Incidental Mutation 'R1759:Tiam2'
| ID |
195237 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
039791-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1759 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 3566278 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 1441
(H1441R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041003]
[ENSMUST00000072156]
[ENSMUST00000169838]
[ENSMUST00000227405]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041003
|
| SMART Domains |
Protein: ENSMUSP00000035291
Gene: ENSMUSG00000036983
| Domain | Start | End | E-Value | Type |
|---|
|
rADc
|
43 |
234 |
5.56e-69 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072156
AA Change: H1441R
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: H1441R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169838
AA Change: H1441R
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: H1441R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226913
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226997
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227405
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9330159F19Rik |
A |
T |
10: 29,094,272 (GRCm39) |
M53L |
possibly damaging |
Het |
| Abca5 |
T |
C |
11: 110,184,674 (GRCm39) |
D944G |
probably benign |
Het |
| Ankdd1b |
T |
C |
13: 96,556,211 (GRCm39) |
Y433C |
probably damaging |
Het |
| Aox3 |
A |
G |
1: 58,209,805 (GRCm39) |
|
probably null |
Het |
| Ap1g1 |
G |
A |
8: 110,559,853 (GRCm39) |
G260E |
probably damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atp13a4 |
T |
A |
16: 29,275,429 (GRCm39) |
T352S |
probably damaging |
Het |
| Ccdc33 |
T |
A |
9: 58,024,729 (GRCm39) |
N166Y |
possibly damaging |
Het |
| Ces2h |
T |
A |
8: 105,743,243 (GRCm39) |
D159E |
probably damaging |
Het |
| Chd1 |
T |
A |
17: 17,607,533 (GRCm39) |
D360E |
probably benign |
Het |
| Col16a1 |
G |
T |
4: 129,978,062 (GRCm39) |
G781V |
probably damaging |
Het |
| Col6a5 |
T |
A |
9: 105,808,045 (GRCm39) |
E1001V |
unknown |
Het |
| Cracdl |
A |
T |
1: 37,664,791 (GRCm39) |
I369N |
probably benign |
Het |
| Cyp3a59 |
T |
G |
5: 146,035,060 (GRCm39) |
M246R |
probably benign |
Het |
| Dcn |
T |
C |
10: 97,349,517 (GRCm39) |
V263A |
probably benign |
Het |
| Dnttip2 |
A |
G |
3: 122,069,798 (GRCm39) |
N338D |
probably benign |
Het |
| Entpd1 |
G |
T |
19: 40,600,968 (GRCm39) |
|
probably null |
Het |
| Epb41l1 |
A |
G |
2: 156,363,894 (GRCm39) |
D801G |
probably benign |
Het |
| Fam186a |
T |
A |
15: 99,864,762 (GRCm39) |
K23* |
probably null |
Het |
| Gbe1 |
T |
C |
16: 70,284,929 (GRCm39) |
M417T |
probably benign |
Het |
| Gmnc |
T |
A |
16: 26,784,497 (GRCm39) |
S3C |
possibly damaging |
Het |
| Gpr156 |
T |
C |
16: 37,768,583 (GRCm39) |
S35P |
probably damaging |
Het |
| Grid1 |
T |
C |
14: 35,167,988 (GRCm39) |
M504T |
possibly damaging |
Het |
| Gsdma3 |
T |
C |
11: 98,526,071 (GRCm39) |
V265A |
possibly damaging |
Het |
| Hsd3b3 |
A |
T |
3: 98,649,399 (GRCm39) |
I308N |
probably damaging |
Het |
| Inpp4b |
A |
G |
8: 82,494,732 (GRCm39) |
D49G |
probably benign |
Het |
| Ipmk |
C |
A |
10: 71,217,133 (GRCm39) |
Q227K |
probably damaging |
Het |
| Kalrn |
T |
A |
16: 34,181,320 (GRCm39) |
D88V |
probably damaging |
Het |
| Kansl1l |
C |
T |
1: 66,841,047 (GRCm39) |
M84I |
probably damaging |
Het |
| Kcnab2 |
T |
G |
4: 152,477,509 (GRCm39) |
K363Q |
probably damaging |
Het |
| Kdm7a |
C |
A |
6: 39,124,633 (GRCm39) |
|
probably null |
Het |
| Kiss1r |
T |
C |
10: 79,757,612 (GRCm39) |
L322P |
probably damaging |
Het |
| Lce1e |
A |
T |
3: 92,615,178 (GRCm39) |
C56* |
probably null |
Het |
| Lrpprc |
T |
C |
17: 85,047,509 (GRCm39) |
K908E |
probably damaging |
Het |
| Mak |
C |
A |
13: 41,210,110 (GRCm39) |
W42L |
probably damaging |
Het |
| Map3k21 |
A |
G |
8: 126,671,519 (GRCm39) |
T936A |
probably benign |
Het |
| Marchf7 |
C |
T |
2: 60,064,888 (GRCm39) |
S388F |
probably damaging |
Het |
| Matcap1 |
A |
T |
8: 106,012,182 (GRCm39) |
S88R |
probably damaging |
Het |
| Mgat2 |
A |
T |
12: 69,232,301 (GRCm39) |
I292F |
probably benign |
Het |
| Myh3 |
C |
A |
11: 66,987,717 (GRCm39) |
R1397S |
probably damaging |
Het |
| Myo5a |
A |
G |
9: 75,089,275 (GRCm39) |
D1135G |
possibly damaging |
Het |
| N4bp2 |
A |
G |
5: 65,983,956 (GRCm39) |
E1667G |
probably damaging |
Het |
| Nbr1 |
A |
G |
11: 101,450,369 (GRCm39) |
T43A |
probably damaging |
Het |
| Nip7 |
A |
G |
8: 107,784,767 (GRCm39) |
N124S |
probably benign |
Het |
| Or3a1 |
G |
A |
11: 74,225,808 (GRCm39) |
S83F |
possibly damaging |
Het |
| Or51l14 |
T |
C |
7: 103,101,356 (GRCm39) |
S271P |
probably benign |
Het |
| Or6c75 |
T |
A |
10: 129,336,775 (GRCm39) |
S7R |
probably benign |
Het |
| Or7g25 |
C |
T |
9: 19,160,384 (GRCm39) |
V104I |
probably benign |
Het |
| Or8b55 |
T |
C |
9: 38,727,194 (GRCm39) |
Y132H |
probably damaging |
Het |
| Otoa |
T |
C |
7: 120,733,326 (GRCm39) |
L731P |
probably damaging |
Het |
| Pcnx2 |
G |
A |
8: 126,500,717 (GRCm39) |
P1458S |
probably damaging |
Het |
| Pfpl |
A |
G |
19: 12,407,224 (GRCm39) |
T492A |
probably damaging |
Het |
| Pgm1 |
A |
G |
4: 99,824,305 (GRCm39) |
D326G |
probably damaging |
Het |
| Plekhh1 |
T |
A |
12: 79,119,535 (GRCm39) |
Y953N |
probably damaging |
Het |
| Pnkd |
G |
A |
1: 74,387,922 (GRCm39) |
A195T |
probably damaging |
Het |
| Ppib |
C |
T |
9: 65,968,764 (GRCm39) |
Q51* |
probably null |
Het |
| Ppip5k1 |
G |
T |
2: 121,181,067 (GRCm39) |
T13K |
probably benign |
Het |
| Psmg2 |
A |
T |
18: 67,781,246 (GRCm39) |
S113C |
probably benign |
Het |
| Rapgef2 |
A |
G |
3: 78,974,038 (GRCm39) |
M1584T |
possibly damaging |
Het |
| Rbm12b1 |
A |
C |
4: 12,145,424 (GRCm39) |
R465S |
probably damaging |
Het |
| Reln |
A |
G |
5: 22,215,287 (GRCm39) |
Y1055H |
probably damaging |
Het |
| Ros1 |
A |
T |
10: 51,996,922 (GRCm39) |
I1250K |
probably damaging |
Het |
| Samd9l |
C |
A |
6: 3,373,401 (GRCm39) |
V1287F |
probably damaging |
Het |
| Sgce |
A |
T |
6: 4,689,765 (GRCm39) |
I356N |
probably damaging |
Het |
| Sh3tc1 |
C |
T |
5: 35,863,248 (GRCm39) |
E980K |
possibly damaging |
Het |
| Sil1 |
T |
C |
18: 35,551,151 (GRCm39) |
E68G |
possibly damaging |
Het |
| Slc18a1 |
A |
G |
8: 69,518,237 (GRCm39) |
I259T |
possibly damaging |
Het |
| Slc6a20b |
A |
C |
9: 123,438,062 (GRCm39) |
|
probably null |
Het |
| Smg7 |
G |
T |
1: 152,724,597 (GRCm39) |
T536K |
probably benign |
Het |
| Smyd4 |
A |
G |
11: 75,273,192 (GRCm39) |
Y84C |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Sorbs2 |
A |
T |
8: 46,216,056 (GRCm39) |
*50C |
probably null |
Het |
| Speg |
A |
T |
1: 75,377,806 (GRCm39) |
M855L |
possibly damaging |
Het |
| Srrt |
G |
T |
5: 137,301,212 (GRCm39) |
H71Q |
probably damaging |
Het |
| St6galnac5 |
A |
G |
3: 152,552,130 (GRCm39) |
S146P |
probably damaging |
Het |
| Syne1 |
T |
A |
10: 5,299,369 (GRCm39) |
Q962L |
probably damaging |
Het |
| Tmem45a |
C |
T |
16: 56,642,765 (GRCm39) |
M135I |
probably benign |
Het |
| Tpr |
A |
T |
1: 150,305,275 (GRCm39) |
E1521D |
probably benign |
Het |
| Uba3 |
C |
T |
6: 97,173,865 (GRCm39) |
G107R |
probably damaging |
Het |
| Unc45b |
G |
T |
11: 82,820,325 (GRCm39) |
V590F |
probably benign |
Het |
| Vmn1r14 |
A |
T |
6: 57,211,297 (GRCm39) |
T292S |
probably benign |
Het |
| Vmn2r102 |
T |
A |
17: 19,914,755 (GRCm39) |
N773K |
probably damaging |
Het |
| Vps13d |
A |
T |
4: 144,882,427 (GRCm39) |
D1055E |
probably benign |
Het |
| Wfs1 |
G |
C |
5: 37,124,359 (GRCm39) |
A844G |
probably damaging |
Het |
| Zfp398 |
A |
G |
6: 47,836,412 (GRCm39) |
T71A |
possibly damaging |
Het |
| Zfp507 |
C |
A |
7: 35,475,403 (GRCm39) |
A145S |
probably damaging |
Het |
| Zfp971 |
A |
T |
2: 177,675,722 (GRCm39) |
E440D |
probably damaging |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTATCACAGAGTGTGCCGTGGAAG -3'
(R):5'- CTTACCCCACCAATATGTGCCTGAC -3'
Sequencing Primer
(F):5'- TGTGCCGTGGAAGGAAATG -3'
(R):5'- gttgtcagagcccacagag -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation