Mutagenetix > Incidental Mutation

Incidental Mutation 'R0017:Dcdc5'

19331

Institutional Source

Beutler Lab

Gene Symbol

Dcdc5

Ensembl Gene

ENSMUSG00000074981

Gene Name

doublecortin domain containing 5

Synonyms

4732421G10Rik, EG436559

MMRRC Submission

038312-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R0017 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

105833674-106236496 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 106187541 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122388

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152776

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 98.8%
3x: 97.7%
10x: 95.0%
20x: 89.2%

Validation Efficiency

96% (76/79)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found, but the full-length nature of some variants is not determined. [provided by RefSeq, Feb 2011]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	G	T	17: 9,226,938 (GRCm39)		probably benign	Het
Abca13	T	A	11: 9,242,775 (GRCm39)	I1546N	probably damaging	Het
Actrt3	A	T	3: 30,652,422 (GRCm39)	M224K	probably benign	Het
Adgrv1	T	C	13: 81,727,065 (GRCm39)	N429S	probably benign	Het
Appbp2	A	C	11: 85,105,129 (GRCm39)	C146G	possibly damaging	Het
Cabp2	A	C	19: 4,136,242 (GRCm39)	D83A	possibly damaging	Het
Ccl1	A	G	11: 82,068,843 (GRCm39)		probably null	Het
Cdca8	T	C	4: 124,814,168 (GRCm39)	T208A	probably benign	Het
Dach1	C	T	14: 98,406,184 (GRCm39)	G188R	probably damaging	Het
Efr3b	C	A	12: 4,043,003 (GRCm39)	C89F	probably damaging	Het
Enpp3	C	T	10: 24,675,051 (GRCm39)		probably null	Het
Ep400	A	T	5: 110,821,395 (GRCm39)	V2467E	probably damaging	Het
Ermap	T	C	4: 119,037,145 (GRCm39)		probably benign	Het
Fig4	A	G	10: 41,149,003 (GRCm39)	Y150H	possibly damaging	Het
Fsip2	G	A	2: 82,822,416 (GRCm39)	V6050M	probably damaging	Het
Gnb1l	T	C	16: 18,359,810 (GRCm39)	W72R	probably damaging	Het
Gpld1	A	G	13: 25,174,101 (GRCm39)	D842G	probably damaging	Het
Hmgcr	A	G	13: 96,788,597 (GRCm39)		probably benign	Het
Hrc	A	G	7: 44,985,794 (GRCm39)	H315R	possibly damaging	Het
Ifit2	A	T	19: 34,550,973 (GRCm39)	N171I	probably damaging	Het
Ipo11	T	A	13: 107,023,238 (GRCm39)	I416L	probably benign	Het
Kcnab1	G	A	3: 65,264,527 (GRCm39)	V259M	probably damaging	Het
Kcng4	T	C	8: 120,360,259 (GRCm39)	Y39C	probably damaging	Het
Kif5c	A	G	2: 49,622,725 (GRCm39)	T526A	probably benign	Het
Kntc1	A	G	5: 123,919,044 (GRCm39)	Y805C	probably damaging	Het
Mal	A	G	2: 127,482,227 (GRCm39)	S59P	probably damaging	Het
Myh15	A	G	16: 48,983,423 (GRCm39)	N1513D	probably damaging	Het
Ncoa2	A	G	1: 13,244,976 (GRCm39)	L574P	probably damaging	Het
Nmd3	A	G	3: 69,643,425 (GRCm39)		probably null	Het
Nucb2	A	G	7: 116,132,386 (GRCm39)	D331G	probably benign	Het
Nwd1	T	C	8: 73,436,053 (GRCm39)		probably benign	Het
Nynrin	T	C	14: 56,109,852 (GRCm39)	F1653S	probably damaging	Het
Or4a80	A	C	2: 89,582,365 (GRCm39)	I269S	possibly damaging	Het
Or7c19	T	A	8: 85,957,706 (GRCm39)	I194N	probably benign	Het
Or8b12b	T	G	9: 37,684,274 (GRCm39)	F106L	probably benign	Het
Pfdn6	T	C	17: 34,158,538 (GRCm39)	R79G	probably damaging	Het
Pkd1	G	T	17: 24,797,513 (GRCm39)		probably null	Het
Pramel4	T	G	4: 143,794,914 (GRCm39)	C434G	probably benign	Het
Ptpn13	T	C	5: 103,634,638 (GRCm39)		probably null	Het
Ptpro	T	C	6: 137,393,825 (GRCm39)	V831A	probably benign	Het
Rabl6	A	T	2: 25,492,579 (GRCm39)		probably benign	Het
Reg3b	T	A	6: 78,349,844 (GRCm39)	M128K	possibly damaging	Het
Rif1	A	G	2: 52,006,686 (GRCm39)	T2207A	probably benign	Het
Rpa1	A	C	11: 75,205,687 (GRCm39)	N223K	probably null	Het
Rras2	T	C	7: 113,647,490 (GRCm39)		probably benign	Het
Ryr1	T	A	7: 28,746,967 (GRCm39)	E3760V	probably damaging	Het
Scyl3	T	A	1: 163,767,538 (GRCm39)	I204N	possibly damaging	Het
Serpinb9h	A	C	13: 33,588,494 (GRCm39)	I360L	probably damaging	Het
Slc16a12	A	G	19: 34,650,098 (GRCm39)		probably benign	Het
Slc22a1	A	G	17: 12,878,646 (GRCm39)	F356L	probably damaging	Het
Slc22a29	A	G	19: 8,195,630 (GRCm39)		probably benign	Het
Slc45a1	C	A	4: 150,714,023 (GRCm39)	D741Y	possibly damaging	Het
Slco1a5	A	T	6: 142,182,061 (GRCm39)		probably benign	Het
Smg5	G	T	3: 88,258,412 (GRCm39)	R461L	probably damaging	Het
Snrk	T	C	9: 121,995,306 (GRCm39)	S362P	probably damaging	Het
Spata31d1b	A	G	13: 59,863,883 (GRCm39)	S344G	probably benign	Het
Sync	G	A	4: 129,187,537 (GRCm39)	V190M	probably damaging	Het
Taf5l	T	C	8: 124,730,383 (GRCm39)	Y67C	probably damaging	Het
Tbkbp1	A	G	11: 97,037,115 (GRCm39)		probably benign	Het
Tshr	A	T	12: 91,504,660 (GRCm39)	I533F	possibly damaging	Het
Tsn	T	C	1: 118,228,589 (GRCm39)	D211G	probably damaging	Het
Ttn	G	A	2: 76,621,988 (GRCm39)	T15518I	probably benign	Het
Unc13c	T	C	9: 73,600,583 (GRCm39)	D1387G	probably benign	Het
Vapb	A	G	2: 173,613,397 (GRCm39)	T99A	probably benign	Het
Vmn2r127	A	G	17: 19,373,879 (GRCm39)		noncoding transcript	Het
Zfp280d	A	T	9: 72,246,292 (GRCm39)		probably null	Het

Other mutations in Dcdc5

Allele	Source	Chr	Coord	Type	Predicted Effect
R0017:Dcdc5	UTSW	2	106,187,541 (GRCm39)	splice site	noncoding transcript
R0544:Dcdc5	UTSW	2	106,181,909 (GRCm39)	exon	noncoding transcript
R0563:Dcdc5	UTSW	2	106,180,035 (GRCm39)	exon	noncoding transcript
R1456:Dcdc5	UTSW	2	106,181,910 (GRCm39)	exon	noncoding transcript
R1476:Dcdc5	UTSW	2	106,188,977 (GRCm39)	exon	noncoding transcript
R1521:Dcdc5	UTSW	2	106,182,014 (GRCm39)	critical splice donor site	noncoding transcript
R1555:Dcdc5	UTSW	2	106,214,480 (GRCm39)	exon	noncoding transcript
R2280:Dcdc5	UTSW	2	106,202,867 (GRCm39)	critical splice donor site	noncoding transcript
R2304:Dcdc5	UTSW	2	106,166,488 (GRCm39)	critical splice donor site	noncoding transcript
R3775:Dcdc5	UTSW	2	106,202,738 (GRCm39)	exon	noncoding transcript
R4820:Dcdc5	UTSW	2	106,166,420 (GRCm39)	exon	noncoding transcript
R4874:Dcdc5	UTSW	2	106,198,451 (GRCm39)	exon	noncoding transcript
R4910:Dcdc5	UTSW	2	106,195,895 (GRCm39)	exon	noncoding transcript
R5285:Dcdc5	UTSW	2	106,198,500 (GRCm39)	exon	noncoding transcript
R5583:Dcdc5	UTSW	2	106,195,778 (GRCm39)	exon	noncoding transcript
R5634:Dcdc5	UTSW	2	106,234,325 (GRCm39)	exon	noncoding transcript
R6313:Dcdc5	UTSW	2	106,198,516 (GRCm39)	critical splice donor site	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- AACAGAGATTCTCATGCAAGAGCCC -3'
(R):5'- CTCAGGACTCACAGGTGGATGAAAC -3'

Sequencing Primer
(F):5'- CCACCTCCGCATGGAAG -3'
(R):5'- CTCACAGGTGGATGAAACTACTG -3'

Posted On

2013-04-11