Incidental Mutation 'R1781:Trip12'
| ID |
195250 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
039812-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1781 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84708342 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 1739
(F1739I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139563
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000187733]
[ENSMUST00000189670]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027421
AA Change: F1772I
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: F1772I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185720
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186465
AA Change: F1772I
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: F1772I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186648
AA Change: F1739I
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: F1739I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187733
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189670
AA Change: F577I
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
AA Change: F577I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191187
|
| Meta Mutation Damage Score |
0.0727 |
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 94.6%
- 20x: 90.1%
|
| Validation Efficiency |
97% (88/91) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
G |
3: 59,932,117 (GRCm39) |
K211E |
probably damaging |
Het |
| Abca13 |
T |
A |
11: 9,219,194 (GRCm39) |
L376Q |
probably damaging |
Het |
| Abca17 |
T |
C |
17: 24,486,531 (GRCm39) |
T1499A |
possibly damaging |
Het |
| Anks6 |
A |
C |
4: 47,043,639 (GRCm39) |
N363K |
possibly damaging |
Het |
| Apob |
T |
A |
12: 8,059,603 (GRCm39) |
I2695N |
possibly damaging |
Het |
| Arhgef18 |
C |
T |
8: 3,430,495 (GRCm39) |
R123W |
probably damaging |
Het |
| Atg14 |
T |
A |
14: 47,786,607 (GRCm39) |
|
probably null |
Het |
| Atg2a |
A |
T |
19: 6,306,243 (GRCm39) |
I1368F |
probably damaging |
Het |
| Btbd9 |
A |
G |
17: 30,732,567 (GRCm39) |
S373P |
probably damaging |
Het |
| Ccdc83 |
T |
C |
7: 89,899,749 (GRCm39) |
E41G |
probably damaging |
Het |
| Ccnh |
T |
C |
13: 85,354,254 (GRCm39) |
S233P |
possibly damaging |
Het |
| Cdh8 |
T |
C |
8: 99,917,094 (GRCm39) |
|
probably null |
Het |
| Cdh8 |
A |
T |
8: 100,006,290 (GRCm39) |
I99N |
probably damaging |
Het |
| Cdr2 |
G |
A |
7: 120,557,268 (GRCm39) |
P419L |
probably benign |
Het |
| Cds1 |
T |
A |
5: 101,960,416 (GRCm39) |
I289K |
possibly damaging |
Het |
| Cherp |
G |
A |
8: 73,221,615 (GRCm39) |
T394I |
probably damaging |
Het |
| Cyp4f17 |
T |
G |
17: 32,742,993 (GRCm39) |
I222S |
possibly damaging |
Het |
| Dcc |
A |
G |
18: 71,511,788 (GRCm39) |
S856P |
probably benign |
Het |
| Dcp1a |
C |
T |
14: 30,235,032 (GRCm39) |
T221I |
probably benign |
Het |
| Ddx10 |
A |
G |
9: 53,118,845 (GRCm39) |
S475P |
probably damaging |
Het |
| Dennd5b |
G |
T |
6: 148,928,896 (GRCm39) |
A759E |
probably damaging |
Het |
| Disp2 |
G |
A |
2: 118,623,042 (GRCm39) |
G1258D |
probably damaging |
Het |
| Fhdc1 |
A |
T |
3: 84,356,111 (GRCm39) |
D444E |
probably damaging |
Het |
| Fhod1 |
T |
C |
8: 106,074,421 (GRCm39) |
|
probably benign |
Het |
| Gcnt7 |
T |
C |
2: 172,296,800 (GRCm39) |
K8R |
probably benign |
Het |
| Gk5 |
C |
T |
9: 96,015,508 (GRCm39) |
T108I |
possibly damaging |
Het |
| Gm8214 |
C |
A |
1: 183,414,129 (GRCm39) |
|
noncoding transcript |
Het |
| Gnl1 |
A |
T |
17: 36,298,638 (GRCm39) |
I434F |
probably damaging |
Het |
| Golga2 |
T |
C |
2: 32,196,588 (GRCm39) |
Y986H |
probably damaging |
Het |
| Gpr21 |
T |
C |
2: 37,407,550 (GRCm39) |
V32A |
probably benign |
Het |
| Grb14 |
A |
T |
2: 64,805,899 (GRCm39) |
|
probably null |
Het |
| H6pd |
A |
T |
4: 150,080,388 (GRCm39) |
F144L |
probably damaging |
Het |
| Hunk |
A |
G |
16: 90,229,448 (GRCm39) |
Y27C |
probably damaging |
Het |
| Ints7 |
C |
T |
1: 191,328,396 (GRCm39) |
T223M |
possibly damaging |
Het |
| Kcnmb2 |
T |
C |
3: 32,233,152 (GRCm39) |
|
probably null |
Het |
| Lilra6 |
A |
T |
7: 3,918,066 (GRCm39) |
L26H |
probably benign |
Het |
| Mc4r |
A |
T |
18: 66,992,918 (GRCm39) |
V65E |
probably damaging |
Het |
| Mgam |
G |
A |
6: 40,646,797 (GRCm39) |
G708R |
probably damaging |
Het |
| Mllt6 |
A |
G |
11: 97,563,395 (GRCm39) |
D326G |
probably benign |
Het |
| Myo7a |
A |
T |
7: 97,722,331 (GRCm39) |
V1198D |
probably damaging |
Het |
| Nampt |
T |
C |
12: 32,883,037 (GRCm39) |
V74A |
probably damaging |
Het |
| Nlrp4b |
G |
C |
7: 10,449,266 (GRCm39) |
V123L |
probably benign |
Het |
| Ntpcr |
T |
A |
8: 126,472,141 (GRCm39) |
L150Q |
probably damaging |
Het |
| Obscn |
C |
T |
11: 58,997,163 (GRCm39) |
E1513K |
probably damaging |
Het |
| Ola1 |
T |
C |
2: 72,987,099 (GRCm39) |
K178E |
possibly damaging |
Het |
| Opalin |
T |
C |
19: 41,056,070 (GRCm39) |
|
probably null |
Het |
| Or10g6 |
A |
G |
9: 39,934,541 (GRCm39) |
N284S |
probably damaging |
Het |
| Or13a20 |
A |
T |
7: 140,232,419 (GRCm39) |
I176F |
probably damaging |
Het |
| Or2ad1 |
C |
T |
13: 21,326,934 (GRCm39) |
V98I |
probably benign |
Het |
| Or2w2 |
C |
T |
13: 21,757,711 (GRCm39) |
G305D |
probably damaging |
Het |
| Or3a10 |
A |
T |
11: 73,935,786 (GRCm39) |
F105I |
probably damaging |
Het |
| Or51ah3 |
C |
T |
7: 103,209,773 (GRCm39) |
P30S |
probably benign |
Het |
| Or52ae9 |
T |
C |
7: 103,390,028 (GRCm39) |
M140V |
probably benign |
Het |
| Or52e15 |
A |
T |
7: 104,645,315 (GRCm39) |
F265L |
possibly damaging |
Het |
| Or5p62 |
A |
G |
7: 107,771,090 (GRCm39) |
V287A |
probably benign |
Het |
| Or7a35 |
T |
C |
10: 78,853,159 (GRCm39) |
M1T |
probably null |
Het |
| P2ry12 |
A |
G |
3: 59,125,199 (GRCm39) |
F159L |
probably benign |
Het |
| Paqr7 |
T |
C |
4: 134,234,592 (GRCm39) |
|
probably null |
Het |
| Parp1 |
T |
C |
1: 180,415,578 (GRCm39) |
S466P |
probably benign |
Het |
| Parp4 |
T |
A |
14: 56,864,838 (GRCm39) |
|
probably null |
Het |
| Pcdh1 |
T |
C |
18: 38,322,977 (GRCm39) |
D952G |
probably damaging |
Het |
| Pde6c |
T |
C |
19: 38,140,146 (GRCm39) |
S336P |
possibly damaging |
Het |
| Pgk2 |
T |
C |
17: 40,519,398 (GRCm39) |
D10G |
probably benign |
Het |
| Phf20l1 |
A |
G |
15: 66,504,674 (GRCm39) |
T771A |
probably damaging |
Het |
| Pkdrej |
A |
G |
15: 85,705,372 (GRCm39) |
V188A |
possibly damaging |
Het |
| Plekhm1 |
A |
G |
11: 103,285,682 (GRCm39) |
L251P |
probably damaging |
Het |
| Prex2 |
A |
T |
1: 11,270,179 (GRCm39) |
N1288I |
probably benign |
Het |
| Sarnp |
T |
C |
10: 128,669,191 (GRCm39) |
L16P |
probably damaging |
Het |
| Scgb3a2 |
T |
C |
18: 43,900,033 (GRCm39) |
|
probably benign |
Het |
| Scn11a |
A |
T |
9: 119,584,148 (GRCm39) |
I1489N |
probably damaging |
Het |
| Scn3a |
A |
T |
2: 65,302,729 (GRCm39) |
L1239Q |
probably damaging |
Het |
| Shisa9 |
T |
C |
16: 12,085,521 (GRCm39) |
S377P |
probably benign |
Het |
| Slc22a30 |
T |
A |
19: 8,313,136 (GRCm39) |
T550S |
probably damaging |
Het |
| Slc25a11 |
T |
C |
11: 70,535,651 (GRCm39) |
T296A |
probably benign |
Het |
| Slc35f1 |
T |
A |
10: 52,938,532 (GRCm39) |
|
probably null |
Het |
| Slc6a13 |
A |
G |
6: 121,311,811 (GRCm39) |
E396G |
probably damaging |
Het |
| Spata31d1c |
T |
C |
13: 65,183,985 (GRCm39) |
I509T |
probably benign |
Het |
| Srsf9 |
C |
A |
5: 115,465,481 (GRCm39) |
Y9* |
probably null |
Het |
| Tasor2 |
T |
C |
13: 3,634,759 (GRCm39) |
T683A |
possibly damaging |
Het |
| Tbx20 |
T |
C |
9: 24,636,795 (GRCm39) |
I431V |
probably benign |
Het |
| Tespa1 |
G |
A |
10: 130,184,119 (GRCm39) |
G67S |
probably benign |
Het |
| Trhde |
A |
T |
10: 114,424,405 (GRCm39) |
V460E |
possibly damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Umodl1 |
G |
A |
17: 31,187,524 (GRCm39) |
R196H |
probably damaging |
Het |
| Vezf1 |
G |
T |
11: 87,972,447 (GRCm39) |
M269I |
probably benign |
Het |
| Vmn1r35 |
A |
T |
6: 66,656,550 (GRCm39) |
M40K |
probably benign |
Het |
| Vmn1r9 |
G |
T |
6: 57,048,300 (GRCm39) |
C125F |
probably benign |
Het |
| Vmn2r12 |
C |
A |
5: 109,239,594 (GRCm39) |
G323V |
probably benign |
Het |
| Vmn2r79 |
A |
T |
7: 86,651,555 (GRCm39) |
H318L |
probably benign |
Het |
| Zfhx3 |
T |
A |
8: 109,520,167 (GRCm39) |
S430T |
probably benign |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAATGAGAAGGTATCCGCTTATGCCTA -3'
(R):5'- GCAGAAATTTGAGTCCCAGTTTGTGGT -3'
Sequencing Primer
(F):5'- agacacacatgcaggcac -3'
(R):5'- AGTCCCAGTTTGTGGTTCTTAATTTC -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation