Incidental Mutation 'IGL00157:Msrb2'
ID 1921
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Msrb2
Ensembl Gene ENSMUSG00000023094
Gene Name methionine sulfoxide reductase B2
Synonyms 2310050L06Rik, Msrb
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL00157
Quality Score
Status
Chromosome 2
Chromosomal Location 19371440-19394976 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 19394341 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 172 (P172T)
Ref Sequence ENSEMBL: ENSMUSP00000023856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023856]
AlphaFold Q78J03
PDB Structure Structure-Functional Analysis of Mammalian MsrB2 protein [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000023856
AA Change: P172T

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000023856
Gene: ENSMUSG00000023094
AA Change: P172T

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
Pfam:SelR 45 172 2.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126894
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153289
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 A G 7: 44,253,451 V331A possibly damaging Het
Casr C A 16: 36,495,810 V633F probably damaging Het
Cblb T G 16: 52,183,307 V716G probably benign Het
Cbln2 C T 18: 86,716,384 Q156* probably null Het
Cnn1 G T 9: 22,099,397 L14F possibly damaging Het
D830013O20Rik T C 12: 73,364,247 noncoding transcript Het
Drd1 A G 13: 54,053,878 S99P probably damaging Het
Fam35a A G 14: 34,268,625 V108A probably benign Het
Fat1 T C 8: 44,951,670 V486A possibly damaging Het
Galnt7 T C 8: 57,540,039 N416S probably damaging Het
Gm10735 T C 13: 113,041,484 probably benign Het
Gm8909 A T 17: 36,165,354 probably null Het
Jag2 T C 12: 112,912,718 T790A probably benign Het
Klhdc1 T A 12: 69,242,008 Y31N possibly damaging Het
Lama1 A T 17: 67,815,928 M2769L probably benign Het
Mms19 A G 19: 41,945,457 probably null Het
Olfr228 T C 2: 86,483,218 S175G probably benign Het
Olfr955 A G 9: 39,470,243 V161A probably benign Het
Pcdhb9 T A 18: 37,403,279 D775E possibly damaging Het
Pkhd1 T C 1: 20,566,874 probably null Het
Preb A T 5: 30,955,964 D375E probably damaging Het
Prkdc T C 16: 15,697,226 I1010T probably damaging Het
Rbp2 A G 9: 98,498,897 probably null Het
Sept9 A G 11: 117,352,184 T66A probably damaging Het
Serpinb9b A T 13: 33,035,625 E178D probably benign Het
Tg A G 15: 66,847,166 Y258C probably damaging Het
Tmprss7 T C 16: 45,663,368 R548G probably benign Het
Uba7 G A 9: 107,979,111 A536T probably benign Het
Vmn2r114 G A 17: 23,291,665 P614S probably damaging Het
Xpc A G 6: 91,492,264 probably benign Het
Yrdc T C 4: 124,853,961 S86P probably damaging Het
Zbed6 G T 1: 133,657,376 A741D probably damaging Het
Other mutations in Msrb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Msrb2 APN 2 19371699 missense unknown
BB002:Msrb2 UTSW 2 19383280 missense probably benign 0.06
BB012:Msrb2 UTSW 2 19383280 missense probably benign 0.06
R0628:Msrb2 UTSW 2 19393280 missense probably damaging 1.00
R1778:Msrb2 UTSW 2 19383303 missense probably benign 0.01
R1975:Msrb2 UTSW 2 19393221 missense probably damaging 1.00
R6029:Msrb2 UTSW 2 19394311 missense probably damaging 1.00
R7925:Msrb2 UTSW 2 19383280 missense probably benign 0.06
R7953:Msrb2 UTSW 2 19394355 makesense probably null
R9065:Msrb2 UTSW 2 19378230 missense possibly damaging 0.84
R9145:Msrb2 UTSW 2 19394255 missense probably benign 0.01
R9243:Msrb2 UTSW 2 19383262 missense probably benign 0.00
Posted On 2011-07-12