Incidental Mutation 'R0035:Il23r'
ID 19408
Institutional Source Beutler Lab
Gene Symbol Il23r
Ensembl Gene ENSMUSG00000049093
Gene Name interleukin 23 receptor
Synonyms
MMRRC Submission 038329-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0035 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 67399916-67468839 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 67450772 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000118364]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000118364
SMART Domains Protein: ENSMUSP00000113342
Gene: ENSMUSG00000049093

DomainStartEndE-ValueType
FN3 140 220 1e-1 SMART
Blast:FN3 235 317 2e-38 BLAST
transmembrane domain 388 410 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.1%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
PHENOTYPE: Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation. [provided by MGI curators]
Allele List at MGI

All alleles(6) : Targeted(6)

Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110040N11Rik T C 7: 81,438,297 (GRCm39) T20A probably benign Het
Aadacl4 A G 4: 144,344,511 (GRCm39) T96A probably damaging Het
Abcb6 A G 1: 75,151,651 (GRCm39) V473A possibly damaging Het
Abo C A 2: 26,733,385 (GRCm39) K273N possibly damaging Het
Acvr1c A G 2: 58,205,791 (GRCm39) probably benign Het
Adcy8 A T 15: 64,571,217 (GRCm39) V1142D probably benign Het
Akna T A 4: 63,300,682 (GRCm39) H591L probably benign Het
Aox1 T C 1: 58,393,581 (GRCm39) V1247A probably benign Het
Ap4b1 T C 3: 103,727,980 (GRCm39) probably benign Het
Armh3 A T 19: 45,879,679 (GRCm39) M558K probably damaging Het
Atm A G 9: 53,424,480 (GRCm39) V607A probably benign Het
Bltp1 T A 3: 37,041,747 (GRCm39) Y2708* probably null Het
Cass4 C T 2: 172,258,412 (GRCm39) P137S probably damaging Het
Cfap53 A G 18: 74,433,278 (GRCm39) E121G probably damaging Het
Chmp6 T C 11: 119,807,508 (GRCm39) V31A probably damaging Het
Clec4a3 T A 6: 122,944,508 (GRCm39) Y185N probably damaging Het
Clic5 A G 17: 44,586,200 (GRCm39) T230A probably damaging Het
Clspn G T 4: 126,458,796 (GRCm39) probably null Het
Cntn1 T A 15: 92,129,969 (GRCm39) probably benign Het
Col4a3 G A 1: 82,650,474 (GRCm39) G577R unknown Het
Defa21 T A 8: 21,515,784 (GRCm39) probably null Het
Deup1 T C 9: 15,511,117 (GRCm39) R221G possibly damaging Het
Dnah8 A T 17: 30,902,595 (GRCm39) probably benign Het
Dnase1l2 A G 17: 24,660,049 (GRCm39) V273A probably damaging Het
Gm5134 T A 10: 75,829,698 (GRCm39) F328Y probably benign Het
Golph3 A T 15: 12,339,776 (GRCm39) E96D probably damaging Het
Hspd1 A G 1: 55,122,942 (GRCm39) V151A probably benign Het
Htr1f A C 16: 64,746,860 (GRCm39) I144S probably damaging Het
Il25 A G 14: 55,170,553 (GRCm39) E42G probably damaging Het
Il36b A T 2: 24,049,890 (GRCm39) H167L probably benign Het
Klrb1-ps1 C T 6: 129,106,306 (GRCm39) A149V possibly damaging Het
Kmt2e T A 5: 23,690,619 (GRCm39) probably benign Het
Ktn1 A G 14: 47,967,836 (GRCm39) N1167D probably benign Het
Lama4 T A 10: 38,948,734 (GRCm39) D832E probably benign Het
Map1b A G 13: 99,571,846 (GRCm39) S292P probably damaging Het
Map6 C T 7: 98,966,815 (GRCm39) T345I probably damaging Het
Mark2 A T 19: 7,262,017 (GRCm39) probably benign Het
Me3 C A 7: 89,500,967 (GRCm39) H559Q probably benign Het
Myo1b A G 1: 51,817,541 (GRCm39) F574L probably damaging Het
Nos2 T C 11: 78,836,553 (GRCm39) S431P probably damaging Het
Nr1h5 T A 3: 102,856,889 (GRCm39) K208* probably null Het
Nup214 T C 2: 31,880,379 (GRCm39) probably null Het
Obp2b T C 2: 25,628,645 (GRCm39) L133P probably damaging Het
Or14a259 T C 7: 86,013,395 (GRCm39) D50G possibly damaging Het
Or5k1 A T 16: 58,617,485 (GRCm39) C241* probably null Het
Osbp2 C T 11: 3,667,997 (GRCm39) probably benign Het
Ptafr C A 4: 132,306,864 (GRCm39) L85I probably benign Het
Ptprk T A 10: 28,139,504 (GRCm39) Y76* probably null Het
Rad50 A G 11: 53,545,854 (GRCm39) probably benign Het
Rasef G T 4: 73,681,091 (GRCm39) probably benign Het
Slitrk6 A T 14: 110,987,364 (GRCm39) L781H probably damaging Het
Tbc1d1 T A 5: 64,414,080 (GRCm39) I18N probably damaging Het
Tbc1d17 T C 7: 44,490,832 (GRCm39) N587D probably benign Het
Trank1 A T 9: 111,195,844 (GRCm39) K1289N probably benign Het
Tspyl3 A G 2: 153,066,240 (GRCm39) S333P probably damaging Het
Ush2a G A 1: 188,089,085 (GRCm39) V347I probably benign Het
Usp17le G T 7: 104,418,269 (GRCm39) S291* probably null Het
Usp24 T A 4: 106,225,224 (GRCm39) S619T probably benign Het
Vmn2r10 T C 5: 109,145,467 (GRCm39) probably benign Het
Vmn2r78 A G 7: 86,569,413 (GRCm39) E102G probably benign Het
Vwa3b G A 1: 37,204,770 (GRCm39) V85I possibly damaging Het
Wwp1 A C 4: 19,631,116 (GRCm39) I639R probably damaging Het
Xpo5 A G 17: 46,551,101 (GRCm39) T1001A probably benign Het
Zc3h12c A T 9: 52,055,047 (GRCm39) M235K probably benign Het
Zfp619 G A 7: 39,186,706 (GRCm39) G912D probably damaging Het
Other mutations in Il23r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00668:Il23r APN 6 67,400,612 (GRCm39) missense probably damaging 0.96
IGL00886:Il23r APN 6 67,450,874 (GRCm39) missense possibly damaging 0.94
IGL00916:Il23r APN 6 67,450,915 (GRCm39) missense probably damaging 1.00
IGL01102:Il23r APN 6 67,400,909 (GRCm39) missense probably damaging 0.98
IGL01466:Il23r APN 6 67,403,626 (GRCm39) missense probably benign 0.30
IGL01627:Il23r APN 6 67,400,412 (GRCm39) missense probably benign 0.17
IGL02160:Il23r APN 6 67,400,562 (GRCm39) missense probably benign 0.09
IGL02394:Il23r APN 6 67,443,256 (GRCm39) splice site probably benign
IGL02418:Il23r APN 6 67,467,656 (GRCm39) missense possibly damaging 0.46
IGL02818:Il23r APN 6 67,463,078 (GRCm39) critical splice donor site probably null
IGL03230:Il23r APN 6 67,400,948 (GRCm39) missense probably benign 0.31
R0029:Il23r UTSW 6 67,455,929 (GRCm39) critical splice donor site probably null
R0029:Il23r UTSW 6 67,455,929 (GRCm39) critical splice donor site probably null
R0035:Il23r UTSW 6 67,450,772 (GRCm39) splice site probably benign
R0085:Il23r UTSW 6 67,463,206 (GRCm39) missense probably damaging 1.00
R0477:Il23r UTSW 6 67,429,361 (GRCm39) missense probably benign 0.00
R0534:Il23r UTSW 6 67,403,572 (GRCm39) missense probably benign 0.00
R0547:Il23r UTSW 6 67,463,235 (GRCm39) missense possibly damaging 0.57
R0547:Il23r UTSW 6 67,400,685 (GRCm39) missense probably benign 0.05
R0666:Il23r UTSW 6 67,411,664 (GRCm39) missense probably benign 0.08
R0702:Il23r UTSW 6 67,443,269 (GRCm39) missense probably damaging 0.97
R0715:Il23r UTSW 6 67,463,317 (GRCm39) missense possibly damaging 0.63
R1077:Il23r UTSW 6 67,450,794 (GRCm39) missense probably benign 0.40
R1202:Il23r UTSW 6 67,455,937 (GRCm39) missense possibly damaging 0.95
R1328:Il23r UTSW 6 67,468,802 (GRCm39) start gained probably benign
R1378:Il23r UTSW 6 67,429,394 (GRCm39) missense possibly damaging 0.68
R1420:Il23r UTSW 6 67,463,181 (GRCm39) missense probably damaging 1.00
R1475:Il23r UTSW 6 67,429,280 (GRCm39) critical splice donor site probably null
R1628:Il23r UTSW 6 67,400,593 (GRCm39) missense probably damaging 1.00
R1745:Il23r UTSW 6 67,443,275 (GRCm39) missense probably damaging 0.98
R1887:Il23r UTSW 6 67,450,785 (GRCm39) missense possibly damaging 0.88
R1901:Il23r UTSW 6 67,400,718 (GRCm39) missense probably benign 0.44
R1902:Il23r UTSW 6 67,400,718 (GRCm39) missense probably benign 0.44
R1928:Il23r UTSW 6 67,400,719 (GRCm39) missense possibly damaging 0.79
R1984:Il23r UTSW 6 67,467,652 (GRCm39) splice site probably null
R1985:Il23r UTSW 6 67,467,652 (GRCm39) splice site probably null
R2264:Il23r UTSW 6 67,403,651 (GRCm39) critical splice acceptor site probably null
R2290:Il23r UTSW 6 67,400,845 (GRCm39) missense probably benign 0.17
R2363:Il23r UTSW 6 67,429,401 (GRCm39) missense probably benign 0.08
R3430:Il23r UTSW 6 67,429,458 (GRCm39) missense probably benign 0.08
R3964:Il23r UTSW 6 67,443,281 (GRCm39) missense probably benign 0.13
R4073:Il23r UTSW 6 67,463,106 (GRCm39) missense probably damaging 1.00
R4164:Il23r UTSW 6 67,400,647 (GRCm39) missense probably benign 0.00
R4643:Il23r UTSW 6 67,400,977 (GRCm39) missense probably benign 0.08
R4700:Il23r UTSW 6 67,450,834 (GRCm39) missense probably damaging 1.00
R4703:Il23r UTSW 6 67,467,686 (GRCm39) missense probably damaging 1.00
R4720:Il23r UTSW 6 67,400,645 (GRCm39) missense probably damaging 1.00
R4828:Il23r UTSW 6 67,408,635 (GRCm39) missense probably benign 0.31
R4911:Il23r UTSW 6 67,400,545 (GRCm39) missense probably benign 0.17
R5119:Il23r UTSW 6 67,443,300 (GRCm39) missense probably damaging 1.00
R5152:Il23r UTSW 6 67,400,725 (GRCm39) missense probably damaging 0.98
R5223:Il23r UTSW 6 67,463,154 (GRCm39) missense probably benign 0.23
R5271:Il23r UTSW 6 67,400,680 (GRCm39) missense probably benign 0.16
R5330:Il23r UTSW 6 67,400,479 (GRCm39) missense probably damaging 1.00
R5331:Il23r UTSW 6 67,400,479 (GRCm39) missense probably damaging 1.00
R5384:Il23r UTSW 6 67,463,275 (GRCm39) missense probably benign 0.10
R5874:Il23r UTSW 6 67,408,629 (GRCm39) missense possibly damaging 0.92
R6037:Il23r UTSW 6 67,455,938 (GRCm39) missense probably damaging 0.99
R6037:Il23r UTSW 6 67,455,938 (GRCm39) missense probably damaging 0.99
R6377:Il23r UTSW 6 67,400,636 (GRCm39) missense probably damaging 0.99
R6925:Il23r UTSW 6 67,400,477 (GRCm39) missense probably damaging 1.00
R6975:Il23r UTSW 6 67,400,352 (GRCm39) missense probably damaging 1.00
R7529:Il23r UTSW 6 67,467,720 (GRCm39) missense possibly damaging 0.84
R7757:Il23r UTSW 6 67,400,965 (GRCm39) missense probably benign 0.02
R7832:Il23r UTSW 6 67,400,846 (GRCm39) missense probably benign 0.08
R7946:Il23r UTSW 6 67,411,648 (GRCm39) missense possibly damaging 0.69
R8078:Il23r UTSW 6 67,400,577 (GRCm39) missense probably damaging 0.99
R8391:Il23r UTSW 6 67,429,374 (GRCm39) missense probably benign 0.27
R8784:Il23r UTSW 6 67,443,401 (GRCm39) missense probably damaging 1.00
R9280:Il23r UTSW 6 67,429,410 (GRCm39) missense probably damaging 1.00
R9352:Il23r UTSW 6 67,403,592 (GRCm39) missense probably damaging 0.98
R9362:Il23r UTSW 6 67,400,384 (GRCm39) missense probably damaging 1.00
R9768:Il23r UTSW 6 67,408,603 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCACATGCCATGCCTTTTACAACAG -3'
(R):5'- ACCATAGCATTCAAAGTTTCTGGAGCA -3'

Sequencing Primer
(F):5'- ATCTGCTCCTGAAAGGTGAC -3'
(R):5'- TGgttggtttgtttgtttgtttg -3'
Posted On 2013-04-11