Incidental Mutation 'R1761:Olfr592'
ID 192772
Institutional Source Beutler Lab
Gene Symbol Olfr592
Ensembl Gene ENSMUSG00000073956
Gene Name olfactory receptor 592
Synonyms MOR0-3P, MOR32-13, GA_x6K02T2PBJ9-5902266-5903204, Olfr1525-ps1, MOR0-3P
MMRRC Submission 039793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R1761 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103184803-103192965 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 103187118 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 172 (C172W)
Ref Sequence ENSEMBL: ENSMUSP00000153755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098207] [ENSMUST00000106893] [ENSMUST00000218618]
AlphaFold A0A2I3BPE8
Predicted Effect probably damaging
Transcript: ENSMUST00000098207
AA Change: C172W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095808
Gene: ENSMUSG00000073956
AA Change: C172W

Pfam:7TM_GPCR_Srsx 38 309 1.4e-6 PFAM
Pfam:7tm_1 44 294 2.6e-26 PFAM
Pfam:7tm_4 141 287 2.3e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106893
AA Change: C172W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102506
Gene: ENSMUSG00000073956
AA Change: C172W

Pfam:7tm_4 34 312 6.9e-112 PFAM
Pfam:7TM_GPCR_Srsx 38 309 1.4e-6 PFAM
Pfam:7tm_1 44 294 1.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000218618
AA Change: C172W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik G A 4: 41,507,223 (GRCm38) P109L probably damaging Het
Abi3bp C T 16: 56,668,309 (GRCm38) H1268Y possibly damaging Het
Acan T A 7: 79,094,085 (GRCm38) Y621* probably null Het
Aig1 T C 10: 13,690,584 (GRCm38) Y152C probably damaging Het
Arhgap33 C T 7: 30,533,063 (GRCm38) probably null Het
Bcl6 G T 16: 23,977,542 (GRCm38) A45D probably damaging Het
Cbx5 T C 15: 103,213,180 (GRCm38) D10G possibly damaging Het
Ccdc191 A G 16: 43,943,510 (GRCm38) I445V probably benign Het
Cdk4 T A 10: 127,064,677 (GRCm38) probably benign Het
Chil6 A G 3: 106,394,338 (GRCm38) F149L probably damaging Het
Cntn5 T C 9: 10,172,054 (GRCm38) T42A probably benign Het
Cpn2 A T 16: 30,260,196 (GRCm38) I229N probably damaging Het
Cpne8 A G 15: 90,648,618 (GRCm38) V62A probably damaging Het
Cr2 A G 1: 195,155,123 (GRCm38) probably null Het
Crnn A T 3: 93,148,651 (GRCm38) H248L probably benign Het
Csn1s1 A G 5: 87,679,035 (GRCm38) S254G probably benign Het
Cubn A G 2: 13,489,317 (GRCm38) probably null Het
Dnah8 A G 17: 30,779,916 (GRCm38) N3525S probably damaging Het
Dpp3 A G 19: 4,921,149 (GRCm38) L220P probably benign Het
Fam110a T C 2: 151,970,205 (GRCm38) E215G probably benign Het
Fam20a A T 11: 109,677,838 (GRCm38) N287K probably damaging Het
Fat4 T C 3: 38,887,489 (GRCm38) V177A possibly damaging Het
Fzd8 C T 18: 9,213,643 (GRCm38) R242C probably damaging Het
Gimap5 A T 6: 48,753,261 (GRCm38) Q255L probably damaging Het
Gm13083 T C 4: 143,615,868 (GRCm38) Y182H probably benign Het
Gm4787 A G 12: 81,377,176 (GRCm38) L736S probably benign Het
Gmeb1 G A 4: 132,234,887 (GRCm38) Q154* probably null Het
Gpr156 T C 16: 37,987,567 (GRCm38) L192P probably damaging Het
Gpr179 A C 11: 97,335,106 (GRCm38) S2074R probably benign Het
Hddc2 G T 10: 31,326,139 (GRCm38) D161Y probably damaging Het
Hlcs T C 16: 94,268,007 (GRCm38) D265G probably benign Het
Hspg2 A T 4: 137,514,673 (GRCm38) I573F possibly damaging Het
Il1b T C 2: 129,365,181 (GRCm38) K220E probably damaging Het
Il5 T C 11: 53,723,730 (GRCm38) I66T probably damaging Het
Irf6 G A 1: 193,169,301 (GRCm38) R400H probably damaging Het
Klra1 A T 6: 130,372,873 (GRCm38) Y201N probably damaging Het
Lmf2 A G 15: 89,352,713 (GRCm38) V442A possibly damaging Het
Mcm2 T C 6: 88,889,788 (GRCm38) I412M possibly damaging Het
Mlkl T A 8: 111,333,723 (GRCm38) L18F possibly damaging Het
Mug2 C A 6: 122,074,705 (GRCm38) H949N probably benign Het
Nf1 T C 11: 79,384,265 (GRCm38) F51L probably damaging Het
Olfr1049 T G 2: 86,255,039 (GRCm38) Y218S probably damaging Het
Olfr77 A T 9: 19,921,149 (GRCm38) *313C probably null Het
P3h2 T C 16: 25,985,050 (GRCm38) E322G probably damaging Het
Psmg2 CTTCAGTT CTTCAGTTCAGTT 18: 67,646,025 (GRCm38) probably null Het
Ptdss1 T C 13: 66,956,412 (GRCm38) V116A possibly damaging Het
Ranbp2 T C 10: 58,485,741 (GRCm38) V2620A probably benign Het
Robo2 A G 16: 74,035,024 (GRCm38) V256A probably damaging Het
Scg3 T A 9: 75,676,758 (GRCm38) I154F probably damaging Het
Scgn A T 13: 23,959,706 (GRCm38) F225Y probably damaging Het
Sec61b T C 4: 47,480,137 (GRCm38) C58R possibly damaging Het
Slc25a46 G T 18: 31,607,262 (GRCm38) Q96K possibly damaging Het
Sptb A G 12: 76,612,608 (GRCm38) F1173L probably damaging Het
Srcap T A 7: 127,534,845 (GRCm38) C893S probably damaging Het
Tet3 T C 6: 83,403,659 (GRCm38) E509G probably damaging Het
Timm10b C T 7: 105,683,708 (GRCm38) R897* probably null Het
Tln2 C T 9: 67,286,514 (GRCm38) A1773T probably benign Het
Tom1 T C 8: 75,051,551 (GRCm38) V87A probably benign Het
Tti1 T C 2: 158,007,697 (GRCm38) I541V probably benign Het
Ttn A T 2: 76,811,243 (GRCm38) L5176Q possibly damaging Het
Tubb1 A G 2: 174,456,896 (GRCm38) S124G probably benign Het
Vgll3 A T 16: 65,839,728 (GRCm38) D310V probably damaging Het
Vmac A G 17: 56,715,788 (GRCm38) L74P probably damaging Het
Zbtb1 A T 12: 76,385,821 (GRCm38) K194* probably null Het
Zfp429 A G 13: 67,396,076 (GRCm38) M76T probably benign Het
Zfp808 T A 13: 62,171,646 (GRCm38) C230S possibly damaging Het
Zfp980 A G 4: 145,702,042 (GRCm38) Y447C probably damaging Het
Zfp985 A G 4: 147,584,045 (GRCm38) T457A probably benign Het
Other mutations in Olfr592
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01546:Olfr592 APN 7 103,187,410 (GRCm38) missense probably damaging 0.99
IGL01650:Olfr592 APN 7 103,187,079 (GRCm38) missense probably benign 0.01
IGL02682:Olfr592 APN 7 103,187,014 (GRCm38) missense probably damaging 0.99
R0925:Olfr592 UTSW 7 103,186,823 (GRCm38) nonsense probably null
R1543:Olfr592 UTSW 7 103,187,214 (GRCm38) missense probably benign 0.26
R2017:Olfr592 UTSW 7 103,186,930 (GRCm38) missense probably benign 0.00
R2152:Olfr592 UTSW 7 103,186,640 (GRCm38) missense probably benign
R4678:Olfr592 UTSW 7 103,186,891 (GRCm38) missense probably damaging 0.97
R4679:Olfr592 UTSW 7 103,187,102 (GRCm38) missense probably benign 0.05
R5177:Olfr592 UTSW 7 103,187,503 (GRCm38) missense probably benign 0.11
R5986:Olfr592 UTSW 7 103,187,528 (GRCm38) missense possibly damaging 0.87
R6808:Olfr592 UTSW 7 103,187,304 (GRCm38) missense probably benign 0.18
R7400:Olfr592 UTSW 7 103,187,380 (GRCm38) missense probably damaging 1.00
R8781:Olfr592 UTSW 7 103,186,875 (GRCm38) missense probably benign 0.01
R9245:Olfr592 UTSW 7 103,186,987 (GRCm38) missense probably damaging 0.99
R9470:Olfr592 UTSW 7 103,187,063 (GRCm38) missense probably benign 0.00
RF005:Olfr592 UTSW 7 103,186,691 (GRCm38) missense possibly damaging 0.94
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-05-23