Incidental Mutation 'R1699:Nin'
| ID |
192549 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
039732-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1699 (G1)
|
| Quality Score |
219 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
70011435-70113717 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 70045563 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 657
(K657N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129648
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021468
AA Change: K657N
PolyPhen 2
Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: K657N
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085314
AA Change: K657N
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: K657N
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000095666
AA Change: K657N
PolyPhen 2
Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: K657N
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169074
AA Change: K657N
PolyPhen 2
Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: K657N
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220689
AA Change: K657N
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222237
AA Change: K657N
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
AA Change: K657N
PolyPhen 2
Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223257
AA Change: K657N
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223316
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001C02Rik |
A |
G |
5: 30,483,866 (GRCm38) |
|
probably null |
Het |
| Abca2 |
A |
G |
2: 25,447,351 (GRCm38) |
E2406G |
possibly damaging |
Het |
| Adam6b |
T |
A |
12: 113,490,585 (GRCm38) |
F341I |
probably benign |
Het |
| Adam8 |
A |
T |
7: 139,983,311 (GRCm38) |
N767K |
possibly damaging |
Het |
| Aig1 |
T |
C |
10: 13,868,622 (GRCm38) |
D46G |
possibly damaging |
Het |
| Alms1 |
A |
G |
6: 85,622,880 (GRCm38) |
I2032V |
possibly damaging |
Het |
| Ankrd16 |
A |
G |
2: 11,784,393 (GRCm38) |
I264V |
probably benign |
Het |
| Areg |
T |
G |
5: 91,143,498 (GRCm38) |
V100G |
probably damaging |
Het |
| Bcan |
A |
G |
3: 87,989,236 (GRCm38) |
Y718H |
probably damaging |
Het |
| Brsk2 |
T |
A |
7: 141,985,463 (GRCm38) |
I188N |
probably damaging |
Het |
| Cdt1 |
T |
C |
8: 122,569,983 (GRCm38) |
Y203H |
probably damaging |
Het |
| Cfap119 |
A |
T |
7: 127,586,856 (GRCm38) |
|
probably null |
Het |
| Chil3 |
A |
C |
3: 106,160,366 (GRCm38) |
|
probably null |
Het |
| Ciao2b |
A |
G |
8: 104,640,086 (GRCm38) |
V132A |
probably damaging |
Het |
| Cth |
A |
G |
3: 157,907,436 (GRCm38) |
L253P |
probably damaging |
Het |
| Cyp11b1 |
A |
G |
15: 74,840,817 (GRCm38) |
F132L |
possibly damaging |
Het |
| Dab1 |
C |
T |
4: 104,731,751 (GRCm38) |
A524V |
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,190,868 (GRCm38) |
S226P |
probably damaging |
Het |
| Egfr |
A |
T |
11: 16,859,019 (GRCm38) |
Q71L |
probably benign |
Het |
| Eml6 |
T |
A |
11: 29,746,282 (GRCm38) |
K1940* |
probably null |
Het |
| Epn2 |
T |
A |
11: 61,523,188 (GRCm38) |
K391* |
probably null |
Het |
| Erich1 |
A |
T |
8: 14,090,259 (GRCm38) |
S2T |
possibly damaging |
Het |
| Evi5 |
A |
C |
5: 107,818,920 (GRCm38) |
L245R |
probably damaging |
Het |
| Evpl |
T |
C |
11: 116,227,588 (GRCm38) |
Y731C |
probably damaging |
Het |
| Exoc3l |
G |
A |
8: 105,295,013 (GRCm38) |
H128Y |
probably benign |
Het |
| Extl1 |
G |
A |
4: 134,364,583 (GRCm38) |
Q320* |
probably null |
Het |
| Fam91a1 |
T |
A |
15: 58,432,948 (GRCm38) |
S416T |
probably benign |
Het |
| Fat3 |
A |
T |
9: 15,938,398 (GRCm38) |
S3903T |
probably damaging |
Het |
| Fer1l4 |
A |
G |
2: 156,029,685 (GRCm38) |
F1392L |
probably benign |
Het |
| Fstl4 |
T |
C |
11: 53,168,178 (GRCm38) |
I488T |
possibly damaging |
Het |
| Gak |
A |
T |
5: 108,604,377 (GRCm38) |
Y338* |
probably null |
Het |
| Garin4 |
T |
A |
1: 191,163,821 (GRCm38) |
E208D |
probably benign |
Het |
| Glp2r |
T |
C |
11: 67,757,541 (GRCm38) |
T112A |
probably benign |
Het |
| Glrb |
G |
A |
3: 80,861,774 (GRCm38) |
T180I |
probably damaging |
Het |
| Gm10118 |
C |
T |
10: 63,926,892 (GRCm38) |
|
probably benign |
Het |
| Gpr19 |
A |
T |
6: 134,870,229 (GRCm38) |
F72I |
possibly damaging |
Het |
| Grin3b |
C |
A |
10: 79,975,882 (GRCm38) |
N740K |
probably damaging |
Het |
| Gstk1 |
A |
T |
6: 42,246,601 (GRCm38) |
T42S |
probably benign |
Het |
| Hoxd1 |
G |
A |
2: 74,764,282 (GRCm38) |
A294T |
probably benign |
Het |
| Hspg2 |
T |
A |
4: 137,548,012 (GRCm38) |
|
probably null |
Het |
| Ift74 |
A |
T |
4: 94,685,703 (GRCm38) |
N472I |
probably benign |
Het |
| Il1a |
C |
T |
2: 129,302,893 (GRCm38) |
D202N |
probably damaging |
Het |
| Islr |
T |
C |
9: 58,157,495 (GRCm38) |
D243G |
probably damaging |
Het |
| Kif21a |
C |
T |
15: 90,959,743 (GRCm38) |
E1098K |
probably damaging |
Het |
| Krtap16-1 |
T |
C |
11: 99,986,026 (GRCm38) |
E184G |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 41,185,962 (GRCm38) |
I1889T |
possibly damaging |
Het |
| Mcpt4 |
A |
G |
14: 56,059,959 (GRCm38) |
*247Q |
probably null |
Het |
| Megf10 |
T |
C |
18: 57,277,730 (GRCm38) |
|
probably null |
Het |
| Mettl2 |
T |
A |
11: 105,139,718 (GRCm38) |
H373Q |
probably benign |
Het |
| Mocos |
A |
G |
18: 24,683,216 (GRCm38) |
K617E |
probably damaging |
Het |
| Ms4a8a |
A |
G |
19: 11,076,397 (GRCm38) |
I115T |
probably damaging |
Het |
| Ndst1 |
T |
C |
18: 60,695,508 (GRCm38) |
Y658C |
probably damaging |
Het |
| Noc4l |
G |
A |
5: 110,649,847 (GRCm38) |
R344* |
probably null |
Het |
| Notch2 |
T |
C |
3: 98,145,127 (GRCm38) |
S1980P |
probably damaging |
Het |
| Npat |
C |
T |
9: 53,562,660 (GRCm38) |
S584L |
probably benign |
Het |
| Nphp4 |
A |
G |
4: 152,496,664 (GRCm38) |
T102A |
probably damaging |
Het |
| Olfml2b |
A |
G |
1: 170,645,073 (GRCm38) |
N51S |
possibly damaging |
Het |
| Or2n1e |
A |
G |
17: 38,275,041 (GRCm38) |
K90R |
probably benign |
Het |
| Or2y16 |
T |
A |
11: 49,444,289 (GRCm38) |
I146N |
possibly damaging |
Het |
| Or5al1 |
T |
C |
2: 86,159,936 (GRCm38) |
I145V |
probably benign |
Het |
| Or5w22 |
A |
G |
2: 87,532,083 (GRCm38) |
T17A |
probably benign |
Het |
| Pced1b |
T |
A |
15: 97,384,877 (GRCm38) |
W266R |
probably damaging |
Het |
| Pdcd6ip |
A |
G |
9: 113,678,354 (GRCm38) |
V378A |
probably damaging |
Het |
| Pde8b |
T |
A |
13: 95,032,866 (GRCm38) |
K683N |
probably damaging |
Het |
| Pfas |
T |
G |
11: 68,998,046 (GRCm38) |
|
probably null |
Het |
| Pirb |
A |
T |
7: 3,717,638 (GRCm38) |
L287Q |
probably benign |
Het |
| Plcd4 |
T |
G |
1: 74,548,235 (GRCm38) |
S51R |
probably benign |
Het |
| Plekhh2 |
T |
A |
17: 84,577,184 (GRCm38) |
Y775* |
probably null |
Het |
| Polr3a |
G |
A |
14: 24,484,164 (GRCm38) |
P91L |
probably damaging |
Het |
| Ppp4r3b |
C |
T |
11: 29,213,765 (GRCm38) |
T47I |
possibly damaging |
Het |
| Pter |
A |
T |
2: 12,994,761 (GRCm38) |
D169V |
probably damaging |
Het |
| Ptpn12 |
A |
G |
5: 20,998,170 (GRCm38) |
S537P |
probably benign |
Het |
| Ptpru |
T |
A |
4: 131,779,050 (GRCm38) |
D1067V |
probably damaging |
Het |
| Rcn1 |
A |
T |
2: 105,399,005 (GRCm38) |
D67E |
probably damaging |
Het |
| Rfc4 |
T |
C |
16: 23,114,233 (GRCm38) |
E318G |
probably benign |
Het |
| Samd13 |
C |
A |
3: 146,662,714 (GRCm38) |
R41L |
probably benign |
Het |
| Shoc1 |
T |
C |
4: 59,113,926 (GRCm38) |
K13R |
unknown |
Het |
| Slc6a2 |
T |
C |
8: 92,972,812 (GRCm38) |
I156T |
possibly damaging |
Het |
| Spag16 |
T |
C |
1: 69,996,856 (GRCm38) |
F348L |
probably benign |
Het |
| Spag4 |
T |
C |
2: 156,065,422 (GRCm38) |
Y21H |
probably damaging |
Het |
| Stam2 |
G |
A |
2: 52,703,175 (GRCm38) |
A368V |
possibly damaging |
Het |
| Stc1 |
A |
T |
14: 69,038,327 (GRCm38) |
M190L |
probably benign |
Het |
| Stxbp1 |
A |
G |
2: 32,800,617 (GRCm38) |
L475P |
probably damaging |
Het |
| Syn3 |
A |
T |
10: 86,080,211 (GRCm38) |
Y304N |
probably damaging |
Het |
| Tbc1d15 |
G |
T |
10: 115,220,314 (GRCm38) |
T251K |
probably benign |
Het |
| Tbpl2 |
A |
T |
2: 24,095,045 (GRCm38) |
M29K |
probably benign |
Het |
| Tead3 |
T |
G |
17: 28,334,724 (GRCm38) |
Q170H |
possibly damaging |
Het |
| Tpbpb |
T |
C |
13: 60,902,163 (GRCm38) |
N51D |
probably benign |
Het |
| Tstd3 |
A |
G |
4: 21,759,400 (GRCm38) |
M124T |
probably benign |
Het |
| Ttyh1 |
T |
A |
7: 4,119,696 (GRCm38) |
H14Q |
possibly damaging |
Het |
| Tubgcp4 |
G |
A |
2: 121,189,893 (GRCm38) |
W449* |
probably null |
Het |
| Txndc11 |
A |
G |
16: 11,087,775 (GRCm38) |
|
probably null |
Het |
| Usp24 |
T |
A |
4: 106,438,827 (GRCm38) |
D2615E |
probably damaging |
Het |
| Vars1 |
A |
G |
17: 35,014,758 (GRCm38) |
E1020G |
possibly damaging |
Het |
| Vmn2r58 |
A |
G |
7: 41,860,527 (GRCm38) |
I542T |
probably benign |
Het |
| Vwf |
A |
G |
6: 125,643,069 (GRCm38) |
Y1570C |
probably damaging |
Het |
| Vwf |
A |
T |
6: 125,685,900 (GRCm38) |
Y2749F |
possibly damaging |
Het |
| Zfand1 |
A |
C |
3: 10,341,055 (GRCm38) |
V198G |
possibly damaging |
Het |
| Zfp536 |
G |
A |
7: 37,569,454 (GRCm38) |
T179I |
probably damaging |
Het |
| Zfp599 |
T |
C |
9: 22,250,404 (GRCm38) |
Y155C |
probably benign |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,030,088 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,026,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,014,793 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,056,758 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,031,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,045,414 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,043,188 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,043,665 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,062,699 (GRCm38) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,045,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,055,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,056,657 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,102,691 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,044,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,020,932 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,035,270 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,031,770 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,026,810 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,056,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,030,113 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,061,186 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,020,962 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,043,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,017,650 (GRCm38) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,044,184 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,014,773 (GRCm38) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,054,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,038,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,031,738 (GRCm38) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,042,669 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,030,938 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,042,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,043,795 (GRCm38) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,030,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,025,477 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,030,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,042,418 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,045,354 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,061,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,054,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,062,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,038,682 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,042,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,078,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,050,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,051,210 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,014,938 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,042,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,042,585 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,038,601 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,043,807 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,090,551 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,044,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,042,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,078,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,045,601 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,030,918 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,045,524 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,019,232 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,043,737 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,014,857 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,045,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,045,181 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,054,534 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,055,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,061,194 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,030,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,102,799 (GRCm38) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,044,239 (GRCm38) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,043,734 (GRCm38) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,044,064 (GRCm38) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,056,029 (GRCm38) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,078,223 (GRCm38) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,062,706 (GRCm38) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,078,182 (GRCm38) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,043,230 (GRCm38) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,042,817 (GRCm38) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,042,898 (GRCm38) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,030,021 (GRCm38) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,031,013 (GRCm38) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,021,019 (GRCm38) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,030,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,078,158 (GRCm38) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,030,012 (GRCm38) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,090,575 (GRCm38) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,028,031 (GRCm38) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,055,988 (GRCm38) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,020,844 (GRCm38) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,102,694 (GRCm38) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,043,125 (GRCm38) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,047,235 (GRCm38) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,049,164 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,054,426 (GRCm38) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,044,095 (GRCm38) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTAAGATTGCTCCAAGCCTCTCACC -3'
(R):5'- CCTTTGGGACAGAAGCACCTGTTG -3'
Sequencing Primer
(F):5'- TCTCCTCAGTCCAGGCAG -3'
(R):5'- GAAGCACCTGTTGCACCC -3'
|
| Posted On |
2014-05-14 |
Incidental Mutation