Incidental Mutation 'R1750:Mapk8ip3'
ID 193465
Institutional Source Beutler Lab
Gene Symbol Mapk8ip3
Ensembl Gene ENSMUSG00000024163
Gene Name mitogen-activated protein kinase 8 interacting protein 3
Synonyms JSAP1c, JSAP1b, JNK-interacting protein 3, Jip3, D17Wsu15e, JSAP1, JSAP1d, Syd2, sunday driver 2, JSAP1a, JUN/SAPK-associated protein 1, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
MMRRC Submission 039782-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.843) question?
Stock # R1750 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 25116480-25155951 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 25133433 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 332 (G332S)
Ref Sequence ENSEMBL: ENSMUSP00000136924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088345] [ENSMUST00000115228] [ENSMUST00000115229] [ENSMUST00000115229] [ENSMUST00000117509] [ENSMUST00000119115] [ENSMUST00000120035] [ENSMUST00000121723] [ENSMUST00000121787] [ENSMUST00000146706] [ENSMUST00000146706] [ENSMUST00000146923] [ENSMUST00000178969] [ENSMUST00000178969]
AlphaFold Q9ESN9
Predicted Effect probably null
Transcript: ENSMUST00000088345
AA Change: G332S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000085683
Gene: ENSMUSG00000024163
AA Change: G332S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.4e-72 PFAM
low complexity region 236 249 N/A INTRINSIC
low complexity region 261 270 N/A INTRINSIC
PDB:2W83|D 417 472 6e-20 PDB
coiled coil region 525 555 N/A INTRINSIC
low complexity region 582 596 N/A INTRINSIC
low complexity region 754 769 N/A INTRINSIC
low complexity region 893 901 N/A INTRINSIC
low complexity region 928 940 N/A INTRINSIC
SCOP:d1flga_ 987 1167 4e-8 SMART
Blast:WD40 1075 1116 6e-18 BLAST
low complexity region 1260 1276 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115228
AA Change: G332S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110883
Gene: ENSMUSG00000024163
AA Change: G332S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.4e-72 PFAM
low complexity region 236 249 N/A INTRINSIC
low complexity region 261 270 N/A INTRINSIC
PDB:2W83|D 411 466 7e-20 PDB
low complexity region 567 581 N/A INTRINSIC
low complexity region 739 754 N/A INTRINSIC
low complexity region 878 886 N/A INTRINSIC
low complexity region 913 925 N/A INTRINSIC
SCOP:d1flga_ 972 1152 3e-8 SMART
Blast:WD40 1060 1101 6e-18 BLAST
low complexity region 1245 1261 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115229
AA Change: G340S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110884
Gene: ENSMUSG00000024163
AA Change: G340S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 184 2.9e-60 PFAM
low complexity region 244 257 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:JIP_LZII 423 493 3.1e-32 PFAM
coiled coil region 533 563 N/A INTRINSIC
low complexity region 590 604 N/A INTRINSIC
low complexity region 762 777 N/A INTRINSIC
low complexity region 901 909 N/A INTRINSIC
low complexity region 936 948 N/A INTRINSIC
SCOP:d1flga_ 995 1175 4e-8 SMART
Blast:WD40 1083 1124 7e-18 BLAST
low complexity region 1268 1284 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115229
AA Change: G340S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110884
Gene: ENSMUSG00000024163
AA Change: G340S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 184 2.9e-60 PFAM
low complexity region 244 257 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:JIP_LZII 423 493 3.1e-32 PFAM
coiled coil region 533 563 N/A INTRINSIC
low complexity region 590 604 N/A INTRINSIC
low complexity region 762 777 N/A INTRINSIC
low complexity region 901 909 N/A INTRINSIC
low complexity region 936 948 N/A INTRINSIC
SCOP:d1flga_ 995 1175 4e-8 SMART
Blast:WD40 1083 1124 7e-18 BLAST
low complexity region 1268 1284 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000117509
AA Change: G309S

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000112712
Gene: ENSMUSG00000024163
AA Change: G309S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.4e-72 PFAM
low complexity region 238 247 N/A INTRINSIC
PDB:2W83|D 394 449 7e-20 PDB
coiled coil region 502 532 N/A INTRINSIC
low complexity region 559 573 N/A INTRINSIC
low complexity region 731 746 N/A INTRINSIC
low complexity region 870 878 N/A INTRINSIC
low complexity region 905 917 N/A INTRINSIC
SCOP:d1flga_ 964 1144 3e-8 SMART
Blast:WD40 1052 1093 6e-18 BLAST
low complexity region 1237 1253 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000119115
AA Change: G300S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112955
Gene: ENSMUSG00000024163
AA Change: G300S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.3e-72 PFAM
low complexity region 229 238 N/A INTRINSIC
PDB:2W83|D 385 440 7e-20 PDB
coiled coil region 493 523 N/A INTRINSIC
low complexity region 550 564 N/A INTRINSIC
low complexity region 722 737 N/A INTRINSIC
low complexity region 861 869 N/A INTRINSIC
low complexity region 896 908 N/A INTRINSIC
SCOP:d1flga_ 955 1135 3e-8 SMART
Blast:WD40 1043 1084 5e-18 BLAST
low complexity region 1228 1244 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000120035
AA Change: G331S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114084
Gene: ENSMUSG00000024163
AA Change: G331S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.4e-72 PFAM
low complexity region 235 248 N/A INTRINSIC
low complexity region 260 269 N/A INTRINSIC
PDB:2W83|D 416 471 6e-20 PDB
coiled coil region 524 554 N/A INTRINSIC
low complexity region 581 595 N/A INTRINSIC
low complexity region 753 768 N/A INTRINSIC
low complexity region 892 900 N/A INTRINSIC
low complexity region 927 939 N/A INTRINSIC
SCOP:d1flga_ 986 1166 3e-8 SMART
Blast:WD40 1074 1115 6e-18 BLAST
low complexity region 1259 1275 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000121723
AA Change: G301S

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000113698
Gene: ENSMUSG00000024163
AA Change: G301S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1e-72 PFAM
low complexity region 230 239 N/A INTRINSIC
PDB:2W83|D 386 441 7e-20 PDB
coiled coil region 494 524 N/A INTRINSIC
low complexity region 551 565 N/A INTRINSIC
low complexity region 723 738 N/A INTRINSIC
low complexity region 862 870 N/A INTRINSIC
low complexity region 897 909 N/A INTRINSIC
SCOP:d1flga_ 956 1136 3e-8 SMART
Blast:WD40 1044 1085 5e-18 BLAST
low complexity region 1229 1245 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000121787
AA Change: G301S

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000113753
Gene: ENSMUSG00000024163
AA Change: G301S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 3.8e-73 PFAM
low complexity region 230 239 N/A INTRINSIC
PDB:2W83|D 380 435 8e-20 PDB
coiled coil region 488 518 N/A INTRINSIC
low complexity region 545 559 N/A INTRINSIC
low complexity region 717 732 N/A INTRINSIC
low complexity region 856 864 N/A INTRINSIC
low complexity region 891 903 N/A INTRINSIC
SCOP:d1flga_ 950 1130 3e-8 SMART
Blast:WD40 1038 1079 6e-18 BLAST
low complexity region 1223 1239 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000146706
AA Change: G126S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000118422
Gene: ENSMUSG00000024163
AA Change: G126S

DomainStartEndE-ValueType
low complexity region 55 64 N/A INTRINSIC
Pfam:JIP_LZII 203 235 1.6e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000146706
AA Change: G126S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000118422
Gene: ENSMUSG00000024163
AA Change: G126S

DomainStartEndE-ValueType
low complexity region 55 64 N/A INTRINSIC
Pfam:JIP_LZII 203 235 1.6e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000146923
AA Change: G332S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114802
Gene: ENSMUSG00000024163
AA Change: G332S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.4e-72 PFAM
low complexity region 236 249 N/A INTRINSIC
low complexity region 261 270 N/A INTRINSIC
PDB:2W83|D 417 472 6e-20 PDB
coiled coil region 525 555 N/A INTRINSIC
low complexity region 582 596 N/A INTRINSIC
low complexity region 754 769 N/A INTRINSIC
low complexity region 893 901 N/A INTRINSIC
low complexity region 928 940 N/A INTRINSIC
SCOP:d1flga_ 987 1167 4e-8 SMART
Blast:WD40 1075 1116 6e-18 BLAST
low complexity region 1260 1276 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000178969
AA Change: G332S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136924
Gene: ENSMUSG00000024163
AA Change: G332S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.1e-72 PFAM
low complexity region 236 249 N/A INTRINSIC
low complexity region 261 270 N/A INTRINSIC
PDB:2W83|D 417 472 6e-20 PDB
coiled coil region 525 555 N/A INTRINSIC
low complexity region 582 596 N/A INTRINSIC
low complexity region 754 769 N/A INTRINSIC
low complexity region 893 901 N/A INTRINSIC
low complexity region 928 940 N/A INTRINSIC
SCOP:d1flga_ 987 1167 3e-8 SMART
Blast:WD40 1075 1116 6e-18 BLAST
low complexity region 1260 1276 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000178969
AA Change: G332S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000136924
Gene: ENSMUSG00000024163
AA Change: G332S

DomainStartEndE-ValueType
Pfam:Jnk-SapK_ap_N 29 186 1.1e-72 PFAM
low complexity region 236 249 N/A INTRINSIC
low complexity region 261 270 N/A INTRINSIC
PDB:2W83|D 417 472 6e-20 PDB
coiled coil region 525 555 N/A INTRINSIC
low complexity region 582 596 N/A INTRINSIC
low complexity region 754 769 N/A INTRINSIC
low complexity region 893 901 N/A INTRINSIC
low complexity region 928 940 N/A INTRINSIC
SCOP:d1flga_ 987 1167 3e-8 SMART
Blast:WD40 1075 1116 6e-18 BLAST
low complexity region 1260 1276 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144336
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126280
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.2%
  • 20x: 91.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 113 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik G T 7: 130,747,859 (GRCm39) N44K probably benign Het
Acd C A 8: 106,425,524 (GRCm39) A270S possibly damaging Het
Acnat1 G A 4: 49,451,042 (GRCm39) T23I probably benign Het
Adam26a T G 8: 44,023,226 (GRCm39) E88A possibly damaging Het
Adgrb1 G A 15: 74,413,676 (GRCm39) V589M probably benign Het
Agbl2 T A 2: 90,646,720 (GRCm39) probably benign Het
Aif1 G A 17: 35,391,127 (GRCm39) P44L probably benign Het
Amh AGCGCCTTGG AG 10: 80,641,419 (GRCm39) probably null Het
Asap2 T C 12: 21,253,999 (GRCm39) L170P probably damaging Het
Btg2 T C 1: 134,006,769 (GRCm39) D8G probably benign Het
Cacna1g A T 11: 94,334,118 (GRCm39) V841E probably damaging Het
Cacna2d1 C T 5: 16,469,286 (GRCm39) P230L probably benign Het
Cacna2d2 A T 9: 107,401,843 (GRCm39) D766V probably damaging Het
Carns1 A G 19: 4,223,156 (GRCm39) W23R possibly damaging Het
Cdk11b T A 4: 155,713,137 (GRCm39) probably null Het
Chrna3 T C 9: 54,923,341 (GRCm39) S156G probably damaging Het
Cmya5 A T 13: 93,232,171 (GRCm39) N972K probably benign Het
Cpne7 C A 8: 123,861,263 (GRCm39) P541T probably damaging Het
Cracd A G 5: 77,005,522 (GRCm39) I628V unknown Het
Csmd1 A T 8: 15,967,303 (GRCm39) L3187I probably damaging Het
Dbt A G 3: 116,339,943 (GRCm39) I404V probably benign Het
Dgki A T 6: 36,893,369 (GRCm39) I819K probably damaging Het
Dip2b T A 15: 100,076,347 (GRCm39) S782T probably benign Het
Dlc1 A T 8: 37,325,244 (GRCm39) probably null Het
Dnajc13 A T 9: 104,098,676 (GRCm39) V459E probably damaging Het
Enam A G 5: 88,651,086 (GRCm39) E790G probably damaging Het
Epb41l4a G C 18: 33,961,261 (GRCm39) Y424* probably null Het
Extl1 A G 4: 134,089,999 (GRCm39) S370P probably benign Het
Fan1 T C 7: 64,022,761 (GRCm39) Y164C probably benign Het
Fbxw15 G A 9: 109,387,314 (GRCm39) S227F probably damaging Het
Fbxw25 A T 9: 109,479,141 (GRCm39) I370N probably benign Het
Fcgbp T A 7: 27,792,868 (GRCm39) Y957* probably null Het
Gkap1 C A 13: 58,384,857 (GRCm39) E77* probably null Het
Gkn1 A T 6: 87,326,105 (GRCm39) N28K unknown Het
Gls2 A G 10: 128,037,194 (GRCm39) E245G probably damaging Het
Glyat G A 19: 12,623,679 (GRCm39) V32I probably benign Het
Gm2431 A T 7: 141,811,762 (GRCm39) C47* probably null Het
Gm5431 T C 11: 48,785,658 (GRCm39) D239G probably benign Het
Ift70a1 C T 2: 75,810,599 (GRCm39) V495I probably benign Het
Inpp5d T C 1: 87,626,803 (GRCm39) F540L probably damaging Het
Kcna1 A C 6: 126,619,771 (GRCm39) I183S probably benign Het
Kpna2 G T 11: 106,882,271 (GRCm39) L212I probably damaging Het
Krt36 C G 11: 99,994,884 (GRCm39) R229S probably benign Het
Krt78 G A 15: 101,854,812 (GRCm39) H1000Y probably benign Het
Krt90 A G 15: 101,461,800 (GRCm39) probably benign Het
Ldlrad4 C A 18: 68,239,758 (GRCm39) F59L probably benign Het
Lrrc3b T C 14: 15,358,601 (GRCm38) N2D probably benign Het
Madd T C 2: 90,998,236 (GRCm39) D239G probably damaging Het
Mastl A T 2: 23,036,093 (GRCm39) L141* probably null Het
Mdh1b T C 1: 63,758,681 (GRCm39) N304D probably benign Het
Mfsd4b3-ps G T 10: 39,823,929 (GRCm39) N110K probably benign Het
Mtus2 T C 5: 148,214,443 (GRCm39) S1035P probably damaging Het
Muc21 T A 17: 35,931,940 (GRCm39) probably benign Het
Myh11 T A 16: 14,018,622 (GRCm39) D1908V probably damaging Het
Myh11 T C 16: 14,033,654 (GRCm39) E1080G probably damaging Het
Mypn A C 10: 62,971,976 (GRCm39) M688R probably benign Het
Nat8l G T 5: 34,158,130 (GRCm39) C180F probably damaging Het
Nip7 T A 8: 107,784,018 (GRCm39) L86Q probably damaging Het
Nisch C T 14: 30,896,839 (GRCm39) probably benign Het
Nop2 A G 6: 125,114,601 (GRCm39) I283V probably benign Het
Oas1h T A 5: 121,009,840 (GRCm39) probably null Het
Or10ag56 T C 2: 87,139,196 (GRCm39) V41A probably benign Het
Or2g25 A C 17: 37,970,564 (GRCm39) I220S probably damaging Het
Or4c101 C A 2: 88,390,402 (GRCm39) D185E possibly damaging Het
Or4c104 T C 2: 88,586,117 (GRCm39) R301G probably benign Het
Or56b1b A T 7: 108,164,564 (GRCm39) L146* probably null Het
Or5w17 T A 2: 87,583,530 (GRCm39) D269V probably damaging Het
Or8b42 T A 9: 38,341,986 (GRCm39) M136K probably damaging Het
P4hb A G 11: 120,453,546 (GRCm39) V373A probably damaging Het
Pappa2 C A 1: 158,590,720 (GRCm39) E1645* probably null Het
Pcdh10 G T 3: 45,336,316 (GRCm39) E877* probably null Het
Pcdhb17 C T 18: 37,618,764 (GRCm39) R185C probably damaging Het
Pcdhb17 A G 18: 37,620,070 (GRCm39) H620R possibly damaging Het
Pdcl3 T A 1: 39,034,946 (GRCm39) F168I probably damaging Het
Pde4a T A 9: 21,114,528 (GRCm39) I365N probably damaging Het
Pdzd2 A G 15: 12,385,950 (GRCm39) V940A probably damaging Het
Picalm T A 7: 89,840,390 (GRCm39) S399T possibly damaging Het
Pigk A T 3: 152,450,101 (GRCm39) I249F probably damaging Het
Plxnb1 C A 9: 108,940,836 (GRCm39) H1570Q probably benign Het
Plxnc1 A G 10: 94,635,359 (GRCm39) Y1321H probably damaging Het
Ppm1g G A 5: 31,363,560 (GRCm39) S114F probably damaging Het
Rassf4 A G 6: 116,617,228 (GRCm39) M259T probably damaging Het
Rbm47 T C 5: 66,176,653 (GRCm39) K557E possibly damaging Het
Rhobtb1 A G 10: 69,115,236 (GRCm39) K21R probably damaging Het
Selenoi T C 5: 30,462,771 (GRCm39) F212S probably benign Het
Shc3 T G 13: 51,603,328 (GRCm39) Y259S probably damaging Het
Skic3 T A 13: 76,288,720 (GRCm39) L951Q possibly damaging Het
Slc11a2 T C 15: 100,299,168 (GRCm39) N134S probably damaging Het
Slc9a7 A T X: 20,028,717 (GRCm39) M368K probably damaging Het
Slx4ip T A 2: 136,888,669 (GRCm39) C117S probably damaging Het
Spata31d1d T A 13: 59,876,509 (GRCm39) Q342L probably benign Het
Spink13 T A 18: 62,740,820 (GRCm39) Y93F probably damaging Het
St6galnac5 A T 3: 152,551,958 (GRCm39) I203N possibly damaging Het
Syne2 T A 12: 76,099,579 (GRCm39) C5335S probably damaging Het
Tagap T A 17: 8,148,742 (GRCm39) D173E probably benign Het
Tekt3 A C 11: 62,960,867 (GRCm39) Y12S probably damaging Het
Tmem81 T A 1: 132,435,321 (GRCm39) N42K probably damaging Het
Tnc A G 4: 63,890,972 (GRCm39) W1728R probably damaging Het
Ttc33 C T 15: 5,241,579 (GRCm39) R135* probably null Het
Unc5c A G 3: 141,533,278 (GRCm39) D842G possibly damaging Het
Usp43 A T 11: 67,770,779 (GRCm39) H618Q probably damaging Het
Vmn2r50 T G 7: 9,786,915 (GRCm39) N64T possibly damaging Het
Vmn2r53 T C 7: 12,315,632 (GRCm39) Y729C probably damaging Het
Vmn2r59 T A 7: 41,695,251 (GRCm39) H387L possibly damaging Het
Vstm2a G T 11: 16,213,166 (GRCm39) V184F possibly damaging Het
Wdr53 T G 16: 32,070,935 (GRCm39) N93K probably damaging Het
Wdr95 A G 5: 149,505,351 (GRCm39) probably null Het
Xpot A T 10: 121,438,932 (GRCm39) probably null Het
Xrcc5 C T 1: 72,364,246 (GRCm39) Q233* probably null Het
Zbtb18 T A 1: 177,275,077 (GRCm39) C137S possibly damaging Het
Zfp58 C A 13: 67,639,598 (GRCm39) G298* probably null Het
Zfp963 A G 8: 70,196,100 (GRCm39) S118P possibly damaging Het
Zmynd15 A T 11: 70,353,393 (GRCm39) Q336L probably benign Het
Other mutations in Mapk8ip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00578:Mapk8ip3 APN 17 25,119,793 (GRCm39) missense probably damaging 1.00
IGL01018:Mapk8ip3 APN 17 25,118,693 (GRCm39) splice site probably benign
IGL01066:Mapk8ip3 APN 17 25,120,692 (GRCm39) missense probably benign 0.00
IGL01656:Mapk8ip3 APN 17 25,137,003 (GRCm39) missense probably damaging 0.99
IGL01991:Mapk8ip3 APN 17 25,146,835 (GRCm39) missense possibly damaging 0.78
IGL02014:Mapk8ip3 APN 17 25,122,254 (GRCm39) splice site probably benign
IGL02219:Mapk8ip3 APN 17 25,118,532 (GRCm39) missense probably damaging 1.00
IGL03006:Mapk8ip3 APN 17 25,120,489 (GRCm39) missense probably benign
ANU74:Mapk8ip3 UTSW 17 25,119,551 (GRCm39) missense possibly damaging 0.94
FR4737:Mapk8ip3 UTSW 17 25,121,093 (GRCm39) splice site probably null
R0028:Mapk8ip3 UTSW 17 25,123,871 (GRCm39) splice site probably benign
R0401:Mapk8ip3 UTSW 17 25,128,145 (GRCm39) intron probably benign
R0496:Mapk8ip3 UTSW 17 25,133,424 (GRCm39) splice site probably benign
R1456:Mapk8ip3 UTSW 17 25,125,923 (GRCm39) missense probably damaging 1.00
R1503:Mapk8ip3 UTSW 17 25,123,897 (GRCm39) missense probably damaging 1.00
R1554:Mapk8ip3 UTSW 17 25,122,033 (GRCm39) missense probably benign 0.14
R1680:Mapk8ip3 UTSW 17 25,119,985 (GRCm39) missense probably damaging 1.00
R1733:Mapk8ip3 UTSW 17 25,155,824 (GRCm39) missense possibly damaging 0.70
R1741:Mapk8ip3 UTSW 17 25,118,828 (GRCm39) missense probably damaging 1.00
R1774:Mapk8ip3 UTSW 17 25,143,119 (GRCm39) critical splice donor site probably null
R1845:Mapk8ip3 UTSW 17 25,133,557 (GRCm39) missense probably benign 0.29
R1911:Mapk8ip3 UTSW 17 25,123,025 (GRCm39) missense probably benign 0.00
R1993:Mapk8ip3 UTSW 17 25,133,562 (GRCm39) missense probably damaging 1.00
R2512:Mapk8ip3 UTSW 17 25,133,677 (GRCm39) nonsense probably null
R2656:Mapk8ip3 UTSW 17 25,131,781 (GRCm39) missense probably damaging 1.00
R2990:Mapk8ip3 UTSW 17 25,124,266 (GRCm39) missense probably benign 0.00
R4587:Mapk8ip3 UTSW 17 25,123,761 (GRCm39) missense probably damaging 1.00
R4617:Mapk8ip3 UTSW 17 25,123,761 (GRCm39) missense probably damaging 1.00
R4627:Mapk8ip3 UTSW 17 25,122,267 (GRCm39) missense probably benign
R4649:Mapk8ip3 UTSW 17 25,123,726 (GRCm39) missense probably damaging 1.00
R4868:Mapk8ip3 UTSW 17 25,120,389 (GRCm39) missense probably benign 0.04
R4903:Mapk8ip3 UTSW 17 25,120,183 (GRCm39) missense probably benign
R4915:Mapk8ip3 UTSW 17 25,128,127 (GRCm39) missense possibly damaging 0.75
R5447:Mapk8ip3 UTSW 17 25,118,163 (GRCm39) missense probably benign
R5642:Mapk8ip3 UTSW 17 25,122,285 (GRCm39) missense possibly damaging 0.63
R6320:Mapk8ip3 UTSW 17 25,125,879 (GRCm39) missense probably damaging 0.99
R6900:Mapk8ip3 UTSW 17 25,128,097 (GRCm39) splice site probably null
R7178:Mapk8ip3 UTSW 17 25,120,728 (GRCm39) missense probably benign 0.02
R7273:Mapk8ip3 UTSW 17 25,125,148 (GRCm39) missense probably benign 0.00
R7317:Mapk8ip3 UTSW 17 25,120,692 (GRCm39) missense probably benign 0.00
R7323:Mapk8ip3 UTSW 17 25,120,135 (GRCm39) missense probably benign
R7701:Mapk8ip3 UTSW 17 25,120,378 (GRCm39) missense possibly damaging 0.93
R7873:Mapk8ip3 UTSW 17 25,125,146 (GRCm39) missense probably benign 0.01
R8070:Mapk8ip3 UTSW 17 25,120,078 (GRCm39) critical splice donor site probably null
R8314:Mapk8ip3 UTSW 17 25,120,748 (GRCm39) missense probably benign 0.09
R8356:Mapk8ip3 UTSW 17 25,123,925 (GRCm39) missense probably damaging 1.00
R8441:Mapk8ip3 UTSW 17 25,139,474 (GRCm39) intron probably benign
R8537:Mapk8ip3 UTSW 17 25,120,652 (GRCm39) nonsense probably null
R8802:Mapk8ip3 UTSW 17 25,124,206 (GRCm39) missense probably damaging 1.00
R8864:Mapk8ip3 UTSW 17 25,118,492 (GRCm39) missense probably damaging 1.00
R8918:Mapk8ip3 UTSW 17 25,131,727 (GRCm39) missense probably damaging 1.00
R9312:Mapk8ip3 UTSW 17 25,146,925 (GRCm39) critical splice acceptor site probably null
R9599:Mapk8ip3 UTSW 17 25,118,124 (GRCm39) missense probably damaging 1.00
R9638:Mapk8ip3 UTSW 17 25,118,023 (GRCm39) missense probably benign
R9640:Mapk8ip3 UTSW 17 25,155,647 (GRCm39) missense possibly damaging 0.46
R9723:Mapk8ip3 UTSW 17 25,132,585 (GRCm39) missense possibly damaging 0.83
X0024:Mapk8ip3 UTSW 17 25,122,947 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- GGCTCACCTCACTCTACAGAGGTCC -3'
(R):5'- TCTGAGTCAGGCCAGTCCTCAGCAG -3'

Sequencing Primer
(F):5'- agcccagcaagaaagacc -3'
(R):5'- GCTGCAACACCCAGTACC -3'
Posted On 2014-05-23