INTRINSIC

Meta Mutation Damage Score

0.0729

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.4%

Validation Efficiency

98% (81/83)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]

Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732465J04Rik	GATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCT	GATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCT	10: 95,629,641 (GRCm39)		probably null	Het
4930583I09Rik	T	C	17: 65,141,444 (GRCm39)	N53S	unknown	Het
4933434E20Rik	T	A	3: 89,963,544 (GRCm39)	S67T	probably benign	Het
Abcc8	T	C	7: 45,765,239 (GRCm39)	I1127V	possibly damaging	Het
Abcg3	G	A	5: 105,111,421 (GRCm39)	Q349*	probably null	Het
Adam2	A	G	14: 66,306,007 (GRCm39)	L158P	probably damaging	Het
Agrn	GCTCT	GCTCTCT	4: 156,250,976 (GRCm39)		probably null	Het
Agrp	G	T	8: 106,293,467 (GRCm39)	T106K	probably damaging	Het
Akap11	C	A	14: 78,750,788 (GRCm39)	S533I	probably benign	Het
Aldh1a2	A	T	9: 71,200,953 (GRCm39)	N517I	probably damaging	Het
Aldh4a1	A	T	4: 139,365,840 (GRCm39)	H277L	possibly damaging	Het
Aldh4a1	G	A	4: 139,361,305 (GRCm39)		probably null	Het
Ankrd27	A	G	7: 35,327,871 (GRCm39)	D742G	possibly damaging	Het
Anpep	C	T	7: 79,488,004 (GRCm39)	E518K	probably benign	Het
Arhgef7	C	A	8: 11,858,712 (GRCm39)		probably benign	Het
Arhgef7	C	A	8: 11,858,713 (GRCm39)		probably null	Het
Armh4	T	C	14: 49,989,121 (GRCm39)	D616G	probably damaging	Het
Arvcf	A	G	16: 18,220,319 (GRCm39)	K568E	possibly damaging	Het
Atp8b3	G	A	10: 80,364,631 (GRCm39)	R521W	probably damaging	Het
Casp16	A	G	17: 23,771,024 (GRCm39)	I127T	possibly damaging	Het
Cd163	A	G	6: 124,306,547 (GRCm39)		probably benign	Het
Cdh8	A	T	8: 99,757,337 (GRCm39)	S754T	probably damaging	Het
Cel	A	G	2: 28,446,789 (GRCm39)	Y461H	probably damaging	Het
Chmp4b	A	G	2: 154,499,240 (GRCm39)	I47V	possibly damaging	Het
Col1a1	A	G	11: 94,839,218 (GRCm39)	M989V	unknown	Het
Cpsf1	A	T	15: 76,486,766 (GRCm39)	S257T	possibly damaging	Het
Csmd1	A	T	8: 17,266,708 (GRCm39)	S73T	possibly damaging	Het
Csnk2a2	T	C	8: 96,182,436 (GRCm39)		probably null	Het
Dact2	A	T	17: 14,418,175 (GRCm39)	W177R	probably benign	Het
Ddx10	A	G	9: 53,071,253 (GRCm39)	V680A	probably benign	Het
Eif5	T	A	12: 111,508,651 (GRCm39)	D215E	probably benign	Het
Evpl	C	T	11: 116,116,318 (GRCm39)	A817T	probably benign	Het
Fmo6	T	A	1: 162,753,821 (GRCm39)	R131*	probably null	Het
Fsd2	T	C	7: 81,184,857 (GRCm39)	T680A	probably benign	Het
Fsip2	T	C	2: 82,805,289 (GRCm39)	V536A	possibly damaging	Het
Fzd8	T	C	18: 9,214,364 (GRCm39)	F482S	probably damaging	Het
Gabrb1	A	T	5: 72,265,694 (GRCm39)		probably null	Het
Galnt9	T	G	5: 110,744,078 (GRCm39)	I304S	probably benign	Het
Glra3	G	T	8: 56,393,942 (GRCm39)	A18S	probably benign	Het
Gm5334	A	C	7: 68,268,725 (GRCm39)		noncoding transcript	Het
Grcc10	A	T	6: 124,717,476 (GRCm39)		probably benign	Het
Hmcn1	T	C	1: 150,734,937 (GRCm39)	T192A	probably damaging	Het
Ip6k1	G	A	9: 107,918,195 (GRCm39)	E77K	possibly damaging	Het
Irgm2	T	A	11: 58,111,461 (GRCm39)	L396Q	probably damaging	Het
Ksr2	T	A	5: 117,809,514 (GRCm39)	C426S	probably damaging	Het
Lair1	A	G	7: 4,013,788 (GRCm39)	F153S	probably damaging	Het
Lrrd1	T	C	5: 3,900,580 (GRCm39)	F295S	probably damaging	Het
Meis1	T	A	11: 18,960,608 (GRCm39)		probably benign	Het
Mkln1	T	A	6: 31,484,579 (GRCm39)	I156K	probably benign	Het
Mmd2	T	C	5: 142,561,105 (GRCm39)		probably benign	Het
Morc1	A	G	16: 48,272,840 (GRCm39)	I156V	probably benign	Het
Muc4	A	G	16: 32,753,405 (GRCm38)	T1094A	possibly damaging	Het
Nckap1	A	G	2: 80,343,014 (GRCm39)		probably benign	Het
Neb	A	G	2: 52,198,759 (GRCm39)	I394T	possibly damaging	Het
Or12e1	A	T	2: 87,022,247 (GRCm39)	N72I	probably benign	Het
Or2t49	T	A	11: 58,392,885 (GRCm39)	M166L	probably benign	Het
Or4e2	T	C	14: 52,688,296 (GRCm39)	V142A	probably benign	Het
Or5as1	A	T	2: 86,980,150 (GRCm39)	L285*	probably null	Het
Or8d1b	C	T	9: 38,887,706 (GRCm39)	L245F	probably damaging	Het
Pcdha1	T	C	18: 37,065,237 (GRCm39)	S634P	probably benign	Het
Pcdhb12	T	A	18: 37,569,841 (GRCm39)	V329E	probably damaging	Het
Pcf11	A	T	7: 92,312,793 (GRCm39)	D193E	probably benign	Het
Pcsk1	G	C	13: 75,258,947 (GRCm39)	M240I	probably damaging	Het
Pdc	T	A	1: 150,208,892 (GRCm39)	I125N	probably damaging	Het
Plch2	C	T	4: 155,082,729 (GRCm39)	G564S	probably benign	Het
Rasgrf1	G	T	9: 89,835,966 (GRCm39)	Q231H	probably damaging	Het
Riok1	T	A	13: 38,236,926 (GRCm39)	I389N	probably damaging	Het
Ror1	T	A	4: 100,160,135 (GRCm39)	S50R	probably benign	Het
Samd13	T	C	3: 146,352,070 (GRCm39)	T75A	probably benign	Het
Siglec1	G	A	2: 130,915,876 (GRCm39)	H1329Y	possibly damaging	Het
Siglec1	T	C	2: 130,925,932 (GRCm39)	N258S	probably damaging	Het
Slbp	G	A	5: 33,802,946 (GRCm39)	A126V	probably benign	Het
Slc12a4	A	T	8: 106,674,203 (GRCm39)		probably null	Het
Specc1	A	G	11: 62,019,218 (GRCm39)	I686V	possibly damaging	Het
Synpo2	C	A	3: 122,906,203 (GRCm39)	V1038F	probably damaging	Het
Tbk1	G	A	10: 121,397,550 (GRCm39)	T374I	probably benign	Het
Tktl2	G	A	8: 66,964,999 (GRCm39)	V186M	probably damaging	Het
Tmem190	T	C	7: 4,787,132 (GRCm39)	L112P	probably damaging	Het
Tsc2	C	T	17: 24,816,042 (GRCm39)	R1715Q	probably damaging	Het
Ulbp3	A	T	10: 3,075,050 (GRCm39)		noncoding transcript	Het
Vmn1r46	T	C	6: 89,953,811 (GRCm39)	L220P	probably damaging	Het
Vwa3a	A	G	7: 120,392,609 (GRCm39)	Q816R	probably benign	Het
Zfhx4	T	C	3: 5,468,164 (GRCm39)	I2799T	probably benign	Het
Zfp105	T	C	9: 122,759,696 (GRCm39)	S456P	probably damaging	Het

Other mutations in Lrp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Lrp1	APN	10	127,378,074 (GRCm39)	missense	possibly damaging	0.89
IGL01065:Lrp1	APN	10	127,410,907 (GRCm39)	missense	probably benign	0.10
IGL01121:Lrp1	APN	10	127,419,722 (GRCm39)	nonsense	probably null
IGL01360:Lrp1	APN	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
IGL01402:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01404:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01411:Lrp1	APN	10	127,417,634 (GRCm39)	nonsense	probably null
IGL01469:Lrp1	APN	10	127,420,283 (GRCm39)	missense	probably damaging	1.00
IGL01552:Lrp1	APN	10	127,424,379 (GRCm39)	nonsense	probably null
IGL01682:Lrp1	APN	10	127,410,847 (GRCm39)	missense	probably benign	0.00
IGL01760:Lrp1	APN	10	127,409,370 (GRCm39)	missense	probably benign	0.00
IGL01918:Lrp1	APN	10	127,390,458 (GRCm39)	missense	probably damaging	0.99
IGL01989:Lrp1	APN	10	127,413,998 (GRCm39)	missense	probably damaging	1.00
IGL02105:Lrp1	APN	10	127,380,448 (GRCm39)	missense	probably damaging	1.00
IGL02158:Lrp1	APN	10	127,390,140 (GRCm39)	missense	probably benign	0.02
IGL02164:Lrp1	APN	10	127,399,536 (GRCm39)	missense	probably benign	0.39
IGL02337:Lrp1	APN	10	127,412,756 (GRCm39)	missense	possibly damaging	0.87
IGL02425:Lrp1	APN	10	127,407,756 (GRCm39)	critical splice donor site	probably null
IGL02493:Lrp1	APN	10	127,417,647 (GRCm39)	missense	probably damaging	0.99
IGL02563:Lrp1	APN	10	127,387,555 (GRCm39)	missense	probably damaging	1.00
IGL02590:Lrp1	APN	10	127,388,660 (GRCm39)	missense	probably damaging	1.00
IGL02624:Lrp1	APN	10	127,408,291 (GRCm39)	missense	probably damaging	0.98
IGL02625:Lrp1	APN	10	127,410,355 (GRCm39)	missense	probably damaging	1.00
IGL02825:Lrp1	APN	10	127,378,474 (GRCm39)	missense	probably damaging	1.00
IGL02880:Lrp1	APN	10	127,376,091 (GRCm39)	missense	probably benign	0.12
IGL02900:Lrp1	APN	10	127,412,516 (GRCm39)	splice site	probably benign
IGL02956:Lrp1	APN	10	127,380,428 (GRCm39)	missense	probably benign	0.00
IGL02974:Lrp1	APN	10	127,390,885 (GRCm39)	missense	probably damaging	0.99
IGL02983:Lrp1	APN	10	127,386,068 (GRCm39)	missense	probably damaging	1.00
IGL03002:Lrp1	APN	10	127,425,505 (GRCm39)	missense	probably damaging	1.00
IGL03091:Lrp1	APN	10	127,394,993 (GRCm39)	missense	probably benign	0.30
IGL03109:Lrp1	APN	10	127,402,514 (GRCm39)	missense	probably benign
IGL03194:Lrp1	APN	10	127,404,554 (GRCm39)	missense	probably damaging	1.00
IGL03232:Lrp1	APN	10	127,375,245 (GRCm39)	missense	probably damaging	1.00
calculus	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
Delimiter	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
extremis	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
Jockey	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
peripheral	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
tangential	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
P0015:Lrp1	UTSW	10	127,402,532 (GRCm39)	missense	probably damaging	0.99
PIT4519001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
PIT4520001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
R0004:Lrp1	UTSW	10	127,377,694 (GRCm39)	splice site	probably null
R0034:Lrp1	UTSW	10	127,381,520 (GRCm39)	missense	probably benign	0.42
R0091:Lrp1	UTSW	10	127,376,848 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0143:Lrp1	UTSW	10	127,429,811 (GRCm39)	missense	probably damaging	1.00
R0372:Lrp1	UTSW	10	127,428,005 (GRCm39)	missense	probably damaging	1.00
R0379:Lrp1	UTSW	10	127,430,838 (GRCm39)	missense	probably damaging	1.00
R0445:Lrp1	UTSW	10	127,426,505 (GRCm39)	nonsense	probably null
R0529:Lrp1	UTSW	10	127,377,463 (GRCm39)	splice site	probably null
R0551:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R0570:Lrp1	UTSW	10	127,390,878 (GRCm39)	nonsense	probably null
R0600:Lrp1	UTSW	10	127,403,252 (GRCm39)	missense	probably benign	0.00
R0626:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0647:Lrp1	UTSW	10	127,407,346 (GRCm39)	missense	probably damaging	1.00
R0680:Lrp1	UTSW	10	127,425,530 (GRCm39)	missense	probably damaging	1.00
R0792:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R0792:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0848:Lrp1	UTSW	10	127,389,231 (GRCm39)	splice site	probably null
R0866:Lrp1	UTSW	10	127,375,147 (GRCm39)	missense	probably damaging	1.00
R0918:Lrp1	UTSW	10	127,429,834 (GRCm39)	missense	probably damaging	1.00
R1076:Lrp1	UTSW	10	127,399,666 (GRCm39)	splice site	probably benign
R1107:Lrp1	UTSW	10	127,393,304 (GRCm39)	missense	probably damaging	1.00
R1346:Lrp1	UTSW	10	127,441,735 (GRCm39)	missense	probably damaging	1.00
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1496:Lrp1	UTSW	10	127,374,880 (GRCm39)	missense	probably damaging	1.00
R1522:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R1522:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R1525:Lrp1	UTSW	10	127,375,398 (GRCm39)	missense	probably damaging	1.00
R1539:Lrp1	UTSW	10	127,420,250 (GRCm39)	splice site	probably null
R1589:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1591:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1663:Lrp1	UTSW	10	127,392,790 (GRCm39)	missense	probably damaging	1.00
R1682:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,399,534 (GRCm39)	missense	probably damaging	1.00
R1758:Lrp1	UTSW	10	127,424,453 (GRCm39)	missense	possibly damaging	0.76
R1826:Lrp1	UTSW	10	127,389,576 (GRCm39)	missense	probably damaging	1.00
R1842:Lrp1	UTSW	10	127,409,337 (GRCm39)	missense	possibly damaging	0.93
R1844:Lrp1	UTSW	10	127,431,152 (GRCm39)	critical splice donor site	probably null
R1845:Lrp1	UTSW	10	127,414,542 (GRCm39)	missense	probably damaging	1.00
R1896:Lrp1	UTSW	10	127,395,867 (GRCm39)	missense	possibly damaging	0.64
R1952:Lrp1	UTSW	10	127,403,300 (GRCm39)	missense	probably damaging	1.00
R2009:Lrp1	UTSW	10	127,380,385 (GRCm39)	missense	probably damaging	1.00
R2015:Lrp1	UTSW	10	127,376,563 (GRCm39)	missense	probably benign	0.00
R2116:Lrp1	UTSW	10	127,412,362 (GRCm39)	nonsense	probably null
R2161:Lrp1	UTSW	10	127,391,607 (GRCm39)	missense	probably damaging	1.00
R2199:Lrp1	UTSW	10	127,382,709 (GRCm39)	missense	probably damaging	1.00
R2213:Lrp1	UTSW	10	127,376,571 (GRCm39)	missense	probably damaging	1.00
R2300:Lrp1	UTSW	10	127,392,784 (GRCm39)	nonsense	probably null
R2324:Lrp1	UTSW	10	127,402,455 (GRCm39)	missense	possibly damaging	0.92
R2849:Lrp1	UTSW	10	127,378,165 (GRCm39)	missense	probably damaging	1.00
R2926:Lrp1	UTSW	10	127,423,982 (GRCm39)	missense	probably damaging	0.98
R2993:Lrp1	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
R3522:Lrp1	UTSW	10	127,389,424 (GRCm39)	missense	probably damaging	1.00
R3702:Lrp1	UTSW	10	127,430,972 (GRCm39)	missense	probably damaging	1.00
R3789:Lrp1	UTSW	10	127,407,838 (GRCm39)	missense	possibly damaging	0.94
R3898:Lrp1	UTSW	10	127,427,969 (GRCm39)	nonsense	probably null
R3941:Lrp1	UTSW	10	127,389,265 (GRCm39)	missense	probably damaging	1.00
R3958:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R4369:Lrp1	UTSW	10	127,386,155 (GRCm39)	missense	possibly damaging	0.87
R4510:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4511:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4576:Lrp1	UTSW	10	127,376,057 (GRCm39)	small deletion	probably benign
R4583:Lrp1	UTSW	10	127,377,241 (GRCm39)	missense	probably benign	0.00
R4662:Lrp1	UTSW	10	127,388,054 (GRCm39)	nonsense	probably null
R4721:Lrp1	UTSW	10	127,390,928 (GRCm39)	missense	possibly damaging	0.58
R4728:Lrp1	UTSW	10	127,399,606 (GRCm39)	missense	probably damaging	1.00
R4745:Lrp1	UTSW	10	127,385,813 (GRCm39)	missense	probably benign	0.20
R4785:Lrp1	UTSW	10	127,394,002 (GRCm39)	missense	probably benign	0.12
R4841:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4842:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4855:Lrp1	UTSW	10	127,446,311 (GRCm39)	missense	probably benign	0.03
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4891:Lrp1	UTSW	10	127,377,621 (GRCm39)	missense	probably damaging	1.00
R4925:Lrp1	UTSW	10	127,410,944 (GRCm39)	nonsense	probably null
R4970:Lrp1	UTSW	10	127,375,389 (GRCm39)	missense	probably benign	0.11
R4999:Lrp1	UTSW	10	127,389,648 (GRCm39)	missense	probably damaging	1.00
R5044:Lrp1	UTSW	10	127,403,364 (GRCm39)	missense	probably damaging	1.00
R5127:Lrp1	UTSW	10	127,375,503 (GRCm39)	intron	probably benign
R5188:Lrp1	UTSW	10	127,443,821 (GRCm39)	missense	probably damaging	1.00
R5218:Lrp1	UTSW	10	127,384,488 (GRCm39)	missense	probably damaging	1.00
R5225:Lrp1	UTSW	10	127,391,965 (GRCm39)	missense	probably benign	0.04
R5291:Lrp1	UTSW	10	127,429,747 (GRCm39)	missense	probably damaging	1.00
R5386:Lrp1	UTSW	10	127,427,983 (GRCm39)	missense	probably damaging	1.00
R5395:Lrp1	UTSW	10	127,431,166 (GRCm39)	missense	probably damaging	1.00
R5413:Lrp1	UTSW	10	127,423,936 (GRCm39)	critical splice donor site	probably null
R5430:Lrp1	UTSW	10	127,376,930 (GRCm39)	missense	probably damaging	0.99
R5499:Lrp1	UTSW	10	127,408,813 (GRCm39)	missense	possibly damaging	0.58
R5526:Lrp1	UTSW	10	127,391,593 (GRCm39)	missense	probably benign	0.37
R5580:Lrp1	UTSW	10	127,424,389 (GRCm39)	missense	probably benign
R5583:Lrp1	UTSW	10	127,424,332 (GRCm39)	missense	probably benign	0.08
R5599:Lrp1	UTSW	10	127,429,738 (GRCm39)	missense	probably damaging	1.00
R5639:Lrp1	UTSW	10	127,429,708 (GRCm39)	missense	probably damaging	0.99
R5677:Lrp1	UTSW	10	127,410,298 (GRCm39)	missense	probably damaging	1.00
R5730:Lrp1	UTSW	10	127,419,703 (GRCm39)	missense	probably benign	0.00
R5742:Lrp1	UTSW	10	127,384,216 (GRCm39)	missense	probably damaging	0.98
R5764:Lrp1	UTSW	10	127,431,187 (GRCm39)	missense	probably benign	0.41
R5864:Lrp1	UTSW	10	127,403,374 (GRCm39)	missense	possibly damaging	0.58
R5937:Lrp1	UTSW	10	127,419,745 (GRCm39)	missense	possibly damaging	0.93
R5947:Lrp1	UTSW	10	127,425,423 (GRCm39)	critical splice donor site	probably null
R5976:Lrp1	UTSW	10	127,419,770 (GRCm39)	missense	probably damaging	1.00
R6021:Lrp1	UTSW	10	127,413,883 (GRCm39)	missense	probably damaging	1.00
R6026:Lrp1	UTSW	10	127,409,272 (GRCm39)	missense	probably damaging	1.00
R6045:Lrp1	UTSW	10	127,402,469 (GRCm39)	missense	probably damaging	0.98
R6057:Lrp1	UTSW	10	127,403,359 (GRCm39)	missense	probably damaging	1.00
R6084:Lrp1	UTSW	10	127,396,422 (GRCm39)	missense	probably benign	0.09
R6131:Lrp1	UTSW	10	127,396,026 (GRCm39)	missense	probably benign
R6235:Lrp1	UTSW	10	127,424,046 (GRCm39)	missense	probably damaging	1.00
R6280:Lrp1	UTSW	10	127,425,453 (GRCm39)	missense	probably benign	0.04
R6307:Lrp1	UTSW	10	127,427,944 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,377,551 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,385,276 (GRCm39)	missense	probably damaging	1.00
R6536:Lrp1	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
R6605:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6607:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6631:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R6676:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6678:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6809:Lrp1	UTSW	10	127,390,925 (GRCm39)	missense	probably benign	0.04
R6884:Lrp1	UTSW	10	127,394,986 (GRCm39)	missense	probably benign	0.00
R6925:Lrp1	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
R6987:Lrp1	UTSW	10	127,410,874 (GRCm39)	missense	probably damaging	1.00
R7016:Lrp1	UTSW	10	127,395,836 (GRCm39)	critical splice donor site	probably null
R7030:Lrp1	UTSW	10	127,388,745 (GRCm39)	missense	probably damaging	0.97
R7053:Lrp1	UTSW	10	127,376,963 (GRCm39)	missense	probably damaging	1.00
R7076:Lrp1	UTSW	10	127,386,052 (GRCm39)	critical splice donor site	probably null
R7136:Lrp1	UTSW	10	127,394,491 (GRCm39)	missense	probably damaging	1.00
R7180:Lrp1	UTSW	10	127,392,834 (GRCm39)	missense	probably damaging	1.00
R7199:Lrp1	UTSW	10	127,409,325 (GRCm39)	missense	probably damaging	0.99
R7219:Lrp1	UTSW	10	127,393,097 (GRCm39)	missense	probably benign	0.40
R7233:Lrp1	UTSW	10	127,430,930 (GRCm39)	missense	probably damaging	1.00
R7251:Lrp1	UTSW	10	127,408,423 (GRCm39)	missense	probably damaging	1.00
R7264:Lrp1	UTSW	10	127,427,962 (GRCm39)	missense	probably damaging	1.00
R7302:Lrp1	UTSW	10	127,374,856 (GRCm39)	missense	probably benign	0.01
R7313:Lrp1	UTSW	10	127,389,337 (GRCm39)	missense	probably damaging	1.00
R7322:Lrp1	UTSW	10	127,381,433 (GRCm39)	missense	probably benign	0.24
R7354:Lrp1	UTSW	10	127,407,277 (GRCm39)	missense	probably damaging	1.00
R7375:Lrp1	UTSW	10	127,375,217 (GRCm39)	missense	probably damaging	1.00
R7388:Lrp1	UTSW	10	127,419,766 (GRCm39)	nonsense	probably null
R7404:Lrp1	UTSW	10	127,418,577 (GRCm39)	missense
R7405:Lrp1	UTSW	10	127,417,620 (GRCm39)	missense	possibly damaging	0.93
R7477:Lrp1	UTSW	10	127,404,789 (GRCm39)	missense	probably damaging	1.00
R7555:Lrp1	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
R7600:Lrp1	UTSW	10	127,391,575 (GRCm39)	missense	probably benign
R7678:Lrp1	UTSW	10	127,409,922 (GRCm39)	missense	probably damaging	1.00
R7679:Lrp1	UTSW	10	127,424,297 (GRCm39)	nonsense	probably null
R7951:Lrp1	UTSW	10	127,374,933 (GRCm39)	nonsense	probably null
R7964:Lrp1	UTSW	10	127,410,913 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrp1	UTSW	10	127,425,488 (GRCm39)	missense	probably damaging	1.00
R8021:Lrp1	UTSW	10	127,384,215 (GRCm39)	missense	possibly damaging	0.92
R8098:Lrp1	UTSW	10	127,410,324 (GRCm39)	missense	possibly damaging	0.78
R8112:Lrp1	UTSW	10	127,441,715 (GRCm39)	missense	probably damaging	1.00
R8210:Lrp1	UTSW	10	127,412,354 (GRCm39)	missense	probably damaging	1.00
R8249:Lrp1	UTSW	10	127,441,412 (GRCm39)	missense	probably benign
R8291:Lrp1	UTSW	10	127,425,572 (GRCm39)	missense	probably damaging	1.00
R8332:Lrp1	UTSW	10	127,407,805 (GRCm39)	missense	probably damaging	1.00
R8435:Lrp1	UTSW	10	127,392,199 (GRCm39)	missense	probably damaging	0.97
R8467:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8468:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8474:Lrp1	UTSW	10	127,375,572 (GRCm39)	missense	probably damaging	1.00
R8481:Lrp1	UTSW	10	127,404,779 (GRCm39)	missense	probably damaging	1.00
R8483:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8485:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8488:Lrp1	UTSW	10	127,396,356 (GRCm39)	missense	probably damaging	1.00
R8715:Lrp1	UTSW	10	127,396,490 (GRCm39)	missense	possibly damaging	0.77
R8790:Lrp1	UTSW	10	127,374,946 (GRCm39)	missense	probably damaging	1.00
R8854:Lrp1	UTSW	10	127,378,968 (GRCm39)	missense	probably damaging	1.00
R8926:Lrp1	UTSW	10	127,381,671 (GRCm39)	missense	probably benign
R8949:Lrp1	UTSW	10	127,425,405 (GRCm39)	intron	probably benign
R8971:Lrp1	UTSW	10	127,391,896 (GRCm39)	missense	possibly damaging	0.94
R9103:Lrp1	UTSW	10	127,430,979 (GRCm39)	nonsense	probably null
R9108:Lrp1	UTSW	10	127,390,206 (GRCm39)	missense	probably damaging	0.99
R9130:Lrp1	UTSW	10	127,382,281 (GRCm39)	missense	probably benign	0.18
R9157:Lrp1	UTSW	10	127,410,209 (GRCm39)	missense	probably damaging	1.00
R9162:Lrp1	UTSW	10	127,441,368 (GRCm39)	missense	probably benign	0.32
R9205:Lrp1	UTSW	10	127,430,850 (GRCm39)	nonsense	probably null
R9228:Lrp1	UTSW	10	127,382,807 (GRCm39)	missense	probably damaging	0.98
R9231:Lrp1	UTSW	10	127,382,268 (GRCm39)	missense	probably benign	0.06
R9287:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R9381:Lrp1	UTSW	10	127,441,337 (GRCm39)	missense	probably benign	0.17
R9412:Lrp1	UTSW	10	127,409,287 (GRCm39)	missense	probably damaging	1.00
R9434:Lrp1	UTSW	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
R9463:Lrp1	UTSW	10	127,429,334 (GRCm39)	nonsense	probably null
R9526:Lrp1	UTSW	10	127,431,229 (GRCm39)	missense	probably damaging	0.96
R9548:Lrp1	UTSW	10	127,388,733 (GRCm39)	missense	probably damaging	0.99
R9599:Lrp1	UTSW	10	127,410,246 (GRCm39)	missense	probably damaging	1.00
R9649:Lrp1	UTSW	10	127,409,368 (GRCm39)	missense	probably benign	0.14
R9687:Lrp1	UTSW	10	127,402,562 (GRCm39)	missense	probably damaging	1.00
R9707:Lrp1	UTSW	10	127,408,414 (GRCm39)	missense	probably benign	0.08
R9770:Lrp1	UTSW	10	127,420,268 (GRCm39)	missense	probably damaging	1.00
V3553:Lrp1	UTSW	10	127,407,311 (GRCm39)	missense	probably damaging	1.00
Y5406:Lrp1	UTSW	10	127,390,152 (GRCm39)	missense	probably damaging	1.00
Z1088:Lrp1	UTSW	10	127,420,248 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrp1	UTSW	10	127,390,831 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AATTCATTGGGGCCGCAGGTTG -3'
(R):5'- GCCGTGCGTTTAAGGAGATCACAG -3'

Sequencing Primer
(F):5'- ACTCACCACACTCAGGGGATT -3'
(R):5'- GCTACCACTCATGTTGCAGG -3'

Posted On

2014-05-14