Incidental Mutation 'R1750:Pappa2'
| ID |
193348 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
PAPP-A2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PLAC3, Pappe |
| MMRRC Submission |
039782-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1750 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
158539297-158788019 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 158590720 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Stop codon
at position 1645
(E1645*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000159861
AA Change: E1645*
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: E1645*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161589
|
| SMART Domains |
Protein: ENSMUSP00000124316
Gene: ENSMUSG00000073530
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
32 |
N/A |
INTRINSIC |
|
CCP
|
67 |
130 |
4.97e0 |
SMART |
|
CCP
|
135 |
192 |
4.81e-1 |
SMART |
|
CCP
|
196 |
245 |
2.84e0 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.9%
- 10x: 95.2%
- 20x: 91.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402N03Rik |
G |
T |
7: 130,747,859 (GRCm39) |
N44K |
probably benign |
Het |
| Acd |
C |
A |
8: 106,425,524 (GRCm39) |
A270S |
possibly damaging |
Het |
| Acnat1 |
G |
A |
4: 49,451,042 (GRCm39) |
T23I |
probably benign |
Het |
| Adam26a |
T |
G |
8: 44,023,226 (GRCm39) |
E88A |
possibly damaging |
Het |
| Adgrb1 |
G |
A |
15: 74,413,676 (GRCm39) |
V589M |
probably benign |
Het |
| Agbl2 |
T |
A |
2: 90,646,720 (GRCm39) |
|
probably benign |
Het |
| Aif1 |
G |
A |
17: 35,391,127 (GRCm39) |
P44L |
probably benign |
Het |
| Amh |
AGCGCCTTGG |
AG |
10: 80,641,419 (GRCm39) |
|
probably null |
Het |
| Asap2 |
T |
C |
12: 21,253,999 (GRCm39) |
L170P |
probably damaging |
Het |
| Btg2 |
T |
C |
1: 134,006,769 (GRCm39) |
D8G |
probably benign |
Het |
| Cacna1g |
A |
T |
11: 94,334,118 (GRCm39) |
V841E |
probably damaging |
Het |
| Cacna2d1 |
C |
T |
5: 16,469,286 (GRCm39) |
P230L |
probably benign |
Het |
| Cacna2d2 |
A |
T |
9: 107,401,843 (GRCm39) |
D766V |
probably damaging |
Het |
| Carns1 |
A |
G |
19: 4,223,156 (GRCm39) |
W23R |
possibly damaging |
Het |
| Cdk11b |
T |
A |
4: 155,713,137 (GRCm39) |
|
probably null |
Het |
| Chrna3 |
T |
C |
9: 54,923,341 (GRCm39) |
S156G |
probably damaging |
Het |
| Cmya5 |
A |
T |
13: 93,232,171 (GRCm39) |
N972K |
probably benign |
Het |
| Cpne7 |
C |
A |
8: 123,861,263 (GRCm39) |
P541T |
probably damaging |
Het |
| Cracd |
A |
G |
5: 77,005,522 (GRCm39) |
I628V |
unknown |
Het |
| Csmd1 |
A |
T |
8: 15,967,303 (GRCm39) |
L3187I |
probably damaging |
Het |
| Dbt |
A |
G |
3: 116,339,943 (GRCm39) |
I404V |
probably benign |
Het |
| Dgki |
A |
T |
6: 36,893,369 (GRCm39) |
I819K |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,076,347 (GRCm39) |
S782T |
probably benign |
Het |
| Dlc1 |
A |
T |
8: 37,325,244 (GRCm39) |
|
probably null |
Het |
| Dnajc13 |
A |
T |
9: 104,098,676 (GRCm39) |
V459E |
probably damaging |
Het |
| Enam |
A |
G |
5: 88,651,086 (GRCm39) |
E790G |
probably damaging |
Het |
| Epb41l4a |
G |
C |
18: 33,961,261 (GRCm39) |
Y424* |
probably null |
Het |
| Extl1 |
A |
G |
4: 134,089,999 (GRCm39) |
S370P |
probably benign |
Het |
| Fan1 |
T |
C |
7: 64,022,761 (GRCm39) |
Y164C |
probably benign |
Het |
| Fbxw15 |
G |
A |
9: 109,387,314 (GRCm39) |
S227F |
probably damaging |
Het |
| Fbxw25 |
A |
T |
9: 109,479,141 (GRCm39) |
I370N |
probably benign |
Het |
| Fcgbp |
T |
A |
7: 27,792,868 (GRCm39) |
Y957* |
probably null |
Het |
| Gkap1 |
C |
A |
13: 58,384,857 (GRCm39) |
E77* |
probably null |
Het |
| Gkn1 |
A |
T |
6: 87,326,105 (GRCm39) |
N28K |
unknown |
Het |
| Gls2 |
A |
G |
10: 128,037,194 (GRCm39) |
E245G |
probably damaging |
Het |
| Glyat |
G |
A |
19: 12,623,679 (GRCm39) |
V32I |
probably benign |
Het |
| Gm2431 |
A |
T |
7: 141,811,762 (GRCm39) |
C47* |
probably null |
Het |
| Gm5431 |
T |
C |
11: 48,785,658 (GRCm39) |
D239G |
probably benign |
Het |
| Ift70a1 |
C |
T |
2: 75,810,599 (GRCm39) |
V495I |
probably benign |
Het |
| Inpp5d |
T |
C |
1: 87,626,803 (GRCm39) |
F540L |
probably damaging |
Het |
| Kcna1 |
A |
C |
6: 126,619,771 (GRCm39) |
I183S |
probably benign |
Het |
| Kpna2 |
G |
T |
11: 106,882,271 (GRCm39) |
L212I |
probably damaging |
Het |
| Krt36 |
C |
G |
11: 99,994,884 (GRCm39) |
R229S |
probably benign |
Het |
| Krt78 |
G |
A |
15: 101,854,812 (GRCm39) |
H1000Y |
probably benign |
Het |
| Krt90 |
A |
G |
15: 101,461,800 (GRCm39) |
|
probably benign |
Het |
| Ldlrad4 |
C |
A |
18: 68,239,758 (GRCm39) |
F59L |
probably benign |
Het |
| Lrrc3b |
T |
C |
14: 15,358,601 (GRCm38) |
N2D |
probably benign |
Het |
| Madd |
T |
C |
2: 90,998,236 (GRCm39) |
D239G |
probably damaging |
Het |
| Mapk8ip3 |
C |
T |
17: 25,133,433 (GRCm39) |
G332S |
probably null |
Het |
| Mastl |
A |
T |
2: 23,036,093 (GRCm39) |
L141* |
probably null |
Het |
| Mdh1b |
T |
C |
1: 63,758,681 (GRCm39) |
N304D |
probably benign |
Het |
| Mfsd4b3-ps |
G |
T |
10: 39,823,929 (GRCm39) |
N110K |
probably benign |
Het |
| Mtus2 |
T |
C |
5: 148,214,443 (GRCm39) |
S1035P |
probably damaging |
Het |
| Muc21 |
T |
A |
17: 35,931,940 (GRCm39) |
|
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,033,654 (GRCm39) |
E1080G |
probably damaging |
Het |
| Myh11 |
T |
A |
16: 14,018,622 (GRCm39) |
D1908V |
probably damaging |
Het |
| Mypn |
A |
C |
10: 62,971,976 (GRCm39) |
M688R |
probably benign |
Het |
| Nat8l |
G |
T |
5: 34,158,130 (GRCm39) |
C180F |
probably damaging |
Het |
| Nip7 |
T |
A |
8: 107,784,018 (GRCm39) |
L86Q |
probably damaging |
Het |
| Nisch |
C |
T |
14: 30,896,839 (GRCm39) |
|
probably benign |
Het |
| Nop2 |
A |
G |
6: 125,114,601 (GRCm39) |
I283V |
probably benign |
Het |
| Oas1h |
T |
A |
5: 121,009,840 (GRCm39) |
|
probably null |
Het |
| Or10ag56 |
T |
C |
2: 87,139,196 (GRCm39) |
V41A |
probably benign |
Het |
| Or2g25 |
A |
C |
17: 37,970,564 (GRCm39) |
I220S |
probably damaging |
Het |
| Or4c101 |
C |
A |
2: 88,390,402 (GRCm39) |
D185E |
possibly damaging |
Het |
| Or4c104 |
T |
C |
2: 88,586,117 (GRCm39) |
R301G |
probably benign |
Het |
| Or56b1b |
A |
T |
7: 108,164,564 (GRCm39) |
L146* |
probably null |
Het |
| Or5w17 |
T |
A |
2: 87,583,530 (GRCm39) |
D269V |
probably damaging |
Het |
| Or8b42 |
T |
A |
9: 38,341,986 (GRCm39) |
M136K |
probably damaging |
Het |
| P4hb |
A |
G |
11: 120,453,546 (GRCm39) |
V373A |
probably damaging |
Het |
| Pcdh10 |
G |
T |
3: 45,336,316 (GRCm39) |
E877* |
probably null |
Het |
| Pcdhb17 |
C |
T |
18: 37,618,764 (GRCm39) |
R185C |
probably damaging |
Het |
| Pcdhb17 |
A |
G |
18: 37,620,070 (GRCm39) |
H620R |
possibly damaging |
Het |
| Pdcl3 |
T |
A |
1: 39,034,946 (GRCm39) |
F168I |
probably damaging |
Het |
| Pde4a |
T |
A |
9: 21,114,528 (GRCm39) |
I365N |
probably damaging |
Het |
| Pdzd2 |
A |
G |
15: 12,385,950 (GRCm39) |
V940A |
probably damaging |
Het |
| Picalm |
T |
A |
7: 89,840,390 (GRCm39) |
S399T |
possibly damaging |
Het |
| Pigk |
A |
T |
3: 152,450,101 (GRCm39) |
I249F |
probably damaging |
Het |
| Plxnb1 |
C |
A |
9: 108,940,836 (GRCm39) |
H1570Q |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,635,359 (GRCm39) |
Y1321H |
probably damaging |
Het |
| Ppm1g |
G |
A |
5: 31,363,560 (GRCm39) |
S114F |
probably damaging |
Het |
| Rassf4 |
A |
G |
6: 116,617,228 (GRCm39) |
M259T |
probably damaging |
Het |
| Rbm47 |
T |
C |
5: 66,176,653 (GRCm39) |
K557E |
possibly damaging |
Het |
| Rhobtb1 |
A |
G |
10: 69,115,236 (GRCm39) |
K21R |
probably damaging |
Het |
| Selenoi |
T |
C |
5: 30,462,771 (GRCm39) |
F212S |
probably benign |
Het |
| Shc3 |
T |
G |
13: 51,603,328 (GRCm39) |
Y259S |
probably damaging |
Het |
| Skic3 |
T |
A |
13: 76,288,720 (GRCm39) |
L951Q |
possibly damaging |
Het |
| Slc11a2 |
T |
C |
15: 100,299,168 (GRCm39) |
N134S |
probably damaging |
Het |
| Slc9a7 |
A |
T |
X: 20,028,717 (GRCm39) |
M368K |
probably damaging |
Het |
| Slx4ip |
T |
A |
2: 136,888,669 (GRCm39) |
C117S |
probably damaging |
Het |
| Spata31d1d |
T |
A |
13: 59,876,509 (GRCm39) |
Q342L |
probably benign |
Het |
| Spink13 |
T |
A |
18: 62,740,820 (GRCm39) |
Y93F |
probably damaging |
Het |
| St6galnac5 |
A |
T |
3: 152,551,958 (GRCm39) |
I203N |
possibly damaging |
Het |
| Syne2 |
T |
A |
12: 76,099,579 (GRCm39) |
C5335S |
probably damaging |
Het |
| Tagap |
T |
A |
17: 8,148,742 (GRCm39) |
D173E |
probably benign |
Het |
| Tekt3 |
A |
C |
11: 62,960,867 (GRCm39) |
Y12S |
probably damaging |
Het |
| Tmem81 |
T |
A |
1: 132,435,321 (GRCm39) |
N42K |
probably damaging |
Het |
| Tnc |
A |
G |
4: 63,890,972 (GRCm39) |
W1728R |
probably damaging |
Het |
| Ttc33 |
C |
T |
15: 5,241,579 (GRCm39) |
R135* |
probably null |
Het |
| Unc5c |
A |
G |
3: 141,533,278 (GRCm39) |
D842G |
possibly damaging |
Het |
| Usp43 |
A |
T |
11: 67,770,779 (GRCm39) |
H618Q |
probably damaging |
Het |
| Vmn2r50 |
T |
G |
7: 9,786,915 (GRCm39) |
N64T |
possibly damaging |
Het |
| Vmn2r53 |
T |
C |
7: 12,315,632 (GRCm39) |
Y729C |
probably damaging |
Het |
| Vmn2r59 |
T |
A |
7: 41,695,251 (GRCm39) |
H387L |
possibly damaging |
Het |
| Vstm2a |
G |
T |
11: 16,213,166 (GRCm39) |
V184F |
possibly damaging |
Het |
| Wdr53 |
T |
G |
16: 32,070,935 (GRCm39) |
N93K |
probably damaging |
Het |
| Wdr95 |
A |
G |
5: 149,505,351 (GRCm39) |
|
probably null |
Het |
| Xpot |
A |
T |
10: 121,438,932 (GRCm39) |
|
probably null |
Het |
| Xrcc5 |
C |
T |
1: 72,364,246 (GRCm39) |
Q233* |
probably null |
Het |
| Zbtb18 |
T |
A |
1: 177,275,077 (GRCm39) |
C137S |
possibly damaging |
Het |
| Zfp58 |
C |
A |
13: 67,639,598 (GRCm39) |
G298* |
probably null |
Het |
| Zfp963 |
A |
G |
8: 70,196,100 (GRCm39) |
S118P |
possibly damaging |
Het |
| Zmynd15 |
A |
T |
11: 70,353,393 (GRCm39) |
Q336L |
probably benign |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,684,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,592,674 (GRCm39) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,642,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,684,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,764,089 (GRCm39) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,611,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,672,695 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,589,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,542,571 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,764,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,678,786 (GRCm39) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,764,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,609,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,678,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,764,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,682,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,592,637 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,682,419 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,592,671 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,675,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,590,628 (GRCm39) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,590,625 (GRCm39) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,660,343 (GRCm39) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,544,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,672,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,764,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,784,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,784,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Pappa2
|
UTSW |
1 |
158,641,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,684,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,631,073 (GRCm39) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,578,133 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,662,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,784,214 (GRCm39) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,684,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,592,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,763,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,642,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4739:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4788:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,684,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,666,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,784,703 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,589,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,642,355 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,666,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,784,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,675,615 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,544,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,763,820 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,542,567 (GRCm39) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,699,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,662,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,764,438 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,675,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,784,753 (GRCm39) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,590,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,784,096 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,764,456 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,642,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,678,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,764,010 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,589,131 (GRCm39) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,609,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,675,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,764,126 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,763,555 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,764,234 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,682,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,592,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,764,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,678,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,764,518 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,763,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,763,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,684,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,763,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,672,614 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,764,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,784,542 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,642,029 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,784,817 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,609,818 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,675,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,611,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,641,967 (GRCm39) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,764,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,784,503 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCCAGCCACAGATGGATGCAC -3'
(R):5'- GAAGCAAGAGCTTGTCTTAGGTTCCC -3'
Sequencing Primer
(F):5'- GGATGCACTCCGAGTCCTAAAG -3'
(R):5'- cttcccttcccttccctttg -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation