Incidental Mutation 'R1690:Taar8a'
ID 191724
Institutional Source Beutler Lab
Gene Symbol Taar8a
Ensembl Gene ENSMUSG00000096442
Gene Name trace amine-associated receptor 8A
Synonyms LOC215859
MMRRC Submission 039723-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R1690 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 23952398-23953432 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23952813 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 139 (Y139C)
Ref Sequence ENSEMBL: ENSMUSP00000062719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051133]
AlphaFold Q5QD07
Predicted Effect probably damaging
Transcript: ENSMUST00000051133
AA Change: Y139C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062719
Gene: ENSMUSG00000096442
AA Change: Y139C

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 40 244 3.9e-8 PFAM
Pfam:7TM_GPCR_Srsx 42 327 7.1e-15 PFAM
Pfam:7tm_1 48 312 9.1e-58 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn4 A G 7: 28,610,950 (GRCm39) S263P probably damaging Het
Adcy10 A G 1: 165,347,494 (GRCm39) E403G probably damaging Het
Adgrg7 A T 16: 56,615,993 (GRCm39) V11E probably damaging Het
Arhgap35 A G 7: 16,297,206 (GRCm39) C620R probably damaging Het
Cfap43 A G 19: 47,739,505 (GRCm39) probably null Het
Cfap54 A G 10: 92,871,304 (GRCm39) S639P possibly damaging Het
Csf2rb T C 15: 78,232,844 (GRCm39) V717A probably benign Het
D17H6S53E A G 17: 35,346,188 (GRCm39) D33G possibly damaging Het
Dpf2 C T 19: 5,955,490 (GRCm39) R131Q probably damaging Het
Dtx3l C T 16: 35,753,638 (GRCm39) A323T probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fgf15 A G 7: 144,453,665 (GRCm39) S213G probably damaging Het
Fmn1 T A 2: 113,355,827 (GRCm39) F756Y unknown Het
Hnrnpk T A 13: 58,548,168 (GRCm39) T13S probably benign Het
Htr3b T A 9: 48,848,394 (GRCm39) M284L possibly damaging Het
Itgal T C 7: 126,901,289 (GRCm39) M225T possibly damaging Het
Lipi A G 16: 75,338,013 (GRCm39) Y454H probably damaging Het
Lrit3 T C 3: 129,594,394 (GRCm39) K61R probably damaging Het
Lta4h A G 10: 93,320,554 (GRCm39) D583G probably benign Het
Mettl17 T A 14: 52,128,918 (GRCm39) V396D probably damaging Het
Nlrc4 G A 17: 74,744,518 (GRCm39) R788* probably null Het
Or8k25 T A 2: 86,244,298 (GRCm39) I33F probably benign Het
Pepd G A 7: 34,730,782 (GRCm39) G278D probably damaging Het
Pramel23 T C 4: 143,424,693 (GRCm39) E250G probably benign Het
Prkcsh T A 9: 21,921,871 (GRCm39) D245E probably damaging Het
Prlr A T 15: 10,317,676 (GRCm39) D84V probably damaging Het
Pth2r C T 1: 65,411,462 (GRCm39) T333I probably benign Het
Ptk2 T A 15: 73,134,459 (GRCm39) I547F probably damaging Het
Rab11fip2 A T 19: 59,925,732 (GRCm39) S162T probably damaging Het
Rnf41 C A 10: 128,271,329 (GRCm39) Q80K possibly damaging Het
Scn7a T G 2: 66,506,287 (GRCm39) D1534A probably damaging Het
Septin12 A G 16: 4,806,378 (GRCm39) V261A probably damaging Het
Sh2d4a T C 8: 68,747,101 (GRCm39) S110P probably benign Het
Soat1 A T 1: 156,272,144 (GRCm39) S114T probably benign Het
Tcf12 A G 9: 71,777,354 (GRCm39) probably null Het
Tmem202 T A 9: 59,426,391 (GRCm39) R258S possibly damaging Het
Ttc39b A T 4: 83,145,414 (GRCm39) I604N probably damaging Het
Vit A G 17: 78,932,294 (GRCm39) D467G probably damaging Het
Zc3hc1 A G 6: 30,390,940 (GRCm39) V21A probably damaging Het
Zfp608 T A 18: 55,120,706 (GRCm39) I294F possibly damaging Het
Zfp825 T A 13: 74,628,781 (GRCm39) H227L probably benign Het
Other mutations in Taar8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Taar8a APN 10 23,952,759 (GRCm39) missense probably damaging 1.00
IGL01546:Taar8a APN 10 23,952,813 (GRCm39) missense possibly damaging 0.95
IGL01597:Taar8a APN 10 23,952,756 (GRCm39) missense possibly damaging 0.96
IGL02387:Taar8a APN 10 23,953,260 (GRCm39) missense possibly damaging 0.93
IGL02815:Taar8a APN 10 23,953,278 (GRCm39) missense probably benign 0.02
R0762:Taar8a UTSW 10 23,952,975 (GRCm39) missense probably benign 0.34
R2891:Taar8a UTSW 10 23,953,028 (GRCm39) missense probably benign 0.02
R3889:Taar8a UTSW 10 23,952,923 (GRCm39) missense probably benign 0.00
R3962:Taar8a UTSW 10 23,953,054 (GRCm39) missense probably damaging 0.99
R4090:Taar8a UTSW 10 23,953,062 (GRCm39) missense probably damaging 0.96
R6580:Taar8a UTSW 10 23,952,791 (GRCm39) missense probably damaging 0.99
R6605:Taar8a UTSW 10 23,952,674 (GRCm39) missense possibly damaging 0.88
R7422:Taar8a UTSW 10 23,952,762 (GRCm39) missense probably damaging 1.00
R7571:Taar8a UTSW 10 23,953,306 (GRCm39) nonsense probably null
R8265:Taar8a UTSW 10 23,952,839 (GRCm39) missense probably damaging 1.00
R9317:Taar8a UTSW 10 23,952,753 (GRCm39) missense probably benign 0.00
R9371:Taar8a UTSW 10 23,952,753 (GRCm39) missense probably benign 0.00
R9710:Taar8a UTSW 10 23,952,714 (GRCm39) missense probably damaging 0.97
R9755:Taar8a UTSW 10 23,952,995 (GRCm39) missense probably benign 0.01
X0022:Taar8a UTSW 10 23,953,406 (GRCm39) missense possibly damaging 0.93
X0062:Taar8a UTSW 10 23,953,279 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATGGTCAGGTCCATTGAGAGCTGC -3'
(R):5'- GAGGATGATTCACCTCTGTTGCCAC -3'

Sequencing Primer
(F):5'- CATTGAGAGCTGCTGGTACTTTG -3'
(R):5'- ACCTCTGTTGCCACTTACAGAAG -3'
Posted On 2014-05-14