Incidental Mutation 'R0035:Kmt2e'
| ID |
19406 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kmt2e
|
| Ensembl Gene |
ENSMUSG00000029004 |
| Gene Name |
lysine (K)-specific methyltransferase 2E |
| Synonyms |
D230038D11Rik, 9530077A04Rik, 1810033J14Rik, Mll5 |
| MMRRC Submission |
038329-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0035 (G1)
|
| Quality Score |
183 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
23434441-23504235 bp(+) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 23485621 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142568
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094962]
[ENSMUST00000115128]
[ENSMUST00000146375]
[ENSMUST00000196260]
[ENSMUST00000196889]
|
| AlphaFold |
Q3UG20 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094962
|
| SMART Domains |
Protein: ENSMUSP00000092569
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115128
|
| SMART Domains |
Protein: ENSMUSP00000110781
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146375
|
| SMART Domains |
Protein: ENSMUSP00000142547
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
117 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000157545
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196260
|
| SMART Domains |
Protein: ENSMUSP00000143791
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
62 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196889
|
| SMART Domains |
Protein: ENSMUSP00000142568
Gene: ENSMUSG00000029004
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
2.7e-10 |
SMART |
|
Blast:SET
|
216 |
327 |
6e-61 |
BLAST |
|
Blast:SET
|
328 |
377 |
3e-26 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200330
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 97.8%
- 10x: 94.7%
- 20x: 87.1%
|
| Validation Efficiency |
99% (70/71) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110040N11Rik |
T |
C |
7: 81,788,549 (GRCm38) |
T20A |
probably benign |
Het |
| 4932438A13Rik |
T |
A |
3: 36,987,598 (GRCm38) |
Y2708* |
probably null |
Het |
| 9130011E15Rik |
A |
T |
19: 45,891,240 (GRCm38) |
M558K |
probably damaging |
Het |
| Aadacl4 |
A |
G |
4: 144,617,941 (GRCm38) |
T96A |
probably damaging |
Het |
| Abcb6 |
A |
G |
1: 75,175,007 (GRCm38) |
V473A |
possibly damaging |
Het |
| Abo |
C |
A |
2: 26,843,373 (GRCm38) |
K273N |
possibly damaging |
Het |
| Acvr1c |
A |
G |
2: 58,315,779 (GRCm38) |
|
probably benign |
Het |
| Adcy8 |
A |
T |
15: 64,699,368 (GRCm38) |
V1142D |
probably benign |
Het |
| Akna |
T |
A |
4: 63,382,445 (GRCm38) |
H591L |
probably benign |
Het |
| Aox2 |
T |
C |
1: 58,354,422 (GRCm38) |
V1247A |
probably benign |
Het |
| Ap4b1 |
T |
C |
3: 103,820,664 (GRCm38) |
|
probably benign |
Het |
| Atm |
A |
G |
9: 53,513,180 (GRCm38) |
V607A |
probably benign |
Het |
| Cass4 |
C |
T |
2: 172,416,492 (GRCm38) |
P137S |
probably damaging |
Het |
| Cfap53 |
A |
G |
18: 74,300,207 (GRCm38) |
E121G |
probably damaging |
Het |
| Chmp6 |
T |
C |
11: 119,916,682 (GRCm38) |
V31A |
probably damaging |
Het |
| Clec4a3 |
T |
A |
6: 122,967,549 (GRCm38) |
Y185N |
probably damaging |
Het |
| Clic5 |
A |
G |
17: 44,275,313 (GRCm38) |
T230A |
probably damaging |
Het |
| Clspn |
G |
T |
4: 126,565,003 (GRCm38) |
|
probably null |
Het |
| Cntn1 |
T |
A |
15: 92,232,088 (GRCm38) |
|
probably benign |
Het |
| Col4a3 |
G |
A |
1: 82,672,753 (GRCm38) |
G577R |
unknown |
Het |
| Defa21 |
T |
A |
8: 21,025,768 (GRCm38) |
|
probably null |
Het |
| Deup1 |
T |
C |
9: 15,599,821 (GRCm38) |
R221G |
possibly damaging |
Het |
| Dnah8 |
A |
T |
17: 30,683,621 (GRCm38) |
|
probably benign |
Het |
| Dnase1l2 |
A |
G |
17: 24,441,075 (GRCm38) |
V273A |
probably damaging |
Het |
| Gm5134 |
T |
A |
10: 75,993,864 (GRCm38) |
F328Y |
probably benign |
Het |
| Golph3 |
A |
T |
15: 12,339,690 (GRCm38) |
E96D |
probably damaging |
Het |
| Hspd1 |
A |
G |
1: 55,083,783 (GRCm38) |
V151A |
probably benign |
Het |
| Htr1f |
A |
C |
16: 64,926,497 (GRCm38) |
I144S |
probably damaging |
Het |
| Il1f8 |
A |
T |
2: 24,159,878 (GRCm38) |
H167L |
probably benign |
Het |
| Il23r |
A |
G |
6: 67,473,788 (GRCm38) |
|
probably benign |
Het |
| Il25 |
A |
G |
14: 54,933,096 (GRCm38) |
E42G |
probably damaging |
Het |
| Klrb1-ps1 |
C |
T |
6: 129,129,343 (GRCm38) |
A149V |
possibly damaging |
Het |
| Ktn1 |
A |
G |
14: 47,730,379 (GRCm38) |
N1167D |
probably benign |
Het |
| Lama4 |
T |
A |
10: 39,072,738 (GRCm38) |
D832E |
probably benign |
Het |
| Map1b |
A |
G |
13: 99,435,338 (GRCm38) |
S292P |
probably damaging |
Het |
| Map6 |
C |
T |
7: 99,317,608 (GRCm38) |
T345I |
probably damaging |
Het |
| Mark2 |
A |
T |
19: 7,284,652 (GRCm38) |
|
probably benign |
Het |
| Me3 |
C |
A |
7: 89,851,759 (GRCm38) |
H559Q |
probably benign |
Het |
| Myo1b |
A |
G |
1: 51,778,382 (GRCm38) |
F574L |
probably damaging |
Het |
| Nos2 |
T |
C |
11: 78,945,727 (GRCm38) |
S431P |
probably damaging |
Het |
| Nr1h5 |
T |
A |
3: 102,949,573 (GRCm38) |
K208* |
probably null |
Het |
| Nup214 |
T |
C |
2: 31,990,367 (GRCm38) |
|
probably null |
Het |
| Obp2b |
T |
C |
2: 25,738,633 (GRCm38) |
L133P |
probably damaging |
Het |
| Olfr173 |
A |
T |
16: 58,797,122 (GRCm38) |
C241* |
probably null |
Het |
| Olfr305 |
T |
C |
7: 86,364,187 (GRCm38) |
D50G |
possibly damaging |
Het |
| Osbp2 |
C |
T |
11: 3,717,997 (GRCm38) |
|
probably benign |
Het |
| Ptafr |
C |
A |
4: 132,579,553 (GRCm38) |
L85I |
probably benign |
Het |
| Ptprk |
T |
A |
10: 28,263,508 (GRCm38) |
Y76* |
probably null |
Het |
| Rad50 |
A |
G |
11: 53,655,027 (GRCm38) |
|
probably benign |
Het |
| Rasef |
G |
T |
4: 73,762,854 (GRCm38) |
|
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,749,932 (GRCm38) |
L781H |
probably damaging |
Het |
| Tbc1d1 |
T |
A |
5: 64,256,737 (GRCm38) |
I18N |
probably damaging |
Het |
| Tbc1d17 |
T |
C |
7: 44,841,408 (GRCm38) |
N587D |
probably benign |
Het |
| Trank1 |
A |
T |
9: 111,366,776 (GRCm38) |
K1289N |
probably benign |
Het |
| Tspyl3 |
A |
G |
2: 153,224,320 (GRCm38) |
S333P |
probably damaging |
Het |
| Ush2a |
G |
A |
1: 188,356,888 (GRCm38) |
V347I |
probably benign |
Het |
| Usp17le |
G |
T |
7: 104,769,062 (GRCm38) |
S291* |
probably null |
Het |
| Usp24 |
T |
A |
4: 106,368,027 (GRCm38) |
S619T |
probably benign |
Het |
| Vmn2r10 |
T |
C |
5: 108,997,601 (GRCm38) |
|
probably benign |
Het |
| Vmn2r78 |
A |
G |
7: 86,920,205 (GRCm38) |
E102G |
probably benign |
Het |
| Vwa3b |
G |
A |
1: 37,165,689 (GRCm38) |
V85I |
possibly damaging |
Het |
| Wwp1 |
A |
C |
4: 19,631,116 (GRCm38) |
I639R |
probably damaging |
Het |
| Xpo5 |
A |
G |
17: 46,240,175 (GRCm38) |
T1001A |
probably benign |
Het |
| Zc3h12c |
A |
T |
9: 52,143,747 (GRCm38) |
M235K |
probably benign |
Het |
| Zfp619 |
G |
A |
7: 39,537,282 (GRCm38) |
G912D |
probably damaging |
Het |
|
| Other mutations in Kmt2e |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00783:Kmt2e
|
APN |
5 |
23,492,358 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01330:Kmt2e
|
APN |
5 |
23,497,948 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL01457:Kmt2e
|
APN |
5 |
23,502,019 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
IGL01691:Kmt2e
|
APN |
5 |
23,497,091 (GRCm38) |
missense |
probably benign |
|
|
IGL02274:Kmt2e
|
APN |
5 |
23,500,760 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02934:Kmt2e
|
APN |
5 |
23,497,884 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02964:Kmt2e
|
APN |
5 |
23,467,100 (GRCm38) |
splice site |
probably benign |
|
|
IGL03011:Kmt2e
|
APN |
5 |
23,497,542 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03291:Kmt2e
|
APN |
5 |
23,499,291 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0446:Kmt2e
|
UTSW |
5 |
23,497,534 (GRCm38) |
splice site |
probably null |
|
|
R0498:Kmt2e
|
UTSW |
5 |
23,478,972 (GRCm38) |
nonsense |
probably null |
|
|
R0699:Kmt2e
|
UTSW |
5 |
23,473,583 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0701:Kmt2e
|
UTSW |
5 |
23,473,583 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0761:Kmt2e
|
UTSW |
5 |
23,503,034 (GRCm38) |
nonsense |
probably null |
|
|
R1110:Kmt2e
|
UTSW |
5 |
23,502,655 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1295:Kmt2e
|
UTSW |
5 |
23,502,404 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1432:Kmt2e
|
UTSW |
5 |
23,450,321 (GRCm38) |
missense |
probably benign |
0.39 |
|
R1495:Kmt2e
|
UTSW |
5 |
23,499,327 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1505:Kmt2e
|
UTSW |
5 |
23,500,535 (GRCm38) |
missense |
probably null |
0.01 |
|
R1623:Kmt2e
|
UTSW |
5 |
23,482,502 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1675:Kmt2e
|
UTSW |
5 |
23,482,453 (GRCm38) |
nonsense |
probably null |
|
|
R1691:Kmt2e
|
UTSW |
5 |
23,464,849 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1778:Kmt2e
|
UTSW |
5 |
23,492,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1820:Kmt2e
|
UTSW |
5 |
23,473,547 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1846:Kmt2e
|
UTSW |
5 |
23,499,486 (GRCm38) |
intron |
probably benign |
|
|
R1912:Kmt2e
|
UTSW |
5 |
23,492,395 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2070:Kmt2e
|
UTSW |
5 |
23,501,995 (GRCm38) |
missense |
probably benign |
|
|
R2195:Kmt2e
|
UTSW |
5 |
23,502,196 (GRCm38) |
splice site |
probably null |
|
|
R2571:Kmt2e
|
UTSW |
5 |
23,501,887 (GRCm38) |
missense |
probably benign |
0.08 |
|
R3901:Kmt2e
|
UTSW |
5 |
23,501,642 (GRCm38) |
missense |
probably benign |
0.02 |
|
R3902:Kmt2e
|
UTSW |
5 |
23,501,642 (GRCm38) |
missense |
probably benign |
0.02 |
|
R3905:Kmt2e
|
UTSW |
5 |
23,501,626 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3906:Kmt2e
|
UTSW |
5 |
23,501,626 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3909:Kmt2e
|
UTSW |
5 |
23,501,626 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3956:Kmt2e
|
UTSW |
5 |
23,496,025 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4242:Kmt2e
|
UTSW |
5 |
23,502,822 (GRCm38) |
unclassified |
probably benign |
|
|
R4299:Kmt2e
|
UTSW |
5 |
23,464,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4448:Kmt2e
|
UTSW |
5 |
23,464,790 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R4528:Kmt2e
|
UTSW |
5 |
23,473,558 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R4574:Kmt2e
|
UTSW |
5 |
23,492,407 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R4719:Kmt2e
|
UTSW |
5 |
23,492,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4754:Kmt2e
|
UTSW |
5 |
23,482,441 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4787:Kmt2e
|
UTSW |
5 |
23,463,083 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4812:Kmt2e
|
UTSW |
5 |
23,502,587 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4853:Kmt2e
|
UTSW |
5 |
23,502,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5138:Kmt2e
|
UTSW |
5 |
23,502,695 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5306:Kmt2e
|
UTSW |
5 |
23,499,333 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5659:Kmt2e
|
UTSW |
5 |
23,497,807 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5907:Kmt2e
|
UTSW |
5 |
23,464,706 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5920:Kmt2e
|
UTSW |
5 |
23,499,442 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R6280:Kmt2e
|
UTSW |
5 |
23,499,516 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6353:Kmt2e
|
UTSW |
5 |
23,493,245 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6375:Kmt2e
|
UTSW |
5 |
23,499,519 (GRCm38) |
missense |
probably benign |
|
|
R6553:Kmt2e
|
UTSW |
5 |
23,463,026 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6572:Kmt2e
|
UTSW |
5 |
23,497,581 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R6678:Kmt2e
|
UTSW |
5 |
23,499,295 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R6791:Kmt2e
|
UTSW |
5 |
23,499,476 (GRCm38) |
intron |
probably benign |
|
|
R6792:Kmt2e
|
UTSW |
5 |
23,499,476 (GRCm38) |
intron |
probably benign |
|
|
R6794:Kmt2e
|
UTSW |
5 |
23,499,476 (GRCm38) |
intron |
probably benign |
|
|
R6797:Kmt2e
|
UTSW |
5 |
23,482,507 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R6947:Kmt2e
|
UTSW |
5 |
23,497,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7023:Kmt2e
|
UTSW |
5 |
23,500,487 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7036:Kmt2e
|
UTSW |
5 |
23,478,743 (GRCm38) |
missense |
probably null |
1.00 |
|
R7173:Kmt2e
|
UTSW |
5 |
23,464,857 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kmt2e
|
UTSW |
5 |
23,492,294 (GRCm38) |
unclassified |
probably benign |
|
|
R7563:Kmt2e
|
UTSW |
5 |
23,500,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7571:Kmt2e
|
UTSW |
5 |
23,478,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7604:Kmt2e
|
UTSW |
5 |
23,501,765 (GRCm38) |
missense |
not run |
|
|
R7722:Kmt2e
|
UTSW |
5 |
23,497,018 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7758:Kmt2e
|
UTSW |
5 |
23,496,070 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7794:Kmt2e
|
UTSW |
5 |
23,464,716 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8137:Kmt2e
|
UTSW |
5 |
23,501,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8341:Kmt2e
|
UTSW |
5 |
23,499,453 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8383:Kmt2e
|
UTSW |
5 |
23,485,541 (GRCm38) |
missense |
probably benign |
0.08 |
|
R8400:Kmt2e
|
UTSW |
5 |
23,497,092 (GRCm38) |
missense |
probably benign |
0.17 |
|
R8546:Kmt2e
|
UTSW |
5 |
23,481,244 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8750:Kmt2e
|
UTSW |
5 |
23,493,217 (GRCm38) |
missense |
probably benign |
|
|
R8786:Kmt2e
|
UTSW |
5 |
23,464,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9211:Kmt2e
|
UTSW |
5 |
23,464,772 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9660:Kmt2e
|
UTSW |
5 |
23,478,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9786:Kmt2e
|
UTSW |
5 |
23,497,984 (GRCm38) |
missense |
probably benign |
0.16 |
|
RF026:Kmt2e
|
UTSW |
5 |
23,478,509 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
RF028:Kmt2e
|
UTSW |
5 |
23,478,509 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
RF040:Kmt2e
|
UTSW |
5 |
23,478,509 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
RF042:Kmt2e
|
UTSW |
5 |
23,478,509 (GRCm38) |
critical splice acceptor site |
probably benign |
|
|
Z1177:Kmt2e
|
UTSW |
5 |
23,481,208 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTCAAGGAAAATCCAGAGTGCC -3'
(R):5'- TGGAGCACCAACAGAGAACTTGCC -3'
Sequencing Primer
(F):5'- TGTTCTCAAGCGAAGCTCG -3'
(R):5'- ACTTGCCAAGGGTATGGTAGC -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation