Incidental Mutation 'R1758:Cux1'
| ID |
195067 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| MMRRC Submission |
039790-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.847)
|
| Stock # |
R1758 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 136421176 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 183
(D183E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135892
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000177297]
[ENSMUST00000176778]
[ENSMUST00000176745]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000004097
AA Change: D98E
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: D98E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148082
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
AA Change: D61E
PolyPhen 2
Score 0.320 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
AA Change: D61E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000175975
AA Change: D98E
PolyPhen 2
Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: D98E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176172
AA Change: D87E
PolyPhen 2
Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: D87E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176216
AA Change: D98E
PolyPhen 2
Score 0.849 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
AA Change: D98E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176501
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177297
AA Change: D98E
PolyPhen 2
Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
AA Change: D98E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176778
AA Change: D183E
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: D183E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
AA Change: D98E
PolyPhen 2
Score 0.439 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
AA Change: D98E
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
T |
C |
8: 13,612,237 (GRCm39) |
R38G |
possibly damaging |
Het |
| 4930590J08Rik |
T |
C |
6: 91,892,203 (GRCm39) |
V155A |
possibly damaging |
Het |
| Adgb |
A |
G |
10: 10,302,349 (GRCm39) |
S406P |
probably damaging |
Het |
| Adgrb2 |
C |
A |
4: 129,905,668 (GRCm39) |
T893N |
probably damaging |
Het |
| Adgrf5 |
T |
C |
17: 43,735,484 (GRCm39) |
|
probably null |
Het |
| Alms1 |
T |
A |
6: 85,605,487 (GRCm39) |
I2379N |
probably damaging |
Het |
| Arap3 |
C |
T |
18: 38,122,965 (GRCm39) |
V512I |
probably benign |
Het |
| Atf4 |
C |
T |
15: 80,141,414 (GRCm39) |
T268I |
probably benign |
Het |
| Cblif |
G |
A |
19: 11,735,179 (GRCm39) |
M266I |
probably damaging |
Het |
| Ccdc154 |
T |
C |
17: 25,382,156 (GRCm39) |
L25P |
probably damaging |
Het |
| Ccdc9 |
G |
A |
7: 16,010,161 (GRCm39) |
S381F |
probably damaging |
Het |
| Cdk17 |
C |
T |
10: 93,044,112 (GRCm39) |
T17M |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,314,352 (GRCm39) |
N142S |
probably benign |
Het |
| Cep78 |
A |
G |
19: 15,936,900 (GRCm39) |
I602T |
probably damaging |
Het |
| Clasp1 |
C |
T |
1: 118,475,755 (GRCm39) |
T935I |
probably damaging |
Het |
| Cnr1 |
T |
C |
4: 33,945,000 (GRCm39) |
S463P |
probably damaging |
Het |
| Cntnap1 |
T |
A |
11: 101,075,449 (GRCm39) |
W876R |
probably damaging |
Het |
| Cntnap5c |
A |
G |
17: 58,349,545 (GRCm39) |
D286G |
probably damaging |
Het |
| Copa |
C |
T |
1: 171,931,711 (GRCm39) |
R321C |
probably damaging |
Het |
| Cspg4b |
A |
G |
13: 113,505,266 (GRCm39) |
T2132A |
possibly damaging |
Het |
| Ctla2a |
T |
G |
13: 61,083,256 (GRCm39) |
E98A |
probably damaging |
Het |
| Cxcl15 |
A |
C |
5: 90,949,323 (GRCm39) |
T163P |
unknown |
Het |
| Ddias |
T |
C |
7: 92,508,571 (GRCm39) |
N448S |
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,657,564 (GRCm39) |
F1152S |
probably damaging |
Het |
| Dnah12 |
C |
A |
14: 26,488,071 (GRCm39) |
Q992K |
probably benign |
Het |
| Eno3 |
G |
T |
11: 70,552,251 (GRCm39) |
W301L |
possibly damaging |
Het |
| Faap100 |
A |
T |
11: 120,268,059 (GRCm39) |
V238E |
probably damaging |
Het |
| Fgf4 |
A |
G |
7: 144,416,049 (GRCm39) |
S137G |
probably benign |
Het |
| Fhod3 |
A |
C |
18: 25,253,367 (GRCm39) |
D1439A |
possibly damaging |
Het |
| Frem2 |
A |
G |
3: 53,560,778 (GRCm39) |
L1243P |
probably damaging |
Het |
| Gkn3 |
T |
G |
6: 87,365,817 (GRCm39) |
M1L |
probably benign |
Het |
| Gm10250 |
T |
C |
15: 5,150,509 (GRCm39) |
|
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,798,859 (GRCm39) |
T545A |
possibly damaging |
Het |
| Gm14226 |
T |
A |
2: 154,867,378 (GRCm39) |
L445H |
probably damaging |
Het |
| Gm3404 |
A |
T |
5: 146,463,036 (GRCm39) |
M73L |
probably benign |
Het |
| Gm973 |
G |
T |
1: 59,673,169 (GRCm39) |
R976S |
unknown |
Het |
| Gpr146 |
A |
T |
5: 139,379,137 (GRCm39) |
H313L |
probably benign |
Het |
| Gys2 |
T |
A |
6: 142,418,432 (GRCm39) |
E32D |
probably damaging |
Het |
| Igsf10 |
G |
A |
3: 59,236,617 (GRCm39) |
T1188I |
probably benign |
Het |
| Igsf9b |
A |
T |
9: 27,245,548 (GRCm39) |
T1172S |
possibly damaging |
Het |
| Itga8 |
T |
A |
2: 12,270,144 (GRCm39) |
N114I |
possibly damaging |
Het |
| Itsn2 |
T |
A |
12: 4,708,160 (GRCm39) |
V795E |
possibly damaging |
Het |
| Kdm1b |
T |
A |
13: 47,214,244 (GRCm39) |
S197T |
probably benign |
Het |
| Kif5c |
G |
A |
2: 49,613,145 (GRCm39) |
R161Q |
probably benign |
Het |
| Krt33b |
T |
C |
11: 99,916,361 (GRCm39) |
Y232C |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Lrp1 |
A |
T |
10: 127,424,453 (GRCm39) |
N744K |
possibly damaging |
Het |
| Mcm10 |
C |
A |
2: 5,008,861 (GRCm39) |
L369F |
probably damaging |
Het |
| Muc5ac |
T |
A |
7: 141,355,268 (GRCm39) |
I1018N |
possibly damaging |
Het |
| Myom2 |
T |
C |
8: 15,115,795 (GRCm39) |
L70P |
probably benign |
Het |
| Myt1l |
T |
A |
12: 29,877,241 (GRCm39) |
N297K |
unknown |
Het |
| Ncr1 |
C |
T |
7: 4,343,807 (GRCm39) |
T98I |
probably benign |
Het |
| Nek3 |
T |
C |
8: 22,650,278 (GRCm39) |
E78G |
probably damaging |
Het |
| Nfatc3 |
T |
A |
8: 106,825,768 (GRCm39) |
N606K |
probably damaging |
Het |
| Nup107 |
T |
G |
10: 117,597,248 (GRCm39) |
D669A |
probably damaging |
Het |
| Or10ag52 |
A |
T |
2: 87,043,758 (GRCm39) |
Q174L |
probably benign |
Het |
| Or10c1 |
A |
T |
17: 37,522,204 (GRCm39) |
I180N |
possibly damaging |
Het |
| Or4c3 |
T |
C |
2: 89,851,673 (GRCm39) |
T246A |
probably benign |
Het |
| Or8b55 |
A |
T |
9: 38,726,871 (GRCm39) |
H24L |
probably benign |
Het |
| Pcnx1 |
T |
C |
12: 82,030,258 (GRCm39) |
V1711A |
probably benign |
Het |
| Pik3c3 |
A |
G |
18: 30,410,063 (GRCm39) |
D99G |
probably damaging |
Het |
| Pinx1 |
C |
A |
14: 64,157,024 (GRCm39) |
T317K |
probably benign |
Het |
| Ppargc1b |
G |
T |
18: 61,431,857 (GRCm39) |
|
probably null |
Het |
| Pradc1 |
T |
A |
6: 85,424,203 (GRCm39) |
I119F |
possibly damaging |
Het |
| Psat1 |
G |
T |
19: 15,892,243 (GRCm39) |
T242K |
probably damaging |
Het |
| Psma6 |
G |
A |
12: 55,454,317 (GRCm39) |
C28Y |
probably damaging |
Het |
| Pyurf |
A |
T |
6: 57,668,817 (GRCm39) |
C58* |
probably null |
Het |
| Rab3gap2 |
C |
A |
1: 185,016,081 (GRCm39) |
A1331E |
probably benign |
Het |
| Rnase4 |
T |
C |
14: 51,342,722 (GRCm39) |
*149Q |
probably null |
Het |
| Ruvbl2 |
T |
C |
7: 45,074,586 (GRCm39) |
K184R |
probably benign |
Het |
| Scn7a |
T |
G |
2: 66,510,527 (GRCm39) |
M1292L |
probably benign |
Het |
| Scn7a |
A |
T |
2: 66,531,231 (GRCm39) |
Y549N |
probably damaging |
Het |
| Selp |
A |
G |
1: 163,959,854 (GRCm39) |
D370G |
possibly damaging |
Het |
| Slc22a15 |
G |
A |
3: 101,767,769 (GRCm39) |
Q386* |
probably null |
Het |
| Slc22a29 |
A |
G |
19: 8,195,126 (GRCm39) |
|
probably null |
Het |
| Slc26a7 |
A |
C |
4: 14,548,491 (GRCm39) |
I266S |
possibly damaging |
Het |
| Smpd4 |
T |
C |
16: 17,443,872 (GRCm39) |
S112P |
probably damaging |
Het |
| Smpd4 |
T |
A |
16: 17,458,744 (GRCm39) |
L165Q |
probably damaging |
Het |
| Snx33 |
A |
G |
9: 56,833,982 (GRCm39) |
I29T |
probably benign |
Het |
| Spen |
G |
A |
4: 141,203,686 (GRCm39) |
P1647L |
unknown |
Het |
| Strip2 |
T |
C |
6: 29,941,940 (GRCm39) |
|
probably null |
Het |
| Swsap1 |
C |
T |
9: 21,867,280 (GRCm39) |
R75* |
probably null |
Het |
| Tesl1 |
A |
G |
X: 23,772,990 (GRCm39) |
I164V |
probably benign |
Het |
| Tmem210 |
C |
T |
2: 25,178,435 (GRCm39) |
T32I |
probably damaging |
Het |
| Tnn |
C |
T |
1: 159,975,154 (GRCm39) |
R91H |
possibly damaging |
Het |
| Tnni1 |
G |
A |
1: 135,736,420 (GRCm39) |
R94H |
probably damaging |
Het |
| Tnrc6c |
T |
A |
11: 117,651,556 (GRCm39) |
V1693D |
probably benign |
Het |
| Trip4 |
G |
A |
9: 65,782,259 (GRCm39) |
Q158* |
probably null |
Het |
| Ttc39b |
T |
C |
4: 83,155,586 (GRCm39) |
E474G |
probably damaging |
Het |
| Usp50 |
C |
A |
2: 126,617,782 (GRCm39) |
C221F |
probably damaging |
Het |
| Vmn1r171 |
T |
C |
7: 23,331,781 (GRCm39) |
I2T |
probably benign |
Het |
| Wdr62 |
T |
A |
7: 29,967,328 (GRCm39) |
I309F |
probably damaging |
Het |
| Xdh |
A |
T |
17: 74,217,204 (GRCm39) |
V688E |
probably damaging |
Het |
| Zfyve26 |
A |
G |
12: 79,285,718 (GRCm39) |
L2353P |
probably damaging |
Het |
| Zgpat |
C |
A |
2: 181,020,633 (GRCm39) |
R269S |
probably damaging |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTCTGCGATTACATACACGGC -3'
(R):5'- TACATGCTCTCCTCCATGTACGGG -3'
Sequencing Primer
(F):5'- GCGATTACATACACGGCATTTC -3'
(R):5'- gctgaggcaggaggattac -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation