Incidental Mutation 'R1753:Usp24'
| ID |
193716 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Usp24
|
| Ensembl Gene |
ENSMUSG00000028514 |
| Gene Name |
ubiquitin specific peptidase 24 |
| Synonyms |
2700066K03Rik, 2810030C21Rik |
| MMRRC Submission |
039785-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1753 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
106173410-106298519 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 106234756 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 954
(H954Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094933]
[ENSMUST00000165709]
|
| AlphaFold |
B1AY13 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094933
AA Change: H953Q
PolyPhen 2
Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000092538
Gene: ENSMUSG00000028514
AA Change: H953Q
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:UBA
|
5 |
43 |
2e-16 |
BLAST |
|
low complexity region
|
57 |
96 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
348 |
882 |
6e-7 |
SMART |
|
low complexity region
|
1031 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1150 |
N/A |
INTRINSIC |
|
low complexity region
|
1365 |
1378 |
N/A |
INTRINSIC |
|
Pfam:UCH
|
1685 |
2036 |
3.7e-54 |
PFAM |
|
Pfam:UCH_1
|
1686 |
1993 |
1.8e-27 |
PFAM |
|
low complexity region
|
2066 |
2081 |
N/A |
INTRINSIC |
|
low complexity region
|
2256 |
2267 |
N/A |
INTRINSIC |
|
low complexity region
|
2576 |
2592 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165709
AA Change: H954Q
PolyPhen 2
Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000133095
Gene: ENSMUSG00000028514
AA Change: H954Q
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:UBA
|
5 |
43 |
2e-16 |
BLAST |
|
low complexity region
|
57 |
96 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
348 |
883 |
8e-7 |
SMART |
|
low complexity region
|
1032 |
1060 |
N/A |
INTRINSIC |
|
low complexity region
|
1125 |
1151 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1379 |
N/A |
INTRINSIC |
|
Pfam:UCH
|
1686 |
2037 |
2e-49 |
PFAM |
|
Pfam:UCH_1
|
1687 |
1994 |
4e-24 |
PFAM |
|
low complexity region
|
2067 |
2082 |
N/A |
INTRINSIC |
|
low complexity region
|
2257 |
2268 |
N/A |
INTRINSIC |
|
low complexity region
|
2577 |
2593 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
A |
T |
11: 109,864,542 (GRCm39) |
F409I |
probably benign |
Het |
| Adamts19 |
A |
C |
18: 59,140,444 (GRCm39) |
I848L |
possibly damaging |
Het |
| Adamts5 |
T |
C |
16: 85,696,240 (GRCm39) |
S306G |
probably damaging |
Het |
| Adamts8 |
T |
G |
9: 30,865,910 (GRCm39) |
I486S |
probably benign |
Het |
| Adgrg5 |
T |
C |
8: 95,668,680 (GRCm39) |
F499L |
possibly damaging |
Het |
| Akr1c21 |
T |
A |
13: 4,627,134 (GRCm39) |
C145* |
probably null |
Het |
| Anp32b |
T |
G |
4: 46,460,241 (GRCm39) |
|
probably null |
Het |
| Arhgap31 |
A |
G |
16: 38,421,974 (GRCm39) |
V1364A |
possibly damaging |
Het |
| C2cd6 |
T |
C |
1: 59,133,992 (GRCm39) |
R10G |
possibly damaging |
Het |
| Cacna2d1 |
A |
G |
5: 16,507,352 (GRCm39) |
E367G |
possibly damaging |
Het |
| Ccdc81 |
C |
T |
7: 89,515,769 (GRCm39) |
E637K |
probably benign |
Het |
| Cd2 |
A |
T |
3: 101,194,815 (GRCm39) |
M91K |
possibly damaging |
Het |
| Cdc16 |
C |
A |
8: 13,814,688 (GRCm39) |
Y157* |
probably null |
Het |
| Celsr3 |
G |
T |
9: 108,709,056 (GRCm39) |
V1301F |
probably damaging |
Het |
| Cep164 |
C |
T |
9: 45,704,235 (GRCm39) |
G961S |
probably damaging |
Het |
| Cep290 |
T |
C |
10: 100,349,843 (GRCm39) |
V630A |
probably benign |
Het |
| Chd5 |
C |
T |
4: 152,463,272 (GRCm39) |
S1451F |
probably damaging |
Het |
| Cldn23 |
A |
C |
8: 36,293,140 (GRCm39) |
L116R |
possibly damaging |
Het |
| Cngb1 |
A |
T |
8: 96,024,401 (GRCm39) |
|
probably benign |
Het |
| Cpb1 |
G |
T |
3: 20,320,405 (GRCm39) |
N151K |
possibly damaging |
Het |
| Cpn2 |
A |
G |
16: 30,078,918 (GRCm39) |
F261S |
probably damaging |
Het |
| Crlf3 |
A |
C |
11: 79,948,698 (GRCm39) |
V249G |
probably damaging |
Het |
| Csmd1 |
A |
T |
8: 16,207,134 (GRCm39) |
Y1298* |
probably null |
Het |
| Cstf2t |
C |
A |
19: 31,061,085 (GRCm39) |
P207Q |
possibly damaging |
Het |
| Cym |
A |
C |
3: 107,120,741 (GRCm39) |
L288R |
possibly damaging |
Het |
| Cyp2j12 |
C |
T |
4: 96,009,669 (GRCm39) |
|
probably null |
Het |
| Dlx6 |
C |
T |
6: 6,863,665 (GRCm39) |
Q96* |
probably null |
Het |
| Dnah7b |
T |
C |
1: 46,361,495 (GRCm39) |
F3465S |
probably damaging |
Het |
| Dnmt3a |
A |
T |
12: 3,923,342 (GRCm39) |
M181L |
possibly damaging |
Het |
| Duox1 |
T |
A |
2: 122,163,910 (GRCm39) |
M859K |
probably damaging |
Het |
| Eif2b4 |
A |
T |
5: 31,350,284 (GRCm39) |
S13T |
probably benign |
Het |
| Ercc6 |
T |
C |
14: 32,298,956 (GRCm39) |
V1448A |
probably benign |
Het |
| Esp24 |
A |
G |
17: 39,350,893 (GRCm39) |
E31G |
possibly damaging |
Het |
| F2rl2 |
T |
A |
13: 95,837,969 (GRCm39) |
M338K |
probably benign |
Het |
| Fbxl9 |
A |
T |
8: 106,039,824 (GRCm39) |
V517E |
probably damaging |
Het |
| Fgfbp1 |
A |
C |
5: 44,137,265 (GRCm39) |
L9R |
possibly damaging |
Het |
| Gal3st2b |
A |
T |
1: 93,868,338 (GRCm39) |
N188Y |
probably damaging |
Het |
| Gpr179 |
G |
C |
11: 97,237,404 (GRCm39) |
C372W |
probably damaging |
Het |
| Grn |
T |
G |
11: 102,324,093 (GRCm39) |
C61G |
probably damaging |
Het |
| Herc1 |
T |
G |
9: 66,376,292 (GRCm39) |
C3371G |
probably damaging |
Het |
| Herc1 |
T |
C |
9: 66,409,366 (GRCm39) |
|
probably null |
Het |
| Hmcn1 |
C |
T |
1: 150,462,219 (GRCm39) |
G5153D |
possibly damaging |
Het |
| Ifi35 |
A |
T |
11: 101,347,461 (GRCm39) |
R31W |
probably damaging |
Het |
| Ifit1bl1 |
T |
A |
19: 34,571,260 (GRCm39) |
H399L |
probably benign |
Het |
| Irx3 |
G |
A |
8: 92,527,362 (GRCm39) |
P114L |
probably damaging |
Het |
| Kat6a |
T |
A |
8: 23,425,813 (GRCm39) |
D1119E |
probably benign |
Het |
| Kmt2d |
G |
T |
15: 98,741,363 (GRCm39) |
|
probably benign |
Het |
| Kng1 |
A |
T |
16: 22,897,869 (GRCm39) |
H423L |
possibly damaging |
Het |
| Lrp2 |
T |
A |
2: 69,326,833 (GRCm39) |
Q1746L |
possibly damaging |
Het |
| Lrrc63 |
A |
T |
14: 75,323,784 (GRCm39) |
|
probably null |
Het |
| Mad2l1 |
T |
A |
6: 66,516,797 (GRCm39) |
V163E |
possibly damaging |
Het |
| Map3k19 |
A |
G |
1: 127,750,417 (GRCm39) |
M978T |
probably benign |
Het |
| Mon1a |
A |
C |
9: 107,778,562 (GRCm39) |
N262T |
probably damaging |
Het |
| Mpo |
A |
G |
11: 87,686,707 (GRCm39) |
N85D |
probably benign |
Het |
| Mpp4 |
T |
C |
1: 59,183,969 (GRCm39) |
D244G |
probably null |
Het |
| Mstn |
A |
G |
1: 53,105,717 (GRCm39) |
Y353C |
probably damaging |
Het |
| Mx1 |
T |
A |
16: 97,255,358 (GRCm39) |
N232Y |
probably damaging |
Het |
| Mycs |
T |
C |
X: 5,380,157 (GRCm39) |
R308G |
probably benign |
Het |
| Myh11 |
A |
T |
16: 14,095,734 (GRCm39) |
D9E |
probably benign |
Het |
| Nfe2l3 |
A |
T |
6: 51,410,392 (GRCm39) |
Q169L |
probably null |
Het |
| Nr5a1 |
G |
T |
2: 38,598,431 (GRCm39) |
T122N |
possibly damaging |
Het |
| Nras |
A |
G |
3: 102,966,295 (GRCm39) |
T20A |
probably damaging |
Het |
| Obp2b |
T |
A |
2: 25,628,652 (GRCm39) |
|
probably null |
Het |
| Or1l4 |
A |
G |
2: 37,091,439 (GRCm39) |
Y62C |
probably damaging |
Het |
| Or51g2 |
T |
C |
7: 102,622,263 (GRCm39) |
N312S |
probably benign |
Het |
| Or5aq6 |
T |
C |
2: 86,923,571 (GRCm39) |
T57A |
probably damaging |
Het |
| Or5w18 |
T |
A |
2: 87,633,106 (GRCm39) |
F124L |
probably benign |
Het |
| Or9s14 |
G |
A |
1: 92,536,122 (GRCm39) |
V188M |
probably benign |
Het |
| Pcdh17 |
A |
T |
14: 84,715,094 (GRCm39) |
T920S |
probably benign |
Het |
| Pcdh9 |
T |
C |
14: 94,124,661 (GRCm39) |
D503G |
probably benign |
Het |
| Pcdhb12 |
C |
T |
18: 37,569,724 (GRCm39) |
T290I |
probably damaging |
Het |
| Pde6b |
C |
A |
5: 108,536,557 (GRCm39) |
C84* |
probably null |
Het |
| Pex1 |
A |
T |
5: 3,680,044 (GRCm39) |
N914I |
probably damaging |
Het |
| Pign |
A |
G |
1: 105,517,042 (GRCm39) |
V528A |
possibly damaging |
Het |
| Pkhd1 |
T |
G |
1: 20,604,129 (GRCm39) |
D1187A |
possibly damaging |
Het |
| Ppip5k1 |
T |
C |
2: 121,173,112 (GRCm39) |
K489E |
probably damaging |
Het |
| Prob1 |
T |
C |
18: 35,786,305 (GRCm39) |
T650A |
possibly damaging |
Het |
| Radil |
T |
C |
5: 142,481,091 (GRCm39) |
Y572C |
probably damaging |
Het |
| Rapgef2 |
A |
G |
3: 78,996,098 (GRCm39) |
I555T |
possibly damaging |
Het |
| Rgs5 |
G |
A |
1: 169,510,386 (GRCm39) |
|
probably null |
Het |
| Rnaset2b |
G |
A |
17: 7,248,506 (GRCm39) |
|
probably null |
Het |
| S1pr1 |
A |
G |
3: 115,505,587 (GRCm39) |
S336P |
probably benign |
Het |
| Slc24a5 |
A |
G |
2: 124,925,115 (GRCm39) |
E252G |
possibly damaging |
Het |
| Slc34a2 |
A |
T |
5: 53,218,733 (GRCm39) |
I184F |
probably benign |
Het |
| Slc35a3 |
A |
G |
3: 116,471,597 (GRCm39) |
V224A |
possibly damaging |
Het |
| Slc39a9 |
A |
G |
12: 80,723,976 (GRCm39) |
H211R |
probably damaging |
Het |
| Slu7 |
A |
G |
11: 43,330,095 (GRCm39) |
N174S |
probably benign |
Het |
| Smarcd3 |
A |
T |
5: 24,800,820 (GRCm39) |
Y131* |
probably null |
Het |
| Syne1 |
A |
G |
10: 5,317,621 (GRCm39) |
M491T |
probably benign |
Het |
| Tars1 |
G |
A |
15: 11,394,329 (GRCm39) |
Q103* |
probably null |
Het |
| Tmem132d |
C |
A |
5: 127,866,919 (GRCm39) |
E660D |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,575,387 (GRCm39) |
T16842A |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,643,316 (GRCm39) |
E13201G |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,582,605 (GRCm39) |
M22763L |
probably benign |
Het |
| Ubp1 |
A |
T |
9: 113,785,037 (GRCm39) |
I117L |
possibly damaging |
Het |
| Vmn1r174 |
G |
A |
7: 23,453,622 (GRCm39) |
R96H |
probably benign |
Het |
| Vmn2r63 |
G |
A |
7: 42,577,669 (GRCm39) |
Q290* |
probably null |
Het |
| Vnn3 |
T |
C |
10: 23,741,718 (GRCm39) |
I341T |
probably benign |
Het |
| Wbp2nl |
A |
G |
15: 82,189,945 (GRCm39) |
T46A |
probably damaging |
Het |
| Wdr48 |
G |
T |
9: 119,753,313 (GRCm39) |
E625* |
probably null |
Het |
| Wdr6 |
C |
T |
9: 108,452,363 (GRCm39) |
V507I |
probably damaging |
Het |
| Zp2 |
A |
T |
7: 119,737,328 (GRCm39) |
W287R |
probably benign |
Het |
|
| Other mutations in Usp24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00329:Usp24
|
APN |
4 |
106,216,288 (GRCm39) |
missense |
probably benign |
|
|
IGL00340:Usp24
|
APN |
4 |
106,258,336 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00480:Usp24
|
APN |
4 |
106,225,303 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00548:Usp24
|
APN |
4 |
106,198,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00655:Usp24
|
APN |
4 |
106,247,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00674:Usp24
|
APN |
4 |
106,229,876 (GRCm39) |
splice site |
probably benign |
|
|
IGL00718:Usp24
|
APN |
4 |
106,266,901 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL00803:Usp24
|
APN |
4 |
106,242,723 (GRCm39) |
splice site |
probably benign |
|
|
IGL01161:Usp24
|
APN |
4 |
106,294,041 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01344:Usp24
|
APN |
4 |
106,236,582 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01374:Usp24
|
APN |
4 |
106,237,296 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01485:Usp24
|
APN |
4 |
106,219,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01736:Usp24
|
APN |
4 |
106,280,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01737:Usp24
|
APN |
4 |
106,244,931 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01862:Usp24
|
APN |
4 |
106,266,095 (GRCm39) |
splice site |
probably benign |
|
|
IGL01981:Usp24
|
APN |
4 |
106,232,965 (GRCm39) |
splice site |
probably benign |
|
|
IGL02090:Usp24
|
APN |
4 |
106,268,623 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02275:Usp24
|
APN |
4 |
106,244,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02352:Usp24
|
APN |
4 |
106,261,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02359:Usp24
|
APN |
4 |
106,261,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Usp24
|
APN |
4 |
106,264,326 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL02418:Usp24
|
APN |
4 |
106,293,557 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02537:Usp24
|
APN |
4 |
106,249,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02638:Usp24
|
APN |
4 |
106,295,969 (GRCm39) |
splice site |
probably benign |
|
|
IGL02638:Usp24
|
APN |
4 |
106,295,967 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Usp24
|
APN |
4 |
106,204,584 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03125:Usp24
|
APN |
4 |
106,249,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03280:Usp24
|
APN |
4 |
106,237,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03350:Usp24
|
APN |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
BB010:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
BB020:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
IGL03098:Usp24
|
UTSW |
4 |
106,228,230 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0035:Usp24
|
UTSW |
4 |
106,225,224 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0044:Usp24
|
UTSW |
4 |
106,269,281 (GRCm39) |
splice site |
probably benign |
|
|
R0086:Usp24
|
UTSW |
4 |
106,249,557 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0125:Usp24
|
UTSW |
4 |
106,254,496 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0197:Usp24
|
UTSW |
4 |
106,264,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0240:Usp24
|
UTSW |
4 |
106,271,601 (GRCm39) |
nonsense |
probably null |
|
|
R0240:Usp24
|
UTSW |
4 |
106,271,601 (GRCm39) |
nonsense |
probably null |
|
|
R0491:Usp24
|
UTSW |
4 |
106,259,302 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0687:Usp24
|
UTSW |
4 |
106,277,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0973:Usp24
|
UTSW |
4 |
106,270,875 (GRCm39) |
splice site |
probably null |
|
|
R0973:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R0973:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R0974:Usp24
|
UTSW |
4 |
106,270,875 (GRCm39) |
splice site |
probably null |
|
|
R0974:Usp24
|
UTSW |
4 |
106,228,276 (GRCm39) |
nonsense |
probably null |
|
|
R1163:Usp24
|
UTSW |
4 |
106,278,157 (GRCm39) |
missense |
probably benign |
|
|
R1293:Usp24
|
UTSW |
4 |
106,280,750 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1333:Usp24
|
UTSW |
4 |
106,199,550 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1476:Usp24
|
UTSW |
4 |
106,219,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Usp24
|
UTSW |
4 |
106,296,024 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1728:Usp24
|
UTSW |
4 |
106,217,618 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1729:Usp24
|
UTSW |
4 |
106,217,618 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1917:Usp24
|
UTSW |
4 |
106,267,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Usp24
|
UTSW |
4 |
106,258,177 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R2424:Usp24
|
UTSW |
4 |
106,256,310 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2436:Usp24
|
UTSW |
4 |
106,266,842 (GRCm39) |
nonsense |
probably null |
|
|
R2513:Usp24
|
UTSW |
4 |
106,236,602 (GRCm39) |
splice site |
probably null |
|
|
R3824:Usp24
|
UTSW |
4 |
106,236,263 (GRCm39) |
missense |
probably benign |
|
|
R3831:Usp24
|
UTSW |
4 |
106,219,209 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3833:Usp24
|
UTSW |
4 |
106,219,209 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3982:Usp24
|
UTSW |
4 |
106,245,080 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4022:Usp24
|
UTSW |
4 |
106,236,421 (GRCm39) |
splice site |
probably benign |
|
|
R4067:Usp24
|
UTSW |
4 |
106,216,286 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4175:Usp24
|
UTSW |
4 |
106,173,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4766:Usp24
|
UTSW |
4 |
106,273,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Usp24
|
UTSW |
4 |
106,219,377 (GRCm39) |
splice site |
probably null |
|
|
R4798:Usp24
|
UTSW |
4 |
106,217,359 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4809:Usp24
|
UTSW |
4 |
106,270,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4822:Usp24
|
UTSW |
4 |
106,273,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4906:Usp24
|
UTSW |
4 |
106,245,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4934:Usp24
|
UTSW |
4 |
106,283,743 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5074:Usp24
|
UTSW |
4 |
106,277,644 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5151:Usp24
|
UTSW |
4 |
106,256,309 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5220:Usp24
|
UTSW |
4 |
106,239,500 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5279:Usp24
|
UTSW |
4 |
106,242,621 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5280:Usp24
|
UTSW |
4 |
106,198,411 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5285:Usp24
|
UTSW |
4 |
106,264,230 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5292:Usp24
|
UTSW |
4 |
106,275,460 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5294:Usp24
|
UTSW |
4 |
106,219,554 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5394:Usp24
|
UTSW |
4 |
106,265,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5517:Usp24
|
UTSW |
4 |
106,232,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5522:Usp24
|
UTSW |
4 |
106,229,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5546:Usp24
|
UTSW |
4 |
106,273,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5756:Usp24
|
UTSW |
4 |
106,219,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5910:Usp24
|
UTSW |
4 |
106,237,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5972:Usp24
|
UTSW |
4 |
106,225,264 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6285:Usp24
|
UTSW |
4 |
106,231,297 (GRCm39) |
splice site |
probably null |
|
|
R6370:Usp24
|
UTSW |
4 |
106,237,718 (GRCm39) |
missense |
probably null |
0.20 |
|
R6630:Usp24
|
UTSW |
4 |
106,245,032 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6754:Usp24
|
UTSW |
4 |
106,217,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Usp24
|
UTSW |
4 |
106,219,441 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7088:Usp24
|
UTSW |
4 |
106,244,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7129:Usp24
|
UTSW |
4 |
106,219,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7131:Usp24
|
UTSW |
4 |
106,239,500 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7156:Usp24
|
UTSW |
4 |
106,245,116 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7174:Usp24
|
UTSW |
4 |
106,219,878 (GRCm39) |
splice site |
probably null |
|
|
R7236:Usp24
|
UTSW |
4 |
106,263,502 (GRCm39) |
splice site |
probably null |
|
|
R7403:Usp24
|
UTSW |
4 |
106,264,232 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7424:Usp24
|
UTSW |
4 |
106,236,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7475:Usp24
|
UTSW |
4 |
106,199,550 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7505:Usp24
|
UTSW |
4 |
106,236,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Usp24
|
UTSW |
4 |
106,173,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7900:Usp24
|
UTSW |
4 |
106,266,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7933:Usp24
|
UTSW |
4 |
106,285,686 (GRCm39) |
missense |
probably benign |
|
|
R7940:Usp24
|
UTSW |
4 |
106,287,741 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8271:Usp24
|
UTSW |
4 |
106,285,711 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8348:Usp24
|
UTSW |
4 |
106,225,933 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8448:Usp24
|
UTSW |
4 |
106,225,933 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8483:Usp24
|
UTSW |
4 |
106,230,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8546:Usp24
|
UTSW |
4 |
106,259,326 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8798:Usp24
|
UTSW |
4 |
106,236,436 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8822:Usp24
|
UTSW |
4 |
106,269,410 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8992:Usp24
|
UTSW |
4 |
106,234,762 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9002:Usp24
|
UTSW |
4 |
106,275,412 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9037:Usp24
|
UTSW |
4 |
106,236,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9068:Usp24
|
UTSW |
4 |
106,232,875 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9096:Usp24
|
UTSW |
4 |
106,254,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9180:Usp24
|
UTSW |
4 |
106,216,247 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9199:Usp24
|
UTSW |
4 |
106,244,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9201:Usp24
|
UTSW |
4 |
106,277,727 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9251:Usp24
|
UTSW |
4 |
106,217,715 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9423:Usp24
|
UTSW |
4 |
106,288,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9459:Usp24
|
UTSW |
4 |
106,199,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Usp24
|
UTSW |
4 |
106,261,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9483:Usp24
|
UTSW |
4 |
106,219,379 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9534:Usp24
|
UTSW |
4 |
106,264,312 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9653:Usp24
|
UTSW |
4 |
106,204,564 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9712:Usp24
|
UTSW |
4 |
106,204,564 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0024:Usp24
|
UTSW |
4 |
106,217,643 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0028:Usp24
|
UTSW |
4 |
106,225,252 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0066:Usp24
|
UTSW |
4 |
106,212,928 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCTTAGAGCAGTGGTACTCACGG -3'
(R):5'- TGAACATGAGCCATCTCAGGGGTC -3'
Sequencing Primer
(F):5'- GTGCTGGGAGAGGTGGC -3'
(R):5'- gcctttttctactgttctccacc -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation