Incidental Mutation 'R0010:Trappc4'
ID19135
Institutional Source Beutler Lab
Gene Symbol Trappc4
Ensembl Gene ENSMUSG00000032112
Gene Nametrafficking protein particle complex 4
SynonymsHSPC172, PTD009, Sbdn, TRS23, 1500017G03Rik, Sbd
MMRRC Submission 038305-MU
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.961) question?
Stock #R0010 (G1)
Quality Score
Status Validated
Chromosome9
Chromosomal Location44403698-44407600 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to A at 44405231 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034623] [ENSMUST00000053286] [ENSMUST00000080300] [ENSMUST00000165839] [ENSMUST00000213268] [ENSMUST00000213388] [ENSMUST00000217163] [ENSMUST00000216076] [ENSMUST00000217084] [ENSMUST00000216867] [ENSMUST00000215420]
Predicted Effect probably benign
Transcript: ENSMUST00000034623
SMART Domains Protein: ENSMUSP00000034623
Gene: ENSMUSG00000032112

DomainStartEndE-ValueType
Pfam:Sybindin 3 209 2.7e-63 PFAM
Pfam:Sedlin_N 90 207 2.8e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000053286
SMART Domains Protein: ENSMUSP00000053216
Gene: ENSMUSG00000043923

DomainStartEndE-ValueType
Pfam:CCDC84 6 323 2.5e-95 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080300
SMART Domains Protein: ENSMUSP00000079180
Gene: ENSMUSG00000009927

DomainStartEndE-ValueType
Pfam:Ribosomal_S25 4 112 6.2e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165839
SMART Domains Protein: ENSMUSP00000129564
Gene: ENSMUSG00000032114

DomainStartEndE-ValueType
Pfam:MFS_1 17 381 3.5e-48 PFAM
transmembrane domain 395 417 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184353
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213116
Predicted Effect probably benign
Transcript: ENSMUST00000213268
Predicted Effect probably benign
Transcript: ENSMUST00000213388
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213626
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213747
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214370
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215072
Predicted Effect probably benign
Transcript: ENSMUST00000217163
Predicted Effect probably benign
Transcript: ENSMUST00000216076
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217620
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215731
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215402
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215610
Predicted Effect probably benign
Transcript: ENSMUST00000217084
Predicted Effect probably benign
Transcript: ENSMUST00000216867
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217231
Predicted Effect probably benign
Transcript: ENSMUST00000215420
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216134
Coding Region Coverage
  • 1x: 79.6%
  • 3x: 70.9%
  • 10x: 47.0%
  • 20x: 26.4%
Validation Efficiency 91% (78/86)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 C T 5: 81,792,403 A1320V possibly damaging Het
Ahrr G A 13: 74,283,024 probably benign Het
BC037034 T C 5: 138,260,293 probably null Het
Cd74 A T 18: 60,809,071 H124L probably benign Het
Cdk5rap2 T C 4: 70,243,459 E270G probably benign Het
Cldnd1 T A 16: 58,731,259 probably benign Het
Dennd4a T C 9: 64,896,715 L1112P probably benign Het
Evc2 T A 5: 37,417,449 L1016Q probably damaging Het
Fam135b T C 15: 71,622,032 K16R probably damaging Het
Frem1 T C 4: 83,000,098 I536V probably benign Het
Ginm1 T C 10: 7,775,374 probably benign Het
Glrb A T 3: 80,860,315 probably benign Het
Glt6d1 C A 2: 25,794,727 probably null Het
Gm10320 T C 13: 98,489,546 Y110C probably damaging Het
Intu T C 3: 40,654,272 probably benign Het
Ltbp1 A G 17: 75,363,391 T1476A probably damaging Het
Mcoln2 C T 3: 146,183,561 T374M probably damaging Het
Mitf A G 6: 97,807,281 K33R probably benign Het
Nlgn1 G T 3: 25,435,842 probably benign Het
Nup133 A T 8: 123,904,579 I1072N probably damaging Het
Rock1 T A 18: 10,084,380 D951V probably damaging Het
Scgb2b26 T A 7: 33,944,349 E55D probably damaging Het
Scn8a T C 15: 101,013,573 V958A probably damaging Het
Sgk1 G A 10: 21,997,438 probably null Het
Shprh C T 10: 11,151,931 T94I probably benign Het
Smg1 A T 7: 118,171,859 probably benign Het
Spta1 G A 1: 174,217,943 V1556I probably benign Het
Txlna T G 4: 129,629,086 D487A probably benign Het
Ube2d2b T C 5: 107,830,636 F51S possibly damaging Het
Wdfy3 T C 5: 101,848,349 T3234A probably damaging Het
Zbtb41 T G 1: 139,423,530 V127G probably damaging Het
Zfp608 A T 18: 54,895,214 probably benign Het
Other mutations in Trappc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0010:Trappc4 UTSW 9 44405231 splice site probably benign
R1709:Trappc4 UTSW 9 44407211 missense probably benign 0.44
R4881:Trappc4 UTSW 9 44404025 missense probably damaging 1.00
R5884:Trappc4 UTSW 9 44404088 missense probably damaging 1.00
R6801:Trappc4 UTSW 9 44404388 missense probably damaging 0.96
R7218:Trappc4 UTSW 9 44405290 missense probably benign 0.00
R8724:Trappc4 UTSW 9 44405263 missense probably benign 0.38
Posted On2013-03-25