Incidental Mutation 'R1693:Or7e174'
ID 191936
Institutional Source Beutler Lab
Gene Symbol Or7e174
Ensembl Gene ENSMUSG00000044106
Gene Name olfactory receptor family 7 subfamily E member 174
Synonyms MOR145-4, GA_x6K02T2PVTD-13841888-13842802, Olfr868
MMRRC Submission 039726-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R1693 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 20009922-20012986 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20012883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 276 (V276A)
Ref Sequence ENSEMBL: ENSMUSP00000148302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000212767] [ENSMUST00000212999]
AlphaFold Q8VFI8
Predicted Effect probably benign
Transcript: ENSMUST00000050227
AA Change: V276A

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000050040
Gene: ENSMUSG00000044106
AA Change: V276A

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 3.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 38 288 3.6e-7 PFAM
Pfam:7tm_1 44 293 4.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212767
AA Change: V276A

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000212999
AA Change: V276A

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215566
Meta Mutation Damage Score 0.3218 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.2%
  • 20x: 92.2%
Validation Efficiency 96% (69/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 A G 11: 53,287,380 (GRCm39) D378G probably damaging Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Aox1 T C 1: 58,124,701 (GRCm39) Y981H probably damaging Het
Arfgap2 T A 2: 91,100,420 (GRCm39) probably null Het
Ccnf TGGGGG TGGGGGGG 17: 24,445,514 (GRCm39) probably null Het
Cd53 T C 3: 106,676,205 (GRCm39) N54S possibly damaging Het
Cep152 C A 2: 125,408,174 (GRCm39) A1390S probably benign Het
Cfap91 A G 16: 38,162,085 (GRCm39) Y19H probably benign Het
Chd7 T C 4: 8,864,307 (GRCm39) probably null Het
Chrm5 A G 2: 112,309,625 (GRCm39) L497P probably damaging Het
Colec12 G A 18: 9,866,765 (GRCm39) V659M unknown Het
Creb3 C A 4: 43,566,755 (GRCm39) H390Q probably damaging Het
D1Pas1 T C 1: 186,700,226 (GRCm39) F52L probably benign Het
D5Ertd579e A G 5: 36,771,441 (GRCm39) F985L probably damaging Het
Dock4 C T 12: 40,884,721 (GRCm39) P1742S probably benign Het
Ehmt2 G T 17: 35,125,386 (GRCm39) V534L possibly damaging Het
Epcam A G 17: 87,947,324 (GRCm39) D26G probably benign Het
F2 C T 2: 91,459,524 (GRCm39) V420M probably damaging Het
Fbxw16 A T 9: 109,265,327 (GRCm39) D401E possibly damaging Het
Fiz1 T C 7: 5,011,727 (GRCm39) T264A probably benign Het
Fsbp T C 4: 11,583,745 (GRCm39) V148A probably benign Het
Furin A G 7: 80,042,230 (GRCm39) L455P probably damaging Het
Ggt7 G A 2: 155,348,395 (GRCm39) R10W probably damaging Het
Gucy2g T C 19: 55,211,358 (GRCm39) E624G probably damaging Het
Igf2r A G 17: 12,923,203 (GRCm39) F1202S probably damaging Het
Ikzf1 C T 11: 11,657,838 (GRCm39) P32S probably damaging Het
Itgal G A 7: 126,904,453 (GRCm39) V309M probably damaging Het
Kcnk5 C A 14: 20,191,964 (GRCm39) R399L probably damaging Het
Kdm5b C T 1: 134,525,314 (GRCm39) probably benign Het
Lrp2 C T 2: 69,340,762 (GRCm39) V1038M probably damaging Het
Lrp4 T C 2: 91,322,698 (GRCm39) Y1096H probably damaging Het
Lrrc7 C G 3: 157,790,170 (GRCm39) S1465T possibly damaging Het
Map3k5 A G 10: 19,979,988 (GRCm39) N832S probably damaging Het
Mrtfb C A 16: 13,216,334 (GRCm39) L349I possibly damaging Het
Mrtfb T A 16: 13,216,335 (GRCm39) L349Q probably damaging Het
Myh13 A C 11: 67,232,310 (GRCm39) M495L possibly damaging Het
Myh9 A C 15: 77,697,097 (GRCm39) Y106D probably damaging Het
Naa16 A T 14: 79,588,896 (GRCm39) W452R probably damaging Het
Nsd1 T C 13: 55,395,074 (GRCm39) S892P probably benign Het
Nup205 A G 6: 35,187,906 (GRCm39) I939V probably benign Het
Oit3 A G 10: 59,261,239 (GRCm39) F476S probably damaging Het
Panx3 A T 9: 37,580,203 (GRCm39) M50K possibly damaging Het
Panx3 A C 9: 37,580,242 (GRCm39) M37R possibly damaging Het
Pip4p2 T A 4: 14,886,631 (GRCm39) D68E probably benign Het
Ppp2r5e C G 12: 75,516,341 (GRCm39) A239P probably damaging Het
Prkaca T A 8: 84,707,827 (GRCm39) D37E probably benign Het
Prkcq T A 2: 11,259,010 (GRCm39) I310N probably damaging Het
Prrc2c A G 1: 162,546,282 (GRCm39) Y235H probably damaging Het
Ptprj A T 2: 90,280,141 (GRCm39) C1052* probably null Het
Rad52 C A 6: 119,892,996 (GRCm39) P180Q probably damaging Het
Sdhaf3 T A 6: 7,038,964 (GRCm39) D95E probably benign Het
Slitrk6 A G 14: 110,988,360 (GRCm39) I449T probably damaging Het
Spata7 T A 12: 98,630,516 (GRCm39) M358K possibly damaging Het
Tada2a C T 11: 83,972,895 (GRCm39) G178D probably damaging Het
Tap2 G C 17: 34,428,186 (GRCm39) V287L probably benign Het
Tmem200a A G 10: 25,869,877 (GRCm39) F131L possibly damaging Het
Traip A T 9: 107,847,229 (GRCm39) K356M probably damaging Het
Tspan8 T A 10: 115,679,949 (GRCm39) probably benign Het
U2surp A T 9: 95,393,913 (GRCm39) M1K probably null Het
Vars1 A T 17: 35,217,172 (GRCm39) D427E probably benign Het
Vmn1r113 G A 7: 20,521,532 (GRCm39) C108Y probably damaging Het
Vmn2r63 T A 7: 42,577,743 (GRCm39) Q265L probably benign Het
Vps33b T A 7: 79,937,641 (GRCm39) V463E probably damaging Het
Vrtn T C 12: 84,695,429 (GRCm39) S60P probably benign Het
Zfp53 T A 17: 21,729,884 (GRCm39) V639D possibly damaging Het
Zfp964 T A 8: 70,116,800 (GRCm39) S466T possibly damaging Het
Other mutations in Or7e174
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02647:Or7e174 APN 9 20,012,505 (GRCm39) missense probably benign 0.02
IGL03080:Or7e174 APN 9 20,012,705 (GRCm39) missense probably damaging 0.99
R0421:Or7e174 UTSW 9 20,012,771 (GRCm39) missense probably damaging 1.00
R0422:Or7e174 UTSW 9 20,012,744 (GRCm39) nonsense probably null
R1108:Or7e174 UTSW 9 20,012,121 (GRCm39) missense probably benign 0.01
R1386:Or7e174 UTSW 9 20,012,878 (GRCm39) missense probably benign 0.09
R1732:Or7e174 UTSW 9 20,012,796 (GRCm39) missense probably damaging 1.00
R2006:Or7e174 UTSW 9 20,012,165 (GRCm39) missense probably benign 0.03
R4556:Or7e174 UTSW 9 20,012,619 (GRCm39) missense possibly damaging 0.63
R4602:Or7e174 UTSW 9 20,012,540 (GRCm39) missense probably benign 0.07
R5125:Or7e174 UTSW 9 20,012,488 (GRCm39) nonsense probably null
R5178:Or7e174 UTSW 9 20,012,488 (GRCm39) nonsense probably null
R7324:Or7e174 UTSW 9 20,012,726 (GRCm39) missense possibly damaging 0.83
R7358:Or7e174 UTSW 9 20,012,169 (GRCm39) missense probably damaging 1.00
R7536:Or7e174 UTSW 9 20,012,826 (GRCm39) missense probably damaging 0.99
R7539:Or7e174 UTSW 9 20,012,915 (GRCm39) missense probably benign 0.12
R7572:Or7e174 UTSW 9 20,012,154 (GRCm39) missense probably damaging 1.00
R7946:Or7e174 UTSW 9 20,012,780 (GRCm39) missense probably damaging 1.00
R8805:Or7e174 UTSW 9 20,012,580 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- GCAGAGCTTCAAATCCACAGTCCAG -3'
(R):5'- TGTGGCAGTACACACAGTTCTCG -3'

Sequencing Primer
(F):5'- AATCATGAATCCTTGTCGCTGTG -3'
(R):5'- ACACACAGTTCTCGGTGGTTAG -3'
Posted On 2014-05-14