Incidental Mutation 'R1747:Wnt10b'
ID 194074
Institutional Source Beutler Lab
Gene Symbol Wnt10b
Ensembl Gene ENSMUSG00000022996
Gene Name wingless-type MMTV integration site family, member 10B
Synonyms Wnt12
MMRRC Submission 039779-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1747 (G1)
Quality Score 224
Status Validated
Chromosome 15
Chromosomal Location 98668593-98676031 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 98672214 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 168 (S168P)
Ref Sequence ENSEMBL: ENSMUSP00000153930 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023732] [ENSMUST00000166022] [ENSMUST00000226610] [ENSMUST00000226655] [ENSMUST00000226846] [ENSMUST00000228546] [ENSMUST00000228594]
AlphaFold P48614
Predicted Effect probably benign
Transcript: ENSMUST00000023732
AA Change: S168P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000023732
Gene: ENSMUSG00000022996
AA Change: S168P

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
WNT1 50 389 9.1e-128 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166022
AA Change: S168P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000131056
Gene: ENSMUSG00000022996
AA Change: S168P

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
WNT1 50 389 9.1e-128 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000226610
AA Change: S168P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000226655
Predicted Effect probably benign
Transcript: ENSMUST00000226846
Predicted Effect probably benign
Transcript: ENSMUST00000228546
Predicted Effect probably benign
Transcript: ENSMUST00000228594
AA Change: S168P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Meta Mutation Damage Score 0.0849 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.7%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik C T 8: 13,608,814 (GRCm39) S117N probably damaging Het
Acat3 A G 17: 13,143,695 (GRCm39) I349T possibly damaging Het
Add3 A G 19: 53,230,981 (GRCm39) N552S probably benign Het
Ak3 G T 19: 29,000,261 (GRCm39) P217T possibly damaging Het
Aox1 A T 1: 58,378,751 (GRCm39) D1000V probably benign Het
Ap1m2 A G 9: 21,216,982 (GRCm39) M118T probably damaging Het
Arhgap28 C A 17: 68,208,304 (GRCm39) A105S probably benign Het
Arhgef28 T C 13: 98,073,332 (GRCm39) E1368G probably damaging Het
Armc7 G A 11: 115,379,583 (GRCm39) V94I probably benign Het
Asxl1 C A 2: 153,235,374 (GRCm39) T223N possibly damaging Het
Btbd8 T C 5: 107,599,865 (GRCm39) S119P probably damaging Het
Cltc T C 11: 86,597,907 (GRCm39) K1078E probably damaging Het
Cpne8 G A 15: 90,469,118 (GRCm39) T158I probably benign Het
Csn1s2b T C 5: 87,964,529 (GRCm39) probably benign Het
Cyp3a59 A G 5: 146,041,568 (GRCm39) I371V probably benign Het
Dennd4c T C 4: 86,725,675 (GRCm39) F710L probably damaging Het
Diaph3 T C 14: 87,310,773 (GRCm39) D126G probably damaging Het
Dnm3 G A 1: 162,141,153 (GRCm39) R369C probably damaging Het
Dst A C 1: 34,199,790 (GRCm39) Q86P probably damaging Het
Ern2 C A 7: 121,773,042 (GRCm39) probably null Het
Ern2 T A 7: 121,773,043 (GRCm39) probably null Het
Exoc6 T A 19: 37,628,217 (GRCm39) probably null Het
Glg1 G A 8: 111,924,305 (GRCm39) R228C probably damaging Het
Gm4736 G A 6: 132,092,633 (GRCm39) noncoding transcript Het
Hmcn2 G C 2: 31,347,997 (GRCm39) G4881A probably benign Het
Htr2a T G 14: 74,943,593 (GRCm39) F391C probably damaging Het
Htr5b A T 1: 121,455,647 (GRCm39) V91E probably damaging Het
Ifi44 T A 3: 151,454,922 (GRCm39) H101L probably benign Het
Ip6k1 G A 9: 107,918,195 (GRCm39) E77K possibly damaging Het
Klhl6 T A 16: 19,765,778 (GRCm39) H608L probably benign Het
Lrp4 T C 2: 91,322,966 (GRCm39) V1150A probably damaging Het
Lyst T C 13: 13,932,007 (GRCm39) F3545S probably benign Het
Magi3 T C 3: 103,941,489 (GRCm39) D822G possibly damaging Het
Nbas G A 12: 13,385,899 (GRCm39) S721N probably benign Het
Nog T A 11: 89,192,408 (GRCm39) M147L probably benign Het
Npr1 C T 3: 90,365,976 (GRCm39) C605Y possibly damaging Het
Or7e173 A C 9: 19,938,613 (GRCm39) V207G probably benign Het
Or8k21 G A 2: 86,145,211 (GRCm39) L140F probably benign Het
Pgs1 A G 11: 117,892,457 (GRCm39) S10G probably benign Het
Pla2g4c T C 7: 13,071,655 (GRCm39) probably benign Het
Prdm14 C T 1: 13,192,627 (GRCm39) V371I possibly damaging Het
Prom1 C T 5: 44,164,373 (GRCm39) V703I probably benign Het
Ptprk A G 10: 28,230,688 (GRCm39) T260A possibly damaging Het
Scnn1g A T 7: 121,359,686 (GRCm39) I390F probably damaging Het
Scrt2 C T 2: 151,935,638 (GRCm39) H264Y probably damaging Het
Sel1l3 C T 5: 53,302,887 (GRCm39) E661K possibly damaging Het
Skic2 G T 17: 35,066,782 (GRCm39) P162H probably benign Het
Slc10a5 G T 3: 10,400,451 (GRCm39) Q70K probably benign Het
Smg8 A G 11: 86,976,129 (GRCm39) V484A possibly damaging Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Stag1 T A 9: 100,770,353 (GRCm39) S630T probably benign Het
Thyn1 A C 9: 26,916,509 (GRCm39) Q98P probably damaging Het
Ttc7 A G 17: 87,614,443 (GRCm39) R203G possibly damaging Het
Ttn T C 2: 76,708,860 (GRCm39) probably benign Het
Vmn1r236 C T 17: 21,507,179 (GRCm39) S99L probably benign Het
Vmn2r50 T A 7: 9,781,605 (GRCm39) H380L probably benign Het
Vmn2r73 A T 7: 85,507,375 (GRCm39) C646S probably damaging Het
Zc3h7a A G 16: 10,963,117 (GRCm39) M748T possibly damaging Het
Zfp804b C G 5: 6,820,217 (GRCm39) E913Q probably benign Het
Zfp974 G T 7: 27,610,506 (GRCm39) F406L possibly damaging Het
Zic4 G A 9: 91,266,199 (GRCm39) C274Y probably damaging Het
Other mutations in Wnt10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01347:Wnt10b APN 15 98,674,826 (GRCm39) utr 5 prime probably benign
R0555:Wnt10b UTSW 15 98,670,818 (GRCm39) splice site probably benign
R1751:Wnt10b UTSW 15 98,670,556 (GRCm39) missense probably damaging 0.99
R1767:Wnt10b UTSW 15 98,670,556 (GRCm39) missense probably damaging 0.99
R2272:Wnt10b UTSW 15 98,672,228 (GRCm39) missense probably damaging 0.99
R2282:Wnt10b UTSW 15 98,672,102 (GRCm39) missense probably damaging 0.99
R3911:Wnt10b UTSW 15 98,672,219 (GRCm39) missense possibly damaging 0.53
R4997:Wnt10b UTSW 15 98,672,084 (GRCm39) missense probably damaging 0.99
R5226:Wnt10b UTSW 15 98,674,495 (GRCm39) missense probably damaging 1.00
R7514:Wnt10b UTSW 15 98,672,045 (GRCm39) missense probably benign 0.28
R8516:Wnt10b UTSW 15 98,670,761 (GRCm39) missense probably damaging 0.99
R9551:Wnt10b UTSW 15 98,670,713 (GRCm39) missense probably damaging 1.00
R9552:Wnt10b UTSW 15 98,670,713 (GRCm39) missense probably damaging 1.00
R9617:Wnt10b UTSW 15 98,674,609 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTCGGGTGACTACTAGCGACAAGC -3'
(R):5'- TTTCTCCCCAGGTTTCCGTGAGAGTG -3'

Sequencing Primer
(F):5'- gccacacctaacagccac -3'
(R):5'- AGTGCTTTCTCCTTCTCCATGC -3'
Posted On 2014-05-23