Incidental Mutation 'R1693:Zfp964'
ID191933
Institutional Source Beutler Lab
Gene Symbol Zfp964
Ensembl Gene ENSMUSG00000091764
Gene Namezinc finger protein 964
SynonymsGm7187
MMRRC Submission 039726-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #R1693 (G1)
Quality Score225
Status Validated
Chromosome8
Chromosomal Location69654479-69666982 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 69664150 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 466 (S466T)
Ref Sequence ENSEMBL: ENSMUSP00000129822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169125] [ENSMUST00000204285]
Predicted Effect possibly damaging
Transcript: ENSMUST00000169125
AA Change: S466T

PolyPhen 2 Score 0.548 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000129822
Gene: ENSMUSG00000091764
AA Change: S466T

DomainStartEndE-ValueType
KRAB 3 56 5.24e-18 SMART
ZnF_C2H2 216 238 4.54e-4 SMART
ZnF_C2H2 244 266 3.58e-2 SMART
ZnF_C2H2 272 294 2.2e-2 SMART
ZnF_C2H2 300 322 5.5e-3 SMART
ZnF_C2H2 328 350 8.22e-2 SMART
ZnF_C2H2 356 378 2.05e-2 SMART
ZnF_C2H2 384 406 6.32e-3 SMART
ZnF_C2H2 412 434 5.42e-2 SMART
ZnF_C2H2 440 462 1.28e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204062
Predicted Effect unknown
Transcript: ENSMUST00000204285
AA Change: S467T
SMART Domains Protein: ENSMUSP00000145354
Gene: ENSMUSG00000091764
AA Change: S467T

DomainStartEndE-ValueType
KRAB 4 57 5.24e-18 SMART
ZnF_C2H2 217 239 4.54e-4 SMART
ZnF_C2H2 245 267 3.58e-2 SMART
ZnF_C2H2 273 295 2.2e-2 SMART
ZnF_C2H2 301 323 5.5e-3 SMART
ZnF_C2H2 329 351 8.22e-2 SMART
ZnF_C2H2 357 379 2.05e-2 SMART
ZnF_C2H2 385 407 6.32e-3 SMART
ZnF_C2H2 413 435 5.42e-2 SMART
ZnF_C2H2 441 463 1.28e-3 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.2%
  • 20x: 92.2%
Validation Efficiency 96% (69/72)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 A G 11: 53,396,553 D378G probably damaging Het
Anpep C T 7: 79,838,256 E518K probably benign Het
Aox1 T C 1: 58,085,542 Y981H probably damaging Het
Arfgap2 T A 2: 91,270,075 probably null Het
Ccnf TGGGGG TGGGGGGG 17: 24,226,540 probably null Het
Cd53 T C 3: 106,768,889 N54S possibly damaging Het
Cep152 C A 2: 125,566,254 A1390S probably benign Het
Chd7 T C 4: 8,864,307 probably null Het
Chrm5 A G 2: 112,479,280 L497P probably damaging Het
Colec12 G A 18: 9,866,765 V659M unknown Het
Creb3 C A 4: 43,566,755 H390Q probably damaging Het
D1Pas1 T C 1: 186,968,029 F52L probably benign Het
D5Ertd579e A G 5: 36,614,097 F985L probably damaging Het
Dock4 C T 12: 40,834,722 P1742S probably benign Het
Ehmt2 G T 17: 34,906,410 V534L possibly damaging Het
Epcam A G 17: 87,639,896 D26G probably benign Het
F2 C T 2: 91,629,179 V420M probably damaging Het
Fbxw16 A T 9: 109,436,259 D401E possibly damaging Het
Fiz1 T C 7: 5,008,728 T264A probably benign Het
Fsbp T C 4: 11,583,745 V148A probably benign Het
Furin A G 7: 80,392,482 L455P probably damaging Het
Ggt7 G A 2: 155,506,475 R10W probably damaging Het
Gucy2g T C 19: 55,222,926 E624G probably damaging Het
Igf2r A G 17: 12,704,316 F1202S probably damaging Het
Ikzf1 C T 11: 11,707,838 P32S probably damaging Het
Itgal G A 7: 127,305,281 V309M probably damaging Het
Kcnk5 C A 14: 20,141,896 R399L probably damaging Het
Kdm5b C T 1: 134,597,576 probably benign Het
Lrp2 C T 2: 69,510,418 V1038M probably damaging Het
Lrp4 T C 2: 91,492,353 Y1096H probably damaging Het
Lrrc7 C G 3: 158,084,533 S1465T possibly damaging Het
Maats1 A G 16: 38,341,723 Y19H probably benign Het
Map3k5 A G 10: 20,104,242 N832S probably damaging Het
Mkl2 C A 16: 13,398,470 L349I possibly damaging Het
Mkl2 T A 16: 13,398,471 L349Q probably damaging Het
Myh13 A C 11: 67,341,484 M495L possibly damaging Het
Myh9 A C 15: 77,812,897 Y106D probably damaging Het
Naa16 A T 14: 79,351,456 W452R probably damaging Het
Nsd1 T C 13: 55,247,261 S892P probably benign Het
Nup205 A G 6: 35,210,971 I939V probably benign Het
Oit3 A G 10: 59,425,417 F476S probably damaging Het
Olfr868 T C 9: 20,101,587 V276A probably benign Het
Panx3 A T 9: 37,668,907 M50K possibly damaging Het
Panx3 A C 9: 37,668,946 M37R possibly damaging Het
Ppp2r5e C G 12: 75,469,567 A239P probably damaging Het
Prkaca T A 8: 83,981,198 D37E probably benign Het
Prkcq T A 2: 11,254,199 I310N probably damaging Het
Prrc2c A G 1: 162,718,713 Y235H probably damaging Het
Ptprj A T 2: 90,449,797 C1052* probably null Het
Rad52 C A 6: 119,916,035 P180Q probably damaging Het
Sdhaf3 T A 6: 7,038,964 D95E probably benign Het
Slitrk6 A G 14: 110,750,928 I449T probably damaging Het
Spata7 T A 12: 98,664,257 M358K possibly damaging Het
Tada2a C T 11: 84,082,069 G178D probably damaging Het
Tap2 G C 17: 34,209,212 V287L probably benign Het
Tmem200a A G 10: 25,993,979 F131L possibly damaging Het
Tmem55a T A 4: 14,886,631 D68E probably benign Het
Traip A T 9: 107,970,030 K356M probably damaging Het
Tspan8 T A 10: 115,844,044 probably benign Het
U2surp A T 9: 95,511,860 M1K probably null Het
Vars A T 17: 34,998,196 D427E probably benign Het
Vmn1r113 G A 7: 20,787,607 C108Y probably damaging Het
Vmn2r63 T A 7: 42,928,319 Q265L probably benign Het
Vps33b T A 7: 80,287,893 V463E probably damaging Het
Vrtn T C 12: 84,648,655 S60P probably benign Het
Zfp53 T A 17: 21,509,622 V639D possibly damaging Het
Other mutations in Zfp964
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Zfp964 APN 8 69659393 splice site probably null
R0506:Zfp964 UTSW 8 69663937 missense unknown
R0740:Zfp964 UTSW 8 69663178 missense probably damaging 0.98
R0786:Zfp964 UTSW 8 69664081 missense possibly damaging 0.71
R1158:Zfp964 UTSW 8 69663853 missense unknown
R1204:Zfp964 UTSW 8 69664018 missense probably benign 0.08
R1413:Zfp964 UTSW 8 69663070 missense unknown
R1562:Zfp964 UTSW 8 69663004 missense probably benign
R1663:Zfp964 UTSW 8 69664083 splice site probably null
R2029:Zfp964 UTSW 8 69663917 missense unknown
R2847:Zfp964 UTSW 8 69663854 missense unknown
R2849:Zfp964 UTSW 8 69663854 missense unknown
R4111:Zfp964 UTSW 8 69664104 missense probably benign 0.18
R4792:Zfp964 UTSW 8 69664015 missense probably benign 0.18
R4907:Zfp964 UTSW 8 69663322 missense possibly damaging 0.86
R4938:Zfp964 UTSW 8 69664108 missense possibly damaging 0.64
R5688:Zfp964 UTSW 8 69664116 missense probably benign 0.03
R5905:Zfp964 UTSW 8 69663913 missense unknown
R6009:Zfp964 UTSW 8 69663456 missense possibly damaging 0.71
R6021:Zfp964 UTSW 8 69663092 missense unknown
R6028:Zfp964 UTSW 8 69663913 missense unknown
R6374:Zfp964 UTSW 8 69659344 missense possibly damaging 0.93
R6583:Zfp964 UTSW 8 69662983 missense probably damaging 0.98
R7730:Zfp964 UTSW 8 69663710 missense possibly damaging 0.85
R8263:Zfp964 UTSW 8 69663695 missense possibly damaging 0.92
R8309:Zfp964 UTSW 8 69663274 missense possibly damaging 0.53
R8889:Zfp964 UTSW 8 69663755 missense probably damaging 1.00
R8892:Zfp964 UTSW 8 69663755 missense probably damaging 1.00
Predicted Primers
Posted On2014-05-14