Incidental Mutation 'R1694:Plb1'
| ID |
192003 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plb1
|
| Ensembl Gene |
ENSMUSG00000029134 |
| Gene Name |
phospholipase B1 |
| Synonyms |
4632413E21Rik, 4930433E17Rik, 4930539A06Rik |
| MMRRC Submission |
039727-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R1694 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
32390035-32521700 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 32474621 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 661
(N661S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144040
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000101376]
[ENSMUST00000202201]
[ENSMUST00000202220]
|
| AlphaFold |
Q3TTY0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000101376
AA Change: N661S
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000098927
Gene: ENSMUSG00000029134
AA Change: N661S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
Pfam:Lipase_GDSL
|
398 |
672 |
4e-20 |
PFAM |
|
Pfam:Lipase_GDSL
|
745 |
1019 |
1.7e-17 |
PFAM |
|
Pfam:Lipase_GDSL
|
1101 |
1367 |
4.6e-15 |
PFAM |
|
transmembrane domain
|
1420 |
1442 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000202201
AA Change: N661S
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000144401
Gene: ENSMUSG00000029134
AA Change: N661S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
Pfam:Lipase_GDSL
|
398 |
672 |
1.3e-20 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000202220
AA Change: N661S
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000144040
Gene: ENSMUSG00000029134
AA Change: N661S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
Pfam:Lipase_GDSL
|
398 |
672 |
4e-20 |
PFAM |
|
Pfam:Lipase_GDSL
|
745 |
1019 |
1.7e-17 |
PFAM |
|
Pfam:Lipase_GDSL
|
1101 |
1367 |
4.6e-15 |
PFAM |
|
transmembrane domain
|
1420 |
1442 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202688
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202886
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921513I03Rik |
T |
C |
10: 120,614,533 (GRCm39) |
|
probably benign |
Het |
| 4930447C04Rik |
C |
T |
12: 72,931,992 (GRCm39) |
|
probably null |
Het |
| Abca16 |
A |
G |
7: 120,119,307 (GRCm39) |
H1017R |
probably damaging |
Het |
| Actl11 |
A |
G |
9: 107,807,207 (GRCm39) |
Y510C |
probably damaging |
Het |
| Agbl2 |
A |
G |
2: 90,631,664 (GRCm39) |
T341A |
probably damaging |
Het |
| Agbl5 |
A |
G |
5: 31,050,726 (GRCm39) |
Y458C |
probably damaging |
Het |
| Akap5 |
C |
T |
12: 76,376,698 (GRCm39) |
S710L |
probably damaging |
Het |
| Akr1c21 |
A |
G |
13: 4,625,177 (GRCm39) |
E36G |
probably damaging |
Het |
| Arhgap44 |
A |
G |
11: 64,944,023 (GRCm39) |
S163P |
probably damaging |
Het |
| Armc1 |
A |
G |
3: 19,189,050 (GRCm39) |
V205A |
possibly damaging |
Het |
| Asph |
A |
G |
4: 9,610,869 (GRCm39) |
L102P |
probably damaging |
Het |
| Brca1 |
T |
C |
11: 101,422,925 (GRCm39) |
E74G |
probably damaging |
Het |
| Brms1l |
A |
G |
12: 55,888,385 (GRCm39) |
R58G |
probably damaging |
Het |
| C1qbp |
G |
T |
11: 70,869,073 (GRCm39) |
|
probably null |
Het |
| Calcrl |
A |
T |
2: 84,169,631 (GRCm39) |
L350H |
probably damaging |
Het |
| Casr |
A |
T |
16: 36,315,953 (GRCm39) |
F706I |
probably damaging |
Het |
| Ceacam10 |
T |
A |
7: 24,480,491 (GRCm39) |
N87K |
probably benign |
Het |
| Cfap206 |
G |
T |
4: 34,719,058 (GRCm39) |
T316K |
probably damaging |
Het |
| Col4a3 |
A |
T |
1: 82,668,384 (GRCm39) |
|
probably null |
Het |
| Comtd1 |
A |
G |
14: 21,897,398 (GRCm39) |
V183A |
probably damaging |
Het |
| Crygs |
A |
T |
16: 22,625,425 (GRCm39) |
|
probably null |
Het |
| Dact1 |
C |
A |
12: 71,359,551 (GRCm39) |
T139K |
probably damaging |
Het |
| Dlx6 |
T |
C |
6: 6,867,173 (GRCm39) |
W259R |
probably damaging |
Het |
| Dnah9 |
G |
T |
11: 65,845,650 (GRCm39) |
S627* |
probably null |
Het |
| Dnajc11 |
T |
A |
4: 152,063,730 (GRCm39) |
V442D |
probably damaging |
Het |
| Dnajc21 |
A |
T |
15: 10,451,649 (GRCm39) |
S393T |
probably benign |
Het |
| Dpysl3 |
C |
A |
18: 43,461,439 (GRCm39) |
C584F |
possibly damaging |
Het |
| Efcab14 |
A |
G |
4: 115,603,736 (GRCm39) |
K138R |
possibly damaging |
Het |
| Ephb3 |
A |
G |
16: 21,040,495 (GRCm39) |
E577G |
probably damaging |
Het |
| Exoc3 |
C |
T |
13: 74,338,184 (GRCm39) |
|
probably null |
Het |
| Fam171a1 |
A |
G |
2: 3,226,660 (GRCm39) |
S473G |
probably benign |
Het |
| Fbxl2 |
A |
T |
9: 113,832,239 (GRCm39) |
F58L |
probably damaging |
Het |
| Fmo6 |
T |
C |
1: 162,750,241 (GRCm39) |
M272V |
probably benign |
Het |
| Gm10000 |
T |
C |
12: 104,442,859 (GRCm39) |
|
probably benign |
Het |
| Grik1 |
T |
A |
16: 87,746,956 (GRCm39) |
D442V |
probably damaging |
Het |
| Hectd1 |
A |
G |
12: 51,791,375 (GRCm39) |
Y2588H |
probably damaging |
Het |
| Insrr |
A |
C |
3: 87,711,369 (GRCm39) |
T430P |
probably benign |
Het |
| Lats1 |
T |
C |
10: 7,577,709 (GRCm39) |
S278P |
probably benign |
Het |
| Lrch4 |
A |
G |
5: 137,636,723 (GRCm39) |
T463A |
probably benign |
Het |
| Ltbp1 |
A |
G |
17: 75,532,280 (GRCm39) |
Q118R |
possibly damaging |
Het |
| Lyst |
T |
G |
13: 13,835,746 (GRCm39) |
F1809L |
probably damaging |
Het |
| Mad2l1bp |
A |
G |
17: 46,463,770 (GRCm39) |
Y85H |
possibly damaging |
Het |
| Magoh |
G |
T |
4: 107,740,362 (GRCm39) |
R82L |
probably benign |
Het |
| Mdfic2 |
A |
C |
6: 98,215,100 (GRCm39) |
S174R |
probably damaging |
Het |
| Mlh1 |
A |
G |
9: 111,057,543 (GRCm39) |
V756A |
probably damaging |
Het |
| Mlh3 |
T |
C |
12: 85,313,915 (GRCm39) |
E757G |
probably damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,464,947 (GRCm39) |
T1339A |
probably damaging |
Het |
| Myh7b |
A |
T |
2: 155,455,113 (GRCm39) |
E46V |
probably damaging |
Het |
| Naalad2 |
T |
A |
9: 18,238,683 (GRCm39) |
R677S |
probably damaging |
Het |
| Nadsyn1 |
G |
A |
7: 143,361,749 (GRCm39) |
T324I |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,787,886 (GRCm39) |
L1389Q |
probably damaging |
Het |
| Nlrp1b |
A |
G |
11: 71,107,681 (GRCm39) |
|
probably null |
Het |
| Nup210 |
A |
C |
6: 91,039,785 (GRCm39) |
I690S |
probably benign |
Het |
| Or55b3 |
A |
T |
7: 102,126,547 (GRCm39) |
S177T |
probably benign |
Het |
| Or5an11 |
T |
A |
19: 12,246,281 (GRCm39) |
I229N |
probably damaging |
Het |
| Or9r7 |
T |
A |
10: 129,962,123 (GRCm39) |
I268F |
possibly damaging |
Het |
| Otud7a |
C |
A |
7: 63,383,458 (GRCm39) |
H316N |
probably damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,429,995 (GRCm39) |
S1241P |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,570,977 (GRCm39) |
K121E |
probably damaging |
Het |
| Pcmtd1 |
A |
T |
1: 7,217,872 (GRCm39) |
I107L |
probably benign |
Het |
| Pde6c |
A |
G |
19: 38,168,673 (GRCm39) |
I755V |
probably damaging |
Het |
| Pes1 |
CGGAGGAGGAGGAGGAGGAGGAGG |
CGGAGGAGGAGGAGGAGGAGG |
11: 3,927,719 (GRCm39) |
|
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,113,240 (GRCm39) |
I1532N |
probably damaging |
Het |
| Pla2r1 |
A |
G |
2: 60,271,428 (GRCm39) |
|
probably null |
Het |
| Plekhd1 |
A |
G |
12: 80,769,095 (GRCm39) |
K452E |
possibly damaging |
Het |
| Prr12 |
C |
A |
7: 44,678,003 (GRCm39) |
V2003F |
unknown |
Het |
| Ptger1 |
G |
A |
8: 84,395,107 (GRCm39) |
G195R |
probably benign |
Het |
| Ptpn4 |
T |
C |
1: 119,711,240 (GRCm39) |
Q67R |
probably damaging |
Het |
| Rgsl1 |
C |
T |
1: 153,680,422 (GRCm39) |
R760H |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,136,094 (GRCm39) |
|
probably null |
Het |
| Rtn1 |
T |
C |
12: 72,270,298 (GRCm39) |
Y71C |
probably damaging |
Het |
| Rtp4 |
T |
C |
16: 23,431,870 (GRCm39) |
*62Q |
probably null |
Het |
| Scaf4 |
GGCTGCTGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTGCTGCTG |
16: 90,026,745 (GRCm39) |
|
probably benign |
Het |
| Scimp |
G |
T |
11: 70,684,618 (GRCm39) |
P78H |
probably damaging |
Het |
| Scn8a |
C |
A |
15: 100,853,409 (GRCm39) |
S132* |
probably null |
Het |
| Set |
A |
G |
2: 29,959,436 (GRCm39) |
I124M |
probably damaging |
Het |
| Sf3b1 |
C |
G |
1: 55,058,554 (GRCm39) |
E12Q |
possibly damaging |
Het |
| Sgce |
A |
G |
6: 4,689,709 (GRCm39) |
S375P |
probably damaging |
Het |
| Slc4a1ap |
G |
C |
5: 31,701,098 (GRCm39) |
E600Q |
probably damaging |
Het |
| Slit1 |
A |
G |
19: 41,626,031 (GRCm39) |
V577A |
possibly damaging |
Het |
| Sqstm1 |
A |
G |
11: 50,098,307 (GRCm39) |
V153A |
probably benign |
Het |
| Src |
A |
G |
2: 157,311,675 (GRCm39) |
M468V |
possibly damaging |
Het |
| Srrm3 |
A |
G |
5: 135,902,079 (GRCm39) |
|
probably benign |
Het |
| Stk11ip |
C |
T |
1: 75,504,030 (GRCm39) |
R257W |
probably damaging |
Het |
| Tfrc |
T |
A |
16: 32,433,443 (GRCm39) |
D32E |
probably damaging |
Het |
| Tor1aip2 |
A |
T |
1: 155,941,031 (GRCm39) |
I446L |
probably benign |
Het |
| Trmt11 |
T |
C |
10: 30,411,221 (GRCm39) |
H424R |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,563,928 (GRCm39) |
Y1612H |
probably benign |
Het |
| Vcan |
A |
T |
13: 89,836,602 (GRCm39) |
S2981T |
probably damaging |
Het |
| Vdac1 |
G |
C |
11: 52,265,190 (GRCm39) |
G21A |
probably damaging |
Het |
| Vmn2r76 |
A |
G |
7: 85,879,356 (GRCm39) |
S315P |
probably benign |
Het |
| Xpo1 |
A |
G |
11: 23,231,399 (GRCm39) |
T328A |
probably benign |
Het |
| Xrcc5 |
C |
T |
1: 72,358,255 (GRCm39) |
L197F |
possibly damaging |
Het |
| Zfhx2 |
G |
C |
14: 55,311,401 (GRCm39) |
S431C |
possibly damaging |
Het |
| Zfp410 |
C |
T |
12: 84,372,494 (GRCm39) |
P54S |
probably benign |
Het |
| Zfp560 |
C |
A |
9: 20,259,282 (GRCm39) |
G527* |
probably null |
Het |
| Zfp775 |
A |
G |
6: 48,596,389 (GRCm39) |
T88A |
possibly damaging |
Het |
| Zfp780b |
T |
A |
7: 27,663,808 (GRCm39) |
H249L |
possibly damaging |
Het |
|
| Other mutations in Plb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Plb1
|
APN |
5 |
32,503,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00542:Plb1
|
APN |
5 |
32,427,178 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00835:Plb1
|
APN |
5 |
32,521,516 (GRCm39) |
missense |
unknown |
|
|
IGL00954:Plb1
|
APN |
5 |
32,455,858 (GRCm39) |
splice site |
probably benign |
|
|
IGL01350:Plb1
|
APN |
5 |
32,474,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01527:Plb1
|
APN |
5 |
32,474,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01599:Plb1
|
APN |
5 |
32,499,888 (GRCm39) |
splice site |
probably benign |
|
|
IGL01690:Plb1
|
APN |
5 |
32,471,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01813:Plb1
|
APN |
5 |
32,486,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01826:Plb1
|
APN |
5 |
32,438,489 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02263:Plb1
|
APN |
5 |
32,478,692 (GRCm39) |
splice site |
probably benign |
|
|
IGL02314:Plb1
|
APN |
5 |
32,438,492 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02649:Plb1
|
APN |
5 |
32,519,912 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02701:Plb1
|
APN |
5 |
32,521,541 (GRCm39) |
missense |
unknown |
|
|
IGL02704:Plb1
|
APN |
5 |
32,511,011 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03170:Plb1
|
APN |
5 |
32,442,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03182:Plb1
|
APN |
5 |
32,502,259 (GRCm39) |
splice site |
probably benign |
|
|
IGL03326:Plb1
|
APN |
5 |
32,488,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03046:Plb1
|
UTSW |
5 |
32,485,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Plb1
|
UTSW |
5 |
32,506,959 (GRCm39) |
splice site |
probably benign |
|
|
R0013:Plb1
|
UTSW |
5 |
32,506,959 (GRCm39) |
splice site |
probably benign |
|
|
R0034:Plb1
|
UTSW |
5 |
32,430,457 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0034:Plb1
|
UTSW |
5 |
32,430,457 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0330:Plb1
|
UTSW |
5 |
32,512,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Plb1
|
UTSW |
5 |
32,512,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0721:Plb1
|
UTSW |
5 |
32,521,539 (GRCm39) |
missense |
unknown |
|
|
R0735:Plb1
|
UTSW |
5 |
32,442,264 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1423:Plb1
|
UTSW |
5 |
32,450,601 (GRCm39) |
missense |
probably benign |
|
|
R1428:Plb1
|
UTSW |
5 |
32,422,256 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1469:Plb1
|
UTSW |
5 |
32,512,170 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1469:Plb1
|
UTSW |
5 |
32,512,170 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1801:Plb1
|
UTSW |
5 |
32,450,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Plb1
|
UTSW |
5 |
32,511,041 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1900:Plb1
|
UTSW |
5 |
32,444,191 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1903:Plb1
|
UTSW |
5 |
32,448,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Plb1
|
UTSW |
5 |
32,507,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Plb1
|
UTSW |
5 |
32,471,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2207:Plb1
|
UTSW |
5 |
32,473,984 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2270:Plb1
|
UTSW |
5 |
32,450,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2271:Plb1
|
UTSW |
5 |
32,450,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2311:Plb1
|
UTSW |
5 |
32,427,162 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2850:Plb1
|
UTSW |
5 |
32,450,568 (GRCm39) |
missense |
probably benign |
|
|
R3103:Plb1
|
UTSW |
5 |
32,485,373 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4444:Plb1
|
UTSW |
5 |
32,487,909 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4559:Plb1
|
UTSW |
5 |
32,490,175 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4577:Plb1
|
UTSW |
5 |
32,404,901 (GRCm39) |
nonsense |
probably null |
|
|
R4578:Plb1
|
UTSW |
5 |
32,404,901 (GRCm39) |
nonsense |
probably null |
|
|
R4739:Plb1
|
UTSW |
5 |
32,507,023 (GRCm39) |
splice site |
probably null |
|
|
R4747:Plb1
|
UTSW |
5 |
32,507,003 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4806:Plb1
|
UTSW |
5 |
32,447,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5406:Plb1
|
UTSW |
5 |
32,499,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Plb1
|
UTSW |
5 |
32,521,543 (GRCm39) |
missense |
unknown |
|
|
R5574:Plb1
|
UTSW |
5 |
32,487,291 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5588:Plb1
|
UTSW |
5 |
32,487,293 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5619:Plb1
|
UTSW |
5 |
32,490,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5769:Plb1
|
UTSW |
5 |
32,474,866 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6366:Plb1
|
UTSW |
5 |
32,471,429 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R6700:Plb1
|
UTSW |
5 |
32,490,808 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7162:Plb1
|
UTSW |
5 |
32,507,007 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7379:Plb1
|
UTSW |
5 |
32,502,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Plb1
|
UTSW |
5 |
32,511,028 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7426:Plb1
|
UTSW |
5 |
32,478,591 (GRCm39) |
splice site |
probably null |
|
|
R7643:Plb1
|
UTSW |
5 |
32,404,901 (GRCm39) |
nonsense |
probably null |
|
|
R7657:Plb1
|
UTSW |
5 |
32,487,211 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7780:Plb1
|
UTSW |
5 |
32,483,610 (GRCm39) |
splice site |
probably null |
|
|
R8040:Plb1
|
UTSW |
5 |
32,430,413 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8212:Plb1
|
UTSW |
5 |
32,422,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8312:Plb1
|
UTSW |
5 |
32,485,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8560:Plb1
|
UTSW |
5 |
32,460,023 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8770:Plb1
|
UTSW |
5 |
32,404,853 (GRCm39) |
missense |
unknown |
|
|
R8857:Plb1
|
UTSW |
5 |
32,521,556 (GRCm39) |
missense |
unknown |
|
|
R9029:Plb1
|
UTSW |
5 |
32,439,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9110:Plb1
|
UTSW |
5 |
32,521,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9765:Plb1
|
UTSW |
5 |
32,512,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Plb1
|
UTSW |
5 |
32,443,227 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0019:Plb1
|
UTSW |
5 |
32,511,041 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0027:Plb1
|
UTSW |
5 |
32,427,702 (GRCm39) |
missense |
probably benign |
|
|
X0028:Plb1
|
UTSW |
5 |
32,460,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Plb1
|
UTSW |
5 |
32,468,261 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Plb1
|
UTSW |
5 |
32,468,191 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Plb1
|
UTSW |
5 |
32,442,241 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAATGTGTCCATGCCACGGACC -3'
(R):5'- TGACTGGGCAGAGGAGATGCTATAC -3'
Sequencing Primer
(F):5'- CACGGACCCCGGTAAAG -3'
(R):5'- GGAGGATTCTTACCCTACAGCT -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation