Incidental Mutation 'R1766:Rims2'
| ID |
194406 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
2810036I15Rik, Syt3-rs, RIM2 |
| MMRRC Submission |
039798-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.518)
|
| Stock # |
R1766 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
39198261-39684372 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 39462580 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 769
(D769E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154153
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000227243]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042917
AA Change: D769E
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: D769E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000082054
AA Change: D809E
PolyPhen 2
Score 0.497 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: D809E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227243
AA Change: D769E
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000227381
AA Change: D489E
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933403O08Rik |
T |
C |
X: 112,241,085 (GRCm38) |
Y22H |
probably benign |
Het |
| Afg1l |
T |
C |
10: 42,454,495 (GRCm38) |
T59A |
probably benign |
Het |
| Ankrd17 |
T |
A |
5: 90,264,797 (GRCm38) |
M1223L |
possibly damaging |
Het |
| Ankrd24 |
G |
A |
10: 81,638,638 (GRCm38) |
S68N |
probably benign |
Het |
| Arhgap31 |
A |
G |
16: 38,625,590 (GRCm38) |
I131T |
probably damaging |
Het |
| Arhgef10 |
A |
T |
8: 14,979,836 (GRCm38) |
I874F |
probably damaging |
Het |
| Arl5b |
T |
C |
2: 15,069,837 (GRCm38) |
V43A |
probably benign |
Het |
| BC051665 |
G |
A |
13: 60,785,040 (GRCm38) |
H36Y |
probably benign |
Het |
| Cdh9 |
A |
G |
15: 16,778,306 (GRCm38) |
D69G |
probably damaging |
Het |
| Chd6 |
G |
A |
2: 160,966,639 (GRCm38) |
L1552F |
probably damaging |
Het |
| Chrd |
A |
G |
16: 20,737,441 (GRCm38) |
H584R |
probably damaging |
Het |
| Dnhd1 |
G |
A |
7: 105,693,972 (GRCm38) |
V1508I |
possibly damaging |
Het |
| Dpy19l4 |
C |
T |
4: 11,303,360 (GRCm38) |
G187D |
probably damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,015,526 (GRCm38) |
|
probably null |
Het |
| Ehbp1l1 |
A |
G |
19: 5,716,406 (GRCm38) |
V1303A |
probably damaging |
Het |
| Eif4e1b |
G |
A |
13: 54,786,891 (GRCm38) |
E182K |
probably damaging |
Het |
| Fam170b |
A |
T |
14: 32,835,886 (GRCm38) |
Q226L |
possibly damaging |
Het |
| Fam193a |
C |
T |
5: 34,462,131 (GRCm38) |
P760L |
probably damaging |
Het |
| Gabra5 |
A |
T |
7: 57,508,048 (GRCm38) |
L6H |
probably benign |
Het |
| Gabrq |
G |
A |
X: 72,833,383 (GRCm38) |
R161H |
probably damaging |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 119,160,716 (GRCm38) |
|
probably null |
Het |
| Gm7334 |
T |
A |
17: 50,698,978 (GRCm38) |
D97E |
probably damaging |
Het |
| Gpsm1 |
G |
A |
2: 26,325,383 (GRCm38) |
A286T |
probably damaging |
Het |
| Gsta4 |
C |
A |
9: 78,204,329 (GRCm38) |
Y79* |
probably null |
Het |
| Hcn1 |
T |
A |
13: 117,656,734 (GRCm38) |
V174D |
probably benign |
Het |
| Hic1 |
G |
T |
11: 75,165,794 (GRCm38) |
C756* |
probably null |
Het |
| Hivep3 |
C |
T |
4: 120,096,671 (GRCm38) |
T728I |
probably benign |
Het |
| Ice1 |
T |
C |
13: 70,604,442 (GRCm38) |
E1175G |
possibly damaging |
Het |
| Igsf3 |
T |
A |
3: 101,431,282 (GRCm38) |
L304Q |
probably damaging |
Het |
| Kpna6 |
T |
C |
4: 129,657,442 (GRCm38) |
D90G |
probably benign |
Het |
| Krt73 |
C |
T |
15: 101,793,928 (GRCm38) |
G500D |
probably damaging |
Het |
| Lama3 |
A |
G |
18: 12,402,062 (GRCm38) |
K156E |
probably damaging |
Het |
| Mdm2 |
T |
C |
10: 117,696,022 (GRCm38) |
K94E |
probably damaging |
Het |
| Mitf |
T |
C |
6: 97,941,099 (GRCm38) |
S26P |
probably damaging |
Het |
| Myh4 |
C |
A |
11: 67,256,295 (GRCm38) |
Q1589K |
possibly damaging |
Het |
| Nlrp4c |
T |
A |
7: 6,073,114 (GRCm38) |
V671E |
probably benign |
Het |
| Nop9 |
C |
T |
14: 55,752,134 (GRCm38) |
A407V |
possibly damaging |
Het |
| Nrap |
T |
A |
19: 56,335,042 (GRCm38) |
H1366L |
probably damaging |
Het |
| Ntrk1 |
A |
T |
3: 87,778,518 (GRCm38) |
C766S |
probably damaging |
Het |
| Olfr625-ps1 |
A |
G |
7: 103,682,861 (GRCm38) |
N38D |
possibly damaging |
Het |
| Olfr735 |
T |
C |
14: 50,346,220 (GRCm38) |
Y43C |
probably damaging |
Het |
| Olfr768 |
T |
C |
10: 129,093,747 (GRCm38) |
I76V |
probably benign |
Het |
| Olfr845 |
A |
G |
9: 19,338,858 (GRCm38) |
T133A |
probably benign |
Het |
| Oog3 |
C |
T |
4: 144,159,122 (GRCm38) |
G302D |
possibly damaging |
Het |
| Pdzph1 |
C |
T |
17: 58,973,752 (GRCm38) |
V512I |
probably benign |
Het |
| Phf2 |
A |
C |
13: 48,819,557 (GRCm38) |
S408A |
unknown |
Het |
| Pigk |
T |
G |
3: 152,740,156 (GRCm38) |
L135V |
probably damaging |
Het |
| Ppp2ca |
C |
A |
11: 52,121,946 (GRCm38) |
T301N |
probably benign |
Het |
| Ppp4r3a |
A |
G |
12: 101,058,482 (GRCm38) |
S253P |
probably damaging |
Het |
| Ptgfrn |
A |
T |
3: 101,050,122 (GRCm38) |
I712N |
probably benign |
Het |
| Rapgef2 |
A |
T |
3: 79,092,703 (GRCm38) |
D579E |
probably damaging |
Het |
| Rptor |
T |
A |
11: 119,725,061 (GRCm38) |
C134S |
probably damaging |
Het |
| S100a1 |
A |
G |
3: 90,511,292 (GRCm38) |
F72L |
probably damaging |
Het |
| Scube1 |
T |
A |
15: 83,721,945 (GRCm38) |
D42V |
probably damaging |
Het |
| Sh3glb1 |
T |
C |
3: 144,712,685 (GRCm38) |
D39G |
probably damaging |
Het |
| Sh3pxd2a |
T |
C |
19: 47,273,250 (GRCm38) |
T397A |
probably benign |
Het |
| Siglece |
G |
A |
7: 43,651,532 (GRCm38) |
T453M |
probably damaging |
Het |
| Slc26a1 |
G |
A |
5: 108,671,792 (GRCm38) |
R514W |
probably damaging |
Het |
| Slc4a8 |
T |
C |
15: 100,787,212 (GRCm38) |
V156A |
probably benign |
Het |
| Smchd1 |
A |
T |
17: 71,391,379 (GRCm38) |
V1134E |
probably damaging |
Het |
| Sorbs2 |
A |
G |
8: 45,770,576 (GRCm38) |
Y222C |
probably damaging |
Het |
| Sorcs3 |
G |
T |
19: 48,603,875 (GRCm38) |
W326C |
possibly damaging |
Het |
| Taf2 |
A |
G |
15: 55,071,397 (GRCm38) |
V45A |
probably benign |
Het |
| Tiparp |
A |
T |
3: 65,532,049 (GRCm38) |
H80L |
probably damaging |
Het |
| Tmem71 |
T |
A |
15: 66,541,699 (GRCm38) |
T175S |
probably benign |
Het |
| Tmem87b |
T |
A |
2: 128,839,170 (GRCm38) |
V338D |
probably damaging |
Het |
| Trdn |
A |
G |
10: 33,364,008 (GRCm38) |
K445R |
probably damaging |
Het |
| Trim14 |
A |
G |
4: 46,522,039 (GRCm38) |
F213L |
probably benign |
Het |
| Tubgcp5 |
T |
A |
7: 55,815,020 (GRCm38) |
S550T |
probably benign |
Het |
| Tufm |
A |
G |
7: 126,490,472 (GRCm38) |
D446G |
probably benign |
Het |
| Vipr1 |
A |
T |
9: 121,661,419 (GRCm38) |
Y177F |
possibly damaging |
Het |
| Vmn2r116 |
A |
C |
17: 23,401,766 (GRCm38) |
I825L |
probably damaging |
Het |
| Vmn2r12 |
G |
T |
5: 109,092,044 (GRCm38) |
Q218K |
probably damaging |
Het |
| Vwa7 |
G |
T |
17: 35,023,943 (GRCm38) |
|
probably null |
Het |
| Ywhae |
T |
C |
11: 75,755,665 (GRCm38) |
V119A |
probably damaging |
Het |
| Zfand5 |
A |
G |
19: 21,280,524 (GRCm38) |
R199G |
probably damaging |
Het |
| Zfp810 |
T |
C |
9: 22,278,532 (GRCm38) |
Y360C |
possibly damaging |
Het |
| Zrsr1 |
A |
G |
11: 22,973,637 (GRCm38) |
D137G |
probably benign |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,459,615 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,506,984 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,456,674 (GRCm38) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,292,149 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,472,359 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,457,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,534,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,566,997 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,535,903 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,459,593 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,452,352 (GRCm38) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,476,541 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,462,613 (GRCm38) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,456,733 (GRCm38) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,452,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,476,520 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,534,966 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,534,966 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,534,855 (GRCm38) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,462,615 (GRCm38) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,509,632 (GRCm38) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,567,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,679,625 (GRCm38) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,681,025 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,616,324 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,517,826 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,511,314 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,506,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,292,189 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,679,650 (GRCm38) |
missense |
probably benign |
0.10 |
|
R1779:Rims2
|
UTSW |
15 |
39,681,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,437,043 (GRCm38) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,345,314 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,345,314 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,511,326 (GRCm38) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,478,566 (GRCm38) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,585,652 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,478,575 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,437,845 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,437,924 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,292,208 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,462,560 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,437,526 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,437,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,535,914 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4936:Rims2
|
UTSW |
15 |
39,437,728 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4993:Rims2
|
UTSW |
15 |
39,454,445 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,452,428 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,517,869 (GRCm38) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,462,590 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,437,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,345,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,478,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,345,413 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,437,206 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,535,987 (GRCm38) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,681,045 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,476,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,437,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,292,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,675,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,198,363 (GRCm38) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,452,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,509,696 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,517,812 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,534,855 (GRCm38) |
missense |
probably benign |
0.42 |
|
R6753:Rims2
|
UTSW |
15 |
39,566,973 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R6855:Rims2
|
UTSW |
15 |
39,345,515 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,511,341 (GRCm38) |
missense |
probably benign |
|
|
R7058:Rims2
|
UTSW |
15 |
39,585,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7167:Rims2
|
UTSW |
15 |
39,437,077 (GRCm38) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,476,489 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,437,032 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7289:Rims2
|
UTSW |
15 |
39,437,718 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7459:Rims2
|
UTSW |
15 |
39,517,839 (GRCm38) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,507,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,198,528 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,681,079 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,476,523 (GRCm38) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,616,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,517,843 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,437,362 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,679,648 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,534,954 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,452,390 (GRCm38) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,476,477 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9287:Rims2
|
UTSW |
15 |
39,679,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,292,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,437,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,472,436 (GRCm38) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,437,534 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,681,114 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,478,690 (GRCm38) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,437,769 (GRCm38) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCGTTTAAAGAAGCCTGTTGAGCATTC -3'
(R):5'- TCACCCCAACTTCTGAAAGTGTGATG -3'
Sequencing Primer
(F):5'- CCTGTTGAGCATTCTAAAATAGGAAG -3'
(R):5'- GATTAAAAGAGGGGTTACATATCGTC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation