Mutagenetix > Incidental Mutations

Incidental Mutation 'R0010:Scgb2b26'

19136

Institutional Source

Beutler Lab

Gene Symbol

Scgb2b26

Ensembl Gene

ENSMUSG00000066586

Gene Name

secretoglobin, family 2B, member 26

Synonyms

Abpg, C2d, Abpbg26, Scgb2b4, Abpbg4

MMRRC Submission

038305-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R0010 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

33943002-33945040 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33944349 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 55 (E55D)

Ref Sequence

ENSEMBL: ENSMUSP00000082763 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085623]

Predicted Effect

probably damaging
Transcript: ENSMUST00000085623
AA Change: E55D

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000082763
Gene: ENSMUSG00000066586
AA Change: E55D

Domain	Start	End	E-Value	Type
low complexity region	5	11	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	2.9e-29	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 79.6%
3x: 70.9%
10x: 47.0%
20x: 26.4%

Validation Efficiency

91% (78/86)

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	C	T	5: 81,792,403	A1320V	possibly damaging	Het
Ahrr	G	A	13: 74,283,024		probably benign	Het
BC037034	T	C	5: 138,260,293		probably null	Het
Cd74	A	T	18: 60,809,071	H124L	probably benign	Het
Cdk5rap2	T	C	4: 70,243,459	E270G	probably benign	Het
Cldnd1	T	A	16: 58,731,259		probably benign	Het
Dennd4a	T	C	9: 64,896,715	L1112P	probably benign	Het
Evc2	T	A	5: 37,417,449	L1016Q	probably damaging	Het
Fam135b	T	C	15: 71,622,032	K16R	probably damaging	Het
Frem1	T	C	4: 83,000,098	I536V	probably benign	Het
Ginm1	T	C	10: 7,775,374		probably benign	Het
Glrb	A	T	3: 80,860,315		probably benign	Het
Glt6d1	C	A	2: 25,794,727		probably null	Het
Gm10320	T	C	13: 98,489,546	Y110C	probably damaging	Het
Intu	T	C	3: 40,654,272		probably benign	Het
Ltbp1	A	G	17: 75,363,391	T1476A	probably damaging	Het
Mcoln2	C	T	3: 146,183,561	T374M	probably damaging	Het
Mitf	A	G	6: 97,807,281	K33R	probably benign	Het
Nlgn1	G	T	3: 25,435,842		probably benign	Het
Nup133	A	T	8: 123,904,579	I1072N	probably damaging	Het
Rock1	T	A	18: 10,084,380	D951V	probably damaging	Het
Scn8a	T	C	15: 101,013,573	V958A	probably damaging	Het
Sgk1	G	A	10: 21,997,438		probably null	Het
Shprh	C	T	10: 11,151,931	T94I	probably benign	Het
Smg1	A	T	7: 118,171,859		probably benign	Het
Spta1	G	A	1: 174,217,943	V1556I	probably benign	Het
Trappc4	G	A	9: 44,405,231		probably benign	Het
Txlna	T	G	4: 129,629,086	D487A	probably benign	Het
Ube2d2b	T	C	5: 107,830,636	F51S	possibly damaging	Het
Wdfy3	T	C	5: 101,848,349	T3234A	probably damaging	Het
Zbtb41	T	G	1: 139,423,530	V127G	probably damaging	Het
Zfp608	A	T	18: 54,895,214		probably benign	Het

Other mutations in Scgb2b26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02061:Scgb2b26	APN	7	33943185	missense	probably benign	0.16
R0010:Scgb2b26	UTSW	7	33944349	missense	probably damaging	0.98
R6768:Scgb2b26	UTSW	7	33944954	missense	probably damaging	1.00
R7188:Scgb2b26	UTSW	7	33944954	missense	probably damaging	1.00
R7325:Scgb2b26	UTSW	7	33944357	missense	probably benign	0.14
R8205:Scgb2b26	UTSW	7	33944408	missense	probably benign	0.03
R8679:Scgb2b26	UTSW	7	33944359	missense	probably damaging	0.99
Z1088:Scgb2b26	UTSW	7	33944367	missense	probably benign	0.00

Posted On

2013-03-25