Mutagenetix > Incidental Mutation

Incidental Mutation 'R1698:Dync1h1'

192438

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

039731-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1698 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 110626992 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 1231 (Q1231R)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000018851
AA Change: Q1231R

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: Q1231R

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.6%
20x: 93.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	C	6: 121,645,158 (GRCm38)	E340A	possibly damaging	Het
Abca13	A	G	11: 9,314,507 (GRCm38)	D2963G	probably benign	Het
Actn3	T	C	19: 4,862,207 (GRCm38)	D783G	possibly damaging	Het
Adamtsl2	A	G	2: 27,103,127 (GRCm38)	E723G	possibly damaging	Het
Agrn	G	T	4: 156,166,558 (GRCm38)	Q1931K	probably benign	Het
Ankrd27	G	A	7: 35,614,521 (GRCm38)	A426T	probably benign	Het
Atg9b	C	A	5: 24,388,188 (GRCm38)	G406C	probably damaging	Het
BC005561	C	T	5: 104,520,510 (GRCm38)	A966V	probably benign	Het
C1ra	A	T	6: 124,522,766 (GRCm38)	Q637L	probably benign	Het
Cdhr2	A	T	13: 54,719,581 (GRCm38)	M438L	probably benign	Het
Cep350	T	C	1: 155,953,358 (GRCm38)	I267V	possibly damaging	Het
Chrna5	A	G	9: 55,004,642 (GRCm38)	Y138C	probably damaging	Het
Chst3	T	A	10: 60,185,703 (GRCm38)	M441L	probably benign	Het
Cmya5	G	A	13: 93,063,519 (GRCm38)	P3434S	probably benign	Het
Cog2	T	A	8: 124,525,683 (GRCm38)	L42Q	probably damaging	Het
Cpq	A	T	15: 33,250,126 (GRCm38)	I210F	probably benign	Het
Crnn	C	A	3: 93,148,458 (GRCm38)	Q184K	probably damaging	Het
Csnka2ip	A	T	16: 64,478,059 (GRCm38)	Y647*	probably null	Het
D5Ertd579e	C	T	5: 36,604,530 (GRCm38)	R1331H	probably benign	Het
Dennd5a	C	T	7: 109,917,380 (GRCm38)		probably null	Het
Erbin	T	A	13: 103,833,731 (GRCm38)	I1126F	possibly damaging	Het
Fastkd1	T	C	2: 69,702,469 (GRCm38)	D518G	probably benign	Het
Gcc1	A	G	6: 28,421,111 (GRCm38)	L69P	possibly damaging	Het
Gkn1	T	C	6: 87,347,169 (GRCm38)	Y119C	probably damaging	Het
Gmpr	T	G	13: 45,517,044 (GRCm38)	W81G	probably benign	Het
Gyg	T	A	3: 20,138,051 (GRCm38)	I236F	probably benign	Het
Hcrtr2	T	C	9: 76,246,453 (GRCm38)	Y219C	probably damaging	Het
Hmcn1	G	A	1: 150,565,369 (GRCm38)	Q5379*	probably null	Het
Kank1	T	C	19: 25,411,317 (GRCm38)	C785R	probably benign	Het
Lrp1b	A	T	2: 40,851,806 (GRCm38)	C3036*	probably null	Het
Mdga2	T	C	12: 66,689,335 (GRCm38)	D373G	probably damaging	Het
Mgat2	A	T	12: 69,185,719 (GRCm38)	I356F	probably benign	Het
Miga2	A	G	2: 30,377,997 (GRCm38)	D346G	probably damaging	Het
Mprip	T	A	11: 59,760,258 (GRCm38)	L1596Q	possibly damaging	Het
Mroh2b	G	A	15: 4,914,140 (GRCm38)	R386Q	probably benign	Het
Mst1r	T	A	9: 107,919,980 (GRCm38)	S1349R	probably benign	Het
Mtmr3	C	T	11: 4,492,825 (GRCm38)	R403H	possibly damaging	Het
Mycbpap	G	A	11: 94,508,143 (GRCm38)	Q460*	probably null	Het
Myo9a	T	C	9: 59,868,181 (GRCm38)	V1025A	probably benign	Het
Ncapd2	C	T	6: 125,168,590 (GRCm38)	E1365K	probably null	Het
Nkiras2	C	A	11: 100,625,163 (GRCm38)	D105E	probably damaging	Het
Nolc1	T	G	19: 46,081,431 (GRCm38)		probably null	Het
Nos1	T	C	5: 117,867,232 (GRCm38)	F6L	probably benign	Het
Olfr1112	G	T	2: 87,191,737 (GRCm38)	V17L	probably benign	Het
Olfr1278	T	A	2: 111,292,560 (GRCm38)	C97*	probably null	Het
Olfr1369-ps1	C	T	13: 21,116,565 (GRCm38)	T291I	probably benign	Het
Olfr218	A	T	1: 173,203,371 (GRCm38)	N5I	probably damaging	Het
Olfr325	T	C	11: 58,581,251 (GRCm38)	Y136H	probably damaging	Het
Olfr910	T	A	9: 38,539,256 (GRCm38)	Y120*	probably null	Het
Pfkm	A	G	15: 98,128,318 (GRCm38)	E598G	possibly damaging	Het
Phf2	A	T	13: 48,807,630 (GRCm38)	D861E	unknown	Het
Polr2a	A	G	11: 69,739,877 (GRCm38)		probably null	Het
Popdc2	G	A	16: 38,369,491 (GRCm38)	V167M	probably damaging	Het
Ptpn22	T	C	3: 103,885,798 (GRCm38)	S422P	probably benign	Het
Rasa2	T	C	9: 96,568,375 (GRCm38)	K490R	possibly damaging	Het
Rbfox3	T	A	11: 118,495,221 (GRCm38)	D286V	probably damaging	Het
Rdh13	A	G	7: 4,427,791 (GRCm38)	W223R	probably damaging	Het
Riok3	T	C	18: 12,128,929 (GRCm38)	S7P	probably benign	Het
Rnaseh2b	A	G	14: 62,353,632 (GRCm38)	E144G	probably benign	Het
Rnf20	C	T	4: 49,651,498 (GRCm38)	Q655*	probably null	Het
Rpap2	T	C	5: 107,603,550 (GRCm38)	Y8H	probably damaging	Het
Slc5a10	T	C	11: 61,709,602 (GRCm38)	Y181C	probably benign	Het
Snd1	G	T	6: 28,888,253 (GRCm38)	G896*	probably null	Het
Spast	C	T	17: 74,356,160 (GRCm38)	Q158*	probably null	Het
Tas2r104	G	A	6: 131,685,584 (GRCm38)	S54F	probably damaging	Het
Tcaf2	C	T	6: 42,628,017 (GRCm38)	W611*	probably null	Het
Timp4	G	A	6: 115,250,403 (GRCm38)		probably null	Het
Tmem45a	G	A	16: 56,823,570 (GRCm38)	S72L	probably benign	Het
Tnrc18	T	C	5: 142,788,703 (GRCm38)	T124A	possibly damaging	Het
Tns2	C	T	15: 102,108,934 (GRCm38)	R281C	probably damaging	Het
Ttn	T	C	2: 76,942,915 (GRCm38)	D2381G	probably damaging	Het
Uevld	T	C	7: 46,955,624 (GRCm38)	T41A	possibly damaging	Het
Ugcg	C	T	4: 59,207,798 (GRCm38)	P46S	probably benign	Het
Unc5d	T	C	8: 28,696,478 (GRCm38)	E527G	probably damaging	Het
Vmn2r125	C	T	4: 156,351,038 (GRCm38)	T237I	probably benign	Het
Vmn2r63	A	C	7: 42,933,614 (GRCm38)	I59S	probably benign	Het
Vps72	G	A	3: 95,118,695 (GRCm38)	S106N	probably benign	Het
Zan	A	C	5: 137,409,669 (GRCm38)		probably benign	Het
Zbtb38	T	C	9: 96,685,462 (GRCm38)	K1190E	probably benign	Het
Zc3h6	T	C	2: 129,017,358 (GRCm38)	V1103A	probably benign	Het
Zfp407	G	A	18: 84,562,157 (GRCm38)	T277I	probably damaging	Het
Zfp804b	A	G	5: 6,769,509 (GRCm38)	S1149P	probably damaging	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,649,104 (GRCm38)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,614,107 (GRCm38)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,625,607 (GRCm38)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,626,865 (GRCm38)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,616,692 (GRCm38)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,638,851 (GRCm38)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,658,128 (GRCm38)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,614,940 (GRCm38)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,658,930 (GRCm38)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,652,196 (GRCm38)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,637,124 (GRCm38)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,662,559 (GRCm38)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,663,002 (GRCm38)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,640,888 (GRCm38)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,640,210 (GRCm38)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,659,232 (GRCm38)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,659,272 (GRCm38)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,657,893 (GRCm38)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,666,555 (GRCm38)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,628,734 (GRCm38)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,619,210 (GRCm38)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
Gesund	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
gymnast	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
Lissom	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
Strong	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
waters	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,649,104 (GRCm38)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,616,807 (GRCm38)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,636,446 (GRCm38)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,618,674 (GRCm38)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,631,692 (GRCm38)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,632,788 (GRCm38)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,616,496 (GRCm38)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,651,747 (GRCm38)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,657,192 (GRCm38)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,629,284 (GRCm38)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,612,411 (GRCm38)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,665,213 (GRCm38)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,665,959 (GRCm38)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,649,264 (GRCm38)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,656,357 (GRCm38)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,665,662 (GRCm38)	critical splice acceptor site	probably null
R1767:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,632,928 (GRCm38)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,662,900 (GRCm38)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,662,625 (GRCm38)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,624,636 (GRCm38)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,646,304 (GRCm38)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,662,629 (GRCm38)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,625,732 (GRCm38)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,666,423 (GRCm38)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,614,592 (GRCm38)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,649,588 (GRCm38)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,629,986 (GRCm38)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,640,882 (GRCm38)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,656,631 (GRCm38)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,641,220 (GRCm38)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,643,247 (GRCm38)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,616,891 (GRCm38)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,641,026 (GRCm38)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,640,586 (GRCm38)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,643,129 (GRCm38)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,629,058 (GRCm38)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,665,965 (GRCm38)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,643,190 (GRCm38)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,618,049 (GRCm38)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,632,899 (GRCm38)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,657,139 (GRCm38)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,649,483 (GRCm38)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,638,844 (GRCm38)	missense	probably benign	0.09
R4659:Dync1h1	UTSW	12	110,628,767 (GRCm38)	missense	possibly damaging	0.50
R4676:Dync1h1	UTSW	12	110,662,541 (GRCm38)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,655,528 (GRCm38)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,661,196 (GRCm38)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,639,801 (GRCm38)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,662,855 (GRCm38)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,618,010 (GRCm38)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,626,892 (GRCm38)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,630,535 (GRCm38)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,640,907 (GRCm38)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,617,932 (GRCm38)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,629,680 (GRCm38)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,628,830 (GRCm38)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,615,068 (GRCm38)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,632,665 (GRCm38)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,660,950 (GRCm38)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,641,141 (GRCm38)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,665,988 (GRCm38)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,629,062 (GRCm38)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,646,273 (GRCm38)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,614,220 (GRCm38)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,632,778 (GRCm38)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,620,414 (GRCm38)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,628,006 (GRCm38)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,617,993 (GRCm38)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,646,205 (GRCm38)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,616,737 (GRCm38)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,649,848 (GRCm38)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,658,547 (GRCm38)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,652,180 (GRCm38)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,624,561 (GRCm38)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,638,901 (GRCm38)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,666,087 (GRCm38)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,657,078 (GRCm38)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,601,739 (GRCm38)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,617,762 (GRCm38)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,664,749 (GRCm38)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,665,162 (GRCm38)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,635,642 (GRCm38)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,624,602 (GRCm38)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,634,220 (GRCm38)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,665,675 (GRCm38)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,651,577 (GRCm38)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,614,107 (GRCm38)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,630,625 (GRCm38)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,660,893 (GRCm38)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,618,646 (GRCm38)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,665,766 (GRCm38)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,655,459 (GRCm38)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,643,156 (GRCm38)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,616,457 (GRCm38)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,628,734 (GRCm38)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,616,360 (GRCm38)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,636,474 (GRCm38)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,665,792 (GRCm38)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,618,142 (GRCm38)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,616,743 (GRCm38)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,640,584 (GRCm38)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,614,580 (GRCm38)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,616,827 (GRCm38)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,616,738 (GRCm38)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,642,043 (GRCm38)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,658,168 (GRCm38)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,618,037 (GRCm38)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,620,371 (GRCm38)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,639,963 (GRCm38)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,639,752 (GRCm38)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,656,272 (GRCm38)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,658,589 (GRCm38)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,635,503 (GRCm38)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,658,703 (GRCm38)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,658,371 (GRCm38)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,649,099 (GRCm38)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,640,928 (GRCm38)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,629,917 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,658,517 (GRCm38)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,641,177 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,637,554 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCAGATGCACAGTGCTCTCCAAC -3'
(R):5'- CTCCCAAGTCTGTCAGAAAGAAGCC -3'

Sequencing Primer
(F):5'- CCACAACAGTCGTGAGGTAGAC -3'
(R):5'- GAAGCCATGATGTGCTGC -3'

Posted On

2014-05-14