Incidental Mutation 'IGL00096:Or6y1'
ID 1935
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6y1
Ensembl Gene ENSMUSG00000066671
Gene Name olfactory receptor family 6 subfamily Y member 1
Synonyms EG546747, Olfr413-ps1, GA_x6K02T2P20D-20731742-20730694, Olfr220, MOR103-13P, MOR103-17, GA_x6K02SYWY4V-595-239
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # IGL00096
Quality Score
Status
Chromosome 1
Chromosomal Location 174276191-174277168 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 174276233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 15 (T15S)
Ref Sequence ENSEMBL: ENSMUSP00000141919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085861] [ENSMUST00000194229]
AlphaFold E9Q050
Predicted Effect probably benign
Transcript: ENSMUST00000085861
AA Change: T15S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000083023
Gene: ENSMUSG00000066671
AA Change: T15S

DomainStartEndE-ValueType
Pfam:7tm_4 36 314 1.2e-51 PFAM
Pfam:7tm_1 46 295 3.6e-25 PFAM
low complexity region 315 325 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194229
AA Change: T15S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000141919
Gene: ENSMUSG00000066671
AA Change: T15S

DomainStartEndE-ValueType
Pfam:7tm_1 46 295 6e-33 PFAM
Pfam:7tm_4 144 288 1.4e-44 PFAM
low complexity region 315 325 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acrbp T C 6: 125,027,477 (GRCm39) Y42H probably damaging Het
Alpk1 A T 3: 127,474,692 (GRCm39) F437Y probably damaging Het
Bdp1 T C 13: 100,197,373 (GRCm39) D1004G possibly damaging Het
C9 A C 15: 6,516,137 (GRCm39) Q313H probably benign Het
Carmil1 T A 13: 24,295,821 (GRCm39) N398Y possibly damaging Het
Cyp2s1 A G 7: 25,508,683 (GRCm39) V253A probably damaging Het
Inpp5k T A 11: 75,537,646 (GRCm39) M352K possibly damaging Het
Lef1 C T 3: 130,907,499 (GRCm39) probably benign Het
Naip5 C A 13: 100,382,683 (GRCm39) E9* probably null Het
Peli1 G A 11: 21,092,619 (GRCm39) V89I probably damaging Het
Plb1 A G 5: 32,503,080 (GRCm39) Q1180R probably benign Het
Skic2 T A 17: 35,058,524 (GRCm39) I1198F probably damaging Het
Sorcs3 T A 19: 48,672,097 (GRCm39) probably null Het
Spin2f T A X: 30,905,704 (GRCm39) I51N probably damaging Het
Sptbn4 T C 7: 27,068,859 (GRCm39) K1800E probably damaging Het
Vmn2r67 A T 7: 84,801,138 (GRCm39) V266E probably damaging Het
Other mutations in Or6y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03369:Or6y1 APN 1 174,276,435 (GRCm39) missense probably damaging 1.00
R1792:Or6y1 UTSW 1 174,276,303 (GRCm39) missense probably benign
R4090:Or6y1 UTSW 1 174,276,500 (GRCm39) missense probably benign 0.01
R4169:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R4769:Or6y1 UTSW 1 174,276,524 (GRCm39) missense possibly damaging 0.80
R6652:Or6y1 UTSW 1 174,276,627 (GRCm39) missense probably damaging 1.00
R6930:Or6y1 UTSW 1 174,276,677 (GRCm39) missense probably damaging 1.00
R7237:Or6y1 UTSW 1 174,276,905 (GRCm39) missense probably benign 0.05
R8039:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R8187:Or6y1 UTSW 1 174,276,838 (GRCm39) frame shift probably null
R8518:Or6y1 UTSW 1 174,276,742 (GRCm39) nonsense probably null
R9177:Or6y1 UTSW 1 174,276,923 (GRCm39) missense probably damaging 1.00
R9453:Or6y1 UTSW 1 174,276,233 (GRCm39) missense probably benign 0.00
R9757:Or6y1 UTSW 1 174,276,866 (GRCm39) missense probably damaging 1.00
Posted On 2011-07-12