Mutagenetix > Incidental Mutation

Incidental Mutation 'R1764:Dnah11'

193322

Institutional Source

Beutler Lab

Gene Symbol

Dnah11

Ensembl Gene

ENSMUSG00000018581

Gene Name

dynein, axonemal, heavy chain 11

Synonyms

b2b598Clo, Dnahc11, b2b1289Clo, lrd, b2b1727Clo, b2b1203Clo, b2b1279Clo

MMRRC Submission

039796-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.492) question?

Stock #

R1764 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

117877982-118199043 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 118190825 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 240 (E240G)

Ref Sequence

ENSEMBL: ENSMUSP00000081867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084806]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000084806
AA Change: E240G

PolyPhen 2 Score 0.306 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000081867
Gene: ENSMUSG00000018581
AA Change: E240G

Domain	Start	End	E-Value	Type
low complexity region	18	28	N/A	INTRINSIC
Pfam:DHC_N1	218	794	1.6e-162	PFAM
low complexity region	1266	1282	N/A	INTRINSIC
Pfam:DHC_N2	1297	1705	1e-130	PFAM
low complexity region	1757	1773	N/A	INTRINSIC
AAA	1869	1963	1.51e0	SMART
Pfam:AAA_5	2150	2286	1.6e-12	PFAM
AAA	2474	2619	1.48e-1	SMART
AAA	2819	2931	4.57e-1	SMART
Pfam:MT	3069	3413	3.2e-162	PFAM
Pfam:AAA_9	3434	3656	2.9e-88	PFAM
Pfam:Dynein_heavy	3790	4486	7.1e-235	PFAM

Meta Mutation Damage Score

0.1178

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 92.2%

Validation Efficiency

94% (94/100)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
PHENOTYPE: Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700015F17Rik	A	T	5: 5,478,943 (GRCm38)	I24N	possibly damaging	Het
4930522L14Rik	A	G	5: 109,736,789 (GRCm38)	V401A	probably benign	Het
5830411N06Rik	A	G	7: 140,297,265 (GRCm38)	E831G	probably benign	Het
9930021J03Rik	T	A	19: 29,719,160 (GRCm38)	T978S	possibly damaging	Het
Abca7	G	T	10: 80,008,950 (GRCm38)	W1502L	probably damaging	Het
Adcy7	A	G	8: 88,308,840 (GRCm38)	E124G	probably benign	Het
Aif1l	G	A	2: 31,965,106 (GRCm38)	E66K	probably benign	Het
Aldh8a1	A	T	10: 21,395,493 (GRCm38)	M373L	probably benign	Het
Alg6	T	C	4: 99,741,578 (GRCm38)	Y131H	probably benign	Het
Arhgef6	T	C	X: 57,338,562 (GRCm38)	M5V	probably benign	Het
Arrdc4	A	T	7: 68,741,874 (GRCm38)	I215K	probably damaging	Het
Asb4	A	G	6: 5,390,798 (GRCm38)		probably null	Het
Astn1	T	C	1: 158,504,251 (GRCm38)	I305T	probably benign	Het
Atp5b	T	A	10: 128,084,080 (GRCm38)		probably benign	Het
Atp8a1	C	A	5: 67,631,567 (GRCm38)	M1044I	probably benign	Het
Atp9b	C	T	18: 80,909,591 (GRCm38)		probably null	Het
Btaf1	A	G	19: 36,951,118 (GRCm38)	H113R	probably benign	Het
C87436	G	T	6: 86,453,612 (GRCm38)	C338F	possibly damaging	Het
Casz1	T	C	4: 148,942,900 (GRCm38)		probably benign	Het
Cbr3	T	A	16: 93,690,482 (GRCm38)	H184Q	probably damaging	Het
Cct8l1	T	C	5: 25,517,099 (GRCm38)	S271P	possibly damaging	Het
Cdc34	G	T	10: 79,685,338 (GRCm38)		probably null	Het
Cdc34	A	G	10: 79,685,340 (GRCm38)	K77R	probably benign	Het
Cdh20	A	G	1: 104,934,345 (GRCm38)		probably benign	Het
Celsr3	A	G	9: 108,828,958 (GRCm38)	E880G	probably damaging	Het
Cers1	T	G	8: 70,321,491 (GRCm38)		probably null	Het
Cntn5	T	C	9: 9,673,983 (GRCm38)	I705V	probably benign	Het
Dennd4c	T	A	4: 86,803,010 (GRCm38)	D636E	probably damaging	Het
Dnah2	T	C	11: 69,423,543 (GRCm38)	Y4100C	probably damaging	Het
Dpysl3	T	C	18: 43,363,518 (GRCm38)	E151G	probably damaging	Het
Efcab9	T	G	11: 32,524,457 (GRCm38)	T9P	possibly damaging	Het
Eif4g2	A	T	7: 111,074,487 (GRCm38)	F725Y	probably damaging	Het
Epha6	T	A	16: 59,775,728 (GRCm38)	I867F	probably null	Het
Erbin	T	C	13: 103,843,451 (GRCm38)		probably benign	Het
Evi5l	A	G	8: 4,203,560 (GRCm38)	E468G	probably damaging	Het
Filip1l	C	T	16: 57,570,038 (GRCm38)	R330W	probably damaging	Het
Fmo3	C	T	1: 162,958,573 (GRCm38)	V283M	possibly damaging	Het
Gabarapl1	A	T	6: 129,533,518 (GRCm38)	K24N	possibly damaging	Het
Gigyf1	C	T	5: 137,522,508 (GRCm38)		probably benign	Het
Gm13089	C	A	4: 143,698,270 (GRCm38)	C201F	probably benign	Het
Gm5581	T	A	6: 131,181,399 (GRCm38)		noncoding transcript	Het
Gon4l	G	T	3: 88,892,599 (GRCm38)	K850N	probably damaging	Het
Igf2bp3	C	T	6: 49,109,046 (GRCm38)	R233H	probably damaging	Het
Iqcf4	G	A	9: 106,568,694 (GRCm38)	R85C	probably benign	Het
Kalrn	C	T	16: 34,212,873 (GRCm38)	R473Q	probably damaging	Het
Lmod2	T	A	6: 24,603,377 (GRCm38)	V117E	probably damaging	Het
Mapk11	A	G	15: 89,144,391 (GRCm38)		probably null	Het
Mcm3	G	A	1: 20,805,879 (GRCm38)	R664C	probably damaging	Het
Mex3d	A	G	10: 80,386,936 (GRCm38)	M162T	probably benign	Het
Mrgprb3	A	G	7: 48,643,023 (GRCm38)	I260T	probably benign	Het
Ncor2	G	T	5: 125,028,615 (GRCm38)	A1637D	possibly damaging	Het
Nedd4	T	A	9: 72,730,907 (GRCm38)	D441E	probably damaging	Het
Nek5	A	T	8: 22,109,912 (GRCm38)	C194S	probably damaging	Het
Nos1ap	T	C	1: 170,318,878 (GRCm38)	D369G	possibly damaging	Het
Ntrk1	G	T	3: 87,780,084 (GRCm38)	T681K	probably damaging	Het
Olfr1306	A	G	2: 111,912,181 (GRCm38)	F250L	possibly damaging	Het
Olfr538	T	C	7: 140,574,470 (GRCm38)	W106R	probably damaging	Het
Otogl	C	T	10: 107,899,461 (GRCm38)	W154*	probably null	Het
Pcdh20	T	C	14: 88,469,184 (GRCm38)	T227A	possibly damaging	Het
Pcdhb17	T	C	18: 37,487,271 (GRCm38)	S705P	probably damaging	Het
Piezo2	T	C	18: 63,124,642 (GRCm38)	H335R	possibly damaging	Het
Pkn2	T	C	3: 142,793,854 (GRCm38)	Q954R	probably damaging	Het
Prkcq	G	A	2: 11,232,631 (GRCm38)	V74M	probably damaging	Het
Prkrip1	A	T	5: 136,189,635 (GRCm38)		probably null	Het
Rb1cc1	A	G	1: 6,214,680 (GRCm38)		probably benign	Het
Rbm5	A	T	9: 107,767,564 (GRCm38)	Y11*	probably null	Het
Rsf1	CG	CGACGGCGGTG	7: 97,579,908 (GRCm38)		probably benign	Het
Ryr3	C	A	2: 112,860,460 (GRCm38)	V1082L	probably damaging	Het
Sel1l3	C	A	5: 53,170,447 (GRCm38)	E497*	probably null	Het
Serpina6	A	T	12: 103,653,923 (GRCm38)	I189N	probably damaging	Het
Serpinb11	A	T	1: 107,376,802 (GRCm38)	T166S	probably benign	Het
Skint7	T	C	4: 111,982,073 (GRCm38)	L188S	probably benign	Het
Slc25a45	C	T	19: 5,884,930 (GRCm38)	A269V	probably damaging	Het
Sltm	A	G	9: 70,561,800 (GRCm38)	T114A	probably benign	Het
Sned1	G	A	1: 93,281,654 (GRCm38)	V830M	possibly damaging	Het
Spen	C	A	4: 141,472,950 (GRCm38)	V2766L	probably damaging	Het
Srgap2	T	A	1: 131,319,537 (GRCm38)	I445F	possibly damaging	Het
Stox2	A	T	8: 47,194,016 (GRCm38)	Y200*	probably null	Het
Strada	C	A	11: 106,164,184 (GRCm38)	R384L	probably damaging	Het
Tctn2	G	A	5: 124,619,031 (GRCm38)		noncoding transcript	Het
Tgfbr3l	G	T	8: 4,249,282 (GRCm38)	R461L	probably benign	Het
Tmem65	A	G	15: 58,790,149 (GRCm38)		probably benign	Het
Tpst1	G	T	5: 130,114,502 (GRCm38)	V294F	possibly damaging	Het
Trim23	A	G	13: 104,198,618 (GRCm38)	Y384C	probably damaging	Het
Ube3b	C	G	5: 114,404,617 (GRCm38)	L512V	possibly damaging	Het
Ubxn4	T	A	1: 128,256,179 (GRCm38)	V92E	probably damaging	Het
Vmn2r57	A	T	7: 41,400,643 (GRCm38)	C561S	probably damaging	Het
Vwa8	A	G	14: 78,908,195 (GRCm38)	D104G	probably damaging	Het
Wdr25	T	A	12: 109,026,438 (GRCm38)	L73*	probably null	Het
Wnt9a	G	A	11: 59,330,902 (GRCm38)	A209T	probably benign	Het
Zcchc17	A	C	4: 130,329,595 (GRCm38)	C133G	probably damaging	Het
Zdhhc18	T	A	4: 133,608,676 (GRCm38)	M375L	probably benign	Het
Zfhx3	T	C	8: 108,951,644 (GRCm38)	F3109L	probably benign	Het
Zfp202	T	A	9: 40,210,466 (GRCm38)	D286E	probably benign	Het
Zzef1	T	C	11: 72,893,332 (GRCm38)	L2021P	probably benign	Het

Other mutations in Dnah11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Dnah11	APN	12	118,198,745 (GRCm38)	missense	probably benign	0.28
IGL00422:Dnah11	APN	12	118,068,096 (GRCm38)	missense	probably damaging	1.00
IGL00436:Dnah11	APN	12	118,036,459 (GRCm38)	missense	possibly damaging	0.56
IGL00540:Dnah11	APN	12	118,186,922 (GRCm38)	missense	probably benign	0.01
IGL00687:Dnah11	APN	12	117,922,004 (GRCm38)	splice site	probably benign
IGL00833:Dnah11	APN	12	118,179,580 (GRCm38)	missense	probably damaging	1.00
IGL00906:Dnah11	APN	12	117,911,202 (GRCm38)	missense	probably damaging	1.00
IGL00952:Dnah11	APN	12	118,196,651 (GRCm38)	missense	possibly damaging	0.56
IGL01111:Dnah11	APN	12	118,142,934 (GRCm38)	splice site	probably benign
IGL01121:Dnah11	APN	12	118,050,695 (GRCm38)	missense	probably benign	0.02
IGL01143:Dnah11	APN	12	118,012,740 (GRCm38)	missense	probably damaging	1.00
IGL01359:Dnah11	APN	12	117,982,999 (GRCm38)	missense	probably damaging	0.99
IGL01372:Dnah11	APN	12	118,192,399 (GRCm38)	missense	probably damaging	1.00
IGL01410:Dnah11	APN	12	118,047,256 (GRCm38)	nonsense	probably null
IGL01418:Dnah11	APN	12	117,987,482 (GRCm38)	nonsense	probably null
IGL01444:Dnah11	APN	12	118,020,232 (GRCm38)	missense	possibly damaging	0.91
IGL01606:Dnah11	APN	12	117,983,032 (GRCm38)	missense	probably benign	0.15
IGL01645:Dnah11	APN	12	118,186,998 (GRCm38)	missense	possibly damaging	0.90
IGL01932:Dnah11	APN	12	118,192,270 (GRCm38)	splice site	probably benign
IGL02104:Dnah11	APN	12	118,192,390 (GRCm38)	missense	probably benign
IGL02151:Dnah11	APN	12	118,059,888 (GRCm38)	splice site	probably benign
IGL02189:Dnah11	APN	12	118,082,579 (GRCm38)	missense	probably benign	0.00
IGL02417:Dnah11	APN	12	118,057,180 (GRCm38)	missense	probably damaging	1.00
IGL02421:Dnah11	APN	12	118,186,902 (GRCm38)	missense	probably damaging	1.00
IGL02444:Dnah11	APN	12	117,975,873 (GRCm38)	splice site	probably benign
IGL02474:Dnah11	APN	12	118,027,445 (GRCm38)	splice site	probably null
IGL02526:Dnah11	APN	12	118,179,618 (GRCm38)	missense	possibly damaging	0.70
IGL02887:Dnah11	APN	12	117,911,040 (GRCm38)	missense	probably damaging	1.00
IGL03011:Dnah11	APN	12	118,012,377 (GRCm38)	missense	probably benign	0.08
IGL03061:Dnah11	APN	12	117,903,121 (GRCm38)	missense	probably damaging	1.00
IGL03182:Dnah11	APN	12	118,030,291 (GRCm38)	missense	probably damaging	0.99
IGL03220:Dnah11	APN	12	118,105,985 (GRCm38)	missense	probably benign
IGL03238:Dnah11	APN	12	118,109,898 (GRCm38)	missense	probably damaging	1.00
IGL03493:Dnah11	APN	12	118,012,798 (GRCm38)	missense	probably benign	0.00
P0045:Dnah11	UTSW	12	118,030,327 (GRCm38)	missense	probably benign
R0009:Dnah11	UTSW	12	118,045,522 (GRCm38)	missense	possibly damaging	0.90
R0066:Dnah11	UTSW	12	118,126,886 (GRCm38)	missense	probably benign	0.05
R0172:Dnah11	UTSW	12	117,987,453 (GRCm38)	missense	probably damaging	1.00
R0206:Dnah11	UTSW	12	118,043,774 (GRCm38)	missense	probably damaging	0.98
R0206:Dnah11	UTSW	12	118,043,774 (GRCm38)	missense	probably damaging	0.98
R0208:Dnah11	UTSW	12	118,043,774 (GRCm38)	missense	probably damaging	0.98
R0230:Dnah11	UTSW	12	117,983,056 (GRCm38)	nonsense	probably null
R0270:Dnah11	UTSW	12	118,041,013 (GRCm38)	missense	probably damaging	1.00
R0311:Dnah11	UTSW	12	118,127,133 (GRCm38)	missense	probably benign	0.03
R0325:Dnah11	UTSW	12	118,012,339 (GRCm38)	missense	probably benign
R0370:Dnah11	UTSW	12	117,995,227 (GRCm38)	missense	probably benign
R0416:Dnah11	UTSW	12	117,911,058 (GRCm38)	missense	probably damaging	1.00
R0505:Dnah11	UTSW	12	118,106,510 (GRCm38)	missense	probably damaging	1.00
R0540:Dnah11	UTSW	12	118,082,511 (GRCm38)	missense	probably damaging	1.00
R0554:Dnah11	UTSW	12	117,931,178 (GRCm38)	missense	probably benign	0.01
R0607:Dnah11	UTSW	12	118,082,511 (GRCm38)	missense	probably damaging	1.00
R0620:Dnah11	UTSW	12	117,987,469 (GRCm38)	missense	probably damaging	1.00
R0635:Dnah11	UTSW	12	118,007,996 (GRCm38)	missense	probably damaging	1.00
R0755:Dnah11	UTSW	12	118,198,625 (GRCm38)	missense	probably benign	0.17
R0755:Dnah11	UTSW	12	117,954,829 (GRCm38)	missense	possibly damaging	0.95
R0789:Dnah11	UTSW	12	117,911,232 (GRCm38)	missense	probably damaging	1.00
R0833:Dnah11	UTSW	12	118,196,662 (GRCm38)	missense	probably benign	0.01
R0835:Dnah11	UTSW	12	117,916,788 (GRCm38)	missense	probably damaging	1.00
R0836:Dnah11	UTSW	12	118,196,662 (GRCm38)	missense	probably benign	0.01
R0846:Dnah11	UTSW	12	117,933,850 (GRCm38)	missense	probably damaging	0.97
R0865:Dnah11	UTSW	12	118,190,844 (GRCm38)	nonsense	probably null
R0928:Dnah11	UTSW	12	118,045,562 (GRCm38)	missense	probably damaging	1.00
R0939:Dnah11	UTSW	12	118,060,407 (GRCm38)	missense	probably damaging	1.00
R1203:Dnah11	UTSW	12	117,933,812 (GRCm38)	missense	possibly damaging	0.81
R1394:Dnah11	UTSW	12	117,972,364 (GRCm38)	missense	possibly damaging	0.75
R1398:Dnah11	UTSW	12	118,057,106 (GRCm38)	nonsense	probably null
R1465:Dnah11	UTSW	12	118,038,695 (GRCm38)	missense	probably damaging	1.00
R1465:Dnah11	UTSW	12	118,038,695 (GRCm38)	missense	probably damaging	1.00
R1500:Dnah11	UTSW	12	118,012,829 (GRCm38)	splice site	probably null
R1535:Dnah11	UTSW	12	118,018,730 (GRCm38)	missense	probably damaging	1.00
R1539:Dnah11	UTSW	12	117,931,256 (GRCm38)	missense	probably benign	0.01
R1554:Dnah11	UTSW	12	118,082,499 (GRCm38)	missense	possibly damaging	0.92
R1574:Dnah11	UTSW	12	118,060,317 (GRCm38)	missense	probably damaging	1.00
R1574:Dnah11	UTSW	12	118,060,317 (GRCm38)	missense	probably damaging	1.00
R1615:Dnah11	UTSW	12	118,050,722 (GRCm38)	missense	probably damaging	1.00
R1618:Dnah11	UTSW	12	118,015,465 (GRCm38)	missense	probably damaging	0.98
R1638:Dnah11	UTSW	12	118,015,419 (GRCm38)	missense	possibly damaging	0.81
R1659:Dnah11	UTSW	12	118,120,724 (GRCm38)	missense	possibly damaging	0.94
R1671:Dnah11	UTSW	12	117,916,788 (GRCm38)	missense	probably damaging	1.00
R1678:Dnah11	UTSW	12	117,933,845 (GRCm38)	missense	possibly damaging	0.50
R1699:Dnah11	UTSW	12	118,190,868 (GRCm38)	missense	probably damaging	1.00
R1712:Dnah11	UTSW	12	118,196,644 (GRCm38)	missense	probably benign	0.32
R1728:Dnah11	UTSW	12	117,916,931 (GRCm38)	missense	probably damaging	1.00
R1729:Dnah11	UTSW	12	117,916,931 (GRCm38)	missense	probably damaging	1.00
R1780:Dnah11	UTSW	12	118,027,558 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah11	UTSW	12	118,038,780 (GRCm38)	missense	probably damaging	0.99
R1800:Dnah11	UTSW	12	117,916,788 (GRCm38)	missense	probably damaging	1.00
R1863:Dnah11	UTSW	12	118,063,852 (GRCm38)	missense	possibly damaging	0.92
R1892:Dnah11	UTSW	12	118,106,474 (GRCm38)	missense	possibly damaging	0.53
R1907:Dnah11	UTSW	12	118,127,556 (GRCm38)	missense	possibly damaging	0.66
R1964:Dnah11	UTSW	12	118,142,292 (GRCm38)	missense	possibly damaging	0.56
R1967:Dnah11	UTSW	12	117,916,788 (GRCm38)	missense	probably damaging	1.00
R1997:Dnah11	UTSW	12	118,082,468 (GRCm38)	missense	possibly damaging	0.64
R2086:Dnah11	UTSW	12	118,113,871 (GRCm38)	missense	possibly damaging	0.82
R2092:Dnah11	UTSW	12	118,012,716 (GRCm38)	missense	possibly damaging	0.50
R2108:Dnah11	UTSW	12	118,020,353 (GRCm38)	missense	probably damaging	1.00
R2140:Dnah11	UTSW	12	118,008,810 (GRCm38)	missense	probably benign	0.01
R2261:Dnah11	UTSW	12	117,966,639 (GRCm38)	missense	probably damaging	0.99
R2261:Dnah11	UTSW	12	117,880,025 (GRCm38)	missense	probably benign	0.06
R2262:Dnah11	UTSW	12	117,966,639 (GRCm38)	missense	probably damaging	0.99
R2262:Dnah11	UTSW	12	117,880,025 (GRCm38)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,966,639 (GRCm38)	missense	probably damaging	0.99
R2263:Dnah11	UTSW	12	117,880,025 (GRCm38)	missense	probably benign	0.06
R2328:Dnah11	UTSW	12	117,886,686 (GRCm38)	missense	probably damaging	0.98
R2352:Dnah11	UTSW	12	117,928,330 (GRCm38)	missense	probably damaging	1.00
R2410:Dnah11	UTSW	12	118,027,527 (GRCm38)	missense	probably damaging	1.00
R2885:Dnah11	UTSW	12	117,987,427 (GRCm38)	nonsense	probably null
R3499:Dnah11	UTSW	12	117,911,023 (GRCm38)	missense	probably damaging	1.00
R3741:Dnah11	UTSW	12	118,131,341 (GRCm38)	missense	probably benign	0.05
R3742:Dnah11	UTSW	12	118,131,341 (GRCm38)	missense	probably benign	0.05
R3779:Dnah11	UTSW	12	118,130,713 (GRCm38)	splice site	probably benign
R3785:Dnah11	UTSW	12	118,017,602 (GRCm38)	missense	probably damaging	1.00
R3883:Dnah11	UTSW	12	117,978,453 (GRCm38)	splice site	probably benign
R4014:Dnah11	UTSW	12	117,974,914 (GRCm38)	missense	probably benign	0.16
R4043:Dnah11	UTSW	12	117,879,943 (GRCm38)	missense	probably damaging	1.00
R4072:Dnah11	UTSW	12	118,106,492 (GRCm38)	missense	probably damaging	1.00
R4073:Dnah11	UTSW	12	118,045,678 (GRCm38)	missense	probably benign	0.01
R4074:Dnah11	UTSW	12	118,045,678 (GRCm38)	missense	probably benign	0.01
R4076:Dnah11	UTSW	12	118,045,678 (GRCm38)	missense	probably benign	0.01
R4201:Dnah11	UTSW	12	117,966,659 (GRCm38)	missense	possibly damaging	0.63
R4224:Dnah11	UTSW	12	118,130,892 (GRCm38)	missense	probably benign	0.06
R4233:Dnah11	UTSW	12	117,916,791 (GRCm38)	missense	probably damaging	1.00
R4358:Dnah11	UTSW	12	118,125,843 (GRCm38)	nonsense	probably null
R4430:Dnah11	UTSW	12	117,983,011 (GRCm38)	missense	probably benign	0.26
R4465:Dnah11	UTSW	12	117,987,451 (GRCm38)	missense	probably benign	0.09
R4489:Dnah11	UTSW	12	117,916,896 (GRCm38)	missense	probably benign	0.31
R4572:Dnah11	UTSW	12	118,010,125 (GRCm38)	missense	probably benign	0.00
R4574:Dnah11	UTSW	12	118,012,255 (GRCm38)	critical splice donor site	probably null
R4657:Dnah11	UTSW	12	118,192,427 (GRCm38)	missense	probably benign	0.02
R4709:Dnah11	UTSW	12	118,018,760 (GRCm38)	missense	probably benign	0.26
R4740:Dnah11	UTSW	12	118,120,544 (GRCm38)	missense	probably benign	0.28
R4803:Dnah11	UTSW	12	118,127,608 (GRCm38)	missense	possibly damaging	0.50
R4896:Dnah11	UTSW	12	117,995,200 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah11	UTSW	12	118,126,883 (GRCm38)	missense	probably benign	0.37
R5018:Dnah11	UTSW	12	118,130,728 (GRCm38)	missense	probably benign	0.00
R5071:Dnah11	UTSW	12	118,082,453 (GRCm38)	nonsense	probably null
R5074:Dnah11	UTSW	12	118,082,453 (GRCm38)	nonsense	probably null
R5080:Dnah11	UTSW	12	118,198,830 (GRCm38)	start codon destroyed	probably null	0.01
R5097:Dnah11	UTSW	12	118,017,700 (GRCm38)	missense	probably damaging	1.00
R5131:Dnah11	UTSW	12	117,954,751 (GRCm38)	missense	probably damaging	1.00
R5215:Dnah11	UTSW	12	118,157,361 (GRCm38)	missense	probably benign	0.09
R5252:Dnah11	UTSW	12	118,125,941 (GRCm38)	missense	probably damaging	1.00
R5296:Dnah11	UTSW	12	117,883,416 (GRCm38)	missense	probably damaging	1.00
R5308:Dnah11	UTSW	12	118,085,680 (GRCm38)	missense	possibly damaging	0.60
R5368:Dnah11	UTSW	12	117,954,893 (GRCm38)	missense	probably damaging	1.00
R5383:Dnah11	UTSW	12	118,085,697 (GRCm38)	missense	probably damaging	0.99
R5499:Dnah11	UTSW	12	118,106,474 (GRCm38)	missense	possibly damaging	0.53
R5503:Dnah11	UTSW	12	117,880,451 (GRCm38)	critical splice donor site	probably null
R5546:Dnah11	UTSW	12	117,975,848 (GRCm38)	missense	possibly damaging	0.83
R5578:Dnah11	UTSW	12	118,018,802 (GRCm38)	missense	probably damaging	0.99
R5657:Dnah11	UTSW	12	117,883,617 (GRCm38)	missense	probably damaging	1.00
R5702:Dnah11	UTSW	12	118,113,907 (GRCm38)	missense	probably benign	0.04
R5706:Dnah11	UTSW	12	118,023,935 (GRCm38)	missense	probably damaging	1.00
R5727:Dnah11	UTSW	12	118,127,106 (GRCm38)	missense	probably damaging	1.00
R5737:Dnah11	UTSW	12	118,192,390 (GRCm38)	missense	probably benign
R5884:Dnah11	UTSW	12	118,177,534 (GRCm38)	missense	probably benign	0.00
R5900:Dnah11	UTSW	12	118,082,431 (GRCm38)	splice site	probably null
R5905:Dnah11	UTSW	12	117,954,924 (GRCm38)	missense	probably damaging	1.00
R5928:Dnah11	UTSW	12	117,914,636 (GRCm38)	splice site	probably null
R5973:Dnah11	UTSW	12	118,110,952 (GRCm38)	missense	probably benign	0.02
R6024:Dnah11	UTSW	12	118,030,272 (GRCm38)	missense	probably benign	0.34
R6056:Dnah11	UTSW	12	117,928,456 (GRCm38)	missense	probably benign	0.03
R6075:Dnah11	UTSW	12	118,104,851 (GRCm38)	missense	probably damaging	1.00
R6092:Dnah11	UTSW	12	117,928,456 (GRCm38)	missense	probably benign
R6191:Dnah11	UTSW	12	118,190,897 (GRCm38)	missense	probably benign
R6197:Dnah11	UTSW	12	118,179,747 (GRCm38)	missense	probably benign	0.03
R6262:Dnah11	UTSW	12	117,931,178 (GRCm38)	missense	probably damaging	0.98
R6321:Dnah11	UTSW	12	118,142,292 (GRCm38)	missense	possibly damaging	0.56
R6454:Dnah11	UTSW	12	117,916,855 (GRCm38)	missense	probably benign	0.01
R6614:Dnah11	UTSW	12	117,886,676 (GRCm38)	missense	possibly damaging	0.72
R6694:Dnah11	UTSW	12	118,186,882 (GRCm38)	splice site	probably null
R6712:Dnah11	UTSW	12	118,050,722 (GRCm38)	missense	probably damaging	1.00
R6720:Dnah11	UTSW	12	118,045,646 (GRCm38)	missense	probably damaging	1.00
R6742:Dnah11	UTSW	12	118,113,894 (GRCm38)	missense	possibly damaging	0.82
R6806:Dnah11	UTSW	12	117,987,676 (GRCm38)	splice site	probably null
R6895:Dnah11	UTSW	12	117,995,191 (GRCm38)	missense	probably damaging	0.99
R6939:Dnah11	UTSW	12	118,106,562 (GRCm38)	missense	probably damaging	1.00
R6940:Dnah11	UTSW	12	118,198,768 (GRCm38)	missense	probably benign
R6945:Dnah11	UTSW	12	118,060,310 (GRCm38)	missense	probably damaging	1.00
R6958:Dnah11	UTSW	12	117,933,809 (GRCm38)	missense	probably damaging	1.00
R6970:Dnah11	UTSW	12	118,108,944 (GRCm38)	missense	probably benign	0.00
R6976:Dnah11	UTSW	12	118,198,643 (GRCm38)	missense	probably benign	0.16
R7000:Dnah11	UTSW	12	118,017,661 (GRCm38)	missense	probably damaging	1.00
R7011:Dnah11	UTSW	12	117,922,018 (GRCm38)	frame shift	probably null
R7101:Dnah11	UTSW	12	118,068,145 (GRCm38)	missense	probably benign
R7106:Dnah11	UTSW	12	117,961,149 (GRCm38)	missense	probably benign	0.15
R7203:Dnah11	UTSW	12	118,045,522 (GRCm38)	missense	possibly damaging	0.90
R7219:Dnah11	UTSW	12	118,126,889 (GRCm38)	missense	probably benign	0.00
R7219:Dnah11	UTSW	12	118,041,095 (GRCm38)	missense	possibly damaging	0.95
R7308:Dnah11	UTSW	12	117,995,275 (GRCm38)	missense	probably damaging	1.00
R7361:Dnah11	UTSW	12	118,018,742 (GRCm38)	missense	probably damaging	1.00
R7367:Dnah11	UTSW	12	117,987,442 (GRCm38)	missense	possibly damaging	0.59
R7399:Dnah11	UTSW	12	118,125,785 (GRCm38)	missense	probably damaging	1.00
R7399:Dnah11	UTSW	12	118,027,477 (GRCm38)	missense	probably benign	0.00
R7404:Dnah11	UTSW	12	118,104,808 (GRCm38)	missense	probably benign	0.36
R7473:Dnah11	UTSW	12	117,903,176 (GRCm38)	missense	probably benign	0.19
R7545:Dnah11	UTSW	12	117,931,204 (GRCm38)	missense	probably damaging	1.00
R7608:Dnah11	UTSW	12	118,140,770 (GRCm38)	splice site	probably null
R7625:Dnah11	UTSW	12	118,196,642 (GRCm38)	missense	probably benign
R7761:Dnah11	UTSW	12	118,023,913 (GRCm38)	missense	probably damaging	1.00
R7879:Dnah11	UTSW	12	118,041,009 (GRCm38)	missense	probably damaging	1.00
R7881:Dnah11	UTSW	12	117,987,502 (GRCm38)	missense	probably benign	0.04
R7904:Dnah11	UTSW	12	117,903,268 (GRCm38)	missense	possibly damaging	0.72
R8100:Dnah11	UTSW	12	117,966,633 (GRCm38)	missense	probably damaging	0.99
R8179:Dnah11	UTSW	12	117,878,549 (GRCm38)	missense	possibly damaging	0.90
R8192:Dnah11	UTSW	12	118,012,446 (GRCm38)	missense	probably benign
R8254:Dnah11	UTSW	12	117,878,524 (GRCm38)	missense	possibly damaging	0.89
R8268:Dnah11	UTSW	12	118,027,508 (GRCm38)	nonsense	probably null
R8272:Dnah11	UTSW	12	118,111,017 (GRCm38)	missense	probably benign	0.01
R8344:Dnah11	UTSW	12	118,085,731 (GRCm38)	missense	probably benign	0.00
R8515:Dnah11	UTSW	12	117,975,798 (GRCm38)	missense	probably damaging	1.00
R8528:Dnah11	UTSW	12	118,008,803 (GRCm38)	missense	probably damaging	0.96
R8557:Dnah11	UTSW	12	117,878,512 (GRCm38)	missense	probably benign
R8676:Dnah11	UTSW	12	118,190,804 (GRCm38)	missense	probably damaging	1.00
R8738:Dnah11	UTSW	12	118,085,649 (GRCm38)	critical splice donor site	probably null
R8773:Dnah11	UTSW	12	117,995,215 (GRCm38)	missense	possibly damaging	0.94
R8818:Dnah11	UTSW	12	117,911,029 (GRCm38)	missense	probably damaging	1.00
R8855:Dnah11	UTSW	12	118,192,372 (GRCm38)	missense	probably benign	0.03
R8866:Dnah11	UTSW	12	118,192,372 (GRCm38)	missense	probably benign	0.03
R8881:Dnah11	UTSW	12	118,126,815 (GRCm38)	missense	probably benign	0.05
R8881:Dnah11	UTSW	12	118,113,912 (GRCm38)	missense	probably benign	0.00
R8920:Dnah11	UTSW	12	118,113,939 (GRCm38)	missense	probably damaging	0.99
R8944:Dnah11	UTSW	12	118,127,646 (GRCm38)	missense	possibly damaging	0.63
R8945:Dnah11	UTSW	12	118,023,983 (GRCm38)	missense	probably benign	0.36
R8962:Dnah11	UTSW	12	117,954,895 (GRCm38)	missense	probably damaging	1.00
R8962:Dnah11	UTSW	12	117,952,538 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah11	UTSW	12	118,130,843 (GRCm38)	missense	probably benign	0.00
R9155:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9162:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9164:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9171:Dnah11	UTSW	12	117,931,183 (GRCm38)	missense	probably damaging	0.99
R9186:Dnah11	UTSW	12	118,190,897 (GRCm38)	missense	probably benign
R9205:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9208:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9234:Dnah11	UTSW	12	117,987,360 (GRCm38)	missense	probably damaging	1.00
R9264:Dnah11	UTSW	12	118,027,527 (GRCm38)	missense	probably damaging	1.00
R9290:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9291:Dnah11	UTSW	12	118,027,516 (GRCm38)	missense	probably damaging	0.99
R9315:Dnah11	UTSW	12	118,179,606 (GRCm38)	missense	probably benign	0.11
R9353:Dnah11	UTSW	12	118,179,699 (GRCm38)	missense	probably benign	0.00
R9375:Dnah11	UTSW	12	117,920,968 (GRCm38)	missense	possibly damaging	0.67
R9392:Dnah11	UTSW	12	118,177,555 (GRCm38)	missense	probably benign	0.00
R9392:Dnah11	UTSW	12	118,047,320 (GRCm38)	nonsense	probably null
R9433:Dnah11	UTSW	12	118,012,272 (GRCm38)	missense	probably damaging	1.00
R9511:Dnah11	UTSW	12	117,914,617 (GRCm38)	missense	probably damaging	1.00
R9526:Dnah11	UTSW	12	118,186,976 (GRCm38)	missense	probably damaging	0.98
R9566:Dnah11	UTSW	12	117,974,993 (GRCm38)	missense	possibly damaging	0.69
R9673:Dnah11	UTSW	12	118,018,778 (GRCm38)	missense	possibly damaging	0.91
R9705:Dnah11	UTSW	12	118,131,035 (GRCm38)	missense	probably damaging	1.00
R9716:Dnah11	UTSW	12	118,060,413 (GRCm38)	missense	probably damaging	0.99
R9746:Dnah11	UTSW	12	117,878,576 (GRCm38)	nonsense	probably null
R9764:Dnah11	UTSW	12	117,920,969 (GRCm38)	missense	probably benign	0.05
RF023:Dnah11	UTSW	12	117,954,850 (GRCm38)	missense	probably damaging	1.00
RF047:Dnah11	UTSW	12	118,010,083 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,895,012 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,982,969 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah11	UTSW	12	118,130,799 (GRCm38)	missense	probably damaging	0.97
Z1176:Dnah11	UTSW	12	118,127,119 (GRCm38)	missense	probably benign	0.00
Z1176:Dnah11	UTSW	12	117,931,177 (GRCm38)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- AGGCAATCAGTCTCTGTCGTCCTTA -3'
(R):5'- CCAGGAGCATGAAAGCAATGGGTTT -3'

Sequencing Primer
(F):5'- TCCTGTGACAGCATTTCAGAG -3'
(R):5'- CATGAAAGCAATGGGTTTTGAAGG -3'

Posted On

2014-05-23