Mutagenetix > Incidental Mutation

Incidental Mutation 'R1751:Mycbp2'

193546

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2, E3 ubiquitin protein ligase

Synonyms

Phr1, Pam, C130061D10Rik

MMRRC Submission

039783-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1751 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103350847-103584250 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 103485841 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 1040 (H1040Q)

Ref Sequence

ENSEMBL: ENSMUSP00000124601 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000159855
AA Change: H1073Q

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: H1073Q

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000160758
AA Change: H1040Q

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: H1040Q

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Meta Mutation Damage Score

0.1043

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.3%
20x: 92.5%

Validation Efficiency

99% (85/86)

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26b	T	A	8: 43,972,948 (GRCm39)	I685F	probably benign	Het
Alcam	A	T	16: 52,091,077 (GRCm39)	N480K	probably damaging	Het
Arhgef2	A	G	3: 88,551,260 (GRCm39)	Q778R	probably damaging	Het
Ascc3	T	A	10: 50,594,472 (GRCm39)	I1189N	probably damaging	Het
AU040320	G	A	4: 126,734,517 (GRCm39)	G713D	probably damaging	Het
Bank1	G	T	3: 135,940,375 (GRCm39)	R203S	probably benign	Het
Bank1	A	G	3: 135,960,698 (GRCm39)	V53A	probably benign	Het
Cacna1g	T	C	11: 94,350,628 (GRCm39)	S406G	probably benign	Het
Ccdc198	G	A	14: 49,473,341 (GRCm39)	T128I	probably benign	Het
Ccdc40	T	A	11: 119,121,522 (GRCm39)		probably null	Het
Cdc5l	A	T	17: 45,718,731 (GRCm39)	D628E	probably benign	Het
Chd3	G	A	11: 69,244,727 (GRCm39)		probably benign	Het
Clstn3	A	T	6: 124,408,958 (GRCm39)	W860R	probably damaging	Het
Cntn4	G	A	6: 106,595,371 (GRCm39)		probably null	Het
Coq10b	A	G	1: 55,100,513 (GRCm39)	R66G	probably damaging	Het
Cpn2	A	T	16: 30,078,485 (GRCm39)	Y405*	probably null	Het
Cyp2b9	T	C	7: 25,886,100 (GRCm39)	V89A	probably benign	Het
Depdc1a	T	C	3: 159,228,924 (GRCm39)	C559R	probably damaging	Het
Ephx1	C	T	1: 180,822,242 (GRCm39)	G101S	probably damaging	Het
Fam20a	A	T	11: 109,568,664 (GRCm39)	N287K	probably damaging	Het
Flg	A	T	3: 93,187,220 (GRCm39)	Y224F	possibly damaging	Het
Fzd8	C	T	18: 9,213,643 (GRCm39)	R242C	probably damaging	Het
Gart	A	C	16: 91,439,837 (GRCm39)		probably benign	Het
Gm11116	T	C	5: 88,259,311 (GRCm39)		probably benign	Het
Gm5519	T	C	19: 33,802,391 (GRCm39)	Y145H	possibly damaging	Het
Gmeb1	G	A	4: 131,962,198 (GRCm39)	Q154*	probably null	Het
Gnas	T	A	2: 174,139,687 (GRCm39)		probably benign	Het
Greb1	A	G	12: 16,773,439 (GRCm39)		probably benign	Het
Grin3a	A	T	4: 49,844,423 (GRCm39)	V220E	probably damaging	Het
Gstt2	T	C	10: 75,670,098 (GRCm39)	D8G	probably damaging	Het
Gucy2c	A	T	6: 136,725,773 (GRCm39)		probably benign	Het
Igf2r	A	C	17: 12,916,328 (GRCm39)	S1677A	possibly damaging	Het
Jmjd1c	T	C	10: 67,061,469 (GRCm39)	L1274P	probably benign	Het
Krt13	A	C	11: 100,011,926 (GRCm39)	H132Q	possibly damaging	Het
L1td1	T	C	4: 98,625,686 (GRCm39)	V627A	probably benign	Het
Lrp6	A	G	6: 134,441,531 (GRCm39)	L1145S	probably damaging	Het
Lrrn4cl	A	G	19: 8,829,135 (GRCm39)	T38A	probably benign	Het
Ly96	A	G	1: 16,776,399 (GRCm39)	T112A	probably benign	Het
Meltf	G	T	16: 31,702,747 (GRCm39)	C158F	probably damaging	Het
Nol8	A	T	13: 49,820,884 (GRCm39)	T914S	probably benign	Het
Npas4	G	A	19: 5,038,211 (GRCm39)	P199L	probably benign	Het
Or12d17	A	T	17: 37,777,792 (GRCm39)	M232L	probably benign	Het
Pcdh10	A	T	3: 45,338,612 (GRCm39)	H923L	probably damaging	Het
Pcp4	A	C	16: 96,326,689 (GRCm39)	Q290P	probably damaging	Het
Pdlim1	C	T	19: 40,240,348 (GRCm39)		probably benign	Het
Pias3	T	C	3: 96,608,719 (GRCm39)	S228P	probably damaging	Het
Pign	A	G	1: 105,580,917 (GRCm39)	V154A	probably benign	Het
Pik3c2a	A	C	7: 115,945,471 (GRCm39)	V1445G	probably damaging	Het
Plod3	T	A	5: 137,019,030 (GRCm39)	V305E	possibly damaging	Het
Plxnc1	A	G	10: 94,685,677 (GRCm39)		probably benign	Het
Prkra	G	T	2: 76,477,584 (GRCm39)	H40Q	possibly damaging	Het
Retnlg	A	T	16: 48,693,991 (GRCm39)	D49V	possibly damaging	Het
Rfx2	A	G	17: 57,091,754 (GRCm39)	V313A	probably benign	Het
Robo2	A	G	16: 73,831,912 (GRCm39)	V256A	probably damaging	Het
Rtp1	A	G	16: 23,250,124 (GRCm39)	E163G	probably damaging	Het
Sbpl	A	G	17: 24,173,777 (GRCm39)		probably null	Het
Scg3	G	A	9: 75,576,622 (GRCm39)	T251M	probably damaging	Het
Setbp1	T	C	18: 78,900,613 (GRCm39)	D1018G	probably damaging	Het
Slc38a11	T	A	2: 65,180,452 (GRCm39)	I182F	probably benign	Het
Slc6a20a	T	A	9: 123,466,165 (GRCm39)	I522F	probably damaging	Het
Smarca2	T	C	19: 26,617,780 (GRCm39)		probably benign	Het
Ssbp3	G	T	4: 106,904,612 (GRCm39)	D336Y	probably damaging	Het
Stox1	T	C	10: 62,495,445 (GRCm39)	T943A	probably damaging	Het
Sun2	A	G	15: 79,609,758 (GRCm39)	S694P	probably benign	Het
Tdp1	G	A	12: 99,857,602 (GRCm39)		probably null	Het
Tfap2a	A	T	13: 40,878,613 (GRCm39)	I204N	probably damaging	Het
Tfip11	T	A	5: 112,482,298 (GRCm39)	W519R	probably damaging	Het
Tie1	T	C	4: 118,333,373 (GRCm39)	E831G	possibly damaging	Het
Tln2	C	T	9: 67,193,796 (GRCm39)	A1773T	probably benign	Het
Tmem39b	A	C	4: 129,586,976 (GRCm39)	I78M	possibly damaging	Het
Trank1	T	C	9: 111,220,547 (GRCm39)	V2428A	probably benign	Het
Trim35	A	G	14: 66,541,617 (GRCm39)	E247G	probably damaging	Het
Trpc7	T	A	13: 56,923,956 (GRCm39)	D743V	probably damaging	Het
Trrap	T	C	5: 144,751,385 (GRCm39)		probably null	Het
Tsc1	A	G	2: 28,566,038 (GRCm39)	I485V	probably damaging	Het
Tsc22d1	T	C	14: 76,655,542 (GRCm39)	S674P	probably damaging	Het
Tsn	A	T	1: 118,228,618 (GRCm39)	D201E	probably damaging	Het
Tsr3	T	C	17: 25,461,613 (GRCm39)	I317T	possibly damaging	Het
Tubb1	A	G	2: 174,298,689 (GRCm39)	S124G	probably benign	Het
Vmn1r192	A	G	13: 22,371,441 (GRCm39)	S260P	probably benign	Het
Vmn2r108	A	T	17: 20,682,786 (GRCm39)	V806E	probably damaging	Het
Wnt10b	A	T	15: 98,670,556 (GRCm39)	L228Q	probably damaging	Het
Zfp108	C	A	7: 23,961,321 (GRCm39)	H637Q	probably damaging	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,460,486 (GRCm39)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,393,244 (GRCm39)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,438,788 (GRCm39)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,432,057 (GRCm39)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,364,189 (GRCm39)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,528,719 (GRCm39)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,466,820 (GRCm39)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,410,078 (GRCm39)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,359,983 (GRCm39)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,392,946 (GRCm39)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,466,928 (GRCm39)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,378,305 (GRCm39)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,528,723 (GRCm39)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,365,415 (GRCm39)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,372,640 (GRCm39)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,425,937 (GRCm39)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,380,647 (GRCm39)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,392,343 (GRCm39)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,461,802 (GRCm39)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,479,643 (GRCm39)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,551,811 (GRCm39)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,522,709 (GRCm39)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,442,621 (GRCm39)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,457,560 (GRCm39)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,392,697 (GRCm39)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,351,678 (GRCm39)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,367,428 (GRCm39)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,414,715 (GRCm39)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,441,805 (GRCm39)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,536,212 (GRCm39)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,392,889 (GRCm39)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,536,134 (GRCm39)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,426,025 (GRCm39)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
compost	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
decompose	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
moulder	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,461,898 (GRCm39)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,389,578 (GRCm39)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,394,070 (GRCm39)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,551,761 (GRCm39)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,394,103 (GRCm39)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,372,569 (GRCm39)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,419,895 (GRCm39)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,433,827 (GRCm39)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,432,024 (GRCm39)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,412,230 (GRCm39)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,457,449 (GRCm39)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,513,293 (GRCm39)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,500,129 (GRCm39)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,422,271 (GRCm39)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,378,353 (GRCm39)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,412,262 (GRCm39)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,437,588 (GRCm39)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,357,999 (GRCm39)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,446,218 (GRCm39)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,393,334 (GRCm39)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,536,303 (GRCm39)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,441,825 (GRCm39)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,470,033 (GRCm39)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,407,287 (GRCm39)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,464,947 (GRCm39)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,461,852 (GRCm39)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,485,841 (GRCm39)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,419,855 (GRCm39)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,393,150 (GRCm39)	missense	possibly damaging	0.94
R1916:Mycbp2	UTSW	14	103,422,319 (GRCm39)	missense	probably damaging	1.00
R1944:Mycbp2	UTSW	14	103,466,840 (GRCm39)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,383,407 (GRCm39)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,485,839 (GRCm39)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,497,675 (GRCm39)	missense	probably damaging	1.00
R2048:Mycbp2	UTSW	14	103,469,960 (GRCm39)	critical splice donor site	probably null
R2061:Mycbp2	UTSW	14	103,524,696 (GRCm39)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,457,512 (GRCm39)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,438,666 (GRCm39)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,383,378 (GRCm39)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,407,291 (GRCm39)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,407,295 (GRCm39)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,500,185 (GRCm39)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,381,774 (GRCm39)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,412,386 (GRCm39)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,437,554 (GRCm39)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,368,681 (GRCm39)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,392,691 (GRCm39)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,534,794 (GRCm39)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,446,179 (GRCm39)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,437,550 (GRCm39)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,372,553 (GRCm39)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,466,866 (GRCm39)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,393,850 (GRCm39)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,371,224 (GRCm39)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,434,721 (GRCm39)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,412,233 (GRCm39)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,364,149 (GRCm39)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,441,936 (GRCm39)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,532,688 (GRCm39)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,376,161 (GRCm39)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,389,593 (GRCm39)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,485,893 (GRCm39)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,360,881 (GRCm39)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,524,664 (GRCm39)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,372,702 (GRCm39)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,371,225 (GRCm39)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,425,938 (GRCm39)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,393,094 (GRCm39)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,583,733 (GRCm39)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,414,749 (GRCm39)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,426,027 (GRCm39)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,457,380 (GRCm39)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,466,873 (GRCm39)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,448,731 (GRCm39)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,383,382 (GRCm39)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,524,675 (GRCm39)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,497,821 (GRCm39)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,393,946 (GRCm39)	missense	probably benign	0.21
R5038:Mycbp2	UTSW	14	103,534,375 (GRCm39)	missense	probably damaging	1.00
R5044:Mycbp2	UTSW	14	103,376,671 (GRCm39)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,583,650 (GRCm39)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,583,757 (GRCm39)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,423,119 (GRCm39)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,479,868 (GRCm39)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,543,697 (GRCm39)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,438,837 (GRCm39)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,437,562 (GRCm39)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,479,615 (GRCm39)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,411,250 (GRCm39)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,532,673 (GRCm39)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,520,081 (GRCm39)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,372,679 (GRCm39)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,380,203 (GRCm39)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,528,769 (GRCm39)	missense	probably damaging	0.98
R5590:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	1.00
R5592:Mycbp2	UTSW	14	103,432,113 (GRCm39)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,426,051 (GRCm39)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,426,044 (GRCm39)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,407,346 (GRCm39)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,528,778 (GRCm39)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,520,101 (GRCm39)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,357,955 (GRCm39)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,385,986 (GRCm39)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,371,410 (GRCm39)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,361,839 (GRCm39)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,364,120 (GRCm39)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,394,159 (GRCm39)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,372,582 (GRCm39)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,460,482 (GRCm39)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,513,323 (GRCm39)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,522,836 (GRCm39)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,392,945 (GRCm39)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,536,183 (GRCm39)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,384,453 (GRCm39)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,497,665 (GRCm39)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,392,862 (GRCm39)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,500,176 (GRCm39)	missense	possibly damaging	0.93
R6329:Mycbp2	UTSW	14	103,393,288 (GRCm39)	missense	probably benign	0.00
R6439:Mycbp2	UTSW	14	103,392,911 (GRCm39)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,373,993 (GRCm39)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,380,317 (GRCm39)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,429,003 (GRCm39)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,376,845 (GRCm39)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,497,630 (GRCm39)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,522,703 (GRCm39)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,392,342 (GRCm39)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,444,117 (GRCm39)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,412,417 (GRCm39)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,393,534 (GRCm39)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,360,039 (GRCm39)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,391,513 (GRCm39)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,520,115 (GRCm39)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,497,636 (GRCm39)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,371,282 (GRCm39)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,452,773 (GRCm39)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,393,733 (GRCm39)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,446,345 (GRCm39)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,434,679 (GRCm39)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,358,027 (GRCm39)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,434,793 (GRCm39)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,513,829 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,480,564 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,389,627 (GRCm39)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,526,180 (GRCm39)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,434,690 (GRCm39)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,583,701 (GRCm39)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,450,059 (GRCm39)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,429,045 (GRCm39)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,429,055 (GRCm39)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,485,840 (GRCm39)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,364,533 (GRCm39)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,376,851 (GRCm39)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,414,729 (GRCm39)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,384,267 (GRCm39)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,393,741 (GRCm39)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,393,582 (GRCm39)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,437,621 (GRCm39)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,392,674 (GRCm39)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,452,898 (GRCm39)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,367,400 (GRCm39)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,436,110 (GRCm39)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,392,640 (GRCm39)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,372,701 (GRCm39)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,398,111 (GRCm39)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,376,250 (GRCm39)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,446,267 (GRCm39)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,392,895 (GRCm39)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,450,155 (GRCm39)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,460,586 (GRCm39)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,466,871 (GRCm39)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,393,781 (GRCm39)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,361,857 (GRCm39)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,446,232 (GRCm39)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,551,752 (GRCm39)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,479,796 (GRCm39)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,469,974 (GRCm39)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,434,753 (GRCm39)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,425,960 (GRCm39)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,497,642 (GRCm39)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,497,705 (GRCm39)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,372,697 (GRCm39)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,433,817 (GRCm39)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,371,474 (GRCm39)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,448,749 (GRCm39)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,434,852 (GRCm39)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,520,229 (GRCm39)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,551,806 (GRCm39)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,384,378 (GRCm39)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,583,685 (GRCm39)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,394,073 (GRCm39)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,407,309 (GRCm39)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,372,559 (GRCm39)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,364,499 (GRCm39)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- CCTCCAAGCCCACAAGGAATGTAGTAT -3'
(R):5'- GACAACTGGGAAGACCCATTTTGGAT -3'

Sequencing Primer
(F):5'- AGGTTGGGTCACCATAATCTC -3'
(R):5'- GGGAAGACCCATTTTGGATATACC -3'

Posted On

2014-05-23