Incidental Mutation 'R0006:Msantd4'
ID19156
Institutional Source Beutler Lab
Gene Symbol Msantd4
Ensembl Gene ENSMUSG00000041124
Gene NameMyb/SANT-like DNA-binding domain containing 4 with coiled-coils
Synonyms
MMRRC Submission 041980-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.293) question?
Stock #R0006 (G1)
Quality Score
Status Validated
Chromosome9
Chromosomal Location4376562-4386870 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 4384099 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 140 (E140G)
Ref Sequence ENSEMBL: ENSMUSP00000148805 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047173] [ENSMUST00000212075]
Predicted Effect probably damaging
Transcript: ENSMUST00000047173
AA Change: E140G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038267
Gene: ENSMUSG00000041124
AA Change: E140G

DomainStartEndE-ValueType
Pfam:Myb_DNA-bind_5 8 86 7.6e-26 PFAM
low complexity region 154 162 N/A INTRINSIC
coiled coil region 202 344 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000212075
AA Change: E140G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.1221 question?
Coding Region Coverage
  • 1x: 77.9%
  • 3x: 66.3%
  • 10x: 36.9%
  • 20x: 17.4%
Validation Efficiency 95% (74/78)
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Appl2 A G 10: 83,602,898 F556L probably damaging Het
Atad2b T A 12: 4,942,030 S210T possibly damaging Het
Aurka A G 2: 172,359,753 probably null Het
Chd8 A G 14: 52,235,293 I351T possibly damaging Het
Chid1 T A 7: 141,496,426 probably benign Het
Dnase2b T A 3: 146,582,489 I284F probably damaging Het
Dst C T 1: 34,228,918 T5325I probably benign Het
Erbb3 A G 10: 128,573,410 probably null Het
Fancl A G 11: 26,469,695 N316S possibly damaging Het
Gabrd C A 4: 155,388,601 V72L probably damaging Het
Hephl1 T A 9: 15,076,764 T683S probably benign Het
Jazf1 A G 6: 52,894,086 probably benign Het
Kntc1 T A 5: 123,789,138 S1219T probably benign Het
L3mbtl1 A T 2: 162,964,569 Y460F possibly damaging Het
Map1b C T 13: 99,435,302 V304M probably damaging Het
Myo16 A G 8: 10,475,988 K843E probably damaging Het
Rap1gds1 G T 3: 138,983,871 probably null Het
Rsph4a T C 10: 33,909,148 C148R probably damaging Het
Slc7a9 A T 7: 35,470,100 probably benign Het
Sptbn1 A G 11: 30,123,855 S1405P probably damaging Het
Tex35 T C 1: 157,099,744 K154E possibly damaging Het
Tpm3 T A 3: 90,087,661 probably benign Het
Ubr4 T C 4: 139,431,649 F2438L probably benign Het
Wfdc8 T C 2: 164,599,064 D253G probably damaging Het
Zfp451 A T 1: 33,802,780 probably benign Het
Zfp687 A G 3: 95,011,456 I335T probably damaging Het
Other mutations in Msantd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02021:Msantd4 APN 9 4385163 missense probably damaging 1.00
IGL02347:Msantd4 APN 9 4384734 splice site probably benign
IGL02947:Msantd4 APN 9 4384787 missense probably damaging 0.97
IGL02949:Msantd4 APN 9 4385196 missense probably damaging 1.00
FR4548:Msantd4 UTSW 9 4384937 missense possibly damaging 0.50
FR4976:Msantd4 UTSW 9 4384937 missense possibly damaging 0.50
R0436:Msantd4 UTSW 9 4385180 missense probably damaging 0.98
R1403:Msantd4 UTSW 9 4384023 missense probably benign 0.19
R1403:Msantd4 UTSW 9 4384023 missense probably benign 0.19
R1512:Msantd4 UTSW 9 4384138 missense probably benign 0.02
R1639:Msantd4 UTSW 9 4385199 missense probably damaging 1.00
R3819:Msantd4 UTSW 9 4385237 missense probably damaging 1.00
R6021:Msantd4 UTSW 9 4384063 missense probably benign 0.34
R6982:Msantd4 UTSW 9 4384061 missense possibly damaging 0.79
Posted On2013-03-25