Incidental Mutation 'R1694:Ptpn4'
| ID |
191979 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptpn4
|
| Ensembl Gene |
ENSMUSG00000026384 |
| Gene Name |
protein tyrosine phosphatase, non-receptor type 4 |
| Synonyms |
testis-enriched phosphatase, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), hPTP-MEG, TEP, PTPMEG, TEP/mPTPMEG |
| MMRRC Submission |
039727-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.257)
|
| Stock # |
R1694 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
119580197-119765281 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 119711240 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 67
(Q67R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127998
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064091]
[ENSMUST00000163179]
[ENSMUST00000163435]
[ENSMUST00000163621]
[ENSMUST00000164086]
[ENSMUST00000166422]
[ENSMUST00000168303]
|
| AlphaFold |
Q9WU22 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000064091
AA Change: Q73R
PolyPhen 2
Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000067614
Gene: ENSMUSG00000026384
AA Change: Q73R
| Domain | Start | End | E-Value | Type |
|---|
|
B41
|
25 |
222 |
7.33e-80 |
SMART |
|
FERM_C
|
226 |
316 |
6.48e-34 |
SMART |
|
FA
|
322 |
368 |
3.28e-12 |
SMART |
|
PDZ
|
526 |
605 |
2.47e-14 |
SMART |
|
PTPc
|
654 |
913 |
1.38e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163179
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163435
AA Change: Q73R
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000127713
Gene: ENSMUSG00000026384
AA Change: Q73R
| Domain | Start | End | E-Value | Type |
|---|
|
B41
|
25 |
222 |
7.33e-80 |
SMART |
|
FERM_C
|
226 |
316 |
6.48e-34 |
SMART |
|
FA
|
322 |
368 |
3.28e-12 |
SMART |
|
PDB:3NFL|D
|
499 |
552 |
4e-30 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163621
AA Change: Q73R
PolyPhen 2
Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000130808
Gene: ENSMUSG00000026384
AA Change: Q73R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FERM_N
|
33 |
86 |
1e-13 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164086
AA Change: Q67R
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000127998
Gene: ENSMUSG00000026384
AA Change: Q67R
| Domain | Start | End | E-Value | Type |
|---|
|
B41
|
19 |
133 |
4.88e-2 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166422
AA Change: Q73R
PolyPhen 2
Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000129180
Gene: ENSMUSG00000026384
AA Change: Q73R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FERM_N
|
33 |
85 |
1.1e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168303
|
| SMART Domains |
Protein: ENSMUSP00000129521
Gene: ENSMUSG00000026384
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FERM_N
|
11 |
75 |
2.7e-9 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168653
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168429
|
| SMART Domains |
Protein: ENSMUSP00000130299
Gene: ENSMUSG00000026384
| Domain | Start | End | E-Value | Type |
|---|
|
B41
|
13 |
142 |
9.36e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921513I03Rik |
T |
C |
10: 120,614,533 (GRCm39) |
|
probably benign |
Het |
| 4930447C04Rik |
C |
T |
12: 72,931,992 (GRCm39) |
|
probably null |
Het |
| Abca16 |
A |
G |
7: 120,119,307 (GRCm39) |
H1017R |
probably damaging |
Het |
| Actl11 |
A |
G |
9: 107,807,207 (GRCm39) |
Y510C |
probably damaging |
Het |
| Agbl2 |
A |
G |
2: 90,631,664 (GRCm39) |
T341A |
probably damaging |
Het |
| Agbl5 |
A |
G |
5: 31,050,726 (GRCm39) |
Y458C |
probably damaging |
Het |
| Akap5 |
C |
T |
12: 76,376,698 (GRCm39) |
S710L |
probably damaging |
Het |
| Akr1c21 |
A |
G |
13: 4,625,177 (GRCm39) |
E36G |
probably damaging |
Het |
| Arhgap44 |
A |
G |
11: 64,944,023 (GRCm39) |
S163P |
probably damaging |
Het |
| Armc1 |
A |
G |
3: 19,189,050 (GRCm39) |
V205A |
possibly damaging |
Het |
| Asph |
A |
G |
4: 9,610,869 (GRCm39) |
L102P |
probably damaging |
Het |
| Brca1 |
T |
C |
11: 101,422,925 (GRCm39) |
E74G |
probably damaging |
Het |
| Brms1l |
A |
G |
12: 55,888,385 (GRCm39) |
R58G |
probably damaging |
Het |
| C1qbp |
G |
T |
11: 70,869,073 (GRCm39) |
|
probably null |
Het |
| Calcrl |
A |
T |
2: 84,169,631 (GRCm39) |
L350H |
probably damaging |
Het |
| Casr |
A |
T |
16: 36,315,953 (GRCm39) |
F706I |
probably damaging |
Het |
| Ceacam10 |
T |
A |
7: 24,480,491 (GRCm39) |
N87K |
probably benign |
Het |
| Cfap206 |
G |
T |
4: 34,719,058 (GRCm39) |
T316K |
probably damaging |
Het |
| Col4a3 |
A |
T |
1: 82,668,384 (GRCm39) |
|
probably null |
Het |
| Comtd1 |
A |
G |
14: 21,897,398 (GRCm39) |
V183A |
probably damaging |
Het |
| Crygs |
A |
T |
16: 22,625,425 (GRCm39) |
|
probably null |
Het |
| Dact1 |
C |
A |
12: 71,359,551 (GRCm39) |
T139K |
probably damaging |
Het |
| Dlx6 |
T |
C |
6: 6,867,173 (GRCm39) |
W259R |
probably damaging |
Het |
| Dnah9 |
G |
T |
11: 65,845,650 (GRCm39) |
S627* |
probably null |
Het |
| Dnajc11 |
T |
A |
4: 152,063,730 (GRCm39) |
V442D |
probably damaging |
Het |
| Dnajc21 |
A |
T |
15: 10,451,649 (GRCm39) |
S393T |
probably benign |
Het |
| Dpysl3 |
C |
A |
18: 43,461,439 (GRCm39) |
C584F |
possibly damaging |
Het |
| Efcab14 |
A |
G |
4: 115,603,736 (GRCm39) |
K138R |
possibly damaging |
Het |
| Ephb3 |
A |
G |
16: 21,040,495 (GRCm39) |
E577G |
probably damaging |
Het |
| Exoc3 |
C |
T |
13: 74,338,184 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
A |
G |
2: 3,226,660 (GRCm39) |
S473G |
probably benign |
Het |
| Fbxl2 |
A |
T |
9: 113,832,239 (GRCm39) |
F58L |
probably damaging |
Het |
| Fmo6 |
T |
C |
1: 162,750,241 (GRCm39) |
M272V |
probably benign |
Het |
| Gm10000 |
T |
C |
12: 104,442,859 (GRCm39) |
|
probably benign |
Het |
| Grik1 |
T |
A |
16: 87,746,956 (GRCm39) |
D442V |
probably damaging |
Het |
| Hectd1 |
A |
G |
12: 51,791,375 (GRCm39) |
Y2588H |
probably damaging |
Het |
| Insrr |
A |
C |
3: 87,711,369 (GRCm39) |
T430P |
probably benign |
Het |
| Lats1 |
T |
C |
10: 7,577,709 (GRCm39) |
S278P |
probably benign |
Het |
| Lrch4 |
A |
G |
5: 137,636,723 (GRCm39) |
T463A |
probably benign |
Het |
| Ltbp1 |
A |
G |
17: 75,532,280 (GRCm39) |
Q118R |
possibly damaging |
Het |
| Lyst |
T |
G |
13: 13,835,746 (GRCm39) |
F1809L |
probably damaging |
Het |
| Mad2l1bp |
A |
G |
17: 46,463,770 (GRCm39) |
Y85H |
possibly damaging |
Het |
| Magoh |
G |
T |
4: 107,740,362 (GRCm39) |
R82L |
probably benign |
Het |
| Mdfic2 |
A |
C |
6: 98,215,100 (GRCm39) |
S174R |
probably damaging |
Het |
| Mlh1 |
A |
G |
9: 111,057,543 (GRCm39) |
V756A |
probably damaging |
Het |
| Mlh3 |
T |
C |
12: 85,313,915 (GRCm39) |
E757G |
probably damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,464,947 (GRCm39) |
T1339A |
probably damaging |
Het |
| Myh7b |
A |
T |
2: 155,455,113 (GRCm39) |
E46V |
probably damaging |
Het |
| Naalad2 |
T |
A |
9: 18,238,683 (GRCm39) |
R677S |
probably damaging |
Het |
| Nadsyn1 |
G |
A |
7: 143,361,749 (GRCm39) |
T324I |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,787,886 (GRCm39) |
L1389Q |
probably damaging |
Het |
| Nlrp1b |
A |
G |
11: 71,107,681 (GRCm39) |
|
probably null |
Het |
| Nup210 |
A |
C |
6: 91,039,785 (GRCm39) |
I690S |
probably benign |
Het |
| Or55b3 |
A |
T |
7: 102,126,547 (GRCm39) |
S177T |
probably benign |
Het |
| Or5an11 |
T |
A |
19: 12,246,281 (GRCm39) |
I229N |
probably damaging |
Het |
| Or9r7 |
T |
A |
10: 129,962,123 (GRCm39) |
I268F |
possibly damaging |
Het |
| Otud7a |
C |
A |
7: 63,383,458 (GRCm39) |
H316N |
probably damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,429,995 (GRCm39) |
S1241P |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,570,977 (GRCm39) |
K121E |
probably damaging |
Het |
| Pcmtd1 |
A |
T |
1: 7,217,872 (GRCm39) |
I107L |
probably benign |
Het |
| Pde6c |
A |
G |
19: 38,168,673 (GRCm39) |
I755V |
probably damaging |
Het |
| Pes1 |
CGGAGGAGGAGGAGGAGGAGGAGG |
CGGAGGAGGAGGAGGAGGAGG |
11: 3,927,719 (GRCm39) |
|
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,113,240 (GRCm39) |
I1532N |
probably damaging |
Het |
| Pla2r1 |
A |
G |
2: 60,271,428 (GRCm39) |
|
probably null |
Het |
| Plb1 |
A |
G |
5: 32,474,621 (GRCm39) |
N661S |
probably null |
Het |
| Plekhd1 |
A |
G |
12: 80,769,095 (GRCm39) |
K452E |
possibly damaging |
Het |
| Prr12 |
C |
A |
7: 44,678,003 (GRCm39) |
V2003F |
unknown |
Het |
| Ptger1 |
G |
A |
8: 84,395,107 (GRCm39) |
G195R |
probably benign |
Het |
| Rgsl1 |
C |
T |
1: 153,680,422 (GRCm39) |
R760H |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,136,094 (GRCm39) |
|
probably null |
Het |
| Rtn1 |
T |
C |
12: 72,270,298 (GRCm39) |
Y71C |
probably damaging |
Het |
| Rtp4 |
T |
C |
16: 23,431,870 (GRCm39) |
*62Q |
probably null |
Het |
| Scaf4 |
GGCTGCTGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTGCTGCTG |
16: 90,026,745 (GRCm39) |
|
probably benign |
Het |
| Scimp |
G |
T |
11: 70,684,618 (GRCm39) |
P78H |
probably damaging |
Het |
| Scn8a |
C |
A |
15: 100,853,409 (GRCm39) |
S132* |
probably null |
Het |
| Set |
A |
G |
2: 29,959,436 (GRCm39) |
I124M |
probably damaging |
Het |
| Sf3b1 |
C |
G |
1: 55,058,554 (GRCm39) |
E12Q |
possibly damaging |
Het |
| Sgce |
A |
G |
6: 4,689,709 (GRCm39) |
S375P |
probably damaging |
Het |
| Slc4a1ap |
G |
C |
5: 31,701,098 (GRCm39) |
E600Q |
probably damaging |
Het |
| Slit1 |
A |
G |
19: 41,626,031 (GRCm39) |
V577A |
possibly damaging |
Het |
| Sqstm1 |
A |
G |
11: 50,098,307 (GRCm39) |
V153A |
probably benign |
Het |
| Src |
A |
G |
2: 157,311,675 (GRCm39) |
M468V |
possibly damaging |
Het |
| Srrm3 |
A |
G |
5: 135,902,079 (GRCm39) |
|
probably benign |
Het |
| Stk11ip |
C |
T |
1: 75,504,030 (GRCm39) |
R257W |
probably damaging |
Het |
| Tfrc |
T |
A |
16: 32,433,443 (GRCm39) |
D32E |
probably damaging |
Het |
| Tor1aip2 |
A |
T |
1: 155,941,031 (GRCm39) |
I446L |
probably benign |
Het |
| Trmt11 |
T |
C |
10: 30,411,221 (GRCm39) |
H424R |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,563,928 (GRCm39) |
Y1612H |
probably benign |
Het |
| Vcan |
A |
T |
13: 89,836,602 (GRCm39) |
S2981T |
probably damaging |
Het |
| Vdac1 |
G |
C |
11: 52,265,190 (GRCm39) |
G21A |
probably damaging |
Het |
| Vmn2r76 |
A |
G |
7: 85,879,356 (GRCm39) |
S315P |
probably benign |
Het |
| Xpo1 |
A |
G |
11: 23,231,399 (GRCm39) |
T328A |
probably benign |
Het |
| Xrcc5 |
C |
T |
1: 72,358,255 (GRCm39) |
L197F |
possibly damaging |
Het |
| Zfhx2 |
G |
C |
14: 55,311,401 (GRCm39) |
S431C |
possibly damaging |
Het |
| Zfp410 |
C |
T |
12: 84,372,494 (GRCm39) |
P54S |
probably benign |
Het |
| Zfp560 |
C |
A |
9: 20,259,282 (GRCm39) |
G527* |
probably null |
Het |
| Zfp775 |
A |
G |
6: 48,596,389 (GRCm39) |
T88A |
possibly damaging |
Het |
| Zfp780b |
T |
A |
7: 27,663,808 (GRCm39) |
H249L |
possibly damaging |
Het |
|
| Other mutations in Ptpn4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00825:Ptpn4
|
APN |
1 |
119,587,655 (GRCm39) |
splice site |
probably benign |
|
|
IGL00885:Ptpn4
|
APN |
1 |
119,730,093 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL00973:Ptpn4
|
APN |
1 |
119,669,101 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01867:Ptpn4
|
APN |
1 |
119,603,329 (GRCm39) |
missense |
probably benign |
|
|
IGL01870:Ptpn4
|
APN |
1 |
119,603,277 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02101:Ptpn4
|
APN |
1 |
119,615,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02344:Ptpn4
|
APN |
1 |
119,700,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02348:Ptpn4
|
APN |
1 |
119,610,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02693:Ptpn4
|
APN |
1 |
119,643,699 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03281:Ptpn4
|
APN |
1 |
119,587,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
alto
|
UTSW |
1 |
119,612,311 (GRCm39) |
nonsense |
probably null |
|
|
blinding
|
UTSW |
1 |
119,649,592 (GRCm39) |
critical splice donor site |
probably null |
|
|
botched
|
UTSW |
1 |
119,671,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bungled
|
UTSW |
1 |
119,615,335 (GRCm39) |
splice site |
probably null |
|
|
Fovea
|
UTSW |
1 |
119,606,552 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
hash
|
UTSW |
1 |
119,693,649 (GRCm39) |
nonsense |
probably null |
|
|
Hoechter
|
UTSW |
1 |
119,607,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lumens
|
UTSW |
1 |
119,595,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB008:Ptpn4
|
UTSW |
1 |
119,607,925 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB018:Ptpn4
|
UTSW |
1 |
119,607,925 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0105:Ptpn4
|
UTSW |
1 |
119,615,335 (GRCm39) |
splice site |
probably null |
|
|
R0105:Ptpn4
|
UTSW |
1 |
119,615,335 (GRCm39) |
splice site |
probably null |
|
|
R0504:Ptpn4
|
UTSW |
1 |
119,693,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Ptpn4
|
UTSW |
1 |
119,612,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1148:Ptpn4
|
UTSW |
1 |
119,612,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1148:Ptpn4
|
UTSW |
1 |
119,603,439 (GRCm39) |
splice site |
probably benign |
|
|
R1662:Ptpn4
|
UTSW |
1 |
119,692,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1733:Ptpn4
|
UTSW |
1 |
119,643,773 (GRCm39) |
splice site |
probably null |
|
|
R2083:Ptpn4
|
UTSW |
1 |
119,615,489 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2226:Ptpn4
|
UTSW |
1 |
119,610,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2276:Ptpn4
|
UTSW |
1 |
119,612,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2277:Ptpn4
|
UTSW |
1 |
119,612,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3123:Ptpn4
|
UTSW |
1 |
119,693,153 (GRCm39) |
splice site |
probably null |
|
|
R3425:Ptpn4
|
UTSW |
1 |
119,635,560 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4568:Ptpn4
|
UTSW |
1 |
119,607,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4716:Ptpn4
|
UTSW |
1 |
119,649,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4819:Ptpn4
|
UTSW |
1 |
119,587,580 (GRCm39) |
missense |
probably benign |
|
|
R4959:Ptpn4
|
UTSW |
1 |
119,692,826 (GRCm39) |
nonsense |
probably null |
|
|
R5161:Ptpn4
|
UTSW |
1 |
119,635,593 (GRCm39) |
nonsense |
probably null |
|
|
R5345:Ptpn4
|
UTSW |
1 |
119,693,207 (GRCm39) |
missense |
probably benign |
|
|
R5471:Ptpn4
|
UTSW |
1 |
119,693,649 (GRCm39) |
nonsense |
probably null |
|
|
R5826:Ptpn4
|
UTSW |
1 |
119,612,246 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5933:Ptpn4
|
UTSW |
1 |
119,615,453 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6075:Ptpn4
|
UTSW |
1 |
119,692,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Ptpn4
|
UTSW |
1 |
119,649,592 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6389:Ptpn4
|
UTSW |
1 |
119,649,684 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6392:Ptpn4
|
UTSW |
1 |
119,700,853 (GRCm39) |
missense |
probably benign |
|
|
R6769:Ptpn4
|
UTSW |
1 |
119,643,698 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6771:Ptpn4
|
UTSW |
1 |
119,643,698 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6794:Ptpn4
|
UTSW |
1 |
119,671,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Ptpn4
|
UTSW |
1 |
119,700,878 (GRCm39) |
intron |
probably benign |
|
|
R6967:Ptpn4
|
UTSW |
1 |
119,612,311 (GRCm39) |
nonsense |
probably null |
|
|
R6980:Ptpn4
|
UTSW |
1 |
119,671,151 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7150:Ptpn4
|
UTSW |
1 |
119,619,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7247:Ptpn4
|
UTSW |
1 |
119,617,764 (GRCm39) |
makesense |
probably null |
|
|
R7283:Ptpn4
|
UTSW |
1 |
119,610,261 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7459:Ptpn4
|
UTSW |
1 |
119,587,564 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7732:Ptpn4
|
UTSW |
1 |
119,620,532 (GRCm39) |
missense |
probably benign |
|
|
R7794:Ptpn4
|
UTSW |
1 |
119,653,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8061:Ptpn4
|
UTSW |
1 |
119,619,330 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8236:Ptpn4
|
UTSW |
1 |
119,606,552 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8929:Ptpn4
|
UTSW |
1 |
119,595,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8979:Ptpn4
|
UTSW |
1 |
119,671,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9334:Ptpn4
|
UTSW |
1 |
119,730,114 (GRCm39) |
missense |
probably benign |
|
|
RF014:Ptpn4
|
UTSW |
1 |
119,612,195 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGAGTGGACTCACACACCCT -3'
(R):5'- AAAAGGCATCGAGAGATAGCATTGACTT -3'
Sequencing Primer
(F):5'- GTGGACTCACACACCCTAAAATC -3'
(R):5'- cactcagcaggcagagac -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation