Incidental Mutation 'R1753:Duox1'
| ID |
193703 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
039785-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1753 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 122163910 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 859
(M859K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099461]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099461
AA Change: M859K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: M859K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
A |
T |
11: 109,864,542 (GRCm39) |
F409I |
probably benign |
Het |
| Adamts19 |
A |
C |
18: 59,140,444 (GRCm39) |
I848L |
possibly damaging |
Het |
| Adamts5 |
T |
C |
16: 85,696,240 (GRCm39) |
S306G |
probably damaging |
Het |
| Adamts8 |
T |
G |
9: 30,865,910 (GRCm39) |
I486S |
probably benign |
Het |
| Adgrg5 |
T |
C |
8: 95,668,680 (GRCm39) |
F499L |
possibly damaging |
Het |
| Akr1c21 |
T |
A |
13: 4,627,134 (GRCm39) |
C145* |
probably null |
Het |
| Anp32b |
T |
G |
4: 46,460,241 (GRCm39) |
|
probably null |
Het |
| Arhgap31 |
A |
G |
16: 38,421,974 (GRCm39) |
V1364A |
possibly damaging |
Het |
| C2cd6 |
T |
C |
1: 59,133,992 (GRCm39) |
R10G |
possibly damaging |
Het |
| Cacna2d1 |
A |
G |
5: 16,507,352 (GRCm39) |
E367G |
possibly damaging |
Het |
| Ccdc81 |
C |
T |
7: 89,515,769 (GRCm39) |
E637K |
probably benign |
Het |
| Cd2 |
A |
T |
3: 101,194,815 (GRCm39) |
M91K |
possibly damaging |
Het |
| Cdc16 |
C |
A |
8: 13,814,688 (GRCm39) |
Y157* |
probably null |
Het |
| Celsr3 |
G |
T |
9: 108,709,056 (GRCm39) |
V1301F |
probably damaging |
Het |
| Cep164 |
C |
T |
9: 45,704,235 (GRCm39) |
G961S |
probably damaging |
Het |
| Cep290 |
T |
C |
10: 100,349,843 (GRCm39) |
V630A |
probably benign |
Het |
| Chd5 |
C |
T |
4: 152,463,272 (GRCm39) |
S1451F |
probably damaging |
Het |
| Cldn23 |
A |
C |
8: 36,293,140 (GRCm39) |
L116R |
possibly damaging |
Het |
| Cngb1 |
A |
T |
8: 96,024,401 (GRCm39) |
|
probably benign |
Het |
| Cpb1 |
G |
T |
3: 20,320,405 (GRCm39) |
N151K |
possibly damaging |
Het |
| Cpn2 |
A |
G |
16: 30,078,918 (GRCm39) |
F261S |
probably damaging |
Het |
| Crlf3 |
A |
C |
11: 79,948,698 (GRCm39) |
V249G |
probably damaging |
Het |
| Csmd1 |
A |
T |
8: 16,207,134 (GRCm39) |
Y1298* |
probably null |
Het |
| Cstf2t |
C |
A |
19: 31,061,085 (GRCm39) |
P207Q |
possibly damaging |
Het |
| Cym |
A |
C |
3: 107,120,741 (GRCm39) |
L288R |
possibly damaging |
Het |
| Cyp2j12 |
C |
T |
4: 96,009,669 (GRCm39) |
|
probably null |
Het |
| Dlx6 |
C |
T |
6: 6,863,665 (GRCm39) |
Q96* |
probably null |
Het |
| Dnah7b |
T |
C |
1: 46,361,495 (GRCm39) |
F3465S |
probably damaging |
Het |
| Dnmt3a |
A |
T |
12: 3,923,342 (GRCm39) |
M181L |
possibly damaging |
Het |
| Eif2b4 |
A |
T |
5: 31,350,284 (GRCm39) |
S13T |
probably benign |
Het |
| Ercc6 |
T |
C |
14: 32,298,956 (GRCm39) |
V1448A |
probably benign |
Het |
| Esp24 |
A |
G |
17: 39,350,893 (GRCm39) |
E31G |
possibly damaging |
Het |
| F2rl2 |
T |
A |
13: 95,837,969 (GRCm39) |
M338K |
probably benign |
Het |
| Fbxl9 |
A |
T |
8: 106,039,824 (GRCm39) |
V517E |
probably damaging |
Het |
| Fgfbp1 |
A |
C |
5: 44,137,265 (GRCm39) |
L9R |
possibly damaging |
Het |
| Gal3st2b |
A |
T |
1: 93,868,338 (GRCm39) |
N188Y |
probably damaging |
Het |
| Gpr179 |
G |
C |
11: 97,237,404 (GRCm39) |
C372W |
probably damaging |
Het |
| Grn |
T |
G |
11: 102,324,093 (GRCm39) |
C61G |
probably damaging |
Het |
| Herc1 |
T |
G |
9: 66,376,292 (GRCm39) |
C3371G |
probably damaging |
Het |
| Herc1 |
T |
C |
9: 66,409,366 (GRCm39) |
|
probably null |
Het |
| Hmcn1 |
C |
T |
1: 150,462,219 (GRCm39) |
G5153D |
possibly damaging |
Het |
| Ifi35 |
A |
T |
11: 101,347,461 (GRCm39) |
R31W |
probably damaging |
Het |
| Ifit1bl1 |
T |
A |
19: 34,571,260 (GRCm39) |
H399L |
probably benign |
Het |
| Irx3 |
G |
A |
8: 92,527,362 (GRCm39) |
P114L |
probably damaging |
Het |
| Kat6a |
T |
A |
8: 23,425,813 (GRCm39) |
D1119E |
probably benign |
Het |
| Kmt2d |
G |
T |
15: 98,741,363 (GRCm39) |
|
probably benign |
Het |
| Kng1 |
A |
T |
16: 22,897,869 (GRCm39) |
H423L |
possibly damaging |
Het |
| Lrp2 |
T |
A |
2: 69,326,833 (GRCm39) |
Q1746L |
possibly damaging |
Het |
| Lrrc63 |
A |
T |
14: 75,323,784 (GRCm39) |
|
probably null |
Het |
| Mad2l1 |
T |
A |
6: 66,516,797 (GRCm39) |
V163E |
possibly damaging |
Het |
| Map3k19 |
A |
G |
1: 127,750,417 (GRCm39) |
M978T |
probably benign |
Het |
| Mon1a |
A |
C |
9: 107,778,562 (GRCm39) |
N262T |
probably damaging |
Het |
| Mpo |
A |
G |
11: 87,686,707 (GRCm39) |
N85D |
probably benign |
Het |
| Mpp4 |
T |
C |
1: 59,183,969 (GRCm39) |
D244G |
probably null |
Het |
| Mstn |
A |
G |
1: 53,105,717 (GRCm39) |
Y353C |
probably damaging |
Het |
| Mx1 |
T |
A |
16: 97,255,358 (GRCm39) |
N232Y |
probably damaging |
Het |
| Mycs |
T |
C |
X: 5,380,157 (GRCm39) |
R308G |
probably benign |
Het |
| Myh11 |
A |
T |
16: 14,095,734 (GRCm39) |
D9E |
probably benign |
Het |
| Nfe2l3 |
A |
T |
6: 51,410,392 (GRCm39) |
Q169L |
probably null |
Het |
| Nr5a1 |
G |
T |
2: 38,598,431 (GRCm39) |
T122N |
possibly damaging |
Het |
| Nras |
A |
G |
3: 102,966,295 (GRCm39) |
T20A |
probably damaging |
Het |
| Obp2b |
T |
A |
2: 25,628,652 (GRCm39) |
|
probably null |
Het |
| Or1l4 |
A |
G |
2: 37,091,439 (GRCm39) |
Y62C |
probably damaging |
Het |
| Or51g2 |
T |
C |
7: 102,622,263 (GRCm39) |
N312S |
probably benign |
Het |
| Or5aq6 |
T |
C |
2: 86,923,571 (GRCm39) |
T57A |
probably damaging |
Het |
| Or5w18 |
T |
A |
2: 87,633,106 (GRCm39) |
F124L |
probably benign |
Het |
| Or9s14 |
G |
A |
1: 92,536,122 (GRCm39) |
V188M |
probably benign |
Het |
| Pcdh17 |
A |
T |
14: 84,715,094 (GRCm39) |
T920S |
probably benign |
Het |
| Pcdh9 |
T |
C |
14: 94,124,661 (GRCm39) |
D503G |
probably benign |
Het |
| Pcdhb12 |
C |
T |
18: 37,569,724 (GRCm39) |
T290I |
probably damaging |
Het |
| Pde6b |
C |
A |
5: 108,536,557 (GRCm39) |
C84* |
probably null |
Het |
| Pex1 |
A |
T |
5: 3,680,044 (GRCm39) |
N914I |
probably damaging |
Het |
| Pign |
A |
G |
1: 105,517,042 (GRCm39) |
V528A |
possibly damaging |
Het |
| Pkhd1 |
T |
G |
1: 20,604,129 (GRCm39) |
D1187A |
possibly damaging |
Het |
| Ppip5k1 |
T |
C |
2: 121,173,112 (GRCm39) |
K489E |
probably damaging |
Het |
| Prob1 |
T |
C |
18: 35,786,305 (GRCm39) |
T650A |
possibly damaging |
Het |
| Radil |
T |
C |
5: 142,481,091 (GRCm39) |
Y572C |
probably damaging |
Het |
| Rapgef2 |
A |
G |
3: 78,996,098 (GRCm39) |
I555T |
possibly damaging |
Het |
| Rgs5 |
G |
A |
1: 169,510,386 (GRCm39) |
|
probably null |
Het |
| Rnaset2b |
G |
A |
17: 7,248,506 (GRCm39) |
|
probably null |
Het |
| S1pr1 |
A |
G |
3: 115,505,587 (GRCm39) |
S336P |
probably benign |
Het |
| Slc24a5 |
A |
G |
2: 124,925,115 (GRCm39) |
E252G |
possibly damaging |
Het |
| Slc34a2 |
A |
T |
5: 53,218,733 (GRCm39) |
I184F |
probably benign |
Het |
| Slc35a3 |
A |
G |
3: 116,471,597 (GRCm39) |
V224A |
possibly damaging |
Het |
| Slc39a9 |
A |
G |
12: 80,723,976 (GRCm39) |
H211R |
probably damaging |
Het |
| Slu7 |
A |
G |
11: 43,330,095 (GRCm39) |
N174S |
probably benign |
Het |
| Smarcd3 |
A |
T |
5: 24,800,820 (GRCm39) |
Y131* |
probably null |
Het |
| Syne1 |
A |
G |
10: 5,317,621 (GRCm39) |
M491T |
probably benign |
Het |
| Tars1 |
G |
A |
15: 11,394,329 (GRCm39) |
Q103* |
probably null |
Het |
| Tmem132d |
C |
A |
5: 127,866,919 (GRCm39) |
E660D |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,575,387 (GRCm39) |
T16842A |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,643,316 (GRCm39) |
E13201G |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,582,605 (GRCm39) |
M22763L |
probably benign |
Het |
| Ubp1 |
A |
T |
9: 113,785,037 (GRCm39) |
I117L |
possibly damaging |
Het |
| Usp24 |
T |
A |
4: 106,234,756 (GRCm39) |
H954Q |
probably benign |
Het |
| Vmn1r174 |
G |
A |
7: 23,453,622 (GRCm39) |
R96H |
probably benign |
Het |
| Vmn2r63 |
G |
A |
7: 42,577,669 (GRCm39) |
Q290* |
probably null |
Het |
| Vnn3 |
T |
C |
10: 23,741,718 (GRCm39) |
I341T |
probably benign |
Het |
| Wbp2nl |
A |
G |
15: 82,189,945 (GRCm39) |
T46A |
probably damaging |
Het |
| Wdr48 |
G |
T |
9: 119,753,313 (GRCm39) |
E625* |
probably null |
Het |
| Wdr6 |
C |
T |
9: 108,452,363 (GRCm39) |
V507I |
probably damaging |
Het |
| Zp2 |
A |
T |
7: 119,737,328 (GRCm39) |
W287R |
probably benign |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1827:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGACAGAAGTGGGCTACTGATG -3'
(R):5'- AGCATGAAGTGGAAGTCCTCCCAG -3'
Sequencing Primer
(F):5'- ATGTTGTATTGGAGATAGAGAGCC -3'
(R):5'- TTGTCCTGGAAGCCAGACTC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation