Incidental Mutation 'R1694:Insrr'
| ID |
191992 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Insrr
|
| Ensembl Gene |
ENSMUSG00000005640 |
| Gene Name |
insulin receptor-related receptor |
| Synonyms |
|
| MMRRC Submission |
039727-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.285)
|
| Stock # |
R1694 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
87704258-87723408 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 87711369 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 430
(T430P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103208
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029711]
[ENSMUST00000029714]
[ENSMUST00000090981]
[ENSMUST00000107582]
|
| AlphaFold |
Q9WTL4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029711
AA Change: T430P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000029711
Gene: ENSMUSG00000005640
AA Change: T430P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
1.8e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
3.8e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029714
|
| SMART Domains |
Protein: ENSMUSP00000029714
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090981
|
| SMART Domains |
Protein: ENSMUSP00000088503
Gene: ENSMUSG00000028073
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
78 |
N/A |
INTRINSIC |
|
EGF
|
102 |
130 |
3.82e-2 |
SMART |
|
EGF_like
|
132 |
173 |
2.92e1 |
SMART |
|
EGF_like
|
146 |
185 |
1.92e0 |
SMART |
|
EGF_like
|
189 |
246 |
1.99e0 |
SMART |
|
EGF
|
217 |
258 |
1.04e1 |
SMART |
|
EGF_Lam
|
274 |
313 |
1.21e-4 |
SMART |
|
EGF
|
312 |
344 |
4.03e-1 |
SMART |
|
EGF_Lam
|
361 |
402 |
1.33e-1 |
SMART |
|
EGF
|
401 |
433 |
1.18e-2 |
SMART |
|
EGF_like
|
449 |
488 |
1.72e0 |
SMART |
|
EGF
|
487 |
519 |
6.92e0 |
SMART |
|
EGF_Lam
|
535 |
574 |
2.08e-3 |
SMART |
|
EGF
|
573 |
605 |
5.49e-3 |
SMART |
|
EGF_Lam
|
620 |
660 |
1.58e-3 |
SMART |
|
EGF
|
659 |
691 |
3.1e-2 |
SMART |
|
EGF
|
702 |
734 |
2.53e1 |
SMART |
|
transmembrane domain
|
754 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
809 |
822 |
N/A |
INTRINSIC |
|
low complexity region
|
829 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
954 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
993 |
1002 |
N/A |
INTRINSIC |
|
low complexity region
|
1019 |
1031 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107582
AA Change: T430P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000103208
Gene: ENSMUSG00000005640
AA Change: T430P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
47 |
159 |
7.7e-25 |
PFAM |
|
FU
|
225 |
268 |
9.54e-11 |
SMART |
|
Pfam:Recep_L_domain
|
346 |
460 |
1.6e-28 |
PFAM |
|
FN3
|
483 |
586 |
9.19e-1 |
SMART |
|
FN3
|
605 |
798 |
6.45e-5 |
SMART |
|
FN3
|
816 |
899 |
6.35e-4 |
SMART |
|
TyrKc
|
979 |
1246 |
4.61e-128 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166771
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166866
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no anomalies in pancreatic islet morphology, beta-cell mass or pancreatic secretory function. This mutation in combination with Insr mutant mice does not affect the diabetes predisposition of Insr mutant mice. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921513I03Rik |
T |
C |
10: 120,614,533 (GRCm39) |
|
probably benign |
Het |
| 4930447C04Rik |
C |
T |
12: 72,931,992 (GRCm39) |
|
probably null |
Het |
| Abca16 |
A |
G |
7: 120,119,307 (GRCm39) |
H1017R |
probably damaging |
Het |
| Actl11 |
A |
G |
9: 107,807,207 (GRCm39) |
Y510C |
probably damaging |
Het |
| Agbl2 |
A |
G |
2: 90,631,664 (GRCm39) |
T341A |
probably damaging |
Het |
| Agbl5 |
A |
G |
5: 31,050,726 (GRCm39) |
Y458C |
probably damaging |
Het |
| Akap5 |
C |
T |
12: 76,376,698 (GRCm39) |
S710L |
probably damaging |
Het |
| Akr1c21 |
A |
G |
13: 4,625,177 (GRCm39) |
E36G |
probably damaging |
Het |
| Arhgap44 |
A |
G |
11: 64,944,023 (GRCm39) |
S163P |
probably damaging |
Het |
| Armc1 |
A |
G |
3: 19,189,050 (GRCm39) |
V205A |
possibly damaging |
Het |
| Asph |
A |
G |
4: 9,610,869 (GRCm39) |
L102P |
probably damaging |
Het |
| Brca1 |
T |
C |
11: 101,422,925 (GRCm39) |
E74G |
probably damaging |
Het |
| Brms1l |
A |
G |
12: 55,888,385 (GRCm39) |
R58G |
probably damaging |
Het |
| C1qbp |
G |
T |
11: 70,869,073 (GRCm39) |
|
probably null |
Het |
| Calcrl |
A |
T |
2: 84,169,631 (GRCm39) |
L350H |
probably damaging |
Het |
| Casr |
A |
T |
16: 36,315,953 (GRCm39) |
F706I |
probably damaging |
Het |
| Ceacam10 |
T |
A |
7: 24,480,491 (GRCm39) |
N87K |
probably benign |
Het |
| Cfap206 |
G |
T |
4: 34,719,058 (GRCm39) |
T316K |
probably damaging |
Het |
| Col4a3 |
A |
T |
1: 82,668,384 (GRCm39) |
|
probably null |
Het |
| Comtd1 |
A |
G |
14: 21,897,398 (GRCm39) |
V183A |
probably damaging |
Het |
| Crygs |
A |
T |
16: 22,625,425 (GRCm39) |
|
probably null |
Het |
| Dact1 |
C |
A |
12: 71,359,551 (GRCm39) |
T139K |
probably damaging |
Het |
| Dlx6 |
T |
C |
6: 6,867,173 (GRCm39) |
W259R |
probably damaging |
Het |
| Dnah9 |
G |
T |
11: 65,845,650 (GRCm39) |
S627* |
probably null |
Het |
| Dnajc11 |
T |
A |
4: 152,063,730 (GRCm39) |
V442D |
probably damaging |
Het |
| Dnajc21 |
A |
T |
15: 10,451,649 (GRCm39) |
S393T |
probably benign |
Het |
| Dpysl3 |
C |
A |
18: 43,461,439 (GRCm39) |
C584F |
possibly damaging |
Het |
| Efcab14 |
A |
G |
4: 115,603,736 (GRCm39) |
K138R |
possibly damaging |
Het |
| Ephb3 |
A |
G |
16: 21,040,495 (GRCm39) |
E577G |
probably damaging |
Het |
| Exoc3 |
C |
T |
13: 74,338,184 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
A |
G |
2: 3,226,660 (GRCm39) |
S473G |
probably benign |
Het |
| Fbxl2 |
A |
T |
9: 113,832,239 (GRCm39) |
F58L |
probably damaging |
Het |
| Fmo6 |
T |
C |
1: 162,750,241 (GRCm39) |
M272V |
probably benign |
Het |
| Gm10000 |
T |
C |
12: 104,442,859 (GRCm39) |
|
probably benign |
Het |
| Grik1 |
T |
A |
16: 87,746,956 (GRCm39) |
D442V |
probably damaging |
Het |
| Hectd1 |
A |
G |
12: 51,791,375 (GRCm39) |
Y2588H |
probably damaging |
Het |
| Lats1 |
T |
C |
10: 7,577,709 (GRCm39) |
S278P |
probably benign |
Het |
| Lrch4 |
A |
G |
5: 137,636,723 (GRCm39) |
T463A |
probably benign |
Het |
| Ltbp1 |
A |
G |
17: 75,532,280 (GRCm39) |
Q118R |
possibly damaging |
Het |
| Lyst |
T |
G |
13: 13,835,746 (GRCm39) |
F1809L |
probably damaging |
Het |
| Mad2l1bp |
A |
G |
17: 46,463,770 (GRCm39) |
Y85H |
possibly damaging |
Het |
| Magoh |
G |
T |
4: 107,740,362 (GRCm39) |
R82L |
probably benign |
Het |
| Mdfic2 |
A |
C |
6: 98,215,100 (GRCm39) |
S174R |
probably damaging |
Het |
| Mlh1 |
A |
G |
9: 111,057,543 (GRCm39) |
V756A |
probably damaging |
Het |
| Mlh3 |
T |
C |
12: 85,313,915 (GRCm39) |
E757G |
probably damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,464,947 (GRCm39) |
T1339A |
probably damaging |
Het |
| Myh7b |
A |
T |
2: 155,455,113 (GRCm39) |
E46V |
probably damaging |
Het |
| Naalad2 |
T |
A |
9: 18,238,683 (GRCm39) |
R677S |
probably damaging |
Het |
| Nadsyn1 |
G |
A |
7: 143,361,749 (GRCm39) |
T324I |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,787,886 (GRCm39) |
L1389Q |
probably damaging |
Het |
| Nlrp1b |
A |
G |
11: 71,107,681 (GRCm39) |
|
probably null |
Het |
| Nup210 |
A |
C |
6: 91,039,785 (GRCm39) |
I690S |
probably benign |
Het |
| Or55b3 |
A |
T |
7: 102,126,547 (GRCm39) |
S177T |
probably benign |
Het |
| Or5an11 |
T |
A |
19: 12,246,281 (GRCm39) |
I229N |
probably damaging |
Het |
| Or9r7 |
T |
A |
10: 129,962,123 (GRCm39) |
I268F |
possibly damaging |
Het |
| Otud7a |
C |
A |
7: 63,383,458 (GRCm39) |
H316N |
probably damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,429,995 (GRCm39) |
S1241P |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,570,977 (GRCm39) |
K121E |
probably damaging |
Het |
| Pcmtd1 |
A |
T |
1: 7,217,872 (GRCm39) |
I107L |
probably benign |
Het |
| Pde6c |
A |
G |
19: 38,168,673 (GRCm39) |
I755V |
probably damaging |
Het |
| Pes1 |
CGGAGGAGGAGGAGGAGGAGGAGG |
CGGAGGAGGAGGAGGAGGAGG |
11: 3,927,719 (GRCm39) |
|
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,113,240 (GRCm39) |
I1532N |
probably damaging |
Het |
| Pla2r1 |
A |
G |
2: 60,271,428 (GRCm39) |
|
probably null |
Het |
| Plb1 |
A |
G |
5: 32,474,621 (GRCm39) |
N661S |
probably null |
Het |
| Plekhd1 |
A |
G |
12: 80,769,095 (GRCm39) |
K452E |
possibly damaging |
Het |
| Prr12 |
C |
A |
7: 44,678,003 (GRCm39) |
V2003F |
unknown |
Het |
| Ptger1 |
G |
A |
8: 84,395,107 (GRCm39) |
G195R |
probably benign |
Het |
| Ptpn4 |
T |
C |
1: 119,711,240 (GRCm39) |
Q67R |
probably damaging |
Het |
| Rgsl1 |
C |
T |
1: 153,680,422 (GRCm39) |
R760H |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,136,094 (GRCm39) |
|
probably null |
Het |
| Rtn1 |
T |
C |
12: 72,270,298 (GRCm39) |
Y71C |
probably damaging |
Het |
| Rtp4 |
T |
C |
16: 23,431,870 (GRCm39) |
*62Q |
probably null |
Het |
| Scaf4 |
GGCTGCTGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTGCTGCTG |
16: 90,026,745 (GRCm39) |
|
probably benign |
Het |
| Scimp |
G |
T |
11: 70,684,618 (GRCm39) |
P78H |
probably damaging |
Het |
| Scn8a |
C |
A |
15: 100,853,409 (GRCm39) |
S132* |
probably null |
Het |
| Set |
A |
G |
2: 29,959,436 (GRCm39) |
I124M |
probably damaging |
Het |
| Sf3b1 |
C |
G |
1: 55,058,554 (GRCm39) |
E12Q |
possibly damaging |
Het |
| Sgce |
A |
G |
6: 4,689,709 (GRCm39) |
S375P |
probably damaging |
Het |
| Slc4a1ap |
G |
C |
5: 31,701,098 (GRCm39) |
E600Q |
probably damaging |
Het |
| Slit1 |
A |
G |
19: 41,626,031 (GRCm39) |
V577A |
possibly damaging |
Het |
| Sqstm1 |
A |
G |
11: 50,098,307 (GRCm39) |
V153A |
probably benign |
Het |
| Src |
A |
G |
2: 157,311,675 (GRCm39) |
M468V |
possibly damaging |
Het |
| Srrm3 |
A |
G |
5: 135,902,079 (GRCm39) |
|
probably benign |
Het |
| Stk11ip |
C |
T |
1: 75,504,030 (GRCm39) |
R257W |
probably damaging |
Het |
| Tfrc |
T |
A |
16: 32,433,443 (GRCm39) |
D32E |
probably damaging |
Het |
| Tor1aip2 |
A |
T |
1: 155,941,031 (GRCm39) |
I446L |
probably benign |
Het |
| Trmt11 |
T |
C |
10: 30,411,221 (GRCm39) |
H424R |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,563,928 (GRCm39) |
Y1612H |
probably benign |
Het |
| Vcan |
A |
T |
13: 89,836,602 (GRCm39) |
S2981T |
probably damaging |
Het |
| Vdac1 |
G |
C |
11: 52,265,190 (GRCm39) |
G21A |
probably damaging |
Het |
| Vmn2r76 |
A |
G |
7: 85,879,356 (GRCm39) |
S315P |
probably benign |
Het |
| Xpo1 |
A |
G |
11: 23,231,399 (GRCm39) |
T328A |
probably benign |
Het |
| Xrcc5 |
C |
T |
1: 72,358,255 (GRCm39) |
L197F |
possibly damaging |
Het |
| Zfhx2 |
G |
C |
14: 55,311,401 (GRCm39) |
S431C |
possibly damaging |
Het |
| Zfp410 |
C |
T |
12: 84,372,494 (GRCm39) |
P54S |
probably benign |
Het |
| Zfp560 |
C |
A |
9: 20,259,282 (GRCm39) |
G527* |
probably null |
Het |
| Zfp775 |
A |
G |
6: 48,596,389 (GRCm39) |
T88A |
possibly damaging |
Het |
| Zfp780b |
T |
A |
7: 27,663,808 (GRCm39) |
H249L |
possibly damaging |
Het |
|
| Other mutations in Insrr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00718:Insrr
|
APN |
3 |
87,720,981 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00801:Insrr
|
APN |
3 |
87,721,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01628:Insrr
|
APN |
3 |
87,708,099 (GRCm39) |
nonsense |
probably null |
|
|
IGL01755:Insrr
|
APN |
3 |
87,721,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02100:Insrr
|
APN |
3 |
87,718,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02261:Insrr
|
APN |
3 |
87,708,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02366:Insrr
|
APN |
3 |
87,717,216 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02387:Insrr
|
APN |
3 |
87,720,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02478:Insrr
|
APN |
3 |
87,716,719 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02550:Insrr
|
APN |
3 |
87,711,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02555:Insrr
|
APN |
3 |
87,721,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02673:Insrr
|
APN |
3 |
87,720,368 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02724:Insrr
|
APN |
3 |
87,716,879 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL02798:Insrr
|
APN |
3 |
87,717,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02969:Insrr
|
APN |
3 |
87,721,498 (GRCm39) |
nonsense |
probably null |
|
|
IGL03073:Insrr
|
APN |
3 |
87,717,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL03178:Insrr
|
APN |
3 |
87,709,848 (GRCm39) |
splice site |
probably null |
|
|
IGL03389:Insrr
|
APN |
3 |
87,716,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03399:Insrr
|
APN |
3 |
87,716,638 (GRCm39) |
missense |
probably null |
0.99 |
|
IGL02799:Insrr
|
UTSW |
3 |
87,720,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Insrr
|
UTSW |
3 |
87,716,923 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Insrr
|
UTSW |
3 |
87,715,953 (GRCm39) |
splice site |
probably null |
|
|
R0501:Insrr
|
UTSW |
3 |
87,717,991 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0504:Insrr
|
UTSW |
3 |
87,720,463 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0522:Insrr
|
UTSW |
3 |
87,708,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0555:Insrr
|
UTSW |
3 |
87,721,744 (GRCm39) |
splice site |
probably benign |
|
|
R0558:Insrr
|
UTSW |
3 |
87,718,288 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0599:Insrr
|
UTSW |
3 |
87,720,440 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1312:Insrr
|
UTSW |
3 |
87,707,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1786:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R1892:Insrr
|
UTSW |
3 |
87,721,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Insrr
|
UTSW |
3 |
87,721,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2080:Insrr
|
UTSW |
3 |
87,721,598 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2094:Insrr
|
UTSW |
3 |
87,710,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2130:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2131:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2133:Insrr
|
UTSW |
3 |
87,717,879 (GRCm39) |
splice site |
probably null |
|
|
R2220:Insrr
|
UTSW |
3 |
87,716,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2259:Insrr
|
UTSW |
3 |
87,707,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2404:Insrr
|
UTSW |
3 |
87,709,974 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4027:Insrr
|
UTSW |
3 |
87,716,906 (GRCm39) |
missense |
probably benign |
|
|
R4042:Insrr
|
UTSW |
3 |
87,721,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4511:Insrr
|
UTSW |
3 |
87,715,978 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4571:Insrr
|
UTSW |
3 |
87,708,194 (GRCm39) |
missense |
probably benign |
|
|
R4870:Insrr
|
UTSW |
3 |
87,718,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Insrr
|
UTSW |
3 |
87,722,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5393:Insrr
|
UTSW |
3 |
87,718,007 (GRCm39) |
splice site |
probably null |
|
|
R5685:Insrr
|
UTSW |
3 |
87,707,803 (GRCm39) |
splice site |
probably null |
|
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6039:Insrr
|
UTSW |
3 |
87,716,608 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6047:Insrr
|
UTSW |
3 |
87,711,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Insrr
|
UTSW |
3 |
87,707,826 (GRCm39) |
nonsense |
probably null |
|
|
R6298:Insrr
|
UTSW |
3 |
87,720,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6727:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6728:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6796:Insrr
|
UTSW |
3 |
87,720,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Insrr
|
UTSW |
3 |
87,722,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7169:Insrr
|
UTSW |
3 |
87,715,901 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7270:Insrr
|
UTSW |
3 |
87,710,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Insrr
|
UTSW |
3 |
87,721,623 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7398:Insrr
|
UTSW |
3 |
87,716,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7473:Insrr
|
UTSW |
3 |
87,711,838 (GRCm39) |
splice site |
probably null |
|
|
R7815:Insrr
|
UTSW |
3 |
87,716,002 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8159:Insrr
|
UTSW |
3 |
87,707,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Insrr
|
UTSW |
3 |
87,721,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Insrr
|
UTSW |
3 |
87,717,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8312:Insrr
|
UTSW |
3 |
87,707,791 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8445:Insrr
|
UTSW |
3 |
87,720,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8917:Insrr
|
UTSW |
3 |
87,718,276 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8960:Insrr
|
UTSW |
3 |
87,720,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8989:Insrr
|
UTSW |
3 |
87,722,664 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9015:Insrr
|
UTSW |
3 |
87,720,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9202:Insrr
|
UTSW |
3 |
87,720,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9251:Insrr
|
UTSW |
3 |
87,717,391 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9327:Insrr
|
UTSW |
3 |
87,721,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Insrr
|
UTSW |
3 |
87,721,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF022:Insrr
|
UTSW |
3 |
87,711,792 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Z1177:Insrr
|
UTSW |
3 |
87,708,134 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Z1192:Insrr
|
UTSW |
3 |
87,709,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGGCCCCTCATGAATGTGAGTG -3'
(R):5'- CAAAACGTAGAGTGCGAGTCTGACC -3'
Sequencing Primer
(F):5'- ATGTGAGTGGCTGGCAGAC -3'
(R):5'- AAAGCACCTGCTTCAGGGTC -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation