Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00157:Msrb2'

1921

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Msrb2

Ensembl Gene

ENSMUSG00000023094

Gene Name

methionine sulfoxide reductase B2

Synonyms

2310050L06Rik, Msrb

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

IGL00157

Quality Score

Status

Chromosome

Chromosomal Location

19371440-19394976 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 19394341 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Threonine at position 172 (P172T)

Ref Sequence

ENSEMBL: ENSMUSP00000023856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023856]

AlphaFold

Q78J03

PDB Structure

Structure-Functional Analysis of Mammalian MsrB2 protein [SOLUTION NMR]

Predicted Effect

probably damaging
Transcript: ENSMUST00000023856
AA Change: P172T

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000023856
Gene: ENSMUSG00000023094
AA Change: P172T

Domain	Start	End	E-Value	Type
low complexity region	2	22	N/A	INTRINSIC
Pfam:SelR	45	172	2.2e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126894

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153289

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp4	A	G	7: 44,253,451	V331A	possibly damaging	Het
Casr	C	A	16: 36,495,810	V633F	probably damaging	Het
Cblb	T	G	16: 52,183,307	V716G	probably benign	Het
Cbln2	C	T	18: 86,716,384	Q156*	probably null	Het
Cnn1	G	T	9: 22,099,397	L14F	possibly damaging	Het
D830013O20Rik	T	C	12: 73,364,247		noncoding transcript	Het
Drd1	A	G	13: 54,053,878	S99P	probably damaging	Het
Fam35a	A	G	14: 34,268,625	V108A	probably benign	Het
Fat1	T	C	8: 44,951,670	V486A	possibly damaging	Het
Galnt7	T	C	8: 57,540,039	N416S	probably damaging	Het
Gm10735	T	C	13: 113,041,484		probably benign	Het
Gm8909	A	T	17: 36,165,354		probably null	Het
Jag2	T	C	12: 112,912,718	T790A	probably benign	Het
Klhdc1	T	A	12: 69,242,008	Y31N	possibly damaging	Het
Lama1	A	T	17: 67,815,928	M2769L	probably benign	Het
Mms19	A	G	19: 41,945,457		probably null	Het
Olfr228	T	C	2: 86,483,218	S175G	probably benign	Het
Olfr955	A	G	9: 39,470,243	V161A	probably benign	Het
Pcdhb9	T	A	18: 37,403,279	D775E	possibly damaging	Het
Pkhd1	T	C	1: 20,566,874		probably null	Het
Preb	A	T	5: 30,955,964	D375E	probably damaging	Het
Prkdc	T	C	16: 15,697,226	I1010T	probably damaging	Het
Rbp2	A	G	9: 98,498,897		probably null	Het
Sept9	A	G	11: 117,352,184	T66A	probably damaging	Het
Serpinb9b	A	T	13: 33,035,625	E178D	probably benign	Het
Tg	A	G	15: 66,847,166	Y258C	probably damaging	Het
Tmprss7	T	C	16: 45,663,368	R548G	probably benign	Het
Uba7	G	A	9: 107,979,111	A536T	probably benign	Het
Vmn2r114	G	A	17: 23,291,665	P614S	probably damaging	Het
Xpc	A	G	6: 91,492,264		probably benign	Het
Yrdc	T	C	4: 124,853,961	S86P	probably damaging	Het
Zbed6	G	T	1: 133,657,376	A741D	probably damaging	Het

Other mutations in Msrb2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Msrb2	APN	2	19371699	missense	unknown
BB002:Msrb2	UTSW	2	19383280	missense	probably benign	0.06
BB012:Msrb2	UTSW	2	19383280	missense	probably benign	0.06
R0628:Msrb2	UTSW	2	19393280	missense	probably damaging	1.00
R1778:Msrb2	UTSW	2	19383303	missense	probably benign	0.01
R1975:Msrb2	UTSW	2	19393221	missense	probably damaging	1.00
R6029:Msrb2	UTSW	2	19394311	missense	probably damaging	1.00
R7925:Msrb2	UTSW	2	19383280	missense	probably benign	0.06
R7953:Msrb2	UTSW	2	19394355	makesense	probably null
R9065:Msrb2	UTSW	2	19378230	missense	possibly damaging	0.84
R9145:Msrb2	UTSW	2	19394255	missense	probably benign	0.01
R9243:Msrb2	UTSW	2	19383262	missense	probably benign	0.00

Posted On

2011-07-12