Incidental Mutation 'R0035:Vmn2r78'
| ID |
19415 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r78
|
| Ensembl Gene |
ENSMUSG00000091962 |
| Gene Name |
vomeronasal 2, receptor 78 |
| Synonyms |
|
| MMRRC Submission |
038329-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.091)
|
| Stock # |
R0035 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
7 |
| Chromosomal Location |
86915300-86955177 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86920205 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 102
(E102G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126698
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170835]
|
| AlphaFold |
K7N6U5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170835
AA Change: E102G
PolyPhen 2
Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962
AA Change: E102G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
5.9e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
8.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
1e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 97.8%
- 10x: 94.7%
- 20x: 87.1%
|
| Validation Efficiency |
99% (70/71) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110040N11Rik |
T |
C |
7: 81,788,549 (GRCm38) |
T20A |
probably benign |
Het |
| 4932438A13Rik |
T |
A |
3: 36,987,598 (GRCm38) |
Y2708* |
probably null |
Het |
| 9130011E15Rik |
A |
T |
19: 45,891,240 (GRCm38) |
M558K |
probably damaging |
Het |
| Aadacl4 |
A |
G |
4: 144,617,941 (GRCm38) |
T96A |
probably damaging |
Het |
| Abcb6 |
A |
G |
1: 75,175,007 (GRCm38) |
V473A |
possibly damaging |
Het |
| Abo |
C |
A |
2: 26,843,373 (GRCm38) |
K273N |
possibly damaging |
Het |
| Acvr1c |
A |
G |
2: 58,315,779 (GRCm38) |
|
probably benign |
Het |
| Adcy8 |
A |
T |
15: 64,699,368 (GRCm38) |
V1142D |
probably benign |
Het |
| Akna |
T |
A |
4: 63,382,445 (GRCm38) |
H591L |
probably benign |
Het |
| Aox2 |
T |
C |
1: 58,354,422 (GRCm38) |
V1247A |
probably benign |
Het |
| Ap4b1 |
T |
C |
3: 103,820,664 (GRCm38) |
|
probably benign |
Het |
| Atm |
A |
G |
9: 53,513,180 (GRCm38) |
V607A |
probably benign |
Het |
| Cass4 |
C |
T |
2: 172,416,492 (GRCm38) |
P137S |
probably damaging |
Het |
| Cfap53 |
A |
G |
18: 74,300,207 (GRCm38) |
E121G |
probably damaging |
Het |
| Chmp6 |
T |
C |
11: 119,916,682 (GRCm38) |
V31A |
probably damaging |
Het |
| Clec4a3 |
T |
A |
6: 122,967,549 (GRCm38) |
Y185N |
probably damaging |
Het |
| Clic5 |
A |
G |
17: 44,275,313 (GRCm38) |
T230A |
probably damaging |
Het |
| Clspn |
G |
T |
4: 126,565,003 (GRCm38) |
|
probably null |
Het |
| Cntn1 |
T |
A |
15: 92,232,088 (GRCm38) |
|
probably benign |
Het |
| Col4a3 |
G |
A |
1: 82,672,753 (GRCm38) |
G577R |
unknown |
Het |
| Defa21 |
T |
A |
8: 21,025,768 (GRCm38) |
|
probably null |
Het |
| Deup1 |
T |
C |
9: 15,599,821 (GRCm38) |
R221G |
possibly damaging |
Het |
| Dnah8 |
A |
T |
17: 30,683,621 (GRCm38) |
|
probably benign |
Het |
| Dnase1l2 |
A |
G |
17: 24,441,075 (GRCm38) |
V273A |
probably damaging |
Het |
| Gm5134 |
T |
A |
10: 75,993,864 (GRCm38) |
F328Y |
probably benign |
Het |
| Golph3 |
A |
T |
15: 12,339,690 (GRCm38) |
E96D |
probably damaging |
Het |
| Hspd1 |
A |
G |
1: 55,083,783 (GRCm38) |
V151A |
probably benign |
Het |
| Htr1f |
A |
C |
16: 64,926,497 (GRCm38) |
I144S |
probably damaging |
Het |
| Il1f8 |
A |
T |
2: 24,159,878 (GRCm38) |
H167L |
probably benign |
Het |
| Il23r |
A |
G |
6: 67,473,788 (GRCm38) |
|
probably benign |
Het |
| Il25 |
A |
G |
14: 54,933,096 (GRCm38) |
E42G |
probably damaging |
Het |
| Klrb1-ps1 |
C |
T |
6: 129,129,343 (GRCm38) |
A149V |
possibly damaging |
Het |
| Kmt2e |
T |
A |
5: 23,485,621 (GRCm38) |
|
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,730,379 (GRCm38) |
N1167D |
probably benign |
Het |
| Lama4 |
T |
A |
10: 39,072,738 (GRCm38) |
D832E |
probably benign |
Het |
| Map1b |
A |
G |
13: 99,435,338 (GRCm38) |
S292P |
probably damaging |
Het |
| Map6 |
C |
T |
7: 99,317,608 (GRCm38) |
T345I |
probably damaging |
Het |
| Mark2 |
A |
T |
19: 7,284,652 (GRCm38) |
|
probably benign |
Het |
| Me3 |
C |
A |
7: 89,851,759 (GRCm38) |
H559Q |
probably benign |
Het |
| Myo1b |
A |
G |
1: 51,778,382 (GRCm38) |
F574L |
probably damaging |
Het |
| Nos2 |
T |
C |
11: 78,945,727 (GRCm38) |
S431P |
probably damaging |
Het |
| Nr1h5 |
T |
A |
3: 102,949,573 (GRCm38) |
K208* |
probably null |
Het |
| Nup214 |
T |
C |
2: 31,990,367 (GRCm38) |
|
probably null |
Het |
| Obp2b |
T |
C |
2: 25,738,633 (GRCm38) |
L133P |
probably damaging |
Het |
| Olfr173 |
A |
T |
16: 58,797,122 (GRCm38) |
C241* |
probably null |
Het |
| Olfr305 |
T |
C |
7: 86,364,187 (GRCm38) |
D50G |
possibly damaging |
Het |
| Osbp2 |
C |
T |
11: 3,717,997 (GRCm38) |
|
probably benign |
Het |
| Ptafr |
C |
A |
4: 132,579,553 (GRCm38) |
L85I |
probably benign |
Het |
| Ptprk |
T |
A |
10: 28,263,508 (GRCm38) |
Y76* |
probably null |
Het |
| Rad50 |
A |
G |
11: 53,655,027 (GRCm38) |
|
probably benign |
Het |
| Rasef |
G |
T |
4: 73,762,854 (GRCm38) |
|
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,749,932 (GRCm38) |
L781H |
probably damaging |
Het |
| Tbc1d1 |
T |
A |
5: 64,256,737 (GRCm38) |
I18N |
probably damaging |
Het |
| Tbc1d17 |
T |
C |
7: 44,841,408 (GRCm38) |
N587D |
probably benign |
Het |
| Trank1 |
A |
T |
9: 111,366,776 (GRCm38) |
K1289N |
probably benign |
Het |
| Tspyl3 |
A |
G |
2: 153,224,320 (GRCm38) |
S333P |
probably damaging |
Het |
| Ush2a |
G |
A |
1: 188,356,888 (GRCm38) |
V347I |
probably benign |
Het |
| Usp17le |
G |
T |
7: 104,769,062 (GRCm38) |
S291* |
probably null |
Het |
| Usp24 |
T |
A |
4: 106,368,027 (GRCm38) |
S619T |
probably benign |
Het |
| Vmn2r10 |
T |
C |
5: 108,997,601 (GRCm38) |
|
probably benign |
Het |
| Vwa3b |
G |
A |
1: 37,165,689 (GRCm38) |
V85I |
possibly damaging |
Het |
| Wwp1 |
A |
C |
4: 19,631,116 (GRCm38) |
I639R |
probably damaging |
Het |
| Xpo5 |
A |
G |
17: 46,240,175 (GRCm38) |
T1001A |
probably benign |
Het |
| Zc3h12c |
A |
T |
9: 52,143,747 (GRCm38) |
M235K |
probably benign |
Het |
| Zfp619 |
G |
A |
7: 39,537,282 (GRCm38) |
G912D |
probably damaging |
Het |
|
| Other mutations in Vmn2r78 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01302:Vmn2r78
|
APN |
7 |
86,915,361 (GRCm38) |
missense |
unknown |
|
|
IGL01473:Vmn2r78
|
APN |
7 |
86,920,312 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
IGL01767:Vmn2r78
|
APN |
7 |
86,954,435 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL02322:Vmn2r78
|
APN |
7 |
86,921,479 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02537:Vmn2r78
|
APN |
7 |
86,954,288 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03297:Vmn2r78
|
APN |
7 |
86,920,761 (GRCm38) |
nonsense |
probably null |
|
|
ANU74:Vmn2r78
|
UTSW |
7 |
86,921,065 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R0081:Vmn2r78
|
UTSW |
7 |
86,923,027 (GRCm38) |
missense |
probably benign |
0.35 |
|
R0401:Vmn2r78
|
UTSW |
7 |
86,921,311 (GRCm38) |
missense |
probably benign |
0.04 |
|
R0751:Vmn2r78
|
UTSW |
7 |
86,954,380 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1341:Vmn2r78
|
UTSW |
7 |
86,922,269 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1386:Vmn2r78
|
UTSW |
7 |
86,915,407 (GRCm38) |
missense |
unknown |
|
|
R1526:Vmn2r78
|
UTSW |
7 |
86,922,257 (GRCm38) |
splice site |
probably null |
|
|
R1712:Vmn2r78
|
UTSW |
7 |
86,954,924 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1739:Vmn2r78
|
UTSW |
7 |
86,920,789 (GRCm38) |
missense |
probably benign |
|
|
R1812:Vmn2r78
|
UTSW |
7 |
86,920,787 (GRCm38) |
missense |
probably benign |
0.38 |
|
R2011:Vmn2r78
|
UTSW |
7 |
86,955,079 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R2144:Vmn2r78
|
UTSW |
7 |
86,954,482 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2197:Vmn2r78
|
UTSW |
7 |
86,921,327 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2291:Vmn2r78
|
UTSW |
7 |
86,920,154 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2409:Vmn2r78
|
UTSW |
7 |
86,920,745 (GRCm38) |
splice site |
probably benign |
|
|
R3023:Vmn2r78
|
UTSW |
7 |
86,954,966 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4486:Vmn2r78
|
UTSW |
7 |
86,920,751 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R4512:Vmn2r78
|
UTSW |
7 |
86,920,244 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r78
|
UTSW |
7 |
86,954,258 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4544:Vmn2r78
|
UTSW |
7 |
86,921,191 (GRCm38) |
missense |
probably benign |
|
|
R4546:Vmn2r78
|
UTSW |
7 |
86,954,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4872:Vmn2r78
|
UTSW |
7 |
86,954,708 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4928:Vmn2r78
|
UTSW |
7 |
86,954,627 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5101:Vmn2r78
|
UTSW |
7 |
86,922,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5265:Vmn2r78
|
UTSW |
7 |
86,920,124 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5328:Vmn2r78
|
UTSW |
7 |
86,921,030 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5442:Vmn2r78
|
UTSW |
7 |
86,920,122 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5567:Vmn2r78
|
UTSW |
7 |
86,921,529 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5572:Vmn2r78
|
UTSW |
7 |
86,915,512 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5636:Vmn2r78
|
UTSW |
7 |
86,954,429 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5901:Vmn2r78
|
UTSW |
7 |
86,954,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5977:Vmn2r78
|
UTSW |
7 |
86,954,907 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5977:Vmn2r78
|
UTSW |
7 |
86,920,333 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R6276:Vmn2r78
|
UTSW |
7 |
86,921,110 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6386:Vmn2r78
|
UTSW |
7 |
86,922,337 (GRCm38) |
nonsense |
probably null |
|
|
R6724:Vmn2r78
|
UTSW |
7 |
86,954,258 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6852:Vmn2r78
|
UTSW |
7 |
86,954,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6896:Vmn2r78
|
UTSW |
7 |
86,922,350 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7385:Vmn2r78
|
UTSW |
7 |
86,922,425 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7578:Vmn2r78
|
UTSW |
7 |
86,954,344 (GRCm38) |
nonsense |
probably null |
|
|
R7680:Vmn2r78
|
UTSW |
7 |
86,954,941 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7748:Vmn2r78
|
UTSW |
7 |
86,921,135 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7852:Vmn2r78
|
UTSW |
7 |
86,920,170 (GRCm38) |
nonsense |
probably null |
|
|
R8031:Vmn2r78
|
UTSW |
7 |
86,954,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8070:Vmn2r78
|
UTSW |
7 |
86,922,487 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8085:Vmn2r78
|
UTSW |
7 |
86,954,790 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8163:Vmn2r78
|
UTSW |
7 |
86,954,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8501:Vmn2r78
|
UTSW |
7 |
86,920,886 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8749:Vmn2r78
|
UTSW |
7 |
86,954,305 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R9209:Vmn2r78
|
UTSW |
7 |
86,920,223 (GRCm38) |
missense |
probably benign |
0.08 |
|
RF018:Vmn2r78
|
UTSW |
7 |
86,954,431 (GRCm38) |
nonsense |
probably null |
|
|
Z1177:Vmn2r78
|
UTSW |
7 |
86,954,774 (GRCm38) |
missense |
probably benign |
0.02 |
|
Z1177:Vmn2r78
|
UTSW |
7 |
86,921,207 (GRCm38) |
missense |
probably benign |
0.44 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGAACTGTGTCAACATATGAATGGGTC -3'
(R):5'- ACCAGAAGCATCACTATGAAGCAATGG -3'
Sequencing Primer
(F):5'- AAAATCTTTGCTTAACCCACAATG -3'
(R):5'- TAGTCAACTCAGAAACTCAGACTGTG -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation